Effect of Platelet-Rich Fibrin on Repair of Defect in the Articular Disc in Rabbit Temporomandibular Joint by Platelet-Rich Fibrin

( Hyun Su Baek ),( Hye Sung Lee ),( Bok Joo Kim ),( In Kyo Chung ),( Chul Hoon Kim ),( Sun Mi Jin ),( Hie Sung Hwang ),( Sang Hun Shin2 ) 한국조직공학·재생의학회 2011 조직공학과 재생의학 Vol.8 No.6

The objective of this study was to evaluate platelet-rich fibrin (PRF)’s effectiveness in repairing articular disc defect in the temporomandibular joint (TMJ) of rabbits. Eight rabbits were divided into four groups of two rabbits each, corresponding to groups A, B, C, and D. Both TMJs of all of the rabbits were used in the experiments: the right joints comprised the experimental groups, and the left ones, the control groups. The disc defect was circular and 2 mm in diameter. In the experimental groups, the PRF was compressed into the defect, whereas the control group defects were left untreated. A, B, C, and D groups were sacrificed at the 1st, 2nd, 4th and 6th weeks, respectively. The defects of each control group exhibited no specific changes. Contrastingly, in each experimental group, there was an increased number of chondroblasts at the margins of the defects, along with accelerated cell differentiation and a columnar cell arrangement observable at the time of cell differentiation. The experimental groups showed inflammatory cell infiltrations and fibrosis by the 1st week, maturation of chondrocytes by the 2nd week, and proliferation by the 4th week, after which the defects began to be filled with chondrocytes, a process that was complete after the 6th week. In the histological evaluation (H-E), the experimental groups showed significant increases of chondroblasts after the 2nd and 4th weeks, as well as regular columns of chondrocyte arrays observable during cell division. After 6 weeks, the defects were filled with chondrocytes.

과학교사들의 2009 개정 교육과정 융합형 “과학” 수용에 관한 인과 모델 연구

하민수 ( Min Su Ha ),신세인 ( Se In Shin ),이준기 ( Jun Ki Lee ),박현주 ( Hyun Ju Park ),정덕호 ( Duk Ho Chung ),임재근 ( Jae Keun Lim ) 한국과학교육학회 2014 한국과학교육학회지 Vol.34 No.3

This study aims to explore how in-service science teachers adopt newly developed ‘Science`` focusing on the fusion of science based on ‘the diffusion of innovation`` model. For this study, we have explored five variables (i.e. perception of need, perception of support, innovativeness, perceived usefulness, to measure the level of five variables that in-service science teachers perceive. In addition, the path model of six variables explaining how in-service teachers adopt an innovation was hypothesized by the literature review. A total of 349 in-service teachers have not significantly associated with in-service science teachers` teaching experiences, participation in professional development programs on ‘Science`` curriculum, and majors, In addition, the statistically acceptable model fit indices have illustrated that path model has been statistically valid to explain how in-service science teachers adopt newly developed ‘Science`` focusing on the fusion of science. The results have also illusteated that ‘perception of support`` , perceived usefulness`, and ‘self-efficacy of teaching`` exhibited strong mediating effects between other variables, For the successful estabiishment of newly development of new science teacher professional development programs to promote the level of teachers` intention to adopt innovations.

Spontaneous Pt Deposition on Defective Surfaces of In₂O₃ Nanocrystals Confined within Cavities of Hollow Silica Nanoshells: Pt Catalyst-Modified ITO Electrode with Enhanced ECL Performance

Cho, Young Shin,Kim, Soo Min,Ju, Youngwon,Kim, Junghoon,Jeon, Ki-Wan,Cho, Seung Hwan,Kim, Joohoon,Lee, In Su American Chemical Society 2017 ACS APPLIED MATERIALS & INTERFACES Vol.9 No.24

<P>Although the deposition of metallic domains on a preformed semiconductor nanocrystal provides an effective pathway to access diverse hybrid nanocrystals with synergistic In2O3 metal/semiconductor heterojunction interface, those reactions that take place on the surface of semiconductor nanoscrystals have not been investigated thoroughly, because of the impediments caused by the surface-capping organic surfactants. By exploiting the interfacial reactions occurring between the solution and nanoparticles confined with the cavities of hollow nanoparticles, we propose a novel nanospace-confined strategy for assessing the innate reactivity of surfaces of inorganic semiconductor nanoparticles. This strategy was adopted to investigate the newly discovered process of spontaneous Pt deposition on In2O3 nanocrystals. Through an in-depth examination involving varying key reaction parameters, the Pt deposition process was identified to be templated by the defective In2O3 surface via a unique redox process involving the oxygen vacancies in the In2O3 lattice, whose density can be controlled by high-temperature annealing. The product of the Pt-deposition reaction inside the hollow silica nanoparticle, bearing In2O3-supported Pt catalysts inside the cavity protected by a porous silica shell, was proved to be an effective nanoreactor system which selectively and sustainably catalyzed the reduction reaction of small-sized aromatic nitro-compounds. Moreover, the surfactant-free and electroless Pt deposition protocol, which was devised based on the surface chemistry of the In2O3 nanoparticles, was successfully employed to fabricate Pt-catalyst-modified ITO electrodes.with enhanced electrogenerated chemiluminescece (ECL) performance.</P>

P255 : Relationship between the HLA-G 14bp insertion/ deletion polymorphism and susceptibility to autoimmune disease: a mata-analysis

( June Hyuck Yim ),( Tae In Kim ),( In Jung Kang ),( Ki Heon Jeong ),( Su Kang Kim ),( Joo Ho Chung ),( Min Kyung Shin ),( Mu Hyoung Lee ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2

Background: Numerous studies have investigated the potentialrelationship of human leukocyte antigen (HLA)-G 14bp insertion/deletion (INS/DEL) polymorphism with autoimmune disease (AID). However, results from published data were inconclusive. Objectives: Our aim in this study was to determine whether the 14bp INS/DEL polymorphism in the HLA-G gene contributes to the risk of AID. Methods: A systemic literature search of PubMed and Embase databases was conducted to identify eligible studies investigating the association of HLA-G 14bp INS/DEL polymorphism with AID. The final analysis included 13 publications with a total of 6462 individuals. Results: Overall, no significant association between HLA-G 14-bp INS/DEL polymorphism and overall AID was detected in all comparison models. Further subgroup analyses based on AID types and ethnicity showed no significant association. Conclusion: Our results suggest that the HLA-G 14bp INS/DEL polymorphism might not be related to the development of AID. Further studies with larger sample size are warranted to validate our finding.

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

무선 센서 네트워크에서 효율적인 집계 질의 처리

김정준,신인수,이기영,한기준,Kim, Joung-Joon,Shin, In-Su,Lee, Ki-Young,Han, Ki-Joon 한국공간정보학회 2011 한국공간정보학회지 Vol.19 No.3

최근 무선 센서 네트워크에서 센서로부터 원하는 데이타를 가져오는 네트워크 내 집계 질의처리 기법에 대한 연구가 활발히 진행되고 있다. 기존의 대표적인 네트워크 내 집계 질의 처리 기법들은 집계 질의 처리를 위해 라우팅 알고리즘과 데이타 구조를 제안하고 있다. 그러나 이러한 기법들은 센서 노드들의 에너지 소모가 크고, 질의 처리 결과 정확도가 떨어지고, 또한 질의 처리 시간이 오래 걸리는 문제점들을 가지고 있다. 본 논문에서는 이러한 기존 집계 질의 처리 기법들의 문제점을 해결하고 무선 센서 네트워크에서 보다 효율적인 집계 질의 처리를 위해 BPA(Bucket-based Parallel Aggregation)를 제시하였다. BPA는 질의 영역을 센서 노드 분포에 따라 쿼드 트리로 구성하여 집계 질의를 병렬로 처리하고, 각 센서 노드로 하여금 데이타를 이중 전송하게 함으로써 전송 오류로 인한 데이타 손실을 줄인다. 또한, BPA는 집계 질의 처리시 버켓 기반의 데이타 구조를 이용하고 이러한 버켓 데이타 구조를 버켓내 데이타 개수에 따라 적응적으로 분할 및 합병한다. 특히 버켓내 데이타 크기를 줄이기 위해 데이타를 압축하고 데이타 전송 횟수를 줄이기 위해 필터링을 수행한다. 마지막으로 센서 데이타를 이용한 다양한 실험을 통해 본 논문에서 제안하는 BPA의 우수성을 입증하였다. Recently as efficient processing of aggregate queries for fetching desired data from sensors has been recognized as a crucial part, in-network aggregate query processing techniques are studied intensively in wireless sensor networks. Existing representative in-network aggregate query processing techniques propose routing algorithms and data structures for processing aggregate queries. However, these aggregate query processing techniques have problems such as high energy consumption in sensor nodes, low accuracy of query processing results, and long query processing time. In order to solve these problems and to enhance the efficiency of aggregate query processing in wireless sensor networks, this paper proposes Bucket-based Parallel Aggregation(BPA). BPA divides a query region into several cells according to the distribution of sensor nodes and builds a Quad-tree, and then processes aggregate queries in parallel for each cell region according to routing. And it sends data in duplicate by removing redundant data, which, in turn, enhances the accuracy of query processing results. Also, BPA uses a bucket-based data structure in aggregate query processing, and divides and conquers the bucket data structure adaptively according to the number of data in the bucket. In addition, BPA compresses data in order to reduce the size of data in the bucket and performs data transmission filtering when each sensor node sends data. Finally, in this paper, we prove its superiority through various experiments using sensor data.

Nelumbinis Semen Reverses a Decrease in $5-HT_{1A}$Receptor Binding Induced by Chronic Mild Stress, a Depression-like Symptom

Jang, Choon-Gon,Kang, Moon-Kyu,Cho, Jae-Han,Lee, Sun-Bok,Kim, Hyun-Taek,Park, Soon-Kwon,Lee, Jin-Woo,Park, Seong-Kyu,Hong, Moo-Chang,Shin, Min-Kyu,Shim, In-Sup,Bae , Hyun-Su The Pharmaceutical Society of Korea 2004 Archives of Pharmacal Research Vol.27 No.10

Depression is associated with a dysfunctional serotonin (5-hydroxytryptamine; 5-HT) system. More recently, several lines of evidence suggest that an important factor in the development of depression may be a deficit in the function and expression of $5-HT_{1A}$ receptors. The present study assessed if Nelumbinis Semen (N. s.) had an anti-depression effect through reversing a decrease in $5-HT_{1A}$receptor binding in rats with depression-like symptoms induced by chronic mild stress. Using a $5-HT_{1A}$ receptor binding assay, with a specific $5-HT_{1A}$receptor agonist, 8- OH-DPAT (8-hydroxy-2-(di-n-propylamino) tetralin), the mechanism of the anti-depression effect of N. s. on rats was investigated, and the effects compared with two well-known antidepressants, Hyperium Perforatum (St. Johns Wort) and fluoxetine (Prozac). Animals were divided into five groups: the normal (N) group without chronic mild stress (CMS), the control (C) group under CMS for 8 weeks, the Nelumbinis Semen (N. s.) treatment group under CMS for 8 weeks, the Hyperium Perforatum (H. p.) treatment group under CMS for 8 weeks and finally, the fluoxetine (F) treatment group under CMS for 8 weeks. Each treatment was administered to rats during the last 4 weeks of the 8-week CMS. A sucrose intake test was performed to test the anti-depression effect of N. s. The N. s. treatment significantly reversed the decreased sucrose intake under CMS (P<0.05 compared to control group under CMS). In the CA2 and CA3 regions of the hippocampus, both N. s. and H. p. reversed the CMS-induced decrease in $5-HT_{1A}$receptor binding. In the I to II regions of the frontal cortex, N. s. and H. p. also reversed the CMS-induced decrease in$5-HT_{1A}$receptor binding, and even showed a significant increase in $5-HT_{1A}$receptor binding compared to the F treatment group (N. s. vs. P, p<0.05, H. p. vs. P, p<0.05). However, in the hypothalamus, all treatments reversed the CMSinduced decrease in $5-HT_{1A}$receptor binding. This reversal effect of N. s. on the decrease in $5-HT_{1A}$receptor binding in the frontal cortex, hippocampus and hypothalamus of rat brains was very similar to that of H. p, but different from that of F. It is concluded that N. s. presents an anti-depression effect through enhancing $5-HT_{1A}$receptor binding.

강박증 환자에서 신경 심리 검사를 통한 전두엽 기능에 관한 연구

안경흡,김명선,김연수,박은희,박선희,신민섭,류인균,권준수 大韓神經精神醫學會 2000 신경정신의학 Vol.39 No.3

연구목적 : 강박증 환자에서 비언어적 기억의 장애, 실행능력(executive function)의 장애, 시공간능력의 장애등의 신경 인지 기능의 장애 및 뇌 영상 연구에서 전두엽-기저핵 신경로의 기능장애가 있다는 결과들이 보고되어 왔다. 저자들은 전두엽의 기능을 반영하는 것으로 알려진 신경 심리 검사를 통하여 강박증 환자의 전두엽의 기능적 변화의 유무 및 기타 인지기능에 미치는 영향에 대해서 평가하고자 하였다. 방 법 : 서울대학교병원 강박증 클리닉에 내원한 32명의 강박증 환자군과 28명의 정상 대조군을 대상으로 강박증상의 중증도에 대한 평가와 함께 한국판 단축형 지능검사(Short-form of K-WAIS)와 주로 전두엽 기능을 평가하는데 민감한 것으로 알려진 신경 인지 기능 검사군(위스콘신 카드 분류 검사, Rey-Os-terrieth Complex Figure test, Controlled Oral Word Association test, 선로 잇기 검사, Luria-Nebraska 신경심리 바테리 중 언어학습능력검사)을 시행하였다. 이 검사들의 결과를 연령과 교육연수를 통제한 후에 ANCOVA로 분석하였다. 결 과 ; 강방증 환자군은 범주적 언어 유창성 점수(ANCOVA, F=15.07, df=58, p<0.001), Rey-Os-terrieth Complex Figure test의 즉각 회상 점수(ANCOVA, F=6.33, df=57, p<0.015), Rey-Os-terrieth Complex Figure test의 지연 화상 점수(ANCOVA, F=5.33, df=57, p<0.022)가 정상 대조군에 비하여 유의하게 저하되어 있었다. 결 론 : 이 결과는 강박증 환자들이 전두엽의 특징적인 기능으로 알려진 실행기능보다는 비언어적 기억능력의 장애 및 언어능력의 장애를 가지고 있음을 시사한다. Objective : Non-verbal memory deficits, impairments in executive function and deficits in visuospartial functions have been repeatedly reported in subjects with obsessive-compulsive disorder(OCD). The present study aimed to evaluate the frontal lobe function using neuropsychological test in subjects with OCD and normal control. Methods : A battery of neuropsychological test(Wisconsin Card Sorting test, Rey-Osterrieth Complex Figure test, Controlled Oral Word Association test, Trail Making test, Verbal Learning test) reflecting frontal lobe function was administrated to 32 OCD patients and 28 healthy comparison subjects. Result : There were no significant differences in age, years of education, or estimated IQ between the groups. Scores in category fluency, immediate recall and delayed recall of Rey-Osterrieth Complex Figure test in OCD subjects were significantly lower than those of healthy comparison subjects(ANCOVA, F=15.07, df=58, p<0.001 ;ANCOVA, F=6.33, df=57, p<0.015 ; ANCOVA, F=5.33, df=57, p<0.022, respectively). Conclusion : OCD patients had selective deficits in task involving non-verbal memory and categorical word fluency relative to healthy comparisons.

자기개방성 증진을 위한 3D 상담 플랫폼 제안 - 20대의 심리상담 인식 개선을 중심으로

김새별(Sae-byeol Kim),박규희(Gyu-hee Park),신수영(Su-young Shin),장혜린(Hye-rin Jang),조유정(Yoo-jung Cho),최종인(Jon-in Choi),박수이(Su-E Park) 한국정보통신학회 2022 한국정보통신학회 종합학술대회 논문집 Vol.26 No.1

코로나19 이후 현대인이 겪는 정서적 문제가 높아지는 가운데, 심리상담에 대한 부정적 인식과 물리적 한계로 인한 내담자의 부담은 여전히 높다. 이에 본 연구는 비대면 관계에서 관계에 개방적인 20대의 특성을 이용하여 효과적인 상담을 위한 가상 심리상담 플랫폼을 제안하고자 한다. 이를 위해 20대를 대상으로 설문조사를 실시하고 상담사와의 심층 인터뷰를 진행하였다. 이후 Unity를 통해 3D 가상 상담 환경을 조성하여 PC 기반의 서비스를 구상하였다. 연구 결과, 20대가 상담에서 가장 중요하게 생각하는 요소는 상담사의 성향과 부담감 없는 분위기로 나타났으며 이는 심리 상담에서의 자기개방과 밀접한 관련이 있는 것으로 드러났다. 따라서 편안한 분위기로 조성된 3D 공간에서 상담사 캐릭터를 보며 상담에 참여할 수 있도록 하였고 상담 중 상담사와의 다양한 인터랙션 요소를 제공하였다. 본 연구의 의의는 20대 내담자의 자기개방성을 증진해 내담자의 적극적인 상담 참여를 목표로 한다. 이는 원활한 상담을 통해 심리 문제 개선에 큰 도움을 줄 것으로 보인다. As the emotional problems experienced by modern people after COVID-19 have increased, the burden on clients due to negative perceptions of psychological counseling and physical limitations is still high. Therefore, this study proposes a virtual counseling platform for effective counseling using the characteristics of people in their 20s who are open to relationships in non-face-to-face relationships. To this end, a survey was conducted for those in their 20s and in-depth interviews with counselors were conducted. After that a 3D virtual counseling environment was created through Unity to PC-based service. As a result of the study, it was found that the most important factor in counseling in the 20s was the tendency of counselors and an atmosphere without burden, which was closely related to self-opening in counseling. Therefore, it was possible to participate in counseling while looking at the counselor character in a 3D space created in comfortable atmosphere, and various interaction elements with the counselor were provided during counseling. The significance of this study aims to promote self-openness of clients in their 20s and actively participate in counseling. This is expected to greatly help improve psychological problems through counseling.

Developing Core Elements and Checklist Items for Implementing Antimicrobial Stewardship Programs in Korean General Hospitals: A Modified Delphi Survey

Cheong Hae Suk,Park Kyung-Hwa,Kim Bongyoung,Eun Byung Wook,Kim Hyung-Sook,Kim Yong Chan,Lee Hyukmin,Jeong Su Jin,Moon Chisook,Kim Shin-Woo,Yoon Young Kyung,Hwang In Sun,Park Choon-Seon,Lee Mi Suk,Kim 대한감염학회 2023 Infection and Chemotherapy Vol.55 No.1

Background: Antimicrobial stewardship programs (ASPs) aim to optimize antimicrobial use by minimizing the spread of antimicrobial resistance. The core elements for implementing ASPs in healthcare facilities have been developed by the World Health Organization, international research group and government agencies of various countries. However, to date, there is no documented core elements for implementation of ASP in Korea. This survey aimed to establish a national consensus on a set of core elements and their related checklist items for the implementation of ASPs in Korean general hospitals. Materials and Methods: The survey was conducted from July 2022 to August 2022 by the Korean Society for Antimicrobial Therapy with support from the Korea Disease Control and Prevention Agency. A literature review was conducted by searching Medline and relevant websites to retrieve a list of core elements and checklist items. These core elements and checklist items were evaluated by a multidisciplinary panel of experts using a structured modified Delphi consensus procedure, using two-step survey included online in-depth questionnaires and in-person meeting. Results: The literature review identified 6 core elements (Leadership commitment, Operating system, Action, Tracking, Reporting, and Education) and 37 related checklist items. Fifteen experts participated in the consensus procedures. Ultimately, all 6 core elements were retained, and 28 checklist items were proposed, all with ≥80% agreement; in addition 9 items were merged into 2 items, 2 items were deleted, and 15 items were rephrased. Conclusion: This Delphi survey provides useful indicators for the implementation of ASP in Korea and suggests national policy improvement about the barriers (e.g., shortage of staffing and financial support) existing in Korea for optimal implementation of ASPs.