근긴장성 이영양증 환자 1례에 대한 보고

권용욱,조종훈,정필현,강석 東國大學校醫學硏究所 1997 東國醫學 Vol.4 No.-

근긴장성 이영양증은 1909년 Steinert에 의해 처음으로 보고된 질환으로 상염색체 우성유전으로 발현되며 근긴장증 이외에 전신증상이 함께 나타나는데, 전두두 대머리, 긴 얼굴, 안검하수, 역전된 미소모양의 입술등이 보이고 식도, 대장, 자궁 등의 평활근도 침범하여 연하곤란, 구음장애, 변비, 분만장애 등을 일으킬 수 있다. 또한 심장비대와 심장전도의 이상을 동반하는 경우 이로 인한 부정맥이 주요 사망원인이 될 수 있다. 이러한 특징적인 임상증상 외에 근전도 검사상 일명 dive bomber sound 또는 motorcycle sound를 보이는 운동단위전위가 특징적으로 관찰된다. 본 교실에서는 좌측 근위약을 호소하고 원위부보다 근위부 근력이 더 심하게 약화되어 있는 근긴장성 이 영양증 환자 1례를 경험하였기에 문헌고찰과 함께 보고하는 바이다. Myotonic dystrophy, first described by Steinert in 1909, is an autosomal dominant multisystem diease. Most patients note the insidious onset of weakness in the limb muscles or difficulty relaxing muscles after a strong contraction. The evidence of Multisystem involvement includes early frontal balding, less than average intelligence, posterior subcapsular cataracts, abnormal cardiac conduction and testicular tubular cell atrophy. In addition, there is wasting of the facial musculature, including the temporalis, masseter, and stemocleidomastoid muscles, which produces a characteristic long face with ptosis, hollow temples, and a hanging jaw. Electromyography is extremely helpful in making the diagnosis. The presence of myotonic discharges in affected muscles is characteristic finding in electromygraphy. Both the amplitude of the potentials and the frequency of the discharges wax and wane. The sound of the discharges is quite characteristic and in their recognition which is similar to a dive bomber sound or motorcycle sound. We recently experienced a case of myotonic dystrophy who complained unusual symptoms such as the left side weakness, proximal muscle weakness rather than distal muscle weakness. So we report this case with review of the literatures.

보리등겨로 제조한 간장의 향기성분

권오준,이은정,최웅규,손동화,이석일,정연건,지원대 한국위생과학회 2002 한국위생과학회지 Vol.8 No.2

새로운 장류제품으로서 보리등겨의 이용방안을 모색하기 위하여 간장을 만들어 연구하였다. 보리로 제조한 간장의 갈색화는 점차적으로 증가 하였으며 완만한 변화를 보였다. 향기성분으로는 4-vinyl-2-methoxy-phenol, benzeneacetaldehyde, palmitic acid, 2-furancatboxaldehyde, methyl-9, 12-octadecadienoate, di-(2-ethylhexyl)phthalate, diethyl phtalate, dibytyl-1,2-benzenedicatboxylate, 5-methyl-2-furancarboxaldehyde, 3,4-dimethyl-1h-pyrazole, phenylethyl alcohol, dioctyl-hexanedioate, dimethyl-1,2-benzenedicatboxylate, benzaldehyde, methional, 2-methoxy-phenol, n-furfurylidene-3-methylbutyl amine, 1-furfuryl-2-formyl pyrrole, tetradrcanoic acid, 5-methyl-pyrimidine, 4-methyl-5-hydroxymethyl-imidazole, maltol, 5-(5-methyl-2-furanyl)methyl-2-furancarboxaldehyde 순으로 높은 함량을 차지 하였다. For investigation of new utilization as jang-products, kanjang was prepared using barely bran. This study was conducted to investigate flavor components of kanjang during fermentation time. The optical density was gradually increased. Among the flavor components identified in kanjang made with barley bran, the contents of 4-viny1-2-methoxy-phenol was the most in quantity followed by benzeneacetaldehyde, palmitic acid, 2-furancarboxaldehyde, methyl-9,12-octadecadienoate, di-(2-ethylhexyl)phthalate, diethyl phtalate, dibutyl-1,2-benzendicarboxylate, 5-methyl-2-furancarboxaldehyde, 3,4-dimethyl-1h-pyrazole, phenylethyl alcohol, dioctyl-hexanedioate, dimethyl-1,2-benzenedicarboxylate, benzaldehyde, methional, 2-methoxy-phenol, n-furfurylidene-3-methylbutyl amine, 1-furfuryl-2-formyl pyrrole, tetradecanoic acid, 5-methyl-pyrimidine, 4-methyl-5-hydroxymethyl-imidazole, maltol and 5-(5-methyl-2-furanyl)methyl-2-furancarboxaldegyde.

Flowable 및 microfill 복합레진으로 충전된 제 5급와동에서 load cycling 전,후의 미세변연누출 비교

강석호,김오영,오명환,조병훈,엄정문,권혁춘,손호현 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.2

Low-viscosity composite resins may produce better sealed margins than stiffer compositions (KempScholte and Davidson, 1988; Crim, 1989). Flowable composites have been recommended for use in Class V cavities but it is also controversial because of its high rates of shrinkage. On the other hand, in the study comparing elastic moduli and leakage, the microfil had the least leakage (Rundle et al. 1997). Furthermore, in the 1996 survey of the Reality Editorial Team, microfills were the clear choice for abfraction lesions. The purpose of this study was to evaluate the microleakage of 6 composite resins (2 hybrids, 2 microfills, and 2 flowable composites) with and without load cycling. Notch-shaped Class V cavities were prepared on buccal surface of 180 extracted human upper premolars on cementum margin. The teeth were randomly divided into non-load cycling group (group 1) and load cycling group(group 2) of 90 teeth each. The experimental teeth of each group were randomly divided into 6 subgroups of 15 samples. All preparations were etched, and Single bond was applied. Preparations were restored with the following materials (n=15) : hybrid composite resin [Z250(3M Dental Products Inc. St.Paul, USA), Denfil(Vericom, Ahnyang, Korea)], microfil [Heliomolar RO(Vivadent, Schaan, Liechtenstein), Micronew(Bisco Inc. Schaumburg, IL, USA)], and flowable composite[AeliteFlo(Bisco Inc. Schaumburg, IL, USA), Revolution(Kerr Corp. Orange, CA, USA)]. Teeth of group 2 were subjected to occlusal load (100N for 50,000 cycles) using chewing simulator(MTS 858 Mini Bionix Ⅱ system, MTS Systems Corp., Minn, USA). All samples were coated with nail polish 1mm short of the restoration, placed in 2% methylene blue for 24 hours, and sectioned with a diamond wheel. Enamel and dentin/cementum margins were analyzed for microleakage on a sclale of 0 (no leakage) to 3 (3/3 of wall). Results were statistically analyzed by Kruskal-Wallis One way analysis, Mann-Whitney U-test, and Student-Newmann-Keuls method. (p=0.05) Results: 1. There was significantly less microleage in enamel margins than dentinal margins of all groups. (p<0.05) 2. There was no significant difference between six composite resin in enamel margin of group 1. 3. In dentin margin of group 1, flowable composite had more microleakage than others but not of significant differences. 4. There was no significant difference between six composite resin in enamel margin of group 2. 5. In dentin margin of group 2, the microleakage were R>A=H=M>D>Z. But there was no significant differences. 6. In enamel margins, load cycling did not affect the marginal microleakage in significant degree. 7. In dentin margins, load cycling did affect the marginal microleakage only in Revolution. (p<0.05)

음식물찌꺼기 퇴비로부터 호염성 미생물의 분리 및 동정

최충식,이오석,권기석 7개 국립대학교 환경연구 논문집 공동발행 위원회 2003 공업기술연구 Vol.3 No.-

An halophilic bacterium was isolated from food-waste. The isolated strain was Gram-negative, aerobic bacterium. The range of temperature for growth of the isolate were 30-40℃. NaCl concentration for growth of it was 5-15%. The isolate was catalase and oxidase positive and sensitive to bacterium. It showed starch hydrolyzing and acid forming characteristics. The morphological, physiological and biochemical characteristics of the isolate resembled those of the Halococcus sp., therefore it was identified as Haloarcula sp. CH-667.

인지과학적 시뮬레이션을 통한 朝鮮 性理學의 禮교육 心性모델 개발(1)

유권종,박충식,장숙필 고려대학교 민족문화연구원 2002 民族文化硏究 Vol.37 No.-

이 연구는 유교, 특히 조선 성리학의 도덕교육에 의한 인격변화의 과정과 그 결과를 컴퓨터로 모의 실험하기 위하여, 조선 성리학자들이 이해했던 心의 구조와 그 작동의 모형을 작성해보고자 하는 데 그 궁극적인 목적이 있다. 아울러 그것을 통해서 조선 성리학의 큰 줄기를 형성한 퇴계의 심학과 율곡의 심학을 연구대상으로 포용하고, 그 둘 사이에 나타나는 차이점과 공통점을 살피고, 그 결과를 근거로 일종의 성리학 통합심성모델을 작성해보고자 할 때 필요한 이론적 정지작업을 하는 것이 본 연구의 실제 내용이다. 그 작업을 위하여 먼저 통합심성모델 작성의 이론적 관점과 기반으로서 일종의 구성주의의 관점을 채택한 이유를 밝히고, 그것에 의하여 성리학의 심성론의 해석과 그에 따른 심성모델의 구성 방식을 제시하였다. 아울러 서구의 심리철학에서 이해되는 mind, 인지과학에서 연구되고 있는 인간의 마음, 인공지능에서 이해되는 마음을 분석하고 그것과 구성주의에 의하여 재해석된 성리학자들의 마음과의 비교를 행하였다. 중요한 것은 성리학의 역사로 볼 때 똑같이 주자학 계열의 성리학자이면서도 인간의 심성의 관념에 관해서 대립적인 견해를 지녔던 퇴계와 율곡의 관점을 하나로 묶어서 통합심성모델을 작성하는 작업이다. 이에 대해서 본 연구는 퇴계와 율곡이 근본적으로 禮실천에 의하여 인간의 심성의 순수함과 정직함을 기르고 회복하려는 점에서 동일한 입장이라는 점에 착안하여, 사단과 칠정, 인심과 도심 등에 관한 理氣論적 해석에 차이가 있다고 하더라도 그것을 통합해 볼 수 있는 이론적 체제를 확보하고자 하였다. 현대에 논의되는 서구철학적 관점의 윤리학과는 다소 다른 방향과 관점에서 진행되는 이 논의는 인지과학과 비트겐슈타인류의 언어철학 등의 관점과 상호 통하는 면이 있으며, 현대 서구철학의 윤리학이 해결하지 못하는 인간의 도덕적 앎과 행위와의 괴리를 넘어설 수 있는 이론적 가능성을 보여준다고 전망된다. 그 점을 인지과학자인 프란시스코 바레라, 언어철학자인 허버트 핑가레트 등의 이론을 근거로 추론하였다. 결론적으로 퇴계와 율곡의 성리학 심성모델은 현대 윤리교육에 대해서 인간의 심신관계 및 실천지향의 윤리교육의 기초를 제시할 수 있으며, 나아가서 그에 관한 실용성도 풍부하게 지니는 것으로 생각된다. This study has a purpose to make a structure of mind and its working principles, which had been thought and understood by confucians of Chosun Dynasty, for computer simulating processes of peronalyity changes through Chosun Dynasty's moral education. This study includes Simhak(心學) of famous Chosun confucians, Toegye and Yulgok, and compares commons and differences of two scholar's theory. The key of this study prepares a necessary theoretical foundation for making a Neo-confucian integrated mind model from such results. We explained why we adopt radical constructivism as a theoretical framework for the integrated mind model, and proposed an interpretation of Neo-confucian mind theory and a method of constructing mind model. Futhermore, we look around a mind of western psychological philosophy, a mind of cognitive science, and a mind of artificial intelligence, and we have compared the confucian mind which is re-interpreted as radical constructivism with such minds. An important work is to make an integrated mind model of Toegye and Yulgok because two scholars are same Neo-confucian, but assisted own theories about human mind. Although the interpretations of Sadan(四端) and Chiljung(七情), Insim(人心) and Dosim(道心) are different each other, encouraging and recovering purity and honesty human mind with the practice of rituals is very much alike. Therefore we want to prepare theoretical foundation for integrating both. This argument is different from ethics of modern western philosophy, but have something to do with cognitive science and Wittgenstein-like philosophy of language. We expect that this idea show a theoretical possibility beyond the dissociation between ethical thinking and behavior, which modern western ethics can't solve. Such a conclusion is inferred from the concepts of Francisco Valera, the cognitive scientist, and Herbert Figarette, the linguistic philosoper. Now to conclude, the confucian mind model of Toegye and Yulgok can provide the explainable mind-body relationship and the foundation of practical moral education for modern education. We believe that the model has much possibility for practical use.

大豆未熟子葉祖織의 營養培地條件에 따른 器官分化

元鍾樂,權貞淑,鄭圭和,張權烈 慶尙大學校 1987 論文集 Vol.26 No.1

大豆의 末熟子葉組織을 사용하여 여러가니 營養培地에서 칼루스와 胚狀體로부터 器官을 分化시키고자 하였던 바 얻어진 결과를 要約하면 다음과 같다. 1. 칼루스誘起는 MS 基本培地에 1.0mg/12,4-D,와 2.0mg/1kinetin을 첨가하거나 (M5培地) 하였을 때 가장 효과적이었다. 2. M4培地에 培養한 칼루스로부터 生長點모양의 완전한 구조를 갖춘 細胞群을 組織學的으로 관찰할 수 있었다. 3.칼루스를 器官分化를 위한 培地에 ?代培養하였을때 根分化, 칼루스로부터胚狀體의 形成, 胚狀體로부터 싹이나 잎의 分化는 供試한 大豆系統이나 使用한 營養培地에 따라 약간의 差異는 있으나 비교적 용이할 것으로 여겨졌다. 4. 供試한大豆系統인 뱀콩의 末熟子葉組織을 M4培地에서 칼루스를 誘起시킨 후 MS基本培地에 0.005mg/1 picloram 과 2.0 mg/1 BAP를 첨가한 培地(OM2培地)에 ?代培養하였을 때 칼루스로부터 胚狀體의 形成이 잘 되었고 胚狀體들로 부터 잎이 分化되었다. The experiments were conducted to investigate organ differentatin rom calls and embryoid under various media using immature ctyledon of soybeam. The results obtained were as followings: 1. 1. Omg 2,4-D plus 0.2mg kinetin or 0.2 mg BAP perr litre on MS basal mediu were efective growth regulators for callus induction. 2. Meristematic structure was observed from the callus induced by 1.0mg 2,4-D plus 0.2mg kinetin per litre in MS basal medium in which callus growth showed best response. 3. Root and embryoid from callus and shoot or leaflet from embryoid were differentiated on the medium subcultured for organ different on the soybean lines and media applied. 4. Embryoid from callus and leaflet from the embryoid were differentiated on the nutritional condition subscultured with 0.005mg picloram plus 2.0mg kinetin per litre on MS in immature cotyledon of spybean line Baemkong.

백삼에 있어 수침처리가 체형 및 사포닌 함량에 미치는 영향

한윤경,이이,이문순,권숙희,정찬문 충북대학교 연초연구소 2009 煙草硏究 Vol.22 No.-

본 연구는 수침 처리가 백삼제품의 원형복원에 미치는 영향을 조사하여 백삼제품 제조에 사용한 원료수삼의 품질을 평가하기 위한 기초자료를 얻고자 수행하였던 바 결과를 요약하면 다음과 같다. 백삼의 수침처리는 원료수삼과 같은 수준으로 원형을 복원할 수 있어 제품에 사용된 원료수삼의 뇌두의 경흔적, 동체부위의 피해정도 그리고 내부조직의 나이테 관찰이 용이하여 연근판별 및 품질평가가 가능하였다. 백삼제품의 ginsenoside 함량은 제조회사에 따라 다소 차이가 있었으며 panaxadiol계 사포닌은 ginsenoside-Rb₁이 많고, panaxatriol계 사포닌은 ginsenoside-Rg₁이 높게 나타났다. 그리고 수침에 의한 백삼의ginsenoside 함량은 수침온도가 증가할수록 감소하는 경향이었다. This study was conducted to investigate the effects of soaking treatment in white ginseng and evaluated quality evaluation of raw ginseng and ginsenoside. Restoration to the original state of the raw ginseng can be achieved by soaking treatment in white ginseng. Stem vestige at rhizome and damage of main root of the swelled white ginseng was examined by eyes and annual rings by microscope easily. Soaking treatment made it easy to be examined the identification of root age and quality evaluation of white ginseng. The content of ginsenoside showed difference among the three products. The content of ginsenoside-Rb1 was highest among the constituents of protopanaxadiol saponin and the content of ginsenoside-Rg1 among that of protopanaxatriol saponin. The higher the soaking temperature was, the lower the content of ginsenoside in the white ginseng was.

마우스의 BCG감염이 R.tsutsugamushi의 증식에 미치는 영향

김인재,전창덕,홍영권,정현택,이복수,장우현,김익상,박석돈 대한감염학회 1993 감염 Vol.25 No.2

It has recently been reported that gamma-inteferon(INF-r) and tumor necrosis factor(TNF) or lipopplysaccharide(LPS) activate macrophages to kill intracellular parasites by means of nitrc oxide (NO). It is now generally accepted that NO is the endothelium-derived relaxing factor, and that it also paticipates in the regulation of the nervous and immune systems. Activated macrophages form NO?? and NO?? from the terminal guanidino nitrogen atoms of L-arginine by the process now known to proceed via the formation of NO. This pathway is inhibited by the L-arginine analog(N?? monomethyl-L-arginine; N??MMA), forms L-citrulline as a co-product and is responsible for the cytotoxic action of macrophages. In this study, the authors found that INF-r and/or LPS induced murine macrophages to kill Rickettsiae tsutsugamushi in vitro and macrophages from BCG-infected mice got the host resistance against R.tsutsugamushi in vitro as well as in vivo. The rickettsicidal effect induced by the combination of INF-r and/or LPS induced mice got the host resistance against R.tsutsugamushi in vitro as well as in vivo. The rickettsicidal effect induced by the combination of INF-r and/or LPS can also be completely inhibited by N??MMA, leading to a dose-dependent inhibition of NO production. These datademonstrate that INF-r and/or LPS as well as BCG-activated macrophages mediate host resistance aganist R.tsutsugamushi infection through NO, which is necessary for the intracellular parasite.

백삼에 있어 수침처리가 원형복원에 미치는 영향

한윤경,이이,이문순,권숙희,정찬문 충북대학교 연초연구소 2009 煙草硏究 Vol.22 No.-

본 연구는 시중에서 거래되고 있는 백삼을 구입하여 수침 처리가 백삼의 원형복원 및 사포닌 성분에 미치는 영향을 구명하고자 수행하였다. 시판백삼은 같은 등급 및 편급의 제품이었으나 뇌두, 근장, 근직경 등 조사 형질에서 제품간 차이가 있었다. 그리고 수침처리에 의해 근중, 동체, 근직경, 근장 등은 증가하여 원료삼으로서 수삼상태를 확인할 수 있었다. 또한 이들 백삼은 온도가 증가할수록 체적이 빨리 증가하여 온도에 의한 영향을 크게 받았으며 다시 건조하여 본래 백삼의 상태로 환원하는 것이 가능하였다. 그리고 수침에 의한 근중의 변화는 2배 이상 증가하였는데 근중이 최고도에 달하는 시간은 대략 24시간 후 이었다. This study was conducted to investigate the effects of soaking treatment in white ginseng and evaluated white ginseng on the restoration to the original shape and the quality of raw ginseng. KW-1 white ginseng had longer rhizome length and main root length. KW-2 had larger rhizome diameter, main root diameter and root weight. KW-3 showed lower quality than the other two white ginseng products. Soaking treatment made the root weight, main root diameter and main root length of raw ginseng increased. The decrease of root weight was significant by drying. The effects of soaking and drying treatment on the characters investigated of the raw ginseng and white ginseng showed same tendency. The higher the soaking temperature was, the faster the increasing rate was. The increasing of white ginseng stopped after around 12 hours from soaking at any soaking temperature.

카드뮴이 인간 단핵구 세포주(THP-1)에서 cytokine 유전자 발현에 미치는 영향

신동훈,박관규,강미정,서석권,정인성,양선희 大韓産業醫學會 1997 대한직업환경의학회지 Vol.9 No.2

Cadmium, a potent toxic metal, posses a serious environmental threat but the mechanism of its toxicity remains unclear. Also, cadmium is a known immunotoxic agent in animal studies and induces pathophysiological effects by modulating components of immune system. Cytokines are being increasingly recognized as essential mediators of normal and pathologic immune response. Cells of mononuclear phagocytic system are strategically located at portals of entry in humans and therefore may be particularly at risk for cadmium exposure through contaminated air, food, and drinking water. In the present study, we investigated the effect of cadmium cytotoxicity for the monocyte and expression of cytokine gene in the control and cadmium treated human monocytic cell lines using RT-PCR method. The results showed that cadmium inhibited cell proliferation at 0.1mM cadimium treated cells for 24 hours. The TNF-α mRNA was expressed in both control and cadmium treated cells but not IL-6 and IL-1β. The mRNA levels of TNF-αwere examined during 24 hours culture period, at different time points. The expression of TNF-αmRNA increased in both 0.01mM and 0.1mM cadmium treated cells, but did not show dose-response relationship. According to cadimium treated duration, expression of TNF-αmRNA was more decreased in 24 hours than 6 hours. The decreased levels of mRNA of TNF-α suggest that cadmium suppresses its production at the transcription level.