Captopril과 Nifedipine 병합요법의 강압효과에 관한 임상적 연구

이영수,문언수,김준호,공수정,정시진,주용진,정상만 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

Background: The hypotensive effect of captopril(angiotensin converting enzyme inhibitor) and nifedipine(calcium channel blocker) was studied. Method: Captopril(75mg) and nifedipine(30mg) were administered in 30 hypertensive adults during twelve weeks after a week observation for washout with stepwise increments of the dose according to the patient's blood pressure in every two weeks. Result: The supine blood pressure were decreased from 169.5±22.3/104.0±20.3 mmHg to 130.4±21.3/82.4±19.5mmHg at the end of twelve weeks during therapy.(p<0.05) The standing blood pressure were also decreased conferrably and to the some lower level. Hematologic examination and blood chemistry revealed no discernible abnormal findings before and after the treatment. During the period of the study a few probably drug-related symptom such as cough and headache, gastrointestinal disturbance developed but not troublesome enough to administering. Conclusion: Captopril and nifedipine regimen is well tolerated and effective in the treatment of hypertensive patients.

능이버섯의 藥理作用에 관한 硏究

殷載淳,이중원,黃甲洙 又石大學校 1990 論文集 Vol.12 No.-

The pharmacological effects of Sarcodon aspratus extract were investigated. The extract promoted contraction of isolated stomach and ileum, and this contraction was blocked by atropine(7×10^-7M) and cyproheptadine (1.5×10^-7M). The maximum effective dose of the extract was 1.5×10^-3g/㎖. The extract promoted the peristaltic movement of small intestine, and this movement was blocked by atropine. The extract accelerated the secretion of histamine in serum and gastric acid. The serum glucose and total cholesterol levels in alloxan-induced mice were significantly decreased by oral administration of the extract for 7 days. The pharmacological effects of the extract on the central nervous system were little.

천연자원을 이용한 간기능 증진제 개발 연구 : Benzo(a)pyrene에 의해 유도된 간기능 장해에 미치는 익모초 추출액의 영향 The Effect of Leonuri Herba on Benzo(a)pyrene Induced Hepatotoxicity

정영건,권오진,윤수홍,박은주 효성여자대학교 부설 한국환경위생연구소 1994 환경위생연구 Vol.4 No.1

Benzo(a)pyrene으로 유도한 rats의 간독성 발현에 미치는 익모초 수침액의 예방 및 치료효과를 실험한 결과 익모초 수침액의 투여는 B(a)P투여로 현저하게 증가된 혈청 및 간장의 AST, ALT, LDH, ALP 활성을 유의성 있게 감소시켰고 B(a)P 투여로 변화한 혈청 지질함량에 약간의 회복도를 보이기는 하나 현저한 차이는 없었다. 즉 익모초의 투여는 B(a)P에 의한 간독성 발현을 효소적으로 유의성 있게 감소시켰으며 그 효과는 전처리가 후처리에 비해 우수하다. The present study was undertaken to compare the pharmacological activity of crude Leonuri Herba reported with the clinical uses in the oriental medicine. Crude Leonuri Herba used for the treatment of gynecologic condition, irregular menstration, parturition hemaostater and diuretics. Therefore we tested the effects of Leonuri Herba water extract on the liver-protective activities in the rats. The results obtained from liver microsomal enzyme assay, measurement of serum and liver alanine aspartate aminotransferase and lipid accumulation indicated that Leonuri Herba extract showed significant liver-pro-tective activities against benzp(a)pyrene poisoning.

전합형 인버터에 의한 유도전동기의 속응제어

정은성,조문택,임영배,서영수 明知大學校 産業技術硏究所 1995 産業技術硏究所論文集 Vol.14 No.-

In this paper, the quick response control of induction motor was researched by presenting indirect vector control algorithm to improve the dynamic performance of induction motor, resulting in quick response characteristics such as DC motor. Speed detecting method was used by M/T method and made the simple speed calculation by the presentation of the a1gorithm using the the HSI.0 pin and HSI TIME of 80196KC. It was used each ,PI controller for current controller and speed controller of-control algorithm, 80196KC to CPU for fast velocity processing computation in designing control system, and the way of PWM for removing the current harmonics of voltage source inverter We would like to confirm through experiment the relatively fast response velocity and the superior quick response control characteristics with variable command-speed, applying proposed system to 1[HP] 3ø induction motor.

감탕나무속 식물 잎의 큐티클 미세형태

정은경,황성수,김경식 전북대학교 과학교육연구소 2002 과학과 과학교육 논문지 Vol.27 No.-

감탕나무과 감탕나무속속 12 분류군의 엽신에 발달된 큐티클 미세구조를 전자현미경을 사용하여 관찰하였다. 본 속 엽신에 발달된 큐티클은 다른 분류군에 비해 큐티클이 잘 발달되어 있었다. 본 연구는 본 속 식물 표피의 외면에서는 관찰하기 어려운 미세구조적 특징을 큐티클의 내면구조를 관찰하여 분류 및 계통학적으로 유용한 다량의 새로운 미세구조 형질자료를 획득하였다. 본 연구는 본 속내의 제한적인 종을 연구대상으로 하였기 때문에 계통분류 체계를 정립하기는 다소의 어려움이 있었으나, 본 속의 엽신 내면의 큐티클 미세구조의 새로운 여러 형질의 분류학적으로 유용함이 확인되었다. 따라서 앞으로 본 분류군내 전체 종을 대상으로 계통학적인 연구를 수행할 때 본 연구에서 확인된 형질이 기초자료로 유용하게 사용될 공산이 큰 것으로 생각된다.

인체 자궁암 세포에서 천연 성분이 P-당단백질의 활성에 미치는 영향

정수연,고은정,김나형,성민경,장정옥,이화정 이화여자대학교 약학연구소 2005 藥學硏究論文集 Vol.- No.15

Multidrug resistance (MDR) of cancer cells is, at least in part, associated with the overexpression of P-gly-coprotein (P-gp). Many studies hve demonstrated that natural compounds obtained from fruits, vegetables, teas and medicinal plants may modulate P-gp activity. The objective of the present investigation was to examine the effect of seven natural compounds on the P-gp activity in human uterine sarcoma cell line, MES-SA/DX5. Daunomycin uptake was significantly increased by biochanin A and silymarin (p<0.0001) whereas it was reduced by morin (p<0.01). The efflux of daunomycin from the cells was significantly inhibited by biochanin A, morin, cephalotaxine, berberine (p<0.05) and silymarin (p<0.0001). Biochanin A, berberine and silymarin significantly decreased IC_(50) value of daunomycin (p<0.05) while morin increased it (p<0.05). These results suggest that some natural compounds such as biochanin A and silymarin may inhibit P-gp funciton and can by developed as MDR reversing agents to improve the efficacy of chemotherapeutic drugs when administered concomitantly.

Enterococcus faecium 19-46-4에 의한 Cholic Acid의 생산

정은영,김명수,이철훈,김병홍 한국산업미생물학회 1996 한국미생물·생명공학회지 Vol.24 No.5

항균활성을 갖는 혐기성 미생물에 대한 탐색연구에서 항균활성이 강한 Enterococcus faecium 19-46-4를 선발하여 혐기적 배양으로 이 균주가 생산하는 항생물질의 분리, 정제 및 이화학적 특성 및 구조분석을 행하였다. 40ℓ 균배양액으로부터 iso-butanol extraction, C-18 liguid column chromatography, HPLC등을 통해 약 100mg의 항균물질을 분리정제하여 KIST 194로 명명하였고, KIST 194를 UV, IR, ^1H-NMR, ^13C-NMR, EI-MS와 LC-MS 등의 기기분석을 한 결과 cholic acid (3α, 7α, 12α-trihydroxy-5β-cholan 24-oic acid)로 동정하였다. A facultative anaerobe Enterococcus faecium 19-46-4 was used to study the production of an antimicrobial substance in anaerobic conditions. Major part of the antibiotic activity was found in the culture filtrate of the bacterium. The active compound was extracted by an equal volume of iso-butanol and concentrated in vacuo (at 50℃) before purification by C-18 liguid column chromatography and HPLC. A chromatographically pure compound was obtained by two passages of HPLC columns, The compound appeared as a pale-yellow powder. The yield was about 2.5 mg l^-1 culture filtrate. The compound was named as KIST 194. KIST 194 were identified as cholic acid (3α, 7α, 12α-trihydroxy-5β-cholan 24-oic acid) based on its physico-chemical properties determined by UV, IR, ^1H-NMR, ^13C-NMR, EI-MS and LC-MS.

확장성 심근증의 임상적 특성에 대한 연구

정상만,문언수,정시전 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

Dilated cardiomyopathy is a heart muscle disease in which one or both ventricles are dilated, resulting in decreasing left ventricular contractility and pump failure. Complex arrhythmias are frequent in this disorder and are often associated with poor prognosis. We analysis the clinical parameter, electrocardiographic and echocardiographic findings of the 15 patients who were diagnosed as dilated cardiomyopathy between Aug. 1978 and Dec. 1992 in Kon-Kuk University Minjoog Hospital. The results were as follows: 1) 9 male and 6 female patients with mean age of 56.6 were included in this study. 2) In decreasing order of frequency, the clinical findings were dyspnea on exertion(93.3%) ; fatigue or weakness(46.7%) ; orthopnea(26.7%) ; cough(26.7%) ; edema(20.0%) ; chest pain(20.0%) and palpitation(13.3%). 3) In decreasing order of frequency, the findings of physical examination were apical systolic murmur(53.3%) ; hepatomegaly(33.3%) ; S3 gallop(26.7%) : pretibial pitting edema(7%) ; rales or wheezing(20.0%) and peripheral cyanosis (20.0%). 4) The most common finding of electrocardiography was LVH(33.3%) and atrial fibrillation(33.3%). NSIVCD(26.7%), PVC(20.0%), LBBB(6.7%), atrial flutter(6.7%) were also noted in this study. 5)The echocardiographic study showed markedly increased LVEDD(65.3±11.1mm), LVESD(56.8±10.7mm), LAD(42.9±7.4mm), EPSS(23.3±6.1mm) and decreased EF(28.8±11.0%), IVST(7.6±1.1mm) and LVPWT(7.5±1.3mm). This data showed that congestive heart failure was the major clinical feature and the left ventricular performance was markedly decreased in the patients with dilated cardiomyopathy. Electrocardiographic abnormalities were frequently associated with this disorder. Adequate therapeutic modality and proper follow up were necessary to improve the prognosis of the patients with dilated cardiomyopathy.

銀行員의 情報倫理 水準에 관한 硏究

정경수,김병곤,마은경 慶北大學校 經濟經營硏究所 1998 經商論集 Vol.25 No.2

白茯笭이 肥滿誘導 흰쥐의 體重, 副睾丸,脂肪組織, 血液 및 遺傳子 變化에 미치는 影響

류은경,정석희,이종수,김성수,신현대 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

Objectives : These experimental studies were designed to investigate the effects of Poria cocos extract on the weight control and the lipid metabolism of the obese rats induced by high fat diet. They were designed to find out what was changed in the serum, and how the leptin and the leptin m-RNA were affected. Methods : The measurement has been performed for 6 weeks with obese rats. Results: 1.In the sample I (fat diet & Poria cocos group), the weight decrease significantly occurred throughout the whole research period, whereas in the sample II(normal diet & Poria cocos group), the ratio of weight decrease was significantly observed at the 4th, 5th, and 6th week(p < 0.05) 2.In the sample I, the epididymal fat weight and average size significantly decreased at the 6th week(p < 0.05). 3.In the sample I, the number of epididymal fat cell significantly decreased at the 3rd & 6th week(p < 0.05). 4.With the view of hematologic findings, I observed the increasing tendency of glucose in the sample I & II, and the significant decreasing of triglyceride at the 6th week(p < 0.05). 5.The leptin decreased in the sample I, whereas it came to increasing tendency in the sample II(p > 0.05). 6.The leptin m-RNA decreased a little in the sample I, whereas it increased in the sample(p > 0.05).