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      • 다발성 대장암 간전이 환자의 간절제를 위한 새로운 시도

        주종우,김형철,임철완,신응진,조규석,유기원,송옥평,홍대식,박성진,조준희,이혜경,김희경,권계원,고은석 순천향의학연구소;Soonchunhyang Medical Research Institute 2004 Journal of Soonchunhyang Medical Science Vol.10 No.2

        Multiple bilobar liver matastases (MBLM) are the main cause of low resectability in the colon cancer liver metastases. The authors experienced one case of initially non-resectable colon cancer liver metastases. He was curatively and safely treated with a two-stage hepatectomy using the new method of future remnant liver volume growing. A 54-year-old man was referred to our department with the sigmoid colon cancer combined with MBLM, which were checked in two small metastatic lesions in the left lobe and five large sized lesions in the right lobe in the computed tomogram (CT). A laparoscopic assisted anterior resection was primarily performed. We performed the 1^(st) stage hepatectomy 3 weeks after the colon resection. Intra-operative Ultrasonogram (US) found 9 small superficial metastatic lesions in the left lobe. All that lesions were completely removed by non-anatomical wedge resection. An occlusion ballon catheter was placed in the right portal vein through a small branch of the inferior mesenteric vein at that time. The future remnant liver volume was sufficiently increased 3 weeks after the 1^(st) hepatectomy. A right hepatectomy was safely performed 22 days after the 1^(st) hepatectomy. The patient received a regional chemotherapy (interleukin2 based immuno-chemotherapy through hepatic artery) for 4 months, then received 9 cycles of systemic chemotherapy (biweekly Oxaliplation, leucovorin, plus 5-fluorouracil) without any recurrence evidence.

      • Fine달린 Heat Pipe의 熱傳達 性能

        김종일,김병철,한희석 조선대학교 동력자원연구소 1987 動力資源硏究所誌 Vol.9 No.2

        This study was observed and analysed on the performance of a finned heatpipe used in the thermal energy storage system for the solar energy and heat recovery. For this purpose, a finned heat pipe was constructed with a groove screen wick, copper-water, 38㎜ in diameter and 500㎜ long. As the performance of a finned heat pipe depends upon operating temperature, tilt angle and fill charge, the axial and circumferential temperature of a finned heat pipe was measured and its performance was analysed. The maximum temperature difference, was largely influenced by fill charge, which decreased with increasing tilt angle when input was amall but not effected by tilt angle when input was large. The optimum fill charge was found to be 0.5, the dimensionless evaporator volume.

      • 옥시칼본계 화합물의 포오틀랜드 시멘트 광물에 대한 흡착거동

        김창은,최진호,유종석 연세대학교 산업기술연구소 1983 논문집 Vol.15 No.2

        The rheological properties of the cement mineral-sodium gluconate-water system were investigated by determining the adsorbed amount of sodium gluconate, the sedimentation velocity of cement particles, and viscosity of the cement paste. IR and SEM were used to analyze the adsorbed phase on cement minerals. The results of experiment were as follow: 1. In the case of containing gypsum, the adsorbed amount of sodium gluconate on OPC could be calculated from the sum of that on each mineral component. 2. In general, the fluidity of the cement paste was increased with the equilibrium concentration. 3. There were maximum values of the amount adsorbed and viscosity at equilibrium concentration of 0.3% for C₃A in the solution system. 4. The adsorbed phase of sodium gluconate on C₃A could be identified by the IR analysis with the wavelength region of 3200??(-OH), 2800??(C-H), and 1600??( ?? ) 5. As shown in microstructure analysis with SEM, the layered type structure of hydrated C₃A could incorporate with polar compound or ionic species to form a interlamella complex. Due to the large surface area of layed structure of C₃AHx, the extraordinary high amount of gluconate anion adsorbed C₃A matrix could be well explained also comparing with hydrated C₃S.

      • 염모제 도포방법에 따른 인체 적혈구의 산화스트레스 비교

        김영철,심미자,권정숙 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.2

        To ascertain the effects of hair dyeing application on oxidative stress in human, a mixture of permanent black colored hair dye with the same amount of oxidant containing 6% hydrogen peroxide was used. A hair dyeing with contacting the scalp(conventional dyeing) and a hair dyeing with 3 to 4mm away from the scalp(alternative dyeing) were applied to each 15 young healthy women. Blood was taken from the brachial vein at two sampling times, just before and 6 hours after the hair dyeing, and antioxidant enzyme activities and antioxidant contents were measured in red blood cells. After increased, malondialdehyde(MDA) contents for conventional dyeing group was shown to a tendence for more increased than alternative dyeing group. After dyeing, reduced glutathione(GSH) contents for conventional dyeing group was shown to a tendence of more decreased than alternative dyeing group. After dyeing, superoxide dismutase(SOD) and catalase(CAT) activities were significantly decreased in conventional dyeing group(p<0.01), however, SOD and CAT activities were not significantly decreased in alternative dyeing group. After dyeing, there was no significant decrease in glutathione peroxidase(GPX) activity both for conventional dyeing group and alternative dyeing group. Therefore, after dyeing, the degree of oxidative stress in red blood cells for alternative dyeing group was appeared to be lower than conventional dyeing group.

      • 염모제 사용에 의한 인체림프구의 DNA 손상 변화

        김영철,심미자,권정숙 한국환경독성학회 2004 환경독성보건학회지 Vol.19 No.1

        To ascertain the effects of hair dyeing application on the DNA damage in human lymphocytes, a mixture of permanent black colored hair dye with the same amount of oxidant containing 6% hydrogen peroxide was used. A hair dyeing with contacting the scalp(conventional dyeing) and a hair dyeing with 3 to 4mm away from the scalp(alternative dyeing) were applied to each 15 young healthy women. Blood was taken from the brachial vein at two sampling times, just before and 6 hours after the hair dyeing, and tail extent moment(TEM) and tail length(TL) were measured by using a comet assay. After dyeing, TL was significantly increased in both conventional dyeing group and alternative dyeing group compared with before dyeing as an average of 47% and 28%, respectively, and TL for conventional dyeing group was higher than alternative dyeing group as an average of 1.2 fold. After dyeing, TEM was significantly increased in both conventional dyeing group and alternative dyeing group compared with before dyeing as an average of 192% and 76% respectively, and TEM for conventional dyeing group was significantly higher than alternative dyeing group as an average of 1.7 fold. Therefore, alternative dyeing application was induced to lower lymphocyte DNA damage than conventional dyeing application, and TEM was appeared to be a more sensitive tool for the measurement of lymphocyte DNA damage than TL in this study.

      • 鹽分의 過量攝取가 白鼠 腎臟에 미치는 影響에 對한 電子 顯微鏡的 硏究

        김원석,설종구 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.1

        In Korea, hypertension is the most common cause of death, however, it's pathogenesis is still unknown. There's a well-known hypothesis that essential hypertension is a disorder of accluturated peoples and is caused specifically by the acquired habit of eating salt. The study is made to know the ultrastructural change of rat kidney by salt only. Three different concentrations of salt(0.4%, 4.0%, and 8.0% of diet) were fed for 20 weeks. The results were as follows: 1. There was no specific change in control and low salt(0.4%) diet group. 2. In middle range salt(4.0%)diet group, widening of the glomerular capillary endothelial junction, focal adhesion of foot processes of podocytes, a few myeline formation, and focal irregularity of the capillary basement membrane were observed from 6th week, and the changes were more severe in long-feeding groups. The small arteries were showing marked hypertrophy of the smooth muscle cells with degeneration of the internal elastic lamina. However, the changes were somewhat different between animals. 3. In high salt(8.0%) diet group, the similar change with the middle range salt diet group was noted, but it was more early developed and more severe for time. There was striking myelin formation of the capillary endothlial cells, degeneration of the proximal convoluted tubular cells, widening of the intercellular space of small arterial smooth media, and proliferation of the mesangial cells. These degrees of change were also variable among animals. In summary, the results obtained by present study indicate that high salt intake alone also brings about hyperplastic and degenerative change that is similar to changes of hypertension in rats kidney.

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