원자력 발전소 근로자에서 업무상 질병으로 인정받은 급성 골수성 백혈병 1예

임현술,정해관,김수근,박병찬,이관 약업신문사 1983 의약정보 Vol.9 No.-

Wegener 씨 육아종 증례보고 1예 : A Case Report

정선관,임형근,정은택,노병석,김창근,원종진 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2

Wegener's granulomatosis is characterized by necrotizing and granulomatous disease which involves upper, lower respiratory tract and kidney. The basic pathophysiologic mechanism of Wegener's granulomatosis is still unknown. We report a case of Wegener's granulomatosis which involved lung and pleura and was diagnosed by clinical symptoms, radiologic findings and anti-neutrophilic cytoplasmic autoantibodies.

AMESim를 이용한 유압 굴삭기용 Main Control Valve의 해석에 관한 연구

임태형,최종환,양순용,이병룡,안경관 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

The hydraulic excavator has been a popular research object for automation because of its multi-workings and economic efficiency. When it works crane tasks, most of disasters happen. The objective of this paper is to design each components and to construct boom, arm, bucket circuit. These models modeled with AMESim show us change of variables and behavior of excavator. Simulation model will be used for simulator of excavator.

실험실적 당뇨성 흰쥐에서 acetaminophen의 대사에 관한 연구

임은주,윤병재,윤병재,조희숙,김대재,최종원 경성대학교 환경문제연구소 2000 環境硏報 Vol.10 No.1

Acetaminophen is one of the most important drugs used for the treatment of mild to moderate pain when an anti-inflammatory effect is not necessary. Phenacetin, a prodrug that is metabolized to acetaminophen, is more toxic than its active metabolite and has no rational indications. In this study, we were observed activities of free radical generating enzymes, free radical scavenging enzymes and glutathione-related enzymes as well as detoxification mechanism of against acetaminophen-induced hepatotoxicity in STZ-induced hyperglycemic rat. Activities of cytochrome p450, cytochrome b5, aminopyrine demethylase and aniline hydroxylase were changed by the treatment acetaminophen in hyperglycemic rats. It was also observed that activities of conjugating enzymes as sulfotransferase and UDP-glucuronyltransferase was slightly changes against acetaminophen-induced in hyperglycemic rats. Acetaminophen results in the significantly decrease in the level of hepatic glutathione concentration and √-glutamylcysteon, synthetase activities in hyperglycemic rats. And, glutathine S-transferase, superoxide dismutase and glutathione peroxidase activities were significantly increased against acetaminophen-inducedas in hyperglycemic rats. Glutathione reductase and catalase were not affected for experimental state. Furthemore, acetaminophen highered serum alanine, aspartate aminotransferase, sorbitol dehydrogenase, √-glutamylpeptidase, alkaline phosphatase and lactate dehydrogenase activities in hyperglycemic rats. Key Words: Hepatotoxicity, D/M, Acetaminophen, Glutathione, Glutathlone S-transferase, √-glutamylcystein synthetase

중등학교 체육교육과정 운영의 실제와 기준

임병규,이채산,이병관 圓光大學校附設 生活體育硏究所 2001 生活體育硏究 Vol.12 No.-

The purpose of this study was investigate implications of physical education curriculum's development from inspecting the reality and criteria of physical education curriculum in the secondary school. The conclusions of this study were as follows: First, physical education teacher executed physical education curriculum comparatively without regard to the national physical education curriculum. Second, factors considered in the development of the national physical education curriculum was the need of physical education teacher, the reality of facilities, and the need of students. Especially, the need of physical education teacher was mostly considered. Therefore, the actual place and reality of physical education was concidered in the development of the national physical education curriculum.

원자력 발전소 근로자에서 업무상 질병으로 인정받은 급성 골수성 백혈병 1예

임현술,정해관,김수근,박병찬,이관 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.2

저자들은 10여 년 동안 원자력 발전소 협력업체에 종사하면서 저선량의 방사선에 노출된 근로자로 급성 골수성 백혈병으로 진단 받고 사망 후 업무상 질병으로 인정된 증례를 보고하는 바이다. 증례에 대한 의무기록과 혈액검사 및 조직검사, 세포유전학 검사를 검토하였으며 환자의 작업 내역, 방사선 피폭량 및 동료 근로자에 대하여 조사하였다. 환자는 35세 남자로 1997년 11월 20일 경북 포항시 소재 D 대학병원에서 용접공에 대하여 실시하는 기타 중금속 특수건강진단(망간)에서 백혈구 수가 μL당 108.9×10³개, 혈색소는 8.6g/dL로 급성 백혈병을 의심하였다. 11월 24일 대구광역시에 위치한 K 대학병원을 방문하여 급성 골수성 백혈병으로 확진되었다. 골수검사에서 이소성 B 임파구성 표지자를 지닌 AML M2로 진단되었고, 염색체 검사에서 필라델피아 염색체가 발견되었으며, 46 XY t(1:4)(p32:p16)의 소견을 보였다. 항암 화학요법을 시행하였고 주기적인 항암 약물요법과 추적 관찰을 시행하였다. 1999년 5월 30일 급성 골수성 백혈병에 의한 합병증인 폐렴 및 패혈증으로 사망하였다. 본 증례의 방사선 피폭량은 1,853 mRem (18.53 mSv)이었으며, 방사선에 의한 암발생 원인확률은 미국 기준으로 5.4-6.1%이었다. 우리나라는 업무상 질병인정 기준에 방사선 노출에 의한 백혈병이 인정된다고 명시하고 있어 업무상 질병으로 인정되었다. 그러므로 우리나라 실정에 맞는 전리방사선 피폭량에 따른 업무상 질병 인정기준을 설정하여야 하며 방사선 피폭 근로자에 대하여 방사선 질환의 감시체계를 운영하여야 한다. Acute myelogenous leukemia (AML) has been known as an occupational disease induced by irradiation. We report a case of acute myelogenous leukemia with a history of low dose irradiation in a nuclear power plant. The authors reviewed the clinical and hematologic features of the case. We also reviewed the job contents of his workplace. We also interviewed other workers in the same workplace. The amounts of radiation exposure were reviewed. The worker was a 35-year-old male who had worked in a nuclear power plant for 11 years (1987-1997). Total amounts of radiation exposure during the work period was 1,853 mRem. He had been diagnosed as AML on November, 1997 at a routine periodic health examination. He died of refractory leukemia on May, 1999. The AML developed in this patient seems to be related to the exposure to radiation. To prevent irradiation injury, we must modify work procedures, begin comprehensive medical surveillance, educate workers on risks of radiation, and increase workers awareness of safety regulations in the workplace.

사각 기판의 외형비가 길이진동을 이용하는 초소형 공진자의 공진특성에 미치는 영향

김병효,임대관,이개명 濟州大學校 情報通信硏究所 1999 情報通信硏究所論文集 Vol.2 No.-

The length extensional vibration mode of a piezoelectric ceramic substrate is used in fabricating the ultra-small size resonators and filters. In general. the three side ratios of the substrate effect the resonant characteristics of the resonator using its length extensional vibration. In this paper. their relationships are studied. We know that changing the ratio of its length to its width makes possible to change the resonant frequency of the width vibration without degrading the length extensional vibration.

수면량과 집중력의 상관관계

김병우,류지근,박우진,박계원,김미정,임지은,백대현,최재덕,최윤호,이가현,이관,김덕수 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

수면, 기억 그리고 학습의 연관성은 실제 매우 복잡하다. 많은 연구에도 불구하고 명확한 연구결과는 아직 없다. 우리는 이 연구에서 평소와는 달리 시험 전날 수면 변화 양상이 집중력에 어느 정도 영향력을 미치는지 알아보고자 하였고, 이를 이용해 효율적인 수면 관리를 할 수 있는 기초자료로 삼고자 하였다. 동국대 의대 본과 1학년생 중 지원자 30명과 본과 2학년생 10명을 대상으로 평상시 상태와 시험 직후 수면이 부족한 상태에서 각각 K-PES TEST를 실시하여 총 8항목에 걸쳐 암기력, 판단력, 단순반응의 변화정도를 검사하였다. 또 설문조사를 병행하여 결과에 영향을 미칠 수 있는 다른 인자들도 파악하였다. 수면량에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 인간의 최대 생리학적 기능은 꼭 수면부족에 의해 좌우되는 것은 아니다. 그러나, 수면감소는 피로를 증가시키고, 동기부여를 감소시키나 단, 새로운 사실을 학습하는 데에는 큰 영향을 끼치지 않는다. 즉, 수면부족으로 장시간 깨어있는 것은 정확성과 반응성을 떨어뜨린다. 흡연에 대한 부호 숫자 짝짓기(순간 판단력)을 검사한 결과, 니코틴의 수면에 대한 상호관계는 알려지지 않았고, 인간의 감정이나 의식, 인식에 영향을 주는 것으로 알고있지만, 장기적은 측면에서 흡연이나 알코올은 인식능력과 무관한 것 같다. 카페인에 대한 숫자 외우기(암기력)검사 결과, 카페인은 spacial selective attention에는 특별한 영향을 주지 않지만 지각과정이나 주의 집중에 큰 효과를 주며, 인간의 의식 수행에 긍정적인 효과를 준다. 즉 카페인은 활력, 혼란, 피로상태를 변화시키고 visual analog scales에서 휴식상태에 가까운 양상을 나타낸다. 또 48시간 동안 수면을 취하지 않은 사람에게 카페인은 집중력과 장시간의 좋은 기분을 유지하게 하였다. 그러나 규칙적, 비규칙적으로 먹는 사람간에는 인지수행력의 차이를 보이지 않으며 상용자에서는 상당한 내성이 보인다. 수면패턴에 대한 숫자 더하기(순간 판단력)검사 결과, 집중력은 수면패턴에 의해서도 영향을 받고, 수면패턴이 바뀌게 되면 순간판단력을 저하시킨다. This study was performed to evaluate relationship of sleep and attention, and to control sleep effectively. We conducted a K-PES test of 40 medical students. K-PES contains eight elements, for example, simple response, selective response, color pairing, OddEven discrimination, number addition, number-symbol matching, memory, right-tapping, left tapping. Through these, we tested changes of memory, judgement, simple response. And we conducted a questionnaire survey to exclude bias. Results are as follows. As a results of number-symbol matching test, we know that sleeplessness is not complete responsible for physiologic function for humans. But, decreased sleep increases fatigue and decreases motivation, but no influence on learning new materials. So, long term sleeplessness decreases precision and responsibility. As a results of number-symbol matching test on smoking, a relationship of nicotine and sleep is not certain. A point of view in long term period, smoking and drinking is not related cognition, even if we know that those influence mood, consciousness and cognition. As a results of memory work test on caffeine, caffeine does not influence spacial selective attention, but mainly does perception, attention and consiousness process. Namely caffeine changes energetic activities, chaos, fatigue states and shows resting state in visual analog scales In sleeplessness for 48 hours, caffeine produced attention and good mood for a long time. But, in case of cognitive process no significance shows in regular or irregular diet. Regular diet shows high resistance. As a results of number addition test on sleep patterns, seep patterns influence attention, changes of sleep patterns decrease a moment judgement.

중소기업의 물류정보시스템 품질 평가에 관한 연구

박병권,임채관 동명정보대학교 2002 사이버 비지니스 Vol.1 No.-

The purpose of this study is to evaluate small firms' LIS(logistics information system) and logistics service quality using theoretical model for evaluation of information system and the empirical data of firms. In this study, structural equation model analysis was established for verifying the relationships among the study variables. After examining hypotheses based on the collected data through the survey, all hypotheses were accepted with the statistical significance. The study results showed that the firms' logistics management function influenced on the logistics information system positively, and that logistics information system in turn influenced on logistics service.

ZMP를 이용한 굴삭기의 안정성에 관한 연구

최종환,엄혁,임태형,김승수,양순용,이병룡,안경관 한국공작기계학회 2003 한국공작기계학회 춘계학술대회논문집 Vol.2003 No.-

The hydraulic excavator has been a popular research object for automation because of its multi-workings and economic efficiency. When it works crane tasks, most of disasters happen. The stability of the excavator having crane function has a close relation with excavator's posture, motion and load. In this paper, the stability of tipping-over has been analysed using Zero Moment Point(ZMP),