알츠하이머병 환자에서 행동심리증상의 성별차이

이지영,임우영,김현,이강준,Lee, Ji Young,Im, Woo-Young,Kim, Hyun,Lee, Kang Joon 한국정신신체의학회 2014 정신신체의학 Vol.22 No.2

Objectives : Behavioral and psychological symptoms of dementia(BPSD) represent significant clinical problems, resulting in functional decline, caregiver distress, institutionalization and increased mortality. A recent study showed gender differences have important role in the development of BPSD, but relationship between BPSD and gender has never been studied in Korea. This study was designed to examine whether patients with Alzheimer's disease show gender differences in behavioral and psychological symptoms of dementia(BPSD). Methods : Ninety-eight subjects with Alzheimer's disease were included in this study. We carried out history taking and cognitive assessment for the diagnosis of Alzheimer's disease based on DSM-IV. Cognitive impairment and BPSD were measured using the Mini Mental State Examination(MMSE), Global Deterioration Scale (GDS), Clinical Dementia Rating(CDR) and the Korean Neuropsychiatric Inventory(K-NPI). Independent samples t-test was used to examine the differences across gender in BPSD. Correlation analysis between MMSE, CDR, GDS and NPI was performed using Pearson's correlation coefficient. Results : There were no significant gender differences between the gender in BPSD. We found statistically significant negative correlations between MMSE with NPI total score, and with scores of several sub-domains such as hallucination. Conclusions : This study showed that gender differences in BPSD are not significant. Further research is necessary to identify whether BPSD affect gender differences or individual differences.

The Effect of Splinting with Concomitant Root Planing;Clinical and Digital Subtraction Radiographic Study

이지영,계승범,김원경,이용무,구영,류인철,정종평,최상묵,한수부,Lee, Ji-Young,Kye, Seung-Bum,Kim, Won-Kyoung,Lee, Yong-Moo,Ku, Young,Ryu, In-Chul,Chung, Chong-Pyoung,Choi, Sang-Mook,Han, Soo-Boo The Korean Academy of Periodontoloy 2001 Journal of Periodontal & Implant Science Vol.31 No.1

스프린트는 치주처지료에서 부가적 처치법으로 널리 사용되고 있으며, 한편, 디지털 공제 활영술은 기존방사선촬영술의 한계점을 극복하기 위해 기발된 새로운 방법이다. 이번 연구에서는 치근활택술 단독시행시와 스피린트 병행 처치시의 효과를 임상적, 방사선학적으로 비교하였다. 중정도의 성인성 치주염을 가진 20명의 환자를 대상으로 하되 10명은 치근활택술 단독으로, 나머지 10명은 스프린트 병행처치로 처치하였다. 임상적, 방사선학적인 평가는 처치전, 처치후 6개월에 행하고, 임상적 평가의 경우 3개월에 추가로 실시하였다. 이번 연구에서 사용된 임상 지수로는 치태지수, 치은지수, 치은퇴축, 치주낭깊이, 임상부착수준, 임상부착증가, 탐침시출혈, 치아동요도 등이며, 방사선학적 평가는 기존 방사선촬영술에 의한 방법과 디지털 공제촬영수렝 의한 방법으로 행하였다. 디지털 공제 촬영술에 의한 평가시, 영상은 Digora 프로그램에 의해 획득하고 Emago 프로그램으로 처리 하여 다음과 같은 결론을 얻었다. 1. 처치후 3개월에 치태지수, 치은지수, 치은퇴축, 치주낭깊이, 임상적부착수준, 탐침시 출혈 등의 임상지수들이 변했으며, 특히 이러한 변화는 치주낭깊이, 치은퇴축, 탐침시출혈에서 유의성이 있었다. ( p<0.05 ) 그러나 두군간 차이는 인정되지 않았다. ( p>0.05 ) 2. 처치후 6개월에도 치태지수, 치은지수, 치은퇴축, 치주낭깊이, 임상적부착수준, 탐침시출혈, 치아동요도 등의 임상지수들이 변했으며, 특히 이러한 변화는 치주낭깊이, 치은퇴축, 탐침시출혈, 치태지수, 치아동요도에서 유의성이 있었다. ( p<0.05 ) 그러나 두 군간 차이는 인정되지 않았다. ( p>0.05 ) 3. 켄달 상관분석시, 임상적 평가와 기존 방사선 촬영술에 의한 평가사이의 관련성을 낮았으며 거의 0에 가까운 수치를 보였으며 (r=0.110, p=0.639 ) 임상적 평가와 디지털 공제 방사선 촬영술에 의한 평가사이에서 약간 높은 관련성을 보였다. ( r=0.257, p=0.315 ) 즉 치주치료후의 골변화는 디지털 공제 방사선 촬영술에 의한 평가시 기존 방사선 사진보다 임상적 부착증가와 더욱 긴밀한 관련성을 보여준다. 이상의 결과로 볼 때, 스프린팅 처치는 치주 치료에 있어 치근활택술에 부가적 표과를 제공하지 못한다.

Polyamines Modulate Growth factor-Induced Membrane Protein Phosphorylation in MCF-7 Human Breast Cancer Cells

이지영,김지현,이경희,김병기,Lee, Ji-Young,Kim, Ji-Hyun,Lee, Kyeong-Hee,Kim, Byeong-Gee Korean Society of Life Science 2002 생명과학회지 Vol.12 No.2

Breast cancer cell lines display a wide variety of growth factor receptors, and considerable evidences implicate the importance of signalings from those receptors. A useful prognostic indicator would be the level of activity of a second messenger protein used in common by these receptors. Our studies were designed to obtain preliminary information on the possible role of polyamine as a mediator of the membrane-associated protein phosphorylation and as a regulator of second messenger in mitogenic signal of estrogen or growth factors in MCF-7 human breast lancer cells. DFMO significantly inhibited the phosphorylation induced by $E_2$, TGF-$\alpha$ and EGF in membrane-associated proteins (154, 134, 116, and 104 kDa). Exogenous polyamines abolished the inhibitory effect of DFMO. Tyrosine phosphorylations of membrane-associated proteins were not increased by $E_2$ or growth factor treatments and not affected DFMO treatment. Polyamine administration markedly enhanced the tyrosine phosphorylation of membrane-associated proteins (154, 134, and 116 kDa). In the present study, $E_2$ and TGF-$\alpha$ and EGF enhanced protein phosphorylation in the almost same levels. These data indicate that $E_2$ and growth factor signaling pathway may cross-talk through various protein kinase which phosphorylated many substrate proteins (154, 134, 116 and 104 kDa). Polyamines may be involved in growth signaling pathway of $E_2$ and TGF-$\alpha$ or EGF for the cross-talk through regulation of the protein phosphorylation such as 154, 134, 116 and 104 kDa. Polyamine may also selectively interfere with several different protein kinases, and the specific steps in signal transduction system were effected by polyamines.

대용량 에너지 저장장치용 2세대 고온 초전도 코일의 특성해석

이지영,이세연,김영일,박상호,최경달,이지광,김우석,Lee, Ji-Young,Lee, Seyeon,Kim, Yungil,Park, Sang Ho,Choi, Kyeongdal,Lee, Ji-Kwang,Kim, Woo-Seok 한국전력공사 2015 KEPCO Journal on electric power and energy Vol.1 No.1

Large scale superconducting magnetic energy storage (SMES) system requires very high magnetic energy density in its superconducting coils to enhance the energy capacity and efficiency of the system. The recent high temperature superconducting (HTS) conductors, so called 2G conductors, show very good performance under very high magnetic field so that they seem to be perfect materials for the large scale SMES coils. A general shape of the coil system with the 2G HTS conductor has been a tor oid, because the magnetic field applied perpendicularly to the surface of the 2G HTS conductor could be minimized in this shape of coil. However, a toroid coil requires a 3-dimensional computation to acquire the characteristics of its critical current density - magnetic field relations which needs very complicated numerical calculation, very high computer specification, and long calculation time. In this paper, we suggested an analytic and statistical calculation method to acquire the maximum magnetic flux density applied perpendicularly to the surface of the 2G HTS conductor and the stored energy in the toroid coil system. Although the result with this method includes some errors but we could reduce these errors within 5 percent to get a reasonable estimation of the important parameters for design process of the HTS toroid coil system. As a result, the calculation time by the suggested method could be reduced to 0.1 percent of that by the 3-dimensional numerical calculation.

시뮬레이션을 이용한 통합전력시스템의 위험도 분석

이지영,한영진,윤원영,빈재구,Lee, Ji Young,Han, Young Jin,Yun, Won Young,Bin, Jae Goo 대한산업공학회 2016 대한산업공학회지 Vol.42 No.2

In this paper, we deal with a risk analysis for an IPS (Integrated power system) and propose a simulation model combining the fault tree and event tree in order to estimate the system availability and risk level, together. Firstly, the basic information such as operational scenarios, physical structure, safety systems is explained in order to make the fault tree and event tree of the IPS. Next, we propose a discrete-event simulation model using a next-event time advance technique to advance the simulation time. Also the state transition and activity diagrams are explained to represent the relationship between the objects. By numerical examples, the redundancy allocation is considered in order to decrease the risk level of the IPS.

성장 장애에 관한 임상 연구의 최근 동향 -최근 중의 잡지를 중심으로-

이지영,정민정,최지명,유선애,이승연,Lee, Ji-Young,Jeong, Min-Jeong,Choi, Ji-Myuoung,Yu, Sun-Ae,Lee, Seung-Yeon 대한한방소아과학회 2007 대한한방소아과학회지 Vol.21 No.1

Objectives : The aim of this study was to investigate the treatment of failure to thrive in current Traditional Chinese Medical Journals. Methods : To figure out the failure to thrive, Chinese Medical Journals from China National Knowledge Infrastructure(CNKI) which was published in 1994 to 2005 were analyzed. 矮(小)-whae(so) was searched. Results : Eleven articles were selected. 5 of them were used herbal medicine, and were showed that the total improvement rate was higher than 70% in failure to thrive. 2 of them were used acupuncture, and the last of them were used a therapy of combining Traditional Chinese Medicine with western medicine. Conclusions : The Oriental medical treatments for failure to thrive were presumed to be effective in most articles. But we think that the more studies are needed.

카메라 렌즈 평가용으로 제작된 nodal slide식 실시간 OTF 측정 장치

이지영,송종섭,조재흥,장수,임천석,이윤우,이인원,Lee, Ji-Young,Song, Jong-Sup,Jo, jae-Heung,Chang, Soo,Rim, Cheon-Seog,Lee, Yun-Woo,lee, In-Won 한국광학회 2002 한국광학회지 Vol.13 No.2

A real-time OTF (optical transfer function) measuring system with on- and off-axis nodal slide bench type for the camera lens is fabricated and evaluated. It consists of a nodal slide bench including a T-bar for the OTF measurement of an off-axis object, two dimensional CCD (charge coupled device) with pixel of 9.9${\mu}{\textrm}{m}$$\times$9.6${\mu}{\textrm}{m}$ for real-time OTF measurment, and a collimating lens of focal length of 300 mm for the optimization of this system. The OTF system is corrected by using the OTF of a SIRA lens of fnumber of F/8 and focal length 50 mm. In order to confirm the reliability of the OTF system, two MTFs (modulus transfer functions) of CCTV & VIDEO lens (JAPAN, AVENIR-SE 2514) of focal length of 25mm and field of view 10.6$^{\circ}$are measured by the camera bench type OTF system of reference OTF system and the nodal slide bench type OTF system and compared with each other. As a result, these two values are agree well with each other within 4% from 0 1p/mm to 100 1p/mm.

장기공공임대주택의 지속가능한 리모델링 유형 분석

이지영,윤영호,이지은,Lee, Ji-Young,Yoon, Young-Ho,Lee, Ji-Eun 한국토지주택공사 토지주택연구원 2013 토지주택연구 Vol.4 No.1

The remodeling of long-tern public rental housing (LPRH) have been acknowledged followed by the introduction of th Act of the Life Quality Improvement of the Residents in Long-tern Public Housing. Likewise, the feasible direction of LPRH remodeling should be discussed in order to improve the quality of life of the dwellers and housing facilities. Therefore a purpose of this study is to suggest the remodeling types for increasing their quality of life with regard to sustainability of remodeling. To do so this study employs various cases of public housing remodeling from the UK, France and USA and performed quantitative research that was subject to the residents in 9 LPRH in Seoul and Gyeong-gi. The findings of the analysis demonstrate that comprehensive and sustainable remodeling considering both physical and social environment factors are needed, and that the residents have needs of improvement of deteriorated facilities and negative perception of the public on LPRH. With regard to this, seven types of the LPRH remodeling types are drawn on the combination between physical and social environment factors. Thus it is expected that the types will ultimately be able to increase of the quality of the life of the residents and guarantee sustainable remodeling.

영월 시멘트공장 인근 주민에게서의 진폐증 집단 발생 사례보고

임종한(Jong-Han Leem),조재화(Jae-Hwa Cho),이의철(Eui-Cheol Lee),김정훈(Jeong-Hoon Kim),이동훈(Dong-Hoon Lee),이승준(Seung-Jun Lee),이지영(Ji Young Lee),김환철(Hwan-Cheol Kim) 대한직업환경의학회 2010 대한직업환경의학회지 Vol.22 No.2

Objective: This study investigated case clusters of pneumoconiosis among residents near cement factories in Young_Wol, Korea. Methods: There were 1,396 residents of a total 3,418 residents surveyed for this study. Informations on demographics, health-related behaviors (smoking and drinking), past medical history, and clinical symptoms were collected using a self-administered questionnaire. All study participants underwent a physical examination, including chest X-ray, and physicians’ interview. Chest CT (computerized tomography) was taken if there was abnormal finding on chest X-ray and physicians’ interview. Results: We detected 5 cases of pneumoconiosis. 2 cases were related to occupational exposure to dust, such as underground mining and the breaking up of concrete. However, 3 cases were not related to occupational or environmental exposure, except that persons were living near cement factories and limestone mines. Conclusion: This study suggests that the long-term exposure of cement dust among residents near cement factories and mines may lead to the development of pneumoconiosis.

코호넨의 자기조직화 구조를 이용한 클러스터링 망에 관한 연구

이지영,Lee, Ji-Young 한국정보기술전략혁신학회 2005 情報學硏究 Vol.8 No.1

Learning procedure in the neural network is updating of weights between neurons. Unadequate initial learning coefficient causes excessive iterations of learning process or incorrect learning results and degrades learning efficiency. In this paper, adaptive learning algorithm is proposed to increase the efficient in the learning algorithms of Kohonens Self-Organization Neural networks. The algorithm updates the weights adaptively when learning procedure runs. To prove the efficiency the algorithm is experimented to clustering of the random weight. The result shows improved learning rate about 42~55% ; less iteration counts with correct answer.