만성 간질환 환자의 삶의 질 평가 (논평)

엄상화 ( Sang Hwa Urm ) 대한간학회 2007 Clinical and Molecular Hepatology(대한간학회지) Vol.13 No.1

임플란트 완성 환자의 구강건강관련 삶의 질과 관련 요인

박정현,엄상화,권현숙,조갑숙,허승주,이소영,유병철,Park, Jung-Hyun,Urm, Sang-Hwa,Kwun, Hyeon-Sook,Cho, Gab-Suk,Heo, Seung-Ju,Lee, So-Young,Yu, Byeng-Chul 한국치위생학회 2011 한국치위생학회지 Vol.10 No.2

Objectives : This study was purposed to estimate the level of oral health quality of life and the relationship between health-related factors and oral health quality of life in patients with successful dental implants. Methods : This questionnaire survey was conducted during the period from December 2009 to March 2010 with 126 patients confirmed successful dental implants in Busan. The oral health related quality of life and oral health-related factors were estimated with OHIP-14 and 8 oral health characteristics, respectively. Data analysis was performed with descriptive analysis, t-test, ANOVA, multiple regression analysis using SAS(ver 9.1) program. Results : The score of oral health quality of life in patients with successful dental implants was $12.25{\pm}7.82$. The scores of subscale of the oral health quality of life were $1.24{\pm}1.35$ in social disability, $1.60{\pm}1.37$ in handicap, $1.60{\pm}1.44$ in psychological disability, $1.70{\pm}1.38$ in functional limitation, $1.81{\pm}1.35$ in physical disability, $2.14{\pm}1.46$ in physical pain, $2.17{\pm}1.46$ in psychological discomfort, respectively. The related factors of oral health quality of life in patients with successful dental implants were absence of other type prosthesis and experience of tooth brushing education. Conclusions : The oral health related quality of life in patients with successful dental implants was relatively good condition. Social supports and chances for high quality denture and tooth brushing educations are needed to improve oral health related quality of life in patients with dental implants.

부산, 울산 및 경상남도 만 19세 남자의 고도근시 유병률

이상준,엄상화,유병철,손혜숙,홍영습,노맹석,이용환,Lee, Sang-Joon,Urm, Sang-Hwa,Yu, Byeng-Chul,Sohn, Hae-Sook,Hong, Young-Seoub,Noh, Maeng-Seok,Lee, Yong-Hwan 대한예방의학회 2011 Journal of Preventive Medicine and Public Health Vol.44 No.1

Objectives: The purpose of this study was to estimate the prevalence and correlated factors of high myopia in 19 year-old men in Southeast Korea. Methods: This retrospective study was based on the medical checkup data of conscription during 2005. The study subjects were 19 years old men in Busan, Ulsan and Gyeongsangnam-do. The health checkup data of the conscripts consisted of noncycloplegic autorefraction test, the biometric data and social factors. To analyze the social and biometric effects, we classified the biometric factors into 4 or 5 groups and the social factors into 3 groups. High myopia was defined as a spherical equivalent of under -6.0 diopter. Data analysis was performed using the chi square test for trends and multiple logistic regression analysis. The SAS(version 9.1) program was used for all the analyses. Results: The prevalence of high myopia was 12.39% (6256 / 50 508). The factors correlated with high myopia were the residence area (OR, 2.07; 95% CI, 1.77 to 2.4 for small city; OR, 2.01; 95% CI, 1.72 to 2.34 for metropolis; the reference group was rural area), academic achievement (OR, 1.43; 95% CI, 1.34 to 1.53 for students of 4-and 6-year-course university; the reference group was high school graduates & under) and blood pressure (OR, 1.54; 95% CI, 1.10 to 2.16 for hypertension; OR, 1.09; 95% CI, 1.02 to 1.17 for prehypertension; OR, 1.10; 95% CI, 1.01 to 1.20 for hypotension; the reference group was normal blood pressure). Conclusions: More than one tenth of the young men were high myopia as one of the risk factor for visual loss. Further studies on high myopia and its complications are needed to improve eye health in Southeast Korea.

남성 사무직 관리자의 생활습관, 스트레스 수준과 과민성 대장증후군

김종렬,엄상화,전진호,정수진,이창희,정귀원,최순석,배기택,Kim, Jong-Ryul,Urm, Sang-Hwa,Chun, Jin-Ho,Jeong, Soo-Jin,Lee, Chang-Hee,Jeong, Kui-Won,Choi, Soon-Seok,Pai, Ki-Taek 대한예방의학회 1997 예방의학회지 Vol.30 No.4

Irritable bowel syndrome(IBS) is one of the common health problem that has been considered as stress-induced. This study was conducted to investigate the relationship between life style and the level of stress and IBS by structured questionnaire which included questions on life style, the self-esteemed gastrointestinal symptoms, and Psychosocial Well-being Index(PWI). Subjects were 1,498 male white collars who get the regular health check and participated in survey at Inje University Health Promotion Center from January to ,December, 1996. The overall prevalence of IBS was 37.5%(561 cases), and the level of stress by PWI score was higher in IBS group$(41.8{\pm}14.2)$ than symptom-free group$(34.6{\pm}12.6)$. As the result of comparison between the two groups, heavier smoking (adjusted O.R=2.48, 95% C.I 1.81-3.41), longer daily working time (adjusted O.R=5.19, 95% C.I 3.59-7.56), stimulatory food materials-mainly hot or salty (adjusted O.R=1.87, 95% C.I 1.44-2.45), higher body mass index (adjusted O.R=1.80, 95% C.I 1.27-2.57), and higher level of stress (adjusted O.R=2.81, 95% C.I 1.80-4.43) were estimated as risk factors of IBS. On the contrary, 6-8 hours sleeping per day (adjusted O.R=0.38 95% C.I 0.21-0.70), 3-4 times exercise per week (adjusted O.R=0.57 95% C.I 0.39-0.83), and tenure more than 20 years (adjusted O.R=0.25 95% C.I 0.16-0.35) were considered as protective factors to IBS. In summary, the assessment of the stress level might be placed in the first priority to control IBS, at least by some degree, which suggested that IBS could be controlled by avoiding such risk factors and by encouraging such protective factors.

보건예방사업을 위한 B형간염 표면항체 검사방법 비교

이정녀,엄상화,이종태,전진호,손혜숙,Lee, Jeong-Nyeo,Urm, Sang-Hwa,Lee, Jong-Tae,Chun, Jin-Ho,Sohn, Hae-Sook 대한예방의학회 2000 Journal of Preventive Medicine and Public Health Vol.33 No.2

Objectives : The purpose of this study was to suggest a proper method for the detection of heaptitis B surface antibody(anti-HBs) in a screening program for hepatitis B vaccination. Methods : Sensivitity, specificity and predictive values were compared between Immunochromatographic assay (ICA) and passive hemagglutination(PHA) in 978 subjects(565 males, 413 females, 19-78 years ranging in age, mean 46.5 years old). EIA was used as a standard method for the detection of HBsAb. Results : Sensitivity in the detection of anti-HBs of PHA and ICA was 88.7%, and 94.9%, specificity was 94.3% and 96.6%, negative predictive value was 96.5%, and 98.0%, and positive predictive value was 82.3%, and 91.3%,, respectively. False negative rate(11.3%) of PHA was higher than that(5.1%) of ICA. The higher the titer of anti-HBs in EIA was, the lower the false negative rate was. There was no false negative result in the cases with $101mIU/{\beta}c$ or more in EIA Conclusion : We suggest that ICA should be the choice of screening method in the detection of anti-HBs in Hepatitis B vaccination program.

베트남전 참전자 2세의 건강상태에 관한 조사 - 부산지역 고엽제 위해증 환자를 대상으로 한 설문조사 결과 -

김학준,손혜숙,엄상화,박수경,유병철,이종태,전진호,Kim, Hak-Joon,Sohn, Hae-Sook,Urm, Sang-Hwa,Park, Soo-Kyung,Yu, Byung-Chul,Lee, Jong-Tae,Chun, Jin-Ho 대한예방의학회 2000 Journal of Preventive Medicine and Public Health Vol.33 No.1

Objectives : To propose the referential data to evaluate the health impacts of Vietnam veterans' children whose father were exposed to herbicides in Vietnam War. Methods : Vietnam veterans who visited to Pusan Veteran Hospital for medical care were recruited from April to October, 1998. They were 71 and asked about their own combat history, symptoms and illness, and health status of their 182 children. The informations were collected by direct and phone interview. Exposure estimation was also performed as exposure score depending on year and unit of participation, and personal episodes related to exposure to herbicide in the war. It classified into three groups; lower(<18.0), moderate(18-53), high$(\geq53)$ exposure group. Results : The mean age and the period into the combat of the veterans were 52.8 years and 15.0 months. The mean exposure score was $18.1{\pm}9.9$, and mainly distributed in lower (46.5%) and moderate(52.1%) exposure group. Most(90.1%) of them were diagnosed as sequelae(21 cases) and suspected sequelae(43 cases) of the herbicides by Korean veteran's hospital diagnostic criteria. The major sequelae was peripheral neuropathy 13 cases, chloracne 5 cases, and the major suspected sequelae was hypertension 20 cases, diabetes mellitus 18 cases, liver disease 12 cases, central neuropathy 11 cases, etc. About birth, 42.2% and 16.9% experienced spontaneous abortion and stillbirth, respectively. The mean exposure score was higher in stillbirth experience group(p<0.05). About half of the children(90 cases, 49.5%) hold the abnormal health status: those were skin pigmentation 38 cases, rash 23 cases, congenital anomaly 15 cases, general weakness 12 cases, purpura 8 cases, visual disturbance 8 cases, etc. These health problems had no association with father's exposure level(p>0.05). Conclusions : These results were depend on their own answers, and expectation for compensation did not excluded, therefore, this study may have limitations: inaccuracy of informations due to recall bias and response bias. Nevertheless, through this study, we could image the fundamental aspect for health impacts of Vietnam veterans' children for preparing the national control program and policy. A large scale epidemiologic study with valid exposure assessment on the health impacts of Vietnam veterans' children is recommneded.

VDT 취급 여성 사무직 근로자들의 견관절 기능장애에 대한 운동요법의 효과

최순석,정귀원,엄상화,정수진,이종태,전진호,이채언,배기택,Choi, Soon-Seok,Jeong, Kui-Won,Urm, Sang-Hwa,Jeong, Soo-Jin,Lee, Jong-Tae,Chun, Jin-Ho,Lee, Chae-Un,Pae, Ki-Taek 대한예방의학회 1998 예방의학회지 Vol.31 No.2

Visual display terminal(VDT) is popular in majority of office in modern countries. Musculoskeletal pain due to repetitive work with VDT is a serious industrial accident at present. In recent studies, shoulder pain in VDT users is the most common problem in Korea. The purpose of this study was to evaluate and compare the effect of excercises on shoulder dysfunction in VDT-related female office workers. Of the 119 patients with shoulder dysfunction, 32 patients entered into the study. 16 patients(Group I) were not prescribed excercises, other 16 patients (Group II) performed throughout the specific shoulder excercises such as pendular excercises(for-ward, backward and circumduction) and sidelying external rotation excercises with weights. After 3 months of excercises, the two groups were compared in term of the pain rating scale, disability questionnaire score and range of motion score. The results were summarized as follows ; 1. The pain rating scale in Group I before and after 3 months were not differenced significantly(p value=0.784) and in Group II, the scale before and after excercises were differenced significantly(p value=0.0005). 2. The disability questionnaire scores in Group I before and after 3 months were not differenced significantly(p value=0.437) and in Group II, the scores before and after excercises were differenced significantly(p value=0.0002). 3. The ROM scores of the affected shoulder in Group I before and after 3 months were not differenced significantly(p value=0.876) and in Group II, the scores before and after excercises were differenced significantly(p value=0.0017). In conclusion, that the specific shoulder excercises on shoulder dysfunction in VDT-related female office workers are encouraged.

한국인 폐암환자와 대조군의 CYP2D6 유전적 다형성에 관한 연구

전진호,이창희,엄상화,손병철,박준한,정귀옥,손창학,윤혜경,손춘희,김형인,정진숙,Chun, Jin-Ho,Lee, Chang-Hee,Urm, Sang-Hwa,Son, Byung-Chul,Park, Jun-Han,Jung, Kui-Oak,Sohn, Chang-Hak,Yoon, Hye-Kyoung,Son, Choon-Hee,Kim, Hyung-In,Jeong, J 대한예방의학회 1998 Journal of Preventive Medicine and Public Health Vol.31 No.1

The genetically determined CYP2D6 activity as considered to be associated with cancer susceptibility with inter-individual variation. Genetic polymorphism of CYP2D6(B) and CYP2D6(T) was determined by the two polymerase chain reaction(PCR) and BstN1 and EcoN1 restriction fragment length polymorphisms(RFLP) for 67 lung cancer cases and 95 healthy volunteer controls. The cases were composed of 26 squamous cell carcinoma, 14 small cell carcinoma, 10 adenocarcinoma, 3 large cell undifferentiated carcinoma, and 14 not histologically diagnosed. The results were gained from the 142 subjects (57 cases and 85 controls) who observed successfully in two PCR and BstNl/EcoN1 RELP. Only one and no mutant allele of the CYP2D6(B) and CYP2D6(T) gene was detected, that is, the frequency of mutant allele was very low; 0.7%(1/142) and 0%(0/142), respectively. Detected mutant allele of the CYP2D6(B) was beterozygous type(WM). The odds ratios for lung cancer susceptibility with CYP2D6(B) and CYP2D6(T) genotype were not calculated. These results are similar to the previous understanding that the mutant allele is very rare in Orientals compared to Caucasians, therefore, it considered that CYP2D6(B) and CYP2D6(T) genotypes have maybe no association with lung cancer susceptibility in Koreans. This is the basic data of CYP2D6(B) and CYP2D6(T) genotypes for Koreans. It would be hepful for further study to determine lung cancer susceptibility of Koreans with the data about CYP1A1, CYP2E1, GSTM1 from future study.

임플란트 완성 환자의 구강건강관련 삶의 질과 관련 요인

박정현 ( Jung Hyun Park ),엄상화 ( Sang Hwa Urm ),권현숙 ( Hyeon Sook Kwun ),조갑숙 ( Gab Suk Cho ),허승주 ( Seung Ju Heo ),이소영 ( So Young Lee ),유병철 ( Byeng Chul Yu ) 한국치위생학회(구 한국치위생교육학회) 2011 한국치위생학회지 Vol.11 No.5

Objectives: This study was purposed to estimate the level of oral health quality of life and the relationship between health-related factors and oral health quality of life in patients with successful dental implants. Methods: This questionnaire survey was conducted during the period from December 2009 to March 2010 with 126 patients confirmed successful dental implants in Busan. The oral health related quality of life and oral health-related factors were estimated with OHIP-14 and 8 oral health characteristics, respectively. Data analysis was performed with descriptive analysis, t-test, ANOVA, multiple regression analysis using SAS(ver 9.1) program. Results: The score of oral health quality of life in patients with successful dental implants was 12.25±7.82. The scores of subscale of the oral health quality of life were 1.24±1.35 in social disability, 1.60±1.37 in handicap, 1.60 ±1.44 in psychological disability, 1.70±1.38 in functional limitation, 1.81±1.35 in physical disability, 2.14±1.46 in physical pain, 2.17±1.46 in psychological discomfort, respectively. The related factors of oral health quality of life in patients with successful dental implants were absence of other type prosthesis and experience of tooth brushing education. Conclusions: The oral health related quality of life in patients with successful dental implants was relatively good condition. Social supports and chances for high quality denture and tooth brushing educations are needed to improve oral health related quality of life in patients with dental implants. (J Korean Soc Dent Hygiene 2011;11(5): 617-727)

Rab Effector EHBP1L1 Associates with the Tetratricopeptide Repeat Domain of Kinesin Light Chain 1

Young Joo Jeong(정영주),Sung Woo Park(박성우),Sang-Jin Kim(김상진),Mooseong Kim(김무성),Sang-Hwa Urm(엄상화),Jung Goo Lee(이정구),Dae-Hyun Seog(석대현) 한국생명과학회 2020 생명과학회지 Vol.30 No.1

Kinesin 1은 미세소관을 따라 plus말단으로 이동하는 모터단백질로 세포내 물질 수송에 관여한다. Kinesin 1은 경쇄단위체(light chain subunit)를 통하여 운반체들인, 세포내 소기관, 다양한 소포체, 신경전달물질 수용체 단백질, 세포신호전달 단백질과 여러 단백질 복합체들과 결합하여 운반하는 kinesin superfamily protein (KIFs)의 한 종류이다. Kinesin light chains 1 (KLC1)은 모터 기능이 없는 단위체로서 kinesin heavy chain (KHC)과 결합한다. KLC1은 다양한 매개단백질들과 결합하지만 아직 결합하는 매개단백질이 충분히 밝혀지지 않았다. 본 연구에서는 KLC1의 tetratricopeptide repeat (TPR) 영역과 결합하는 단백질을 분리하기 위하여 효모 two-hybrid 탐색한 결과 EH domain-binding protein 1-like 1 (EHBP1L1) 을 분리하였다. EHBP1L1은 KLC1의 TPR 영역을 포함한 부위와 결합하지만 KIF5B (kinesin 1의 모터 단백질)과 KIF3A (kinesin 2의 모터 단백질)와는 결합하지 않았다. 또한 KLC1은 EHBP1L1의 C-말단에 존재하는 coiled-coil 도메인과 결합하였으며, 다른 EHBP1L1의 isoform인 EHBP1과는 결합하지 않았다. KLC1은 GST와는 결합하지 않지만 GST-EHBP1L1과 GST-EHBP1L1-coiled-coil domain과는 결합하였다. HEK-293T세포에 EHBP1L1과 KLC1을 동시에 발현시켰을 때 두 단백질은 세포 내에서 같은 부위에 존재하며, EHBP1L1을 면역침강한 결과 KLC1뿐만 아니라 KIF5B와도 같이 침강함을 확인하였다. 이러한 결과들은 kinesin 1은 EHBP1L1이 결합한 운반체를 수송함을 시사한다. Kinesin-1 is microtubule-dependent plus-end direct molecular motor protein essential for intracellular transport. It is a member of the kinesin superfamily proteins (KIFs) which transport cargo, including organelles, vesicles, neurotransmitter receptors, cell-signaling molecules, and protein complexes through interaction between its light chain subunit and the cargo. Kinesin light chain 1 (KLC1) is a non-motor subunit that associates with the kinesin heavy chain (KHC). Although KLC1 interacts with many different adaptor proteins and scaffolding proteins, its binding proteins have not yet been fully identified. We used the yeast two-hybrid assay to identify proteins that interact with the tetratricopeptide repeat (TPR) domain of KLC1, and found an interaction between KLC1 and EH domain-binding protein 1 like 1 (EHBP1L1). EHBP1L1 bound to the region containing all six TPR repeats of KLC1 and did not interact with KIF5B (a motor protein of kinesin 1) or KIF3A (a motor protein of kinesin 2) in the yeast two-hybrid assay. The carboxyl-terminus of the coiled-coil domain of EHBP1L1 is essential for interaction with KLC1. However, another EHBP1L1 isoform, EHBP1, did not interact with KLC1 in the yeast two-hybrid assay. KLC1 interacted with GST-EHBP1L1 and its coiled-coil domain but not with GST only. When co-expressed in HEK-293T cells, EHBP1L1 co-localized with KLC1 and co-immunoprecipitated with KLC1 and KIF5B but not KIF3A. These results suggest that kinesin 1 motor protein may transport EHBP1L1-associated cargo in cells.