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Clinical Significance of the Detection of Antinuclear Antibodies in Patients with Acute Hepatitis A
서연석,이광균,정은숙,안형진,김지훈,연종은,변관수,임형준,이홍식,엄순호,김창덕,유호상 거트앤리버 소화기연관학회협의회 2011 Gut and Liver Vol.5 No.3
Background/Aims: The findings of several recent studies suggest that antinuclear antibodies (ANAs) are frequently detected in patients with acute hepatitis A (AHA). However, the clinical significance of a positive ANA test remains uncertain. This study was performed to evaluate the clinical significance of ANAs in AHA patients. Methods: All patients admitted with AHA were consecutively enrolled in this study. An ANA assay was performed by indirect immunofluorescence during hospitalization. ANA positivity was defined as an ANA titer ≥1:80. The peak international normalized ratio (INR), peak alanine aminotransferase (ALT) and peak bilirubin levels were assessed over the duration of the hospitalization, and the incidence of AHA complications was evaluated. Results: A total of 422 patients were enrolled in this study (age, 31±7 years), of which 260 (61.6%) were men. ANAs were detected in 179 AHA patients (42.4%). The proportion of ANA-positive patients varied significantly with AHA status on the day of the ANA assay (4.7% during the prodromal period vs 52.1% during the icteric or recovery period, p<0.001) and sex (56.2% in women vs 33.8% in men, p<0.001). The ANAs became undetectable in all ANA-positive patients within 3 months. The incidence of complications, including mortality, fulminant hepatic failure, renal dysfunction, relapse, and cholestatic hepatitis, did not differ significantly between ANA-positive and ANA-negative patients. Conclusions: ANAs were detected frequently and transiently in patients with AHA, especially after their peak-ALT day. The presence of ANAs may not be associated with the clinical outcome of AHA, but simply with AHA status on the ANA assay day.
춘계학술대회 : 총회구연 ; 라미부딘 내성 만성 B형간염 환자에서 아데포비어 투약 중 아데포비어 내성 A181V/T, N236T 돌연변이 발생양상
서연석,연종은,유상균,김지훈,변관수,홍선표,정현재,지미선,유왕돈,이창홍 대한간학회 2005 Clinical and Molecular Hepatology(대한간학회지) Vol.11 No.3(S)
배경: Adefovir dipovoxil (ADV)은 경구용 핵산 유도체로 야생형 및 lamivudine (LMV) 내성 B형 간염 바이러스 (HBV)의 증식을 효과적으로 억제한다. 치료 기간과 비례하여 약제 내성 바이러스가 발생하는 LMV과는 달리 ADV는 장기간의 투약에도 내성 발현률이 매우 낮은 것으로 보고되어 nucleoside-naive 환자에서의 ADV 내성 변이종 발생은 치료 48, 96, 144, 192주에 각각 0, 1.7, 6, 15%