연령관련황반변성에 의한 맥락막하신생혈관에서 광역학치료와 유리체강내 스테로이드주입술의 치료효과

오현섭,노미인,오상준,이성철,이원영,권오웅,Hyun-Sub Oh,M,D,Mi-In Roh,M,D,Sang-Joon Oh,M,D,Sung-Chul Lee,M,D,Won-Young Lee,M,D,Oh-Woong Kwon,M,D 대한안과학회 2005 대한안과학회지 Vol.46 No.8

Purpose: To evaluate the safety and visual outcome of intravitreal triamcinolone acetonide combined with photodynamic therapy for subfoveal choroidal neovascularization in patients with age-related macular degeneration. Methods: We evaluated 32 eyes of 32 patients with choroidal neovascularization due to age-related macular degeneration. The study group received photodynamic therapy and intravitreal triamcinolone acetonide (combined group), while the control group received photodynamic therapy only (PDT group). Results: Three months after treatment, no difference was detected between the two groups in visual acuity changes (p>0.05), but the leakage in fluorescein angiography and macular edema in optical coherent tomography decreased (p<0.05) in the combined group. The retreatment rate in the combined group (6.0%) after 3 months was lower than that of the PDT group (53.3%). Conclusions: Photodynamic therapy with intravitreal triamcinolone acetonide to choroidal neovascularization reduced the retreatment rate at 3 months significantly. These results may have been be due to the short-term anti-inflammatory effect of steroids.

공중 유·무인복합체계 개발동향 및 발전방안

김미선(Mi-Seon Kim),노유찬(Yu-Chan Roh),오주영(Juyoung Oh) 한국항공우주학회 2021 한국항공우주학회 학술발표회 논문집 Vol.2021 No.11

교사들의 반성적 글쓰기를 통해 본 배움중심수업의 특징과 의미

남미자 ( Mi Ja Nam ),길현주 ( Hyun Joo Ghil ),오춘옥 ( Chun Ock Oh ),노시구 ( Si Ku Roh ) 한국사회과교육학회 2014 시민교육연구 Vol.46 No.1

The purpose of this study is to understand the feature and meaning of Learning Oriented Class through teachers` reflective writing. Gyeonggi Provincial Office of Education push forward to reform class for school reform and the key point of reforming class is the Learning Oriented Class. But Teachers have difficulties in practicing Learning Oriented Class because it is not the method of teaching or manual. This study conducts a qualitative study, adopting reflective writing, on 39 teachers at primary schools, middle schools and high schools. As a result of these analyses, following have appeared as key findings. First, the teacher recognized classroom as dynamic space of unpredictability. Second, teachers pay attention to the relationship between teachers and students. The confidential relationship between teachers and students, students and students must be preceded to students` learning. The such confidential relationship between teachers and students is based on the relationship of the outside class. Third, teachers recognized learning not activities in a classroom but activities in students` daily life. Therefore learning is not tied up knowledge of school subject, but newly borned as connecting students` life. Also teachers are growing by introspecting their life. Through this study teachers can find the clue to improve their class and we expect that teachers, parents, and students can understand the Learning Oriented Class.

Thioacetamide로 유발한 간손상 모델에서 계혈등(鷄血藤)의 간보호 효과

오민혁 ( Min Hyuck Oh ),신미래 ( Mi-rae Shin ),노성수 ( Seong-soo Roh ) 대한본초학회 2021 대한본초학회지 Vol.36 No.2

Objectives : This study was undertaken to investigate the hepatoprotective effect of Spatholobi Caulis water extract (SC) to thioacetamide (TAA)-induced acute liver injury (ALI) in rats. Methods : The rats were injected intraperitoneally with TAA (200 ㎎/㎏ body weight) and orally administered SC (100 or 200 ㎎/㎏ b.w.) daily for 3 days. Liver biomarkers were assessed by serum glutamic oxaloacetic transaminase (GOT), glutamic pyruvic transaminase (GPT), and ammonia levels. Malondialdehyde (MDA) was measured both serum and liver tissue. In addition, nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, anti-oxidant, and inflammation-related proteins were investigated by western blot analysis. Histological examination further confirmed though hematoxylin and eosin stain. Results : The SC treatment reduced liver function markers like GOT and GPT and also remarkably decreased ammonia level. Moreover, the elevated MDA level in TAA-induced group was significantly reduced by SC treatment. NADPH oxidase expression associated with oxidative stress including NOX2, NOX4, and p47^phox markedly inhibited by SC administration. SC treatment exerted anti-oxidant effect through the increase of anti-oxidant enzyme including superoxide dismutase (SOD), Catalase, and heme oxygenase-1 (HO-1). The protein expressions of inflammatory cytokines such as tumor necrosis factor-α (TNF-α), IL-6, and IL-1β induced by nuclear factor-kappa B (NF-κB) activation were modulated through blocking the phosphorylation of inhibitor of nuclear factor κBα (IκB)α. SC treatment also improved histological alterations. Conclusion : These findings suggested that SC administration may be a potential candidate for the prevention or treatment of ALI.

안면홍조에 대한 임상시험 참가자의 증상 발현 양상에 관한 연구

김동일 ( Dong Il Kim ),노진주 ( Jin Ju Roh ),정수경 ( Su Kyoung Jung ),성준호 ( Jun Ho Seung ),이승덕 ( Seung Deok Lee ),안홍엽 ( Hong Yup Ahn ),오달석 ( Dal Seok Oh ),최선미 ( Sun Mi Choi ) 대한한방부인과학회 2006 대한한방부인과학회지 Vol.19 No.4

계혈등 추출물이 급성 간 손상에 미치는 효과

오민혁(Min Hyuck Oh),박해진(Hae-Jin Park),신미래(Mi-Rae Shin),노성수(Seong-Soo Roh) 대한약학회 2021 약학회지 Vol.65 No.4

This study aimed to examine the protective effect of the water extract from Spatholobi Caulis (SC) on rats with acute liver injury (ALI) induced by thioacetamide (TAA) and its underlying mechanism. ALI was induced by intraperitoneal injection with TAA for 3 days in a row and the rats were administered SC (100 or 200 mg/kg) 1 h 30 min prior to the TAA treatment. Myeloperoxidase (MPO) was measured in serum and malondialdehyde (MDA) was measured in serum and liver tissue, as markers related to oxidative stress. Further, inflammation-related proteins and apoptosis proteins were investigated using western blot analysis. SC treatment significantly reduced the levels of MPO and MDA. Further, SC treatment significantly reduces the mitogen-activated protein kinase (MAPK) signaling pathway, including p-JNK, p-ERK, and p-p38, and reduces the expression of pro-inflammatory signaling factors. Furthermore, it effectively decreased the expression of Bax, Cytochrome C, and Cleaved Caspase-3 in liver tissue. Taken together, SC treatment alleviate0d the severity of ALI via inhibition of inflammation through both the MAPK pathway and Matrix metalloproteinase (MMPs)-dependent apoptosis.

증례 : 급성 A형 간염 후 발생한 전격성 제1형 당뇨병 1예

권지연 ( Ji Yeon Kwon ),노미오 ( Mi Oh Roh ),송민수 ( Min Soo Song ),정찬희 ( Chan Hee Jung ),박형규 ( Hyeong Kyu Park ),김여주 ( Yeo Ju Kim ),목지오 ( Ji Oh Mok ),김상진 ( Sang Jin Kim ),김철희 ( Chul Hee Kim ),변동원 ( Dong Won 대한당뇨병학회 2009 임상당뇨병 Vol.10 No.2

전격성 제1형 당뇨병은 췌도에서 급격히 베타세포와 알파세포가 파괴되는 특징을 가진 당뇨병으로 그 기전은 명확하지 않으나 유전적 감수성이 있는 개체에서 바이러스 감염 등의 환경적인 인자와의 연관성이 가능한 병태생리로 제시되고 있으며 이에 대한 추가적인 연구가 필요하다. 저자들은 최근 급증하는 A형 간염 후에 발생한 전격성 제1형 당뇨병 1예를 경험하여 전격성 제1형 당뇨병과 바이러스 감염의 관련성에 대한 근거를 제시하고 이에 대해 보고하는 바이다. Fulminant type 1 diabetes mellitus is a novel subtype of type 1 diabetes, which is characterized by a remarkably abrupt onset, metabolic derangement such as diabetic ketoacidosis at diagnosis, low HbA1c level at onset and negative islet-related autoantibodies. The pathogenesis of this disease remains to be clarified, but the involvement of both genetic background and viruses have been suggested. We recently encountered a case of fulminant type 1 diabetes mellitus in 32-year-old male patient who was diagnosed with acute hepatitis A a month ago. Laboratory findings revealed high blood glucose level as well as evidence of diabetic ketoacidosis, but the HbA1c level was normal. The low level of plasma C-peptide indicated the loss of endogenous insulin secretion. This patient`s laboratory results met the criteria for the diagnosis of fulminant type 1 diabetes. We consider that this report can add to the body of evidence of a viral etiology of fulminant type 1 diabetes. Further study is needed to elucidate the exact pathogenesis. (Korean Clinical Diabetes J 10:118-122, 2009)

대황-황금 혼합물이 만성 역류성 식도염에 미치는 효과

이진아,오민혁,신미래,노성수,박해진,Lee, Jin A,Oh, Min Hyuck,Shin, Mi-Rae,Roh, Seong-Soo,Park, Hae-Jin 한국생약학회 2022 생약학회지 Vol.53 No.1

소시호탕(小柴胡湯)이 thioacetamide로 유발된 간섬유증 동물 모델에 미치는 영향

이세희,오민혁,신미래,이지혜,노성수,Lee, Se Hui,Oh, Min Hyuck,Shin, Mi-Rae,Lee, Ji Hye,Roh, Seong-Soo 대한한방내과학회 2021 대한한방내과학회지 Vol.42 No.6

Objectives: The aim of the current study was to investigate the effect of Sosiho-tang on thioacetamide (TAA)-induced liver fibrosis in mice and to elucidate its underlying mechanisms. Methods: The mice were divided into 4 groups: Normal mice (Normal), TAA-induced control mice (Control), TAA-induced and silymarin-treated (50 mg/kg) mice (Silymarin), and TAA-induced and Sosiho-tang treated (200 mg/kg) mice (SSHT). Liver fibrosis was induced via intraperitoneal injection of TAA three times a week for 8 weeks. Silymarin and Sosiho-tang were concomitantly administered for 8 weeks. Serum and liver tissues were then collected and the anti-oxidant and inflammatory protein levels in the liver tissues were evaluated using western blotting. Results: SSHT administration significantly reduced the levels of AST, ALT, ammonia, and MPO in the serum. SSHT also significantly down-regulated liver NADPH oxidase and regulated the Nrf2/Keap1 signaling pathway. SSHT treatment downregulated the liver NF-κB levels and suppressed inflammatory cytokines. SSHT treatment also decreased bile acid-related factors, such as CYP7A1 and NTCP, and fibrosis-related factors, such as α-SMA and Collagen I. Conclusions: Taken together, these data suggest that SSHT administration suppressed the progression of liver fibrosis by activating the Nrf2/Keap1 pathway and inhibiting NF-κB.

흰쥐 C6 신경교종 세포에서 Venlafaxine 그리고 Dexamethasone 처리가 열충격 단백질 70의 발현에 미치는 영향

유재학,이준석,양병환,최미란,채영규,김석현,노성원,오동열,최인근,Yu, Jae-Hak,Lee, Jun-Seok,Yang, Byung-Hwan,Choi, Mi-Ran,Chai, Young-Gyu,Kim, Seok-Hyeon,Roh, Sung-Won,Oh, Dong-Yul,Choi, Ihn-Geun 대한생물정신의학회 2005 생물정신의학 Vol.12 No.2

Object:The intracellular action of the antidepressant, venlafaxine, was studied in C6-gliomas using heat shock protein 70(HSP70) immunocytochemistry and HSP70 Western blots because HSP70 is associated with stress and depression. Methods:To examine how the glucocorticoid affects the expression of HSP70 in nerve cells, the rat C6 glioma cell was treated with dexamethasone for 6 hours. In addition, venlafaxine was administered to the experimental groups of C6 glioma cells for 1, 6, 24, and 72 hours each, after which the expression of HSP70 was investigated. Finally, venlafaxine and dexamethasone were simultaneously administered to the experimental groups for 1, 6, 24, and 72 hours, followed by an investigation of the expression of HSP70. Results:The short term(1 hour) venlafaxine treatment significantly increased the level of HSP70 expression. The short term treatment of venlafaxine with dexamethasone also increased the level of HSP70 expression but this reduction was not statistically significant. The long term(72 hours) venlafaxine with dexamethasone treatment significantly reduced the level of HSP70 expression. The long term treatment of venlafaxine also reduced the level of HSP70 expression but this reduction was not statistically significant. Dexamethasone(10uM, 6hours) did not affect the level of HSP70 expression compared with controls. Conclusion:Venlafaxine increases the expression of HSP70 at short term treatment, but prolonged treatment with dexamethasone suppresses the expression of HSP70.