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송지혜,강희범,박승호,정지훈,박정진,유양희,이유현,이정민,김응필,최경철,전우진 한국식품영양과학회 2017 Journal of medicinal food Vol.20 No.12
Porphyra tenera, also known as nori, is a red algal species of seaweed. It is cultivated in Asia for culinary purposes. We report that P. tenera extract (PTE) enhances the immune response in mouse macrophages. We found that P. tenera extract regulates the NF-κB IκB kinase (IKK) signaling pathway, and we assessed the expression and translocation of p65, a subunit of NF-κB, in RAW264.7 mouse macrophage cells after treatment with PTE. We also investigated the effects of 10% ethanol PTE (PTE10) in RAW264.7 cells. The production of IL-10, IL-6, TNF-α, and IFN-γ was induced by PTE treatment of the macrophages, and PTE also enhanced p-IκB and p-AKT. PTE10 showed no cytotoxicity at 10–20 μg/mL in RAW264.7 cells. PTE10, in fact, increased cell viability at 24 h, stimulated macrophage cells, and induced the phosphorylation of Akt. Akt stimulates IKK activity through the phosphorylation of IKKα and enhances immune activity through the activation of NF-κB. In this study, NF-κB activation was induced by increasing p-NF-κB and p-IKK. A subunit of NF-κB, p65, was located in the nucleus and increased the expression of various cytokines. PTE thus enhanced the immune response through IκB-α immunostimulation signaling in RAW264.7 cells. PTE10 has potential therefore for development of future treatments requiring immune system stimulation.
송지혜,강희범,김지혜,곽성민,성기준,박승호,정지훈,김현희,이정민,전우진,김용재,최경철 한국식품영양과학회 2018 Journal of medicinal food Vol.21 No.8
Obesity is the most common metabolic disease in developed countries and has become a global epidemic in recent years. Obesity is associated with various metabolic abnormalities, including glucose intolerance, insulin resistance, type 2 diabetes, dyslipidemia, and hypertension. Leaves from the plant Dendropanax morbiferus are beneficial to health as they contain high levels of vitamin C and tannin. There have been seminal studies on the anticancer, antimicrobial, antidiabetes, and antihyperglycemic effects of treatments with D. morbiferus trees. Herein, we investigated the toxicity of D. morbiferus water (DLW) extracts in vitro, and demonstrated no toxicity at 5–500 μg/mL in 24–72-h experiments with 3T3-L1 cells. The DLW increased cell viability at 48 h and inhibited adipogenesis in 3T3-L1 cells by reducing intracellular triglyceride levels and glucose uptake. In addition, mRNA and protein expression levels of adipogenesis-related genes were lowered by DLW, suggesting antiobesity effects in mouse 3T3-L1 cells. Because few studies have demonstrated cholesterol-lowering effects of D. morbiferus, we investigated the activities of adipogenic transcriptional factors following treatments of 3T3-L1 cells with D. morbiferus and observed increased CEBPα, CEBPβ, PPARγ, and SREBP1 activities in the cells, indicating that DLW extracts inhibit adipogenesis.
하의륜,강희범,정회경,He, Yi-Lun,Kang, Hee-beom,Jung, Hoe-kyung 한국정보통신학회 2016 한국정보통신학회논문지 Vol.20 No.6
삶의 편의성이 증대되면서 체질량 지수 (Body Mass Index)가 높은 인구가 급속도로 증가하고 있다. 또한 이에 따라 비만을 관리하고 예방하기 위한 모니터링 시스템의 개발이 요구되고 있는 시점이다. 그러나 대부분의 모니터링 시스템은 사용자가 관리를 받기에는 정보가 적고, 간단한 정보만을 가지고 계산만하여 보여주기 때문에 효율성이 낮고, 질병을 가진 사용자를 정상인과 함께 관리하여 정확도가 떨어졌다. 이에 본 논문에서는 사용자의 체질량 지수를 그래프로 표현하고, BMR(Basal metabolic rate)지수를 등급으로 나누어 사용자가 자신을 관리하는데 정확도를 높였다. 또한 사용자가 사용한 운동 기구를 사용한 회수 별로 나타내 균형 잡힌 운동 기구 선택을 할 수 있게 하였고, 소모한 칼로리를 같이 나타내 운동 계획을 설계하는데 효율성을 높였고, 그래프의 경우 최근 데이터만 나타내 시각성을 높인 웹 기반 모니터링 시스템을 개발하였다. While increasing the convenience of life is a high population BMI (Body Mass Index) is increasing rapidly. Accordingly, the development of the monitoring system to manage and prevent obesity is the time that is required. But most of the monitoring system, the less information it receives management and show to have only simple information calculated this was a low efficiency problem. Also Users with normal and disease Management accuracy is low. In this paper shows the user in a graph of Body Mass Index, BMR (Basal metabolic rate) divided by grade increased accuracy for users to manage their own. Also represented by recovery with exercise machines you used, select a balanced movement mechanism, expressed as a Kcal consumption. If the graph recent data show only increased the visibility. We developed an efficient web-based monitoring system for design a exercise plan.