[정지훈 우리들병원 생명과학기술연구소장 강연] 데이터 웹에서 사람중심의 소셜 웹으로 바뀌었다

정지훈 관훈클럽 2010 관훈저널 Vol.- No.115

Association of Metabolic Syndrome and Benign Prostate Enlargement in Young Korean Males

정지훈,김은탁,김대경 대한비뇨의학회 2011 Investigative and Clinical Urology Vol.52 No.11

Purpose: This study was designed to evaluate the association of metabolic syndrome and benign prostate enlargement in young Korean males. We analyzed the clinical data associated with metabolic syndrome and prostate volume in the study population. Materials and Methods: We retrospectively analyzed the clinical data obtained from 1,506 young men under the age of 60 who visited the health promotion center in our institution for routine checkups. The patients were interviewed with a questionnaire including the International Prostate Symptom Score (IPSS) and were evaluated by medical history, blood chemistry, digital rectal examination, and prostate volume via transrectal ultrasonography. The presence of metabolic syndrome was determined according to the modified National Cholesterol Education Program Expert Panel on Detection, Evalution, And Treatment of High Blood Cholesterol in Adults criteria. We divided the subjects into two groups: those with metabolic syndrome and those without. Logistic regression analysis was carried out to determine which metabolic components were associated with an increased risk of benign prostate enlargement. Results: Significant differences in prostate volume were noted between the groups. The prostate volumes were significantly larger in the metabolic syndrome group than in the non-metabolic syndrome group in all subgroups divided by age (in decades). However, no significant differences in IPSS or voiding or storage subscore were noted. In the multivariate regression analysis, only diabetes and obesity were identified as risk factors for benign prostate enlargement among the metabolic components. Conclusions: Metabolic syndrome and prostate volume were significantly related, even in young males. Diabetes and obesity were identified as significant risk factors for benign prostate enlargement in young males under the age of 60. Purpose: This study was designed to evaluate the association of metabolic syndrome and benign prostate enlargement in young Korean males. We analyzed the clinical data associated with metabolic syndrome and prostate volume in the study population. Materials and Methods: We retrospectively analyzed the clinical data obtained from 1,506 young men under the age of 60 who visited the health promotion center in our institution for routine checkups. The patients were interviewed with a questionnaire including the International Prostate Symptom Score (IPSS) and were evaluated by medical history, blood chemistry, digital rectal examination, and prostate volume via transrectal ultrasonography. The presence of metabolic syndrome was determined according to the modified National Cholesterol Education Program Expert Panel on Detection, Evalution, And Treatment of High Blood Cholesterol in Adults criteria. We divided the subjects into two groups: those with metabolic syndrome and those without. Logistic regression analysis was carried out to determine which metabolic components were associated with an increased risk of benign prostate enlargement. Results: Significant differences in prostate volume were noted between the groups. The prostate volumes were significantly larger in the metabolic syndrome group than in the non-metabolic syndrome group in all subgroups divided by age (in decades). However, no significant differences in IPSS or voiding or storage subscore were noted. In the multivariate regression analysis, only diabetes and obesity were identified as risk factors for benign prostate enlargement among the metabolic components. Conclusions: Metabolic syndrome and prostate volume were significantly related, even in young males. Diabetes and obesity were identified as significant risk factors for benign prostate enlargement in young males under the age of 60.

A study on coalbed methane gas contents estimation of the coal mine in Mongolia

정지훈,권순일,Dongkwon Han,Seungrok Lee 한국자원공학회 2013 Geosystem engineering Vol.16 No.3

This study presents both theoretical and experimental calculations for the amount of desorbed gas, lost gas, and residual gas from the coal core and gas composition analysis in order to measure the coalbed methane content of the studied coal mine in Mongolia. Three wells (1, 2, and 3) were studied, and the results from well 3 were analyzed. The amount of desorbed gas was measured to be 6.740 scf/ton in sample 7. The amount of lost gas was calculated using the direct method and the maximum amount calculated from sample 1 was 0.986 scf/ton. After crushing the sample to ,60 mesh and measuring four samples, the average crushing rate was approximately 71% and no residual gas was detected. Gas composition analysis showed that although methane gas was detected in almost all samples, the amount was only 1.17% in average, whereas nitrogen was detected with an average of 85.29% and with a small amount of carbon dioxide.

청국장 제조과정에서의 Bacterial Phytase에 의한 Phytic Acid의 분해

정지훈,강성국,김용순,정희종 한국산업미생물학회 1990 한국미생물·생명공학회지 Vol.18 No.4

재래식 발효 청국장으로부터 분리한 8균주 중 phytase 생산성이 높은 3균주는 Bacillus subtilis, Bacillus licheniformis, Staphylococcus epidermidis로 동정되었다. 이들 phytase 생산균주를 단독 또는 혼합균주로 하여 35-40℃와 pH7.0의 최적조건에서 5일 동안 청국장을 발효시켰을 때 최대의 phytase 생산성을 보였으며 glutamic acid와 leucine 등의 일부 아미노산과 riboflavin의 함량이 증가되고 phytic acid의 분해율도 재래식 청국장에서 보다 훨씬 높았다. 특히 B. subtilis와 B. licheniformis의 혼합균주로 발효시켰을 때 phytic acid 함량의 감소가 현저하였다. Three strains among 8 isolates from the fermented chungkookjang were shown the strong phytase productivities. The phytase activities in manufacturing cuhngkookjang with thrse bacteria were maximized after incubating at 35-40℃, pH 7.0 for 5 day. The contents of same amino acids and riboflavin were increased in chungkookjang manufactured with these phytase-producing bacteria and the rate of phytic acid degradation was much higher in chungkookjang manufactured with a single or mixed cultures of these bacteria than in traditional chungkookjang.

The Effect of Dehydroepiandrosterone on Isoproterenol-induced Cardiomyopathy in Rats

정지훈,김찬웅,임성혁,신용규,박경화,박은섭 대한약리학회 2006 The Korean Journal of Physiology & Pharmacology Vol.10 No.2

We evaluated therapeutic and preventive properties of dehydroepiandrosterone (DHEA), a weak androgenic steroid, against isoproterenol-induced cardiomyopathy. The cardiomyopathy was induced by daily i.p. administration of isoproterenol to rats for five days. One group of rats were given with daily s.c. for 5 days during isoproterenol and the other group with daily s.c. DHEA for total 10 days, including 5 days before and during isoproterenol. The animals were killed after each treatment, and cardiac muscle failure was evaluated using histopathologic examination and biochemical indices. DHEA was found to reduce the damaged area and inhibit the elevation in the serum levels of glutamic oxaloacetic transaminase (SGOT), lactate dehydrogenase (LDH), skeletal muscle creatine kinase (CK) and heart creatine kinase (CK-MB) induced by isoproterenol. We also assayed widely used oxidative stress parameters, including thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase and glutathion peroxidase (GPx). DHEA decreased the escalated level of TBARS and enhanced the anti oxidant defense reaction with an increase in Mn-SOD and Cu/Zn-SOD. On the other hand, the treatment with DHEA did not affect catalase and GPx activity. The present study indicates that DHEA has a therapeutic and preventive effect against isoproterenol-induced cardiomyopathy and its effects may depend largely on the increase in SOD activity.

『의방유취(醫方類聚)·오장문(五臟門)』의 처방 분석 -처방 제형을 중심으로 -

정지훈,Jung, Ji-Hun 한국의사학회 2018 한국의사학회지 Vol.31 No.1

Most of the prescriptions currently used by Korean medicine institutions to treat patients are delivered in the form of decoctions. The author reviewed the five-viscera section (五臟門) of Euibangyoochui (醫方類聚), which is composed of theory, medicinals, diet, taboo, acupuncture and moxibustion, and exercises. The medicinals cover a total of 1,144 prescriptions cited from 14 medical books, and provides a wide range of prescriptions and delivery options, including decoctions, powders and pills. Of the 1,144 prescriptions, the author notes that among them, 577 prescriptions which use powders (41%) are the most popular; 444 are pills (31%) and are the second most popular; 329 decoctions (23%) are the third most popular, and 64 other prescriptions are 5 percent. Expanding treatment options and delivery of medicinal prescriptions presented in the five-viscera section (五臟門) of Euibangyoochui (醫方類聚), is beneficial to both patients and doctors. The author suggests that expansion of herbal treatment options will provide opportunities to overcome current treatment limitations in the Korean medical service industry.

Performance of Copeptin for Early Diagnosis of Acute Myocardial Infarction in an Emergency Department Setting

정지훈,Yiel Hea Seo,Jeong Yeal Ahn,Kyung Hee Kim,Ja Young Seo,Ka Yeong Chun,Yong Su Lim,Pil Whan Park 대한진단검사의학회 2020 Annals of Laboratory Medicine Vol.40 No.1

Background: Rapid and accurate diagnosis of acute myocardial infarction (AMI) is critical for initiating effective treatment and achieving better prognosis. We investigated the performance of copeptin for early diagnosis of AMI, in comparison with creatine kinase myocardial band (CK-MB) and troponin I (TnI). Methods: We prospectively enrolled 271 patients presenting with chest pain (within six hours of onset), suggestive of acute coronary syndrome, at an emergency department (ED). Serum CK-MB, TnI, and copeptin levels were measured. The diagnostic performance of CK-MB, TnI, and copeptin, alone and in combination, for AMI was assessed by ROC curve analysis by comparing the area under the curve (AUC). Sensitivity, specificity, negative predictive value, and positive predictive value of each marker were obtained, and the characteristics of each marker were analyzed. Results: The patients were diagnosed as having ST elevation myocardial infarction (STEMI; N=43), non-ST elevation myocardial infarction (NSTEMI; N=25), unstable angina (N=78), or other diseases (N=125). AUC comparisons showed copeptin had significantly better diagnostic performance than TnI in patients with chest pain within two hours of onset (AMI: P =0.022, ≤1 hour; STEMI: P =0.017, ≤1 hour and P =0.010, ≤2 hours). In addition, TnI and copeptin in combination exhibited significantly better diagnostic performance than CK-MB plus TnI in AMI and STEMI patients. Conclusions: The combination of TnI and copeptin improves AMI diagnostic performance in patients with early-onset chest pain in an ED setting.

Two Cases of Diffuse Large B-Cell Lymphomas in the Cervical Lymph Nodes in Patients with Low-Grade Gastric Marginal Zone B-cell Lymphoma (MALT Lymphoma)

정지훈,정훈용,윤환,이재광,강지훈,전성진,박영수,김진호 대한소화기내시경학회 2013 Clinical Endoscopy Vol.46 No.3

It is well known that gastric mucosa-associated lymphoid tissue (MALT) lymphomas are associated with Helicobacter pylori infection and have a good prognosis. However, although rare, these low-grade lymphomas transform to the high-grade diffuse large B-cell lymphomas (DLBCLs) which are thought to be the important cause of death in patients with MALT lymphoma. We report two cases of DLBCLs in the cervical lymph nodes that occurred 10 years and 1.5 years after diagnosing low-grade gastric MALT lymphomas.

The Prognostic Value of Serum Levels of Heart-Type Fatty Acid Binding Protein and High Sensitivity C-Reactive Protein in Patients With Increased Levels of Amino-Terminal Pro-B Type Natriuretic Peptide

정지훈,서일혜,안정열,김경희,서자영,김문진,이환태,박필환 대한진단검사의학회 2016 Annals of Laboratory Medicine Vol.36 No.5

Background: Amino-terminal pro-B type natriuretic peptide (NT-proBNP) is a well-established prognostic factor in heart failure (HF). However, numerous causes may lead to elevations in NT-proBNP, and thus, an increased NT-proBNP level alone is not sufficient to predict outcome. The aim of this study was to evaluate the utility of two acute response markers, high sensitivity C-reactive protein (hsCRP) and heart-type fatty acid binding protein (H-FABP), in patients with an increased NT-proBNP level. Methods: The 278 patients were classified into three groups by etiology: 1) acute coronary syndrome (ACS) (n=62), 2) non-ACS cardiac disease (n=156), and 3) infectious disease (n=60). Survival was determined on day 1, 7, 14, 21, 28, 60, 90, 120, and 150 after enrollment. Results: H-FABP (P<0.001), NT-proBNP (P=0.006), hsCRP (P<0.001) levels, and survival (P<0.001) were significantly different in the three disease groups. Patients were divided into three classes by using receiver operating characteristic curves for NT-proBNP, H-FABP, and hsCRP. Patients with elevated NT-proBNP (≥3,856 pg/mL) and H-FABP (≥8.8 ng/mL) levels were associated with higher hazard ratio for mortality (5.15 in NT-proBNP and 3.25 in H-FABP). Area under the receiver operating characteristic curve analysis showed H-FABP was a better predictor of 60-day mortality than NT-proBNP. Conclusions: The combined measurement of H-FABP with NT-proBNP provides a highly reliable means of short-term mortality prediction for patients hospitalized for ACS, non-ACS cardiac disease, or infectious disease.

17세기 중반 윤선거 역학의 성립 배경

정지훈 (사)한국인물사연구회 2012 한국인물사연구 Vol.17 No.-

I-Ching(周易), 처의(處義), Huchon I-Ching(後天易), 17th Century key words The purpose of this paper is to examine the background on the Yun Seon Geo(1610-1669) on I-Ching(周易). Yun Seon Geo is a representative Confucius of Joseon Dynasty in 17th Century. He is a grandson of Ugye, Seonghon who is a origin of academic tradition of Ugye’s School. Yun suceeded to the academic tradition of his family as well as learned from Kim Jip who was a central figure of Yulgok’s School. He was a brilliant student and had a promision future. However Yun’s life was dramatically changed from the war, Byungjahoran(丙子胡亂). After the war, He was surrounded by a criticism, so called ‘cheoyui(處義)’. As a result of that, He gave up anything of the government position and lived the rest of his life in seclusion. In the process, He concentrated on the learning and research of I-Ching for several years. On that reseult, A new theory about I-Ching was produced and Yun called it as a ‘Huchon I-Ching(後天易)’. It was totally different from Seonchon I-Ching(先天易) that was originated in China. Then, Why did Yun create a new I-Ching? This study is for finding out the answers as an investigating his life, experiences, academic tradition and a controversy of the manners(禮) as an important political issue at that period.