지역정보화 추진을 위한 체신관서의 역할 증대 방안 연구

조원경 한국통신학회 1992 한국통신학회 전기통신학술연구과제 Vol.- No.-

Residue 수 체계를 이용한 그래픽 스케일링 프로세서

趙源敬,林寅七 慶熙大學校 1985 論文集 Vol.14 No.-

This paper proposes a new algorithm, which is appropriate for real-time scaling of large scale data using residue Number System. For each arithmetic module is normalized and modules have great independence individually, this algorithm is useful for VLSI design. As the scaling result by real number scaling factor is integer, this algorithm is also useful for the arithmnetic of graphic data that uses only interger. The time that is necessary for the scaling of each data requires 2 clock pulse to implement pipeline circuit.

중년기 직장 남성의 직업에 대한 태도 - 공무원과 일반기업 종사자를 대상으로 -

조원경,한정란 한국직업교육학회 2009 職業 敎育 硏究 Vol.28 No.1

본 연구의 목적은 공무원과 일반기업 종사자를 대상으로 중년기 직장 남성의 사회인구학적 변인에 따른 직업에 대한 태도의 차이를 분석하고, 직업만족도에 영향을 미치는 변인을 분석하는 데 있다. 이 연구의 목적을 달성하기 위하여 충남 및 경기지역 일반기업 근로자 222명과 공무원 150명 등 중년기 직장 남성 372명을 대상으로 직업만족도, 직업안정성, 직업스트레스, 직업지향성 등에 관한 설문조사를 실시하였다. 본 연구의 결과 첫째, 연구 대상자들의 직업에 대한 태도는 영역별로 다소 차이가 있긴 했지만 대체로 중립범위 안에 있었다. 둘째, 사회인구학적 변인에 따른 직업태도의 차이에서 직업만족도는 50대, 배우자가 있는 경우, 자녀가 있는 경우, 경력이 많은 경우에 더 높게 나타났으며, 직업안정성은 일반기업체 종사자보다 공무원들에게 더 높은 것으로 나타났다. 직업스트레스는 50대, 250만원 이하 소득자, 자녀가 없는 경우, 6~10년 경력자들에게 더 낮은 것으로 나타났다. 직업지향성은 50대, 251~350만원 소득자, 자녀가 있는 경우, 21년 이상 경력자에게서 더 높은 것으로 나타났다. 셋째, 직업태도들간의 관계에서는 직업안정성이 높을수록, 직업스트레스가 낮을수록, 직업지향성이 높을수록 직업만족도가 높은 것으로 나타났다. 넷째, 직업만족도에 대한 영향요인을 알아보기 위하여 회귀분석을 실시한 결과 사회인구학적 변인보다는 직업에 대한 태도 변인들 그 중에서도 특히 직업지향성이 직업만족도에 중요한 영향력을 갖는 것으로 나타났다. The purpose of this study was to investigate middle-aged male workers' attitudes to their job. The subjects were 372 employed males(222 company employees and 150 civil servants) of at least 30 years old in Chungnam and Gyeonggi areas. The Findings were as follows: First, most respondents had neutral attitudes toward their job. Second, higher job satisfaction was observed from those who were in 50s, with a spouse, with children, with more career than others. Third, higher job security was observed from civil servants than company employees. Fourth, less job stress was observed from those who were in 50s, with low income, without children, with career of 6 to 10 years than others. Fifth, higher job orientation was observed from those who were in 50s, with income less than 2,500,000 won, with children, with career more than 21 years than others. Sixth, respondents with higher job security, lower job stress, and higher job orientation had higher job satisfaction. Seventh, attitudes toward job such as job security, job stress, and job orientation showed stronger impact than socio-democratic variables such as age, children, and occupation on job satisfaction. Finally, we suggested several implications for future research on the limitations of this study.

인접블록의 움직임벡터를 이용한 고속 움직임추정 방식

조원경,김진상,김영수,서덕영,소현호 한국통신학회 2005 韓國通信學會論文誌 Vol.30 No.12

Feasibility of Selective Neck Irradiation with Lower Elective Radiation Dose in Treating Nasopharynx Cancer Patients

조원경,오동렬,이언주,김태규,이혜빈,남희림,노재명,안용찬 대한암학회 2019 Cancer Research and Treatment Vol.51 No.2

Purpose This study aimed to report the clinical outcomes following selective neck irradiation (SNI) with lower elective radiation therapy (RT) dose in treating nasopharyngeal cancer (NPC) patients. Materials and Methods A total of 347 NPC patients received definitive RT according to our SNI policy and were retrospectively analyzed. The clinical target volumes (CTVs) were subdivided into CTV at high risk (CTV-HR) and CTV at low risk (CTV-LR). The typical doses to gross tumor volume (GTV), CTV-HR, and CTV-LR were 68.4-70.0 Gy, 54.0-60.0 Gy, and 36.0 Gy. Results With the median follow-up of 68.1 months (range, 2.3 to 197.1 months), the 5-year rates of loco-regional control and progression-free survival in all the patients were 85.0% and 70.8%, respectively. Thirty patients developed regional failure and the regional control rates at 3 and 5 years were 92.6% and 91.4%, respectively. The sites of regional failure in relation to the target volume were exclusively inside GTV/CTV-HR in 20, inside and outside GTV/CTVHR in three, and exclusively outside GTV/CTV-HR in seven, which were 5.7%, 0.9%, and 2.0% of total patients, respectively. Conclusion The clinical outcomes by the current SNI policy were feasible and comparable to those following classic elective nodal irradiation policy.

Gastric Complications after Adjuvant Radiotherapy for Breast Cancer

조원경,최두호,박원,김해영,김선우,신명희,차혜정 한국유방암학회 2019 Journal of breast cancer Vol.22 No.3

Purpose: In some patients who receive adjuvant radiotherapy (RT) for the left breast, the stomach is located inside the RT field. This study investigates the incidence of gastric complications following adjuvant RT for breast cancer using data of the Health Insurance Review and Assessment Service in South Korea. Methods: We identified 37,966 women who underwent surgery and received adjuvant RT for breast cancer. The cumulative incidence rate of gastric hemorrhage and gastric cancer was calculated and compared for left and right breast cancers. Results: Among 37,966 patients, 19,531 (51.4%) and 18,435 (48.6%) had right and left breast cancers, respectively. After a median follow-up duration of 6.3 years, the cumulative incidence of gastric cancer and gastric hemorrhage did not differ between right and left breast cancers (p = 0.414 and p = 0.166, respectively). The multivariable analysis revealed that old age was the only factor associated with the development of gastric cancer (p < 0.001) and gastric hemorrhage (p < 0.001). The incidence of gastric cancer and hemorrhage did not differ between patients who received adjuvant RT for right and left breast cancers. Conclusion: Irradiation-related chronic complications of the stomach in patients with breast cancer are minimal. A study with a longer follow-up duration might be needed to assess the risk of gastric cancer.

Risk Potentiality of Frontline Radiotherapy Associated Cataract in Primary Ocular Adnexal Mucosa-associated Lymphoid Tissue Lymphoma

조원경,이성은,백지선,조석구,양석우 대한안과학회 2013 Korean Journal of Ophthalmology Vol.27 No.4

Purpose: To elucidate risk potentiality of frontline radiotherapy associated cataracts in primary ocular adnexal mucosa-associated lymphoid tissue lymphoma (OAML). Methods: Data from eight consecutive patients of 41 total OAML patients who had undergone cataract surgery after frontline radiotherapy were analyzed. Results: The median patient age was 46 years (range, 36 to 69 years). The median total radiation dose was 3,780 cGy (range, 3,060 to 4,500 cGy), and the mean duration from radiation irradiation to cataract surgery was 36.60 ± 8.93 months. Preoperative lens opacification was primarily at the posterior lens subcapsule, and best-corrected visual acuity (BCVA) was 0.43 ± 0.21. Patients underwent the phacoemulsification surgical procedure with posterior chamber intraocular lens insertion. The average BCVA improved to 0.90 ± 0.14after cataract surgery. Two patients underwent posterior continuous curvilinear capsulorhexis, and one had posterior capsule rupture. For posterior capsule opacification (PCO), three patients received Nd:YAG laser posterior capsulotomy after the initial surgery, and one patient is currently under consideration for laser posterior capsulotomy. Conclusions: Radiotherapy increased posterior subcapsule opacification at a relatively young age in primary OAML. Phacoemulsification was a manageable procedure without severe complications, and final visual outcomes were good. However, because after-cataracts progressed earlier than did senile cataracts, close follow-up should be considered for PCO management

비전형 유방 조기발육증과 진성 성조숙증 여아에서 임상 및 생화학적 인자의 비교

조원경,안선아,박소현,한승훈,정민호,서병규 대한소아내분비학회 2009 Annals of Pediatirc Endocrinology & Metabolism Vol.14 No.1

Purpose:We compared anthropomorphic measures and hormone levels in girls with atypical thelarche (AT) and central precocious puberty (CPP) and tried to find out factors discriminating AT from CPP. Methods:We analyzed clinical and laboratory data of 62 girls with precocious breast development from May 2004 to May 2008 at Kangnam St. Marys Hospital. Immunoradiometeric assay (IRMA) was used to estimate gonadotropins and growth related hormones. CPP was diagnosed if peak luteinizing hormone (LH) level was >6.9 IU/L after gonadotropin hormone releasing hormone (GnRH) stimulation test. A multiple logistic regression analysis and the area under the receiver operating characteristics curve (AUC) were used to analyse the prediction capacity of variable factors to diagnose CPP. Result:The basal LH levels (P=0.001), IGF-I levels (P=0.049) and the peak LH levels (P<0.001) in GnRH-stimulation test in girls with CPP were higher than those with AT. Girls with AT had a lower degree of breast maturation than girls with CPP (P=0.001). A multivariate logistic regression model including the basal LH levels and IGF-I levels revealed a strong relation of the basal LH levels to CPP [OR:2.7, 95% confidence interval (CI): 1.1-6.7, P=0.035]. The AUC for basal LH levels showed prediction capacity of basal LH levels to diagnose CPP [AUC: 0.70, 95% CI: 0.57-0.81, P=0.009]. The statistically ideal cut-off value of basal LH levels to discriminate CPP from AT was 2.66 IU/L (sensitivity 40%, specificity 98%) and the clinically meaningful cut-off value was 1.86 IU/L (sensitivity 70%, specificity 62%). Conclusion:These results suggest that the basal LH level using IRMA could be a useful parameter discriminating AT from CPP. Further study with larger number of subjects will be needed. 목 적:비전형 유방조기발육증의 경우 골연령의 증가와 성장 가속 등의 특징이 있어 조기에 진성 성 조숙증과의 감별이 매우 어렵다. 이에 본 저자들은 비전형 유방조기발육증으로 진단된 여아에서 생화학적인 검사소견과 신체계측치의 특징을 진성 성조숙증 군과 비교하고 두 질환의 조기 감별에 기여할 인자를 찾아보고자 하였다. 방 법:2004년 5월부터 2008년 5월까지 강남성모병원 소아청소년과 내분비 외래에 유방발육을 주소로 내원한 8세 이전 여아를 대상으로 하였다. 대상 중 골연령이 역연령보다 앞서 있으면서 성선자극호르몬방출호르몬 자극 검사 후 황체화 호르몬 농도가 6.9 IU/L 이상인 경우를 성조숙증 군으로 하였고 골연령이 역연령보다 앞서 있으나 성선자극호르몬방출호르몬 자극 검사 후 LH농도가 6.9 IU/L 미만인 경우를 미만인 경우 비전형 군으로 하였다. 후향적으로 의무기록을 열람하여 내원 시의 신체검진 소견 및 호르몬 검사결과를 조사하여 비교하였고 E2은 RIA로 측정하였으며 LH, FSH, IGF-I과 IGFBP-3는 IRMA로 측정하였다. 진성 성 조숙증의 조기감별 내지 예측인자를 확인하기 위하여 로지스틱 회귀분석과 ROC 곡선분석을 이용하였다. 결 과:성조숙증 군과 비전형 군사이에 역연령, 골연령, 신장, 체중, BMI, 중간부모키 및 예측성인신장에서 양군간 차이가 없었다. 유방 발육의 정도는 비전형 군이 성조숙 군에 비하여 낮았다(P=0.001). 성 조숙증 군에서 비전형 군에 비하여 기저 LH (2.4±1.1 vs. 1.7±0.6 IU/L, P=0.001), IGF-I (471.0± 192.1 vs. 370.8±146.8 µg/L P=0.049) 그리고 성선자극호르몬방출호르몬 자극 검사 후 최대 LH (12.7±8.2 vs. 3.9±1.3 IU/L, P<0.001)농도가 유의하게 높았다. 기저 LH, E2, IGFBP-3 농도 및 성선자극호르몬방출호르몬 자극 검사 후 최대 FSH 농도는 양군간의 유의한 차이가 없었다. 진성 성 조숙증의 조기감별 내지 예측인자를 확인하기 위한 기저 LH와 IGF-I 농도를 포함한 다변량 로지스틱 회귀분석에서 기저 LH 농도가 상관성을 보였다[OR:2.7, 95% confidence interval (CI):1.1-6.7, P= 0.035]. 기저 LH 농도의 성조숙증 예측 정도를 분석한 결과(area under the curve: 0.70, 95% CI: 0.57-0.81, P=0.009), 통계적으로 적합한 기저 LH 농도는 2.66 IU/L (sensitivity 40%, specificity 98%)이었고 임상적으로 유의할 것으로 생각되는 농도는 1.86 IU/L (sensitivity 70%, specifity 62%)이었다. 결 론:비전형 군에서 성 조숙증군에 비하여 IRMA로 측정한 IGF-I과 기저 LH 농도가 유의하게 낮았으며, 조기 유방발육으로 병원에 온 환아에서 IRMA로 측정한 기저 LH농도가 1.86 IU/L 이상인 경우 이 두 질환의 감별에 도움이 될 것으로 생각된다.

Immunomodulatory effect of captopril and local irradiation on myeloid-derived suppressor cells

조원경,신성원,김신영,홍장원,최창훈,박원,노재명 대한방사선종양학회 2016 Radiation Oncology Journal Vol.34 No.3

Purpose This study is to investigate the effect of captopril when combined with irradiation. Materials and Methods 4T1 (mouse mammary carcinoma) cells were injected in the right hind leg of Balb/c mice. Mice were randomized to four groups; control (group 1), captopril-treated (group 2), irradiated (group 3), irradiated and captopril-treated concurrently (group 4). Captopril was administered by intraperitoneal injection (10 mg/kg) daily and irradiation was delivered on the tumor-bearing leg for 15 Gy in 3 fractions. Surface markers of splenic neutrophils (G-MDSCs) and intratumoral neutrophils (tumor-associated neutrophils [TANs]) were assessed using flow cytometry and expression of vascular endothelial growth factor (VEGF) and hypoxia-inducible factor 1 alpha (HIF-1α) of tumor was evaluated by immunohistochemical (IHC) staining. Results The mean tumor volumes (±standard error) at the 15th day after randomization were 1,382.0 (±201.2) mm3 (group 1), 559.9 (±67.8) mm3 (group 3), and 370.5 (± 48.1) mm3 (group 4), respectively. For G-MDSCs, irradiation reversed decreased expression of CD101 from tumor-bearing mice, and additional increase of CD101 expression was induced by captopril administration. Similar tendency was observed in TANs. The expression of tumor-necrosis factor-associated molecules, CD120 and CD137, are increased by irradiation in both G-MDSCs and TANs. Further increment was observed by captopril except CD120 in TANs. For IHC staining, VEGF and HIF-1α positivity in tumor cells were decreased when treated with captopril. Conclusion Captopril is suggested to have additional effect when combined to irradiation in a murine tumor model by modulation of MDSCs and angiogenesis.

나례(儺禮)와 가면무극(假面舞劇)

조원경 연세대학교 사학연구회 1955 學林 Vol.4 No.-