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- 저자 : ( Kwang Rye Kim ) (검색결과 23 건)
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Young-Rye Kang,Hak-Yong Lee,Jung-Hoon Kim,Dea-In Moon,Min-Young Seo,Sang-Hoon Park,Kwang-Ho Choi,Chang-Ryong Kim,Sang-Hyun Kim,Ji-Hyun Oh,Seong-Wan Cho,Sun-Young Kim,Min-Gul Kim,Soo-Wan Chae,Okjin Kim 한국실험동물학회 2012 Laboratory Animal Research Vol.28 No.1
Yerba Mate, derived from the leaves of the tree, Ilex paraguariensis, is widely-used as a tea or as an ingredient in formulated foods. The aim of the present study was to evaluate the effects of Yerba Mate extract on weight loss, obesity-related biochemical parameters, and diabetes in high-fat diet-fed mice.To this end, by using in vivo animal models of dietary-induced obesity, we have made the interesting observations that Yerba Mate has the ability to decrease the differentiation of pre-adipocytes and to reduce the accumulation of lipids in adipocytes, both of which contribute to a lower growth rate of adipose tissue, lower body weight gain, and obesity. Our data from in vivo studies revealed that Yerba Mate treatment affects food intake, resulting in higher energy expenditure, likely as a result of higher basal metabolism in Yerba Mate-treated mice. Furthermore, in vivo effects of Yerba Mate on lipid metabolism included reductions in serum cholesterol, serum triglycerides, and glucose concentrations in mice that were fed a high fat diet. In conclusion, Yerba Mate can potentially be used to treat obesity and diabetes.
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Hyun-Woo Lee,Hoon Choi,Beom-Ju Shin,Kyung-Hoon Kim,Kyung-Whan Kim,Jaeil Kim,Kwang-Hyun Kim,Jong-Ho Jung,Jae-Hwan Kim,Eun-Young Park,Jong-Sam Kim,Jong-Hwan Kim,Jin-Hee Cho,Namgyu Rye,Jun-Hyun Chun,Yuns IEEE 2012 IEEE journal of solid-state circuits Vol.47 No.6
<P>The digital delay-locked loop (DLL) with racing mode and the countered column address strobe (CAS) latency controller are proposed in this paper. The dual-DLL architecture with racing operation is adopted to achieve low power consumption, low jitter, fast locking, wide range of locking, and stuck-free control. The merged dual coarse delay line (MDCDL) reduces the dynamic power consumption of a variable delay line by 30% by sharing a part of the delay line path in DLL. In addition, jitter is reduced by 45 ps in the 1066-DDR3 operating mode by MDCDL. The proposed DLL utilizes an or-and functioned duty cycle corrector (or-and DCC), which consumes 15% of DLL's power, 0.915 pJ/Hz at tCK=1.5 ns and VDD=1.575 V. The countered CAS latency controller (CCLC) saves IDD3N current because it does not need a DLL clock and does not need to be activated for IDD3N (active non-power down) state. The DLL clock is enabled and CCLC is activated only when the read command is issued. This operation condition saves the IDD3N current by 60% with the proposed DLL. The proposed DLL is employed in 128 M×8 DDR3 SDRAM and 64 M×16 DDR3 SDRAM. The former and the latter are fabricated by 5×nm and by 4× nm DRAM process technology, respectively. Experimental results show that ±10% duty error of the external clock can be corrected to within ±2% duty error in less than 512 cycles of locking time under 1.5 ns of tCK. The proposed DLL and CCLC can operate above 1.0-GHz operating frequency at 1.2 V in 5× nm DDR3 SDRAM and at 1.0 V in 4× nm DDR3 SDRAM, respectively. The proposed DLL fabricated with 4× nm technology consumes 6.1 pJ/Hz at 1.575 V.</P>
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2형 당뇨 환자에 있어서 C형 간염의 유병률에 관한 연구
김구영,서광섭,유광렬,임병욱,채선애,강남훈,김창훈,권영우,김희수,류성태,이정환,박성우,오웅식,김정한 중앙대학교 의과대학 의과학연구소 2003 中央醫大誌 Vol.28 No.1
Background: We have doubt about the truth that Type 2 DM is associated with chronic hepatitis C infection. The aim of our study was to prove a close relationship between chronic HCV infection and type 2 DM in korean patients. Methods: We reviewed the out-patient's medical records of 466 patients with type 2 DM who visit the Sung-ae hospital from March 2000 to August 2001. Diabetic patients were analyzed for the following variables: age, sex, waist circumference, weight, waist/hip ratio, using of self monitoring of blood glucose, method of therapy, duration of disease, experience of previous transfusion, major surgical procedure, accompanied disease, liver function tests (LFT), HbA1 c. We ruled out patients with liver cirrhosis. Results: Hepatitis C virus infection was observed more frequently in patient with Type 2 DM. Of 466 Type 2 DM patients, 13 patients were infected with Hepatitis C virus (2.79%). Compared with mean prevalence of Korean population (1.3~1.6%), it's value is very high. the other hand, 21 patients were infected with Hepatitis B virus (4.5%). Such results are similar to mean prevalence of the general public (4~5%). Conclusions: Prevalence of hepatitis C was closely associated in korean patients with type 2 DM. And an increased prevalence is independent of cirrhosis.
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보문 : 생리활성물질을 이용한 여드름 피부개선에 따른 멜라닌, 홍반, pH값의 변화도
오수정 ( Su Jeong Oh ),김광상 ( Kwang Sang Kim ),김기영 ( Ki Young Kim ),김경례 ( Kyeong Rye Kim ),김경란 ( Kyeong Ran Kim ) 대한미용과학회(구 한국두피모발미용학회) 2010 대한미용학회지 Vol.6 No.3
The purpose of this research is to develop the materials for natural cosmetics that it is possible to use for the improvement of acne skin. For this, this research manufactured the skin lotion and pack including ethanol extract of Caesalpinia sappan which is a bioactive chemical and applied it to the female with acne skin. And then it tried to verify the effect of the lotion and pack by measuring melanin, erythema and the changes of pH value. The objects of this research were 16 women with acne skin in 20`s above KAGS Level II, and the changes of melanin, erythema and pH value on 3 sites of the cheek, forehead and chin on their faces were measured 4 times before and after applying the pack including 15% ethanol extract of Caesalpinia sappan to 8 women (Group A) and the skin lotion including 3% ethanol extract to 8 women (Group B), respectively. The experimental data was analyzed by repeated measures using SPSS version 12.0 program. The experimental results for the changes of melanin, erythema and pH value in accordance with improvement of acne vulgaris after applying the skin lotion and pack including the ethanol extract of Caesalpinia sappan were as followings. As a result of a human closed patch test about the ethanol extract of C. sappan in a stability test, erythema (-), allergy (-), edema (-), blister (-) and so on were not observed. So, it may deem that the skin lotion and pack are stable when applying them to a human body as cosmetics. Both the skin lotion and the pack including ethanol extract of C. sappan had a positive effect on melanin and pH value. Even though there was no large difference between two experimental groups, it showed that the skin lotion influences on erythema larger than the pack. In conclusion, the ethanol extract of Caesalpinia sappan is very meaningful for improvement of acne skin and it is expected that it will become good resource for developing functional cosmetics in future.
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체외수정시술시 배아의 보조부화술을 이용한 임신율 향상에 관한 연구
김석현,김광례,채희동,이재훈,김희선,류범용,오선경,서창석,최영민,김정구,문신용,이진용,Kim, Seok-Hyun,Kim, Kwang-Rye,Chae, Hee-Dong,Lee, Jae-Hoon,Kim, Hee-Sun,Ryu, Buom-Yong,Oh, Sun-Kyung,Suh, Chang-Suk,Choi, Young-Min,Kim, Jung-Gu,Moon, S 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.1
In spite of much progress in vitro fertilization and embryo transfer (IVF-ET) program, the pregnancy rate remains at 20-30%, and the endometrial implantation rate per embryo transferred at 10-15%. As a result, about 90% of embryos may fail to implant to the endometrium, and many attempts such as optimization of follicular development, improvement of in vitro culture system including coculture, and micromanipulation of zona pellucida have been made to improve embryonic implantation after IVF-ET. Recently, several procedures of assisted hatching (AH) using micromanipulation have been introduced, and pregnancies and births have been obtained after AH. To develop and establish AH as an effective procedure to improve embryonic implantation, AH with partial zona dissection (PZD) was performed in 116 cycles of 89 infertile couples who had previous repeated failures of standard IVF-ET more than two times (Group I: 71 cycles in 54 patients), or who had implantation failure of embryos with good quality (Group II: 15 cycles in 13), or who had undergone AH without specific indication (Group III: 30 cycles in 22) from January, 1995 to Februry, 1996, and the outcomes of AH were analyzed according to pregnancy rate. The number of oocytes retrieved after controlled ovarian hyperstimulation (COH) was $9.9{\pm}7.1$ in Group I, $11.5{\pm}4.5$ in Group II, and $7.9{\pm}6.4$ in Group III. The number of embryos transferred after AH was $4.7{\pm}1.8$ in Group I, $5.3{\pm}1.3$ in Group II, and $3.5{\pm}2.4$ in Group III. The mean cumulative embryo score (CES) was $56.8{\pm}30.0$ in Group I, $76.1{\pm}35.9$ in Group II, and $38.5{\pm}29.9$ in Group III. The overall clinical pregnancy rate per cycle and per patient was 12.7% (9/71) and 16.7% (9/54) in Group I, 33.3% (5/15) and 38.5% (5/13) in Group II, and 6.7% (2/30) and 9.1% (2/22) in Group III, respectively. There were significant differences in the numbers of oocytes retrieved and embryos transferred, CES, and the clinical pregnancy rate per cycle among three groups. There was a significant inverse correlation between basal serum FSH level and CES, and no pregnancy occurred in patients with CES less than 20. In conclusion, AH of human embryos with PZD prior to ET has improved the implantation and pregnancy rates in IVF-ET patients with the past history of repeated failures, especially in spite of transfer of embryos with good quality, and AH will provide a range of novel techniques which may contribute much to effective management of infertile couples.
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미수정 및 저수정율의 기왕력을 지닌 체외수정시술 환자에서의 난자 세포질내 정자 주입술을 이용한 미세보조 수정술에 관한 연구
문신용,김석현,채희동,김광례,이재훈,김희선,류범용,오선경,서창석,최영민,김정구,이진용,Moon, Shin-Yong,Kim, Seok-Hyun,Chae, Hee-Dong,Kim, Kwang-Rye,Lee, Jae-Hoon,Kim, Hee-Sun,Ryu, Buom-Yong,Oh, Sun-Kyung,Suh, Chang-Suk,Choi, Young-Min,Kim, 대한생식의학회 1997 Clinical and Experimental Reproductive Medicine Vol.24 No.1
Although IVF-ET is widely applied in the treatment of couples with male factor infertility, it may fail in many infertile couples with normal semen parameters, and certain couples cannot be accepted for standard IVF-ET due to unfertilization or extremely low fertilization rate of oocytes. Recently, several procedures of microassisted fertilization (MAF) using micromanipulation have been introduced, and pregnancies and births have been obtained after partial zona dissection (PZD), subzonal insertion (SUZI), and intracytoplasmic sperm injection (ICSI). This clinical study was performed to develop and establish ICSI as an effective procedure of MAF in infertile couples who could not undergo standard IVF-ET repetitively because of failure in fertilization or extremely low fertilization rate of oocytes with the conventional fertilization technique in the previous IVF-ET cycles. From March, 1995 to May, 1996, 27 cycles of IVF-ET with ICSI in 19 infertile patients were included in study group, and the outcomes of ICSI were analyzed according to fertilization rate, cumulative embryo score (CES), and pregnancy rate. The number of oocytes retrieved after controlled ovarian hyperstimulation (COH) was $10.50{\pm}6.13$ in 30 previous cycles, and $10.57{\pm}5.53$ in 27 ICSI cycles. In ICSI cycles, the number of oocytes optimal for ICSI procedure was $7.89{\pm}4.30$, and the fertilization rate of $67.9{\pm}20.2%$ could be obtained after ICSI. The number of embryos transferred was $1.43{\pm}2.40$ in previous cycles, and $4.36{\pm}1.77$ with the mean CES of $41.8{\pm}27.4$ in ICSI cycles. In ICSI cycles, the overall pregnancy rate was 29.6% (8/27) per cycle and 42.1% (8/19) per patient with the clinical pregnancy rate of 22.2% (6/27) per cycle and 31.6% (6/19) per patient. In conclusion, MAF of human oocytes with ICSI is a promising fertilization method for IVF-ET patients, especially with the past history of failure in fertilization or low fertilization rate of oocytes in the previous IVF-ET cycles, and ICSI using micromanipulation procedures applied to human oocytes will provide a range of novel techniques which may dramatically improve the pregnancy rate in IVF-ET program and contribute much to effective management of infertile couples.
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뇌졸중 편마비 환자의 환측 상지 수행능력에 따른 일상생활활동 독립성 정도: MAL과MBI 상관관계 연구
김지영 ( Ji Young Kim ),임애진 ( Ae Jin Lim ),김성례 ( Sung Rye Kim ),한윤희 ( Yun Hee Han ),한승협 ( Seung Hyup Han ),박용광 ( Yong Kwang Park ),감경윤 ( Kyung Yoon Kam ) 고령자.치매작업치료학회 2010 고령자.치매작업치료학회지 Vol.4 No.2
목적: 이 연구의 목적은 뇌졸중 편마비 환자의 환측 상지의 사용량과 질을 평가하는 검사도구인 Motor Activity Log(MAL)와 일상생활활동의 독립성을 평가하는 Modified Barthel Index(MBI)간상관관계 연구를 통하여 환측 상지의 수행능력에 따른 일상생활활동의 독립성 정도를 알아보고자 하였다. 연구방법: 2010년 2월~6월까지 부산, 경남 지역에서 재활치료를 받은 뇌졸중환자를 편마비로 진단받은 91명을 대상으로 MAL과MBI 평가를 실시하였다. MAL과MBI의 점수간의 상관관계를 분석하기 위해 Pearson 상관분석을 하였다. 연구결과: MBI점수와 환측 상지의 사용량 및 움직임의 질에서 각각 높은 상관관계를 보였다. MBI의 등급에 따른 MAL의 점수는 각 등급별로 유의한 차이가 있었고, 우세손마비와 비우세손마비의 MAL점수에서도 유의한 차이가 있었다. 결론: 환측 상지의 수행능력이 일상생활활동의 독립성과 높은 상관관계가 있으므로 뇌졸중 편마비 환자의 환측 상지 사용량과 움직임의 질을 평가하는 MAL은 일상생활활동에 대한 평가와 치료계획을 세우는 데 활용될 수 있을 것이다. Objective: The purpose of this study was to investigate the independency of Activities of Daily Living(ADL) according to the performance of affected upper extremity, through studying the correlation between the Motor Activity Log(MAL), which measures the Amount Of Used(AOU) and Quality Of Movement(QOM) of affected upper extremity of hemiplegic patients, and the Modified Barthel Index(MBI), which measures the independency of ADL. Method: Of the patients with stroke in Busan and Gyeongnam regions who were given rehabilitation treatment between February and June, 2010, 91 hemiplegics were subjected to the MAL and the MBI assessments. Pearson`s Correlation Analysis was used to find the correlation between the MAL and the MBI scores. Result: A high level of correlation was found between the AOU and QOM of affected upper extremity and MBI scores. Statistically significant differences were showed among the MAL scores of each MBI levels. Significant differences of MAL scores were also showed between dominant and non-dominant hand paralysis. Conclusion: In assessing the ADL of hemiplegic patients with stroke, the MAL which assesses the AOU and the QOM of the affected upper extremity is expected to be useful in evaluating their ADL and establishing treatment plans.
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폐경 후 여성의 에스트로젠 보충요법시 병합 투여된 프로제스테론이 골밀도에 미치는 영향
채희동,김광례,서창석,최영민,김석현,신창제,김정구,문신용,이진용 대한폐경학회 1997 대한폐경학회지 Vol.3 No.1
It is well established that estrogen replacement therapy prevents the bone loss associated with postmenopausal state. And progestogens used alone, given in larger amount than that in estrogen replacement therapy, have been shown to reduce the postmenopausal bone loss. However, the impacts of added progestogen during estrogen replacement therapy on the bone mineral densities(BMD) are not well known. For this purpose, we analysed the changes in BMD of 104 postmenopausal women who underwent estrogen replacement therapy at least for 12 months: 36 women received estrogen only(Premarin 0.625mg/day), 41 women received estrogen with cyclic addition of progestogen(medroxyprogesterone, MPA, 10mg/day for 12 days per month), 27 women received estrogen with daily addition of progestogen(MPA 2.5mg daily). Our data revealed that continuous use of MPA in addition to estrogen for one year significantly increased the BMD of lumbar spines(L2-4) by 7.6±1.9% compared to that of before treatment while therapy with estrogen only did not(1.7±1.0%). Also cyclic addition of MPA for one year increased the BMD of lumbar spines by 6.2±1.3% compared to that of before treatment. And the increases in BMD of lumar spines derived from continuous or cyclic use of MPA in addition to estrogen were significantly greater than that from therapy with estrogen only. There was no significant difference in increases in BMD of lumbar spines between cyclic use and continuous use of MPA. And there was no significant difference in increases in BMD of femur neck among three groups. The patients who showed a decrease in BMD by more than 3% at 12 months of treatment compared to pretreatment were as follows: In BMD of lumbar spines, 16.7%(6/36) in therapy with estrogen-only, 2.4%(1/41) in the cyclic use of MPA, 3.7%(1/27) in the continuous use of MPA; In BMD of femur neck, 25.0%(9/36) in therapy with estrogen-only, 22.0%(9/41) in the cyclic use of MPA, 11.1%(3/27) in the continuous use of MPA. The unine calcium/creatinine ratio decreased during therapy in all gropus without a significant difference among three groups. These data showed that added progestogen(MPA) during estrogen replacement therapy significantly increased the bone mineral densities(BMD) of lumbar spines, and suggest that the continuous combined regimen of estrogen and progestogen may be the regimen of choice for the prevention or treatment of postmenopausal osteoporosis
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