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간내 담석과 동반된 간내 담도암에서의 p53과 Ki-ras의 발현
김명환,이성구,서동완,이승규,남승우,박능화,민영일,김연석,심기남,공경엽 대한소화기학회 1997 대한소화기학회지 Vol.30 No.5
Background/Aims: Hepatolithiasis or primary intrahepatic stones may be accompanied later by intrahepatic cholangiocarcinoma. This cancerous lesion is frequently associated with atypical hyperplastic epithelium that was suspected of being precancerous. To investigate the Ki-ras or p53 mutation may play a role in carcinogenesis, and to determine whether atypical hyperplastic epithelium may be precancerous, this study was performed in intrahepatic cholangiocarcinomas associated with hepatolithiasis. Methods: We examined 12 patients with intrahepatic cholangiocarcinomas associated with hepatolithiasis. Ki-ras point mutations were assessed by direct DNA sequencing. Expressions of p53 protein were immunohistochemically assessed. The overexpression of p53 and point mutation of Ki-ras were examined in normal, hyperplastic, atypical hyperplastic, and can- cerous tissues separately. Results: The expressions of p53 protein were detected in 4 (33%) of 12 cholangiocarcinomas and Ki-ras point mutations at codon 12 were found in 2 (17%) of 12 cholangiocarcinomas. In those two carcinoma cases which contained the mutant sequence of Ki-ras, the same point mutation from wild type GGT (glycine) to GAT (aspartic acid) was. found in the associated atypical hyperplastic epithelium. However, none of the normal and hyperplastic epithelium harbored Ki-ras or p53 mutations. Conclusions: The overexpression of p53 may play a part in the carcinogenesis of some intrahepatic cholangiocarcinomas associated with hepatolithiasis, whereas the role of Ki-ras mutations in those cases is dubious. However, Ki-ras point mutation at codon 12 may be responsible for either cancer or atypical hyperplastic epithelium associated with hepatolithiasis in certain cases, suggesting atypical hyperplastic epithelium may give rise to carcinoma.
수족냉증(手足冷症) 환자(患者)에 대(對)한 컴퓨터 적외선(赤外線) 체열촬영(體熱撮影)의 의의(意義)
조유경,오수완,조남희,김동묵,김진성,류봉하,박동원,류기원,Cho, Yu-Kyung,Oh, Su-Wan,Cho, Nam-Hee,Kim, Dong-Mook,Kim, Jin-Seong,Ryu, Bong-Ha,Park, Dong-Won,Ryu, Ki-Won 대한한방내과학회 1998 大韓韓方內科學會誌 Vol.19 No.2
To make a objective diagnosis of the syndrome of cold-limbs, We investigated the 20 patients with cold limbs and GI trouble and 20 normal people as a control group. And we compared the thermal difference between Chon-jung(CV17) and Chung-wan(CV12 中脘), Chon-jung(CV17) and Ki-hae(氣海 CV6) and we compared the thermal differences of No-gung(PE8 勞宮) and Yong-chon(湧泉 KI1), too. The results were as follows. 1. All 20 patients had GI trouble and cold limbs. They had the symptom-Indigestion(16 cases-80%) with heart burn, tympanites, abdominal distention, hiccup, belching. Beside that symptom they also had constipation(6 cases-30%), diarrhea(3 cases-15%), headache & dizziness(6 cases-30%). And some had the menstrual syndrome, chronic fatigue, palpitation, insomnia, edema, arthralgia. 2. The thermal difference of the palms between the patients group and the control group were $25.70^{\circ}C,\;25.82^{\circ}C$, but they were not significant. 3. The thermal difference of the soles between the patients group and the control group were $23.58^{\circ}C,\;24.42^{\circ}C$ and the significancy was P=0.020 so it was significant(P<0.05). 4. The thermal difference of the palms and Chon-jung(CV17) between the patients group and the control group were $1.08^{\circ}C,\;0.76^{\circ}C$, but they were not significant. 5. The thermal difference of the sales and Chon-jung(CV17) between the patients group and the control group were $3.01^{\circ}C,\;1.90^{\circ}C$ and the significancy was P=0.003 so it was significant(P<0.05). 6. The thermal difference of Chon-jung(CV17) and Chung-wan(CV12 中脘) between the patients group and the control group was $0.30^{\circ}C,\;0.62^{\circ}C$ and the significancy was P=0.793 so it was significant(P<0.05). 7. The thermal difference of Chon-jung(CV17) and Ki-hae(CV6 氣海) between the patients group and the control group was $0.53^{\circ}C,\;0.68^{\circ}C$, but they were not significant. From the above, I could find the significance of D.I.T.I to diagnose the cold-feet not the cold-hands and the thermal difference between the trunk and limbs was more significant on cold-feet than on cold-hand, either.
성기완,길남규,신석우,민택기 충남대학교 산업기술연구소 2000 산업기술연구논문집 Vol.15 No.1
This study dealt with the mechanical properties of aluminum alloy A5083 friction welds contained upset length, tensile test, hardness test, observation of microstructure and tensile fractured surface. The welding conditions of the maximum tensile strength of friction weld were revolution 2000rpm, friction pressure 50MPa, upset pressure 110MPa, friction time 1.0sec, and upset time 6.0sec. This study came to these conclusion as follow : 1.The maximum tensile strength was 355MPa which was 102% of the tensile strength 348MPa of the base material. 2.The conditions when maximum tensile strength was acquired, occurred dimple on the tensile fracture surface and upset length was 4.9mm. 3.The maximum hardness was Hv89 in the weld interface and soft zone was confirmed on the heat affected zone(HAZ).
장기운,이종진,홍주화,김남천,김완주,최우영 충남대학교 농업과학연구소 2007 농업과학연구 Vol.34 No.2
This study was conducted to estimate the humificating grade according to experiment of physico-chemical characterization and phyto-toxicity during composting of using with pig manure and castor meal. The material ratios of the compost which was mixed with pig manure(P), castor meal(C), and saw dust(S) were 5 : 1 : 4(PCS-I), 5 : 2.5 : 2.5(PCS-II) and 5 : 4 : 1(PCS-III) by volume to volume, and they were decomposed for 60 days. In the result, the changes of temperature in all treatments during composting were rapidly increased more than 68℃ at the incipient stage, and gradually decreased within 39℃ at 60 days the after treatment. pH was slowly increased from 7.5 to 7.7, and the C/N ratio was 13∼14 at the final composting stage. The low C/N ratio value in this compost was caused by the castor meal contented high nitrogen level(T-N 5.7 %). G.I.(germination index) was showed 73 to 78 range in all treatments at the 60^(th) day. Among all treatments PCS-I was appeared to be the best condition for composting.
이기완,최충현,이남경 동신대학교 환경연구소 1999 환경연구 Vol.4 No.1
정수처리 공정의 원수 및 응집/침전 상징수와 하수처리 공정의 원수를 대상으로 MF를 적용하여, 각 시료수의 역세척 특성을 파악하였다. MF의 여과지속기간은 시료수의 투과속도가 1/2로 감소되는 시점과 여과압력은 1 kg/cm²의 조건에서 실험을 수행하였다. MF의 투과속도는 정수 및 하수처리 공정의 원수인 경우 1시간이내, 정수처리 공정의 응집/침전 상징수인 경우 2시간 이내로 나타났다. 정수 및 하수처리 공정의 원수인 경우 MF의 역세 회복율 및 역세 소요시간은 각각98%와 5~6분 및 7~8분으로 나타났다. The backwashing characteristics of three kinds of sample water was studied with the application of MF(Micro Filtration) process. The three kinds are raw water and clarified water at water treatment process and raw water at sewage treatment process. The tests were performed with the filtering duration of MF to the half permeability arriving time and the filtering pressure 1 kg/㎠. The MF permeability of the raw water at the both process was less than 1 hour and that of the clarified water at water treatment process was less than 2 hour. The recovery rate and the consume time of backwashing for the raw water were 98%, 5-6 minutes and 99%, 7-8 minutes at the water and sewage treatment process, respectively.
길남규,성기완,안창윤,민택기 충남대학교 공업교육연구소 1999 論文集 Vol.22 No.1
This study deals with the mechanical properties of welding part, by friction welding of SM45C steel rod and SWS41A yoke which have being used Steering-Joint. The experimental results are summrized as follows ; 1. When CO₂welding is replaced with friction welding, we can get benefit manufacture. 2. The result of tensile test showed the highest tensile strength of 612MPa(150% of base metal strength 402MPa). 3. The result of bending test showed the highest bending strength of 1066MPa(80% of base metal strength 1259MPa).
전력선 통신을 이용한 LED 가로등의 원격조도제어 시스템 개발
김기남,유진완,박종연 江原大學校 産業技術硏究所 2010 産業技術硏究 Vol.30 No.B
In this paper, We proposed remote dimming control system for Light Emitting Diode(LED) street light using Power Line Communication(PLC). LED will be used widly by indoor or outdoor lighting because of semi-permanent life and environment restriction. For energy saving of street light, the dimming control system is very necessary and the PLC is a very efficient technique. Thus, in this paper we proposed the remote dimming control system for LED street light using PLC. A performance of the proposed system was validated by experimental results.