신생아 제대혈중 Prolactin 및 Cortisol치와 신생아 호흡곤란증후군과의 관계에 관한 연구

김영덕(YD Kim),이진용(JY Lee) 대한산부인과학회 1983 Obstetrics & Gynecology Science Vol.26 No.12

Respiratory distress syndrome is the major cause of the neonatal mortality experi enced by preterm infants. The development of respiratory distress syndrome is cau sed by the inability of the fetal lung to synthesize adeqate quantities of pulmonary surfactant, which is lecithin rich phospholipid, namely, dipalmitoyl-phosphatidylchol ine. As the fetal lung matures, its capacity to synthesize lecithin increases, a process that is known to occur in fetal alveolar type II cells in late gestation. Since the discovery of the association between a deficiency of surfactant and resp iratory distress syndrome, attempts have been made to determine the physiologic factors which regulate the production of surfactant. Some investigators suggested that fetal Iung maturation could be accelerated by corticosteroids, however, there is no direct evidence that fetal cortisol is the primary stimulus of augmented surfactant synthesis in the human fetus. On the other hand, recent studies suggested that fetal prolactin might be implica ted as a possible mediator of fetal lung maturation, but the role of prolactin in the pathogenesis of respiratory distress syndrome has not been unequivocally demonstra ted. This study was carried out to observe the cord plasma prolactin and cortisol pro files of neonates born during the third trimester of pregnancy and to ascertain the possible role of fetal prolactin or cortisol in respiratory distress syndrome Cord plasma levels of prolactin and cortisol were measured by radioimmunoassay in 38 full term neonates without respiratory distress syndrome. in 21 premature neonates without respiratory distress syndrome and l2 premature neonates with res piratory distress syndrome. Amniotic fluid L/S ratio was measured by thin layer chromatography in 46 subjects. The results were as ollows 1. The cord plasma prolactin level showed positive coorelation with gestational age, however, the cord plasma cortisol level showed no correlation with gestationa1 age during the 3rd trimester. 2. The cord plasma prolactin

주요우울증 환자의 삼환계 항우울제 투여에 따른 임상반응과 뇨 MHPG 및 혈장 Cortisol치와의 관계

오영미,황익근 大韓神經精神醫學會 1993 신경정신의학 Vol.32 No.6

The purpose of this study was to examine the effects of tricyclics on urinary MHPG level and plasma cortisol level and to investigate the interaction of noradrenergic system with HPA axis in major depression. The subjects were 24 inpatients with major depression diagnosed according to DSM-Ⅲ-R. Seventeen medical students and residents served as a control group. 24-hour uinary MHPG and plasma cortisol concentration at 08:00 a.m were measured at various points during treatment. The results were as follows : 1) No significant difference was found between the urinary MHPG excretion for either depressed patients or comparison subjects. 2) The pretreatment urinary MHPG level and therapeutic response to tricyclic antidepressants did not correlate. 3) Significant positive correlation was found between pretreatment 8:00 a.m. plasma cortisol levels and urinary MHPG levels in depressed patients(r=0.54, p<0.05). After tricyclics medication, negative correlation was observed, but was not significant(r=-0.41, p=NS).

騷音暴露가 産卵鷄의 生産性과 血鋌코티솔 水準에 미치는 影響

조문제,김진영,황성구,고태송,이원창 건국대학교 동물자원연구센터 1998 動物資源硏究誌 Vol.19 No.-

소음환경 폭로가 산란계(産卵鷄)의 생산성과 혈액중 코티솔(cortisol) 레벨에 미치는 영향을 조사하기 위하여, 50주령(週齡)의 산란계(Rhode Island Red率 Isabrown種)에 도로변소통 차량소음을 녹음 증폭한 85∼95dB(A)의 소음환경에 노출하여 측정된 산란율, 난중, 산란일량, 사료섭취량 및 사료효율과 혈장 코티솔수준을 대조 와 비교하였다 소음노출이 산란율과 산란일량에 미치는 영향은 통계적으로 유의한 차이는 없었으나, 난중은 낮아지는 경향이 관찰되었다(p<0.08). 소음노출이 사료섭취량은 높이고 사료효율을 감소시티는 경향이 있었다. 소음폭로 시험대상 산란계의 실험전후에 혈쟁중 코티솔 레벨을 비교 관찰한바, 소음환경에 6시간 폭로된 후 1시간 후에 측정된 혈청중의 코티솔 레벨은 실험전에 비하여 약52.4%가 증가되었다. (p<0.05). 다시 1주일 후 동일사간에 채혈된 혈청중의 코티솔 레벨도 전과 비슷한 53.8%의 증가하였으나, 2주일 후에서부터는 감소 추세를 보여서 통계학적으로 유의한 차이를 보이지 않고 있었다. 본 성적은 일정강도 이상의 음향강도는 채란계에 최초에는 스트레스원으로 작용하나 노출시간이 장기화함에 따라 적응하고 있다는 것이 시사되었다. Noise produced by various environmental hazard leads to a patho-physiological lesions often resulting in metabolic disorder and psychiatric confusion in man and domestic animals. To study effects of noise stress in layer, forty two layer of 50 wks-old(Rhode Island Red) exposed to the sound of 85∼95 dB<A> were determined egg production performance and cortisol level in plasma. Noise exposure did not significantly affect egg production and daily egg mass but tended to decrease (p<0.08) egg weight. Noise exposure for 6 hours increased 52.4% and 53% (p<0.05) of plasma cortisol level at day 1 and day 7, respectively, compared to those in layer before noise exposure. Thereafter, layer, however, maintained the higher cortisol levels in plasma. This result indicated that above some dB levels of sounds functions as stressor but accustomed during longer period of noise exposure and requires further investigation of noise exposure for poultry production.

Changes in Plasma Cortisol in Patients with Bronchial Asthma

Kim, Kwan Hyoung,Han, Ki Don,Song, Jeong Sup,Moon, Hwa Sik,Park, Sung Hak,Byun, Hae Won CATHOLIC MEDICAL CENTER 1987 Bulletin of the Clinical Research Institute Vol.15 No.1

To examine the possible contribution of the circardian rhythm of plasma cortisol level to pathogenesis of bronchial asthma, the levels of plasma cortisol were measured at 8 A.M., 11 P.M., before and after ACTH infusion for 8 hours. The observed results were as follows : 1. In patients with bronchial asthma without nocturnal dyspnea, the value of plasma cortisol at 8 A.M. was 15.1 ± 7.0 ug/dl and at 11 p.M.8.8 ± 5,7 ug/dl. 2. In 17 patients with nocturnal or morning dipper asthma, the value of plasma cortisol at 11 P.M. was 3.2 ± 1.1 ug/dl and was lower than that of bronchial asthmatics without noctural dyspnea (p < 0.01). 3. In 20 bronchial asthmatics without nocturnal dyspnea. The value of plasma cortisol before ACTH infusion was 12.6 ± 5.9 ug/dl and after ACTH infusion 35.1 ±3.2 ug/dl. The results of present study show that the patients with bronchial asthma have normal circardian rhythm of cortisol level, but the bronchial asthamtics with nocturnal dyspnea have lower level of plasma cortisol at 11 P.M. than that of bronchial asthmatics without nocturnal dyspnea. The function of adrenal cortisol secretion after stimulation with ACTH infusion was normal. The circardian rhythm of coirticosteroid secretion seems to be a possible factor of nocturnal asthma.

기관지 천식 환자에서의 혈장 Cortisol 의 변화

한기돈(K . D . Han),문화식(H . S . Moon),송정섭(J . S . Song),박성학(S . H . Park),변해원(H . W . Byun) 대한내과학회 1987 대한내과학회지 Vol.34 No.1

N/A In 37 patients with bronchial asthma with or without nocturnal dyspnea, the levels of plasma cortisol were measured at 8 A.M. and 11 P.M., and before and after ACTH infusion for 8 hours. The observed results were as follows: 1) In 20 patients with bronchial asthma without nocturnal dyspnea the value of plasma cortisol at 8 A.M. was 15.1±7.0 ㎍/dl and at 11 P.M. 8.8±5.7 ㎍/dl. 2) In 17 patients with nocturnal or morning dipper asthma, the value of plasma cortisol at 11 P.M. was 3. 2±1.1 ㎍/dl and was lower than that of bronchial asthmatics without nocturnal dyspnea (p < 0. 01). 3) In 20 bronchial asthmatics without noctunal dyspnea, the value of plasma cortisol before ACTH infusion was 12.6±5.9 ㎍/dl and after ACTH infusion 35. 1±3.2 ㎍/dl. The results of present study show that the patients with bronchial asthma have normal circardian rhythm of cortisol level, but the patients with nocturnal asthma have lower level of plasma cortisol at 11 P.M. than that of bronchial asthmatics without nocturnal dyspnea, The function of adrenal cortisol secretion after stimulation with ACTH infusion is normal. The circardian rhythm of corticosteroid secretion seems to be a possible factor of nocturnal asthma.

동물 복지 융합형 디지털 콘텐츠 제작을 위한 야외효력시험에서 이유 자돈의 혈중 Cortisol 분석

최인학,박철,곽상기,정태호,Choi, In-Hag,Park, Chul,Kwak, Sang-Kee,Chung, Tae-Ho 한국환경과학회 2020 한국환경과학회지 Vol.29 No.5

The plasma cortisol of nurserypigs was examined using an outdoor efficacy testwith a digital content-based approach in animal welfare convergence types. Nine nurserypigs,without discriminating between female and male, were classified into 2 groups of 3 pigs each: control and group 1 (effect+nature), control and group 2(effect+nature+music). The control group was the same for group 1 and 2 to compare the effects using a t-test. There was no significant difference in plasma cortisol levels between the control group and group 1 until 4 h after stress induction. However, significant differences were subsequently found between the control group and group 1 from 8 h to 72 h (p<0.05). Further, plasma cortisol was not affected in group 2 at 0 h through 8 h and 72 h. At 12 h through 48 h, group 2 showed a reduction in plasma cortisol level compared to the control group(p<0.05). These results indicated that after stress induction, applying effect plus nature or effect plus nature plus music can effectively decrease plasma cortisol levels in nursery pigs within8 h through 72 h and may serve as a better model for digital content-based approach in animal welfare convergence types.

한국인 주요우울장애 환자에서 혈중 ACTH, Cortisol 농도와 해밀턴 우울 평가 척도의 신체증상 항목과의 상관관계

여혜빈,김린,함병주,심세훈,권영준,정희연,정한용,한상우,이민수,이화영 대한생물치료정신의학회 2011 생물치료정신의학 Vol.17 No.2

Objectives:Hypothalamic-Pituitary-Adrenocortical(HPA) system dysregulation plays an important role in the pathophysiology of major depressive disorder. Medically unexplained somatic symptoms comprised the predominant complaints of korean patients with major depressive disorder. It might be related to dysregulation of HPA system and somatic symptoms. The aim of this study was to investigate the association between Hamilton Depression Rating Scale severity and the Plasma Adrenocorticotropic Hormone(ACTH) & Serum Cortisol level in Korean patients with major depressive disorder. Methods:Our study design was prospective. A total 111 hospitalized patients with major depressive disorder (DSM-IV) at Anam Hospital, Korea University Medical Center between Jan 2009 and May 2011 were selected. Hamilton Depression Rating Scale was measured by psychiatrist. Plasma ACTH, Serum Cortisol levels were analyzed at the time of admission. Results:There are significant correlations(p<0.05) between Hamilton Depression Rating Scale of somatic component(HAM-D 11-15 item) and Plasma ACTH and Serum Cortisol level. However, other HAM-D sub items were not significantly correlated with Plasma ACTH and Serum Cortisol level except somatic component. Conclusion:Our Study results suggest that hyperactivity of HPA axis might be correlation with somatic symptoms in korean patients with major depressive disorder.

복식전자궁적출술에서 술전 저용량 국소마취제와 Morphine을 이용한 경막외차단이 술후통증, 혈장 Cortisol, 혈당에 미치는 영향

박한석,이승철,차문석,Park, Han-Suk,Lee, Sung-Chul,Cha, Moon-Seok 대한통증학회 1999 The Korean Journal of Pain Vol.12 No.1

Background: Preoperative blocking of surgical nociceptive inputs may prevent sensitization of central nervous system (CNS) and reduce postoperative pain. The stress responses to surgical trauma consist of increase in catabolic hormones and decrease in anabolic hormones. We studied whether preoperative low dose epidural bupivacaine and morphine could affect postoperative pain, changes plasma cortisol, and serum glucose. Methods: Thirty patients undergoing total abdominal hysterectomy were randomly assigned to one of three groups. General anesthesia was induced in all patients and after that, epidural blocks were done except the control group (n=10) patients. Preoperative block group (n=10) received 0.5% bupivacaine 50 mg and morphine 2 mg epidurally as a bolus before operation and followed by 0.1% bupivacaine $5\;mghr^{-1}$ and morphine $0.2\;mghr^{-1}$ for 10 hours. Postoperative block group (n=10) received the same doses of bupivacaine and morphine under the same method postoperatively. Postoperative pain relief was provided with i.v. fentanyl through Patient-Controlled-Analgesia Pump. Postoperative pain by visual analogue scores (VAS), analgesic requirement (first requirement time, total amounts used), side effects, plasma cortisol level and serum glucose level were compared. Results: Until postoperative 6 hrs, VAS of control group was higher than those of the epidural groups. No difference was observed in VAS between the two epidural groups. First analgesics requirement time and total amounts of used analgesics were not different between the two epidural groups, but first analgesic requirement time of preoperative block group was significantly prolonged compared with control group. Plasma cortisol and serum glucose levels were not different among groups. Conclusions: Low dose preoperative epidural bupivacaine and morphine could not reduce postoperative pain, plasma cortisol level and serum glucose level compared with postoperative block group.

타액 코르티솔(cortisol)을 이용한 학습 스트레스 측정법에 대한 고찰

박진선,이일선,권용주 한국교원대학교 뇌기반교육연구소 2011 Brain & Learning Vol.1 No.1

Stress-related study is under way in various aspects. What the most fundamental and important in a stress-related study is how the intensity of stress is measured and how to quantify it. Generally, self-report using Likert scale or interview are useful but these have some difficulties in quantify and can be polluted by subjects intent. Physiological measure can complement the disadvantages of self-report. Physiological measure is used stress reaction which is activated by the sympathetic nervous system. That is, physiological measurements is used physiological parameters such as heart rate or biochemical markers such as stress hormones. Cortisol, the end-product of HPA axis has been widely used and including serum, urine and saliva. Measuring cortisol in saliva has many advantages including the ease of sampling and stress-free. Salivary cortisol is a reliable reflection of total plasma values. 스트레스에 대한 연구가 다양한 측면에서 진행되고 있다. 스트레스 관련 연구에서 가장 기본이 되고 중요한 것은 어떻게 스트레스를 측정할 것이며, 어떻게 정량화 할 것이냐 하는 문제이다. 보통은 리커트식이나 상담을 이용한 자기 보고법이 이용되지만, 이 방법은 정량화에는 어려움이 따르며 또한 피험자의 의도에 의해 오염될 가능성이 있다. 자기 보고법의 단점을 보완할 수 있는 방법이 생리적 측정법이다. 스트레스 상황에서 활성화되는 교감신경계의 반응 결과를 측정하는 방법이다. 심장박동 등 생리적 지표 측정법과 스트레스 호르몬 분비량을 측정하는 생화학적 지표를 측정하는 방법이 있다. 그 중에서 HPA 축의 최종 산물인 코르티솔 측정법이 널리 이용되고 있다. 코르티솔은 혈액, 소변, 타액 등을 통해 얻을 수 있는데, 그 중에서도 타액 코르티솔은 샘플 채취 과정이 쉽고, 채취 과정 자체가 스트레스원이 될 우려가 적다. 또한, 실제 코르티솔 분비량을 대표하기에 적합하기 때문에 좋은 스트레스 측정법이다.

주요우울증 환자의 삼환계 항우울제 투여에 따른 임상반응과 뇨 MHPG 및 혈장 Cortis이치와의 관계

오영미,황익근 대한신경정신의학회 1993 신경정신의학 Vol.32 No.6

The purpose of this study was to examine the effects of tricyclics on urinary M H PG level and plasma cortisol level and to investigate the interaction of noradrenergic system with HPA axis in major depression. The subjects were 24 inpatients with major depression diagnosed according to DSM-III-R. Seventeen medical students and residents served as a control group. 24-hour uinary M H PG and plasma cortisol concentration at 08 : 00 a.m were measured at various points during treatment The results were as follows: 1) No significant difference was found between the urinary MH PG excretion for either depressed patients or comparison subjects. 2) The pretreatment urinary M H PG level and therapeutic response to tricyclic antidepressants did not correlate. 3) Significant positive correlation was found between pretreatment 8 : 00 a.m. plasma cortisol levels and urinary M H PG levels in depressed patients(r=0.54, p<0.05). After tricyclics medication, negative correlation was observed, but was not significant(r= — 0.41,p=N S).