난소 성삭종양을 닮은 자궁종양

이일선,정순봉,허방,허만하 대한병리학회 1992 Journal of Pathology and Translational Medicine Vol.26 No.2

3성분계 저발열 시멘트에 조분 시멘트를 치환하는 콘크리트의 특성 분석

이일선,백대현,김기훈,황인성,한민철,한천구 대한건축학회지회연합회 2010 대한건축학회지회연합회 학술발표대회논문집 Vol.2010 No.1

과학시대의 기도

이일선 새가정사 1973 새가정 Vol.- No.-

내 인생 내멋에 산다

이일선 새가정사 1976 새가정 Vol.- No.-

두뇌맞춤 지수 기여도 산출식의 개발 및 적용 : 7학년 과학 "세포의 구조와 기능" 단원을 중심으로

이일선,이준기,권용주 韓國生物敎育學會 2010 생물교육 Vol.38 No.4

과학적 가설평가 과정의 뇌 과학적 분석방법 고찰-Effective connectivity 중심으로-

이일선,권용주 한국교원대학교 뇌기반교육연구소 2011 Brain & Learning Vol.1 No.1

이 연구의 목적은 과학적 가설평가 과정의 뇌 과학적 분석 방법을 effective connectivity 분석 방법 중심으로 고찰해보는 것이다. 분석 방법을 고찰해보기 위해, 이 연구는 두뇌 네트워크 분석 방법과 관련된 선행연구들로부터 effective conncectivity의 3가지 분석방법을 확인하였다: PPI, SEM, DCM. 첫 번째로, 각 항목에 관련된 분석 방법을 파악하기 위하여 connectivity 분석 방법에 대한 15편의 뇌과학 문헌들을 분석하였다. 두 번째로, 과학적 가설평가 과정의 하위 요소들과 관련된 연구들 중 effective connectivity 분석 방법을 사용한 30편의 뇌과학 문헌들을 분석하였다. 그 결과, 과학적 가설평가 과정의 뇌과학적 연구에는 functional connectivity 분석보다 effective connectivity분석이 보다 적절한 것으로 나타났다. 또한 가설평가 과정의 하위 인지요소별 실험결과는 PPI분석을 통해 ROIs를 구성하고 구성된 ROIs들을 SEM을 이용하여 경로 모델을 도출하는 것이 최적의 분석 방법임을 확인하였다. 이러한 분석 방법들은 과학탐구의 다른 하위 과정들의 분석에도 활용 가능할 것으로 전망된다. The purpose of this study was to review how the brain scientific analysis in scientific hypothesis evaluation with a focus on the effective connectivity. To review how the brain scientific analysis, we have found 3 methods of effective conncectivity from previous studies: PPI, SEM, DCM. Firstly, Fifty literatures on the brain network associated connectivity analysis were analyzed to know the characteristic which is related to three methods. Secondly, thirty literatures associated with the sub-element of the hypothesis evaluation process using effecitve connecitivity analysis methods were evaluated. As a result, effective connectivity analysis showed that a more appropriate analysis of functional connectivity. In addition, the PPI analysis consist of ROIs, to derive SEM model using ROIs was the best analysis method. These analysis methods are expected to be utilized in other scientific inquiry process.

농촌과 질병

이일선 새가정사 1970 새가정 Vol.- No.-

두뇌 동기보상 시스템 기반 생명과학 학습동기 증진 학습모형 개발

이일선,변정호,권용주 韓國生物敎育學會 2012 생물교육 Vol.40 No.1

The purpose of this study is to develop a learning model based on the brain motivation and reward system in order to improve motivation for learning biology. To develop the learning model, the brain motivation and reward system associated with biology motivation for learning was identified. Based on the neurologically identified motivation reward system, the learning model to improve motivation for learning was developed through a neurological verification. The result indicates that the brain motivation and learning system related to biology learning motivation includes orbitofrontal cortex, striatum, and midbrain networks. With the analysis results of neurological mechanism in these regions, a learning model was developed. The learning model has the learning flow starting from the midbrain step, through the orbitofrontal cortex step and proceeding to the striatum one. The objectives of respective learning steps are to arouse motivation at the first midbrain step, to reinforce motivation at the second orbitofrontal step, and to retain motivation at the third striatum step. The brain motivation and reward system germane to biology motivation for learning that the current study identified is expected to provide the brain level information with respect to the learning motivation in the biology learning.

濟州島 癩病의 歷史的 및 疫學的 考察

李一善 최신의학사 1976 最新醫學 Vol.19 No.3

Jeju island, located in the southern end of Korea, was a semi-isolated land even before 1945. To review the historical aspect of leprosy in Korea, there were 100 odd leprosy patients in Jeju island, where a population of 63,935 was in the 17th year of King Se-jong(1450, A.D.), and for the first time in the history of Korea, King-Se-jong did a leprosy work. As famine repeated in the island, King Se-jong let the isladers migrate to the Korean mainland, and the island population in the 35th year of the king(1468, A. D.) decreased to only 19,377. Most islanders moved to a part of such provinces as Jolla, Kyungsang and Choong Chung and to the coast of a part of Kangwon province. A historical record was made that leprosy patients were found in the southern area of Korea in 1612 for the first time, 162 years after such migration was made. Leprosy was even in the ancient China, but no leprosy patients were found in the provinces of Pyungan and Hamkyung which were connected closely to the Chinese continent, though the inhabitants traded with China from the ancient time. And there was not any major spread of leprosy in Tangjin, which was the center of Korean trades with China, during the era of Chinese Tang dynasty. Now the leprosy ratio in the area is relatively small, in comparison of population(41 leprosy patients in the Tangjin county population of 172, 955). In the history of neighbouring country, Japan, it is stated that leprosy was found from around the year, 700, A.D. Jeju island, located closest to Japan, had contact with Japan even in the ancient time; so, it is assumed that leprosy in Korea was from Jeju island, and the leprosy in Jeju was from Japan. So, in order to make the historical study of leprosy in Jeju, the author had a research of the geography, history, and indigenes of Jeju, and this study was made in the hope that a direction might be presented for the control of Korean leprosy, by having the effective research on current status of leprosy in Jegu and its epidemilogical study. The results are summarized and concluded as follows: Jeju island, the biggest island of Korea located in the southern end of the country, had the indigenes originated from Korubuk tribe (ancestors(?) of the people now surnamed Ko, Ryang, and Bu in the island) of Kyushu area of Japan; their blood was mixed with that of those who migrated from South Pacific, China, Mongolia, and Korea; as a result, their life and dialect are quite different from those of the people in the Korean mainland(though they are almost assimilated with the people of Korean mainland). (1) The Jeju island leprosy records appearing in the current book of history are: 69 in the SejongSilrok(1445, A. D.) and 100 and more in the Moonjong-Silrok, written in April of the 6th year(1451, A. D.) It shows that leprosy in Korea was initiatiated in the Jeju island. Later, 162 years after that, it is recorded, leprosy spread to the provinces of Kyungsang, Choong Chung and Kangwon, in April of the 4th year of Kwang-hai-koon, as written in the diary Vol. 52. From the facts that most indigenes are composed of the people from Japan, South Pacific, Mongolia, China and Korea, that there is no record of leprosy in Korea in prior to such record, and that the spread of leprosy in Japan preceded Korea by 600 years, therefore, it may be said that leprosy in Korea came from Jeju island, and the leprosy in Jeju came from Japan. (2) The number of leprosy patients registered in the Health Center in Jeju island are 33 among the population of 365,229 (in 1970); the number the author confirmed, however, is 24. It may imply that many of the leprosy patients in Jeju island must be treated in the Korean mainland, in the fear that their disease may be recognized by the general public. (3) As a result from the mass survey of 3,216 students of 8 secondary schools, 26 doubtful cases and 1 leprosy were found out; however, the histological test of the 8 of them revealed "none specific inflammation with dermal fibrosis and no acid fast organism." But it is necessary to keep observing them and it is particularly noticeable that new cases of lepromatous type were found among the boys and girls around 20 years old. Probably many new cases will be found, if the mass survey is carried on for all the students and the youth in Jeju island. (4) According to the statistics made by Ministry of Health and Social Affairs in 1973, all the leprosy patients registered in Korea were 26,917, and 32 in Jeju island; however, there are some Lepromatous type in the new patients of young age, who are inhabited in the urban area where the population is relatively densxr than the rural community. This gives us a concern that leprosy would occur in the urban area more than in rural community in Korea, along with the tendency that population of rural community is moving to the urban area. (5) As to the ratio of sex in the leprosy patients in Jeju island, it is almost equal, unlike the 2 : 1 or 3 : 2 in other provinces. This may be caused by the fact that female exceed male in number in Jeju is well known as an island of many female, and by the fact that outdoor activities of female are nearly same as those of male; it is assumed, therefore, that they may be infected nearly same degree, for skin disclosure is almost same. (6) The King Se-jong appears to be the first leprosy relief worker in the history of Korea. There is no way to find where he did his leprosy work, but the leprosy settlement that is to say, the places for their relief, may be assumed to be Jeju for the present Samyang 2-dong, Jeju city, and Daijung for the present Moseulpo, and juneri for the present Pyosun, from the expression of place in the history books and from the oral instruction.

鬱陵島에 있어서의 癩病이 根絶되어가는 疫學的 硏究

李一善 최신의학사 1976 最新醫學 Vol.19 No.4

The island Ullung-do, semi-isolated in the center of Japan Sea in the east of Korea, administratively belongs, as the Ullung County, to North Kyungsang Province where the spread of leprosy patients is most in Korea. The population is 27,500, in the ratio of 60% fishermen, 30% farmers and 10% others. The author discovered 59 leprosy patients, for the first time, in 1956, through the mass survey of the islander's skin disease: since that they were treated 3-4 times a year. Then, in 1961, the auther migrated to Ullung-do were he founded the Ullung-do Hospital. While discovering leprosy patients among the out patients at the hospital the author engaged in finding, treating and relieving patients by working as the school doctor of the primary schools and secondary schools. For the past 17 years, 1956 through 1973, the author treated 126 leprosy patients in all (including those who removed or treated irregularly) in Ullung-do. The patients who were treated regularly, however, are: 59 in 1956; 48 in 1961; 63 in 1964; 68 in 1966; 65 in 1968; 56 in 1969; 47 in 1970; 38 in 1971; 28 in 1972; 14 in 1973; and 8 in 1974, showing gradual decrease. In view of the fact that leprosy is eradicating in Ullung-do which belongs to North Kyungsang province where the spread of leprosy patients is greatest in Korea, this study has been made to find a possibility of showing a royal way directed to the eradication of leprosy from Korea, through the research and survey on such matters as: how leprosy was brought to Ullung-do, how they were found, how they were treated, the patients' bacteriological test results, how the patients moved, the environmental change of islander's life, the advancement of their education, the economical development, and how the treatment made at home secretly apart from the general society, instead of accommodating them in a settlement, brought better results eventually bringing good effect to the patient's restoration of social life. The results are summarized and concluded as follows: The population of the island Ullung-do, a lost island in the center of Japan sea for from the Korean mainland, has engaged in a semi-isolated life. The record of this island first appeared in a historical book, Sam-kock-sa-ki (512, A.D. ) The indigenes once formed a nation, Woo-San-kock, but they surrendered to Silla, and then in the beginning of the 10th century, the people of WooSan-kock once presented tribute to King Taejo of koryo dynasty (930, A. D.) The island was evacuated in the time of Yi dynasty, but about 100 years ago in the 13th year or King Ko-jong (1877, A. D.) the migration was started again. Internationally speaking, Captain Dagelet of the French Explering Ship “Boussole” discovered the island on May 29, 1787, and it was first recorded as “Dagelet” in the international chart. (1) It is assumed that the indigenes of the island were composed of Japanese (from Tsushima, 9himane, and Sanin-about 500 of them were detected in 1885, A. D. ), and the migrants who first moved to the provinces of Jolla and Kyungsang of Korean mainland from Jeju island because of famine, and mostly scattered in the coastal line finally reaching this Ullung-do. Though it is not clear when leprosy invaded this island, it may be assumed from the formation of indigenes that it took a course from Jeju-do to Jolla-do, Kyungsang-do and to Ullung-do. (2) The author discovered new patients of early stage trough the mass survey in the physical examination of 11 primary school students, 1956-1973, and 3 secondary schools 1961-1973, and from the out-patients of Ullung-do Hospital, 1961-1973. The number of patients found in above surveys are: from primary school students, 1957-1959--------------------------6 from secondary school students, 1957-1965-----------------------18 from the out-patients of Ullung-do Hosp., 1961-1969---- 37 However, no new patients were found: from primary school students, for 14 years, 1960-1973; from secondary school students, for 8 years, 1966-1973; and from out-patients of Ullung-do Hosp., for 4 years, 1970-1973. The first leprosy patients found in the island were 59 in 1956. However, 68 patients were treated in 1967, for new patients were found and some patients moved since the Ullung-do Hospital was founded in 1961. After that the patients decreased as follows: 47 in 1970. 38 in 1971, 28 in 1972. 14 in 1973. and 8 in 1974 and 4 in 1975. (3) The patients were dosed mainly with D.D.S. and CiBA 1906, and most patients regularly treated turned better in results, except 2 patients who were worsening. It maw by caused but their resistance to D. D. S. (4) Since 1971, patients have been released from control under the basis provided by WHO, now to be left only 8. This will mean that leprosy is being eradicated in Ullung-do. (5) It is considered that dosing such sulfone as D.D.S. and CIBA 1906 and taking protein have Contributed greatly to the eradicating leprosy in Ullung-do, accelerating the clinical improvement, and further that semi-isolated patient's life in the highland of this semi-isolated island was a factor to decrease the opportunity of spreading leprosy among the islanders. (6) The cultural advancement and the increase of educational facilities in the island promofed the hygienic sense of islanders, providing indirect or direct enlightenment to the prevention and treatment of this disease. (7) It is evident in the island that the economical growth shown by the increase of farm products, live-stock products and fishing products can influence much to the advancement of national health. For example of 2 leprosy patients in the island, one lepromatous type ( � ) patient residing in a highland was given a dairy goat to allow him to take its milk continuously; on the other hand, a Borderline type patient residing in urban area could not take milk. Clinical and bacteriological comparison made between the former and latter was that the former turned better becoming inactive; while, the latter turned to be a Lepromatous type (N) from the Borderline type. (8) The number of leprosy patients in Korea is still not certain, and even the statistics made from the register in the Ministry of Health and Social Affairs in 1973 is considered to have some error. After releasing from control on the basis made by WHo, the leprosy patients in Ullung-do much decreased. (9) It is considered that the discovery of early stage of leprosy in Korea may be effectively done through the mass survey, especially through the medical check-up of secondary school students, and the physical examination of recruits, and by the careful cooperation of general practitioners in treating local people. (10) In case of even active leprosy patients, the infection can be prevented, '.if we can let them reside in a different room, a little apart from the general community, even though they are not sent to collective settlement. It leprosy patients are treated at home secretly not opening the fact to the general public, the restoration of their normal life in general society will not be a problem. (11) Dosing sulfone together with the supply of enough protein will be necessary for treatment of leprosy patients, and to the patients resistant to sulfone, it may be replaced with such new medicine as Rifampicin, etc. (12) The author could learn from his experience in Ullung-do that the accurate mass survey of leprosy patients and the discovery of early stage to be made through the cooperation of general practitioners and the register and estimate of exact number of the patients, and the early practice of releasing patients from control on the WHO's basis will be royal way to re-arrange the leprosy problem of Korea.