여성 가성 반음양 치험례

구상환,정전은,정영덕 大韓成形外科學會 1989 Archives of Plastic Surgery Vol.16 No.6

Normal sexual differentiation is the result of a series of individual steps that occur in an orderly fashion. Initially, chromosomal factors direct the defferentiation of the indifferent gonad into either an ovary or a testis. Then, under the influence of hormones secreted by the fetal testes, differentiation of the internal ducts and external genitalia is completed. Consequently, normal sexual differentiation can be subdivided into three separate events: differentiation of the gonads, development of the internal ducts and differentiation of the external genitalia. However, during embryogenesis any disturbance of the various steps in normal sexual differentiation may be reflected clinically as a disorder of intersexuality e.g. chromosomal anomalies, female pseudohermaphroditism, and male pseudohermaphroditism, etc. Genetic females with female pseudohermaphroditism have virilization of the external genitalia produced by intrauterine exposure to excessive androgen. But, because they normally developed ovaries and Mullerian derivatives, they are all potentially fertile. The degree of masculinization varies depending on the stage of differentiation at the time of exposure, from clitoral hypertrophy to true phallic-urethral formation with labioscrotal fusion. The most common cause is congenital adrenal hyperplasia in which cortisol synthesis is impaired due to deficiency of 21-hydroxylase. In attempting to compensate for lower cortisol levels, ACTH stimulates the adrenal gland to secrete excessive quantities of androgen. We experienced a 2 year-old girl, who expressed genital anomalies such as greatly enlarged clitoris-like male phallus associated with posterior labial fusion and a single perineal urogenital orifice which were first noticed by her parents since birth. The general assessment was normal and the karyotype was 46XX as normal genetic female. Plasma testosterone, ACTH, DHEAS, progesterone, and urinary 17-KS values were higher than normal, but cortisol was within normal value. Her blood pressure and serum eleotrolytes were normal. IVP, abdominal sonogram, retrograde cystogram and vaginogram were found to be normal. Explorative laparotomy and constructive operation of female external genitalia including vaginoplasty using inverted Y-shaped skin flap and clitoridectomy were performed under general anesthesia. Both adrenal glands revealed hyperplastic only, and both ovary was excised in wedge shape for shitologic examination. She was finally diagnosed as female pseudohermaphroditism due to congenital adrenal hyperplasia accompanied by incomplete deficiency of 21-hydroxlase, and hormonal therapy was started with hydrocortisone 15㎎/day in three divided dose for 1 month. The value of 17-KS in 24 hour urine study during follow-up period was within normal limit as 1.3㎎/day at POD ￠1 month, 0.7㎎/day at POD ￠2 month, 1.0mg/day at POD ￠6 month, 0.8mg/day at POD ￠16 month. Results of vaginoplasty, clitoridectomy, and hormonal therapy was satisfactory, and there was no recurrence or prematurity.

소비자-브랜드 관계가 확장된 브랜드 평가에 미치는 영향

박은아,김태형,성영신,강정석 한국소비자학회 2004 소비자학연구 Vol.15 No.4

본 연구에서는 소비자-브랜드 관계(BRQ)가 확장된 브랜드 평가에 미치는 영향력을 알아보고, 또한 소비자-브랜드 관계의 강도에 따라 확장된 브랜드에 대한 평가시에 적정한 불일치성 효과(MIE)가 나타나는지 검증하고자 하였다. 연구 결과 소비자-브랜드 관계 강도에 따라 확장된 브랜드에 대한 태도와 구매의도는 다른 것으로 나타났으며, BRQ의 여섯 개 하위차원 중에서 확장된 브랜드 평가에 직접 영향을 미치는 것은 관계의 질 차원과 사랑과 열정 차원인 것으로 분석되었다. 한편, BRQ가 높은 집단에서 확장된 브랜드에 대한 적정한 불일치성 효과는 나타나지 않았으며 속성 유사성 효과도 나타나지 않았다. 반면 BRQ가 낮은 집단에서는 기존의 연구들과 마찬가지로 속성 유사성에 따라 확장된 브랜드에 대한 평가가 다른 것으로 분석되었다. 본 연구의 결과는 확장된 브랜드에 대한 평가에는 기존 브랜드와의 BRQ가 중요하며, 관계가 강할 때에는 속성 유사성 정도에 관계없이 확장 브랜드에 대해 호의적인 평가가 일어날 수 있음을 시사하고 있다. We examined how consumer-brand relationship affects the evaluation of extended brands. Specifically, we investigated the effect of the sub-dimensions of consumer- brand relationship quality (BRQ) on the evaluation of extended brands and the existence of moderate incongruity effect (MIE) in high BRQ consumers. The results shows that the BRQ sub-dimensions have different effects to the attitude toward the extended brand and purchase intention to the extended brands. We tested MIE in high BRQ consumers, the result did not support of moderate incongruity effect in brand extension. It means that strong BRQ consumers evaluate positive to the extended brands regardless of the degrees of the product attribute similarities. For the weak BRQ consumers, the product attribute similarities with parent brands affect their attitudes and purchase intentions of extended brands in the same result of the previous study. These results showed that the strong consumer-brand relationship is key important factor to the favorable evaluations to the brand extensions. Finally, theoretical and practical implications and limitations of this study were discussed.

시멘틱 웹 환경에서의 온톨로지 기반의 정보검색

정은경,김영민,변영철,이상준,박경린 濟州大學校 基礎科學硏究所 2003 基礎科學硏究 Vol.16 No.2

온톨로지는 시멘틱 웹을 구현하기 위한 이론이다. 온톨로지는 웹자원의 효과적인 검색, 통합, 재사용을 위한 새로운 기술이고 사람과 이질의 응용 시스템 간에 지식을 공유하고 재사용하기 위한 방법을 제공한다. 온톨로지의 역할은 특별한 개념을 명세화하는 것이다. 도메인과 일반적인 온톨로지는 정보와 지식 시스템을 분석하고 디자인하는 측면에서 공유, 통합, 재사용될 수 있다. 본 연구는 제주도의 숙박과 관광정보를 위한 온톨로지를 디자인하는데 목적이 있다. 그리고 제안된 온톨로지 기반으로 인터넷 웹 검색 시스템을 만드는데 목적이 있다. 본 연구에 의해 클라이언트가 사용하는 표현은 다르지만 뜻이 같은 동의어에 의해 같은 결과를 얻을 수 있다는 것을 알게 되었다. Ontologies are formal theories that are suitable for implementing the semantic web. Which is a new technology that attempts to achieve effective retrieval, integration, and reuse of web resources. Ontologies provide a way of sharing and reusing the knowledge among the people and the heterogeneous application systems. The role of ontologies is that of making explicit specified conceptualizations. In this context, domain and generic ontologies can be shared, reused, and integrated in the analysis and design stage of information and knowledge systems. This study aims to design an ontology for juju lodges and tour, and build an Internet web retrieval system based on the proposed ontologies. This study found that we can take the same result for synonym that cilent use.

다중 장치 지원 모바일 응용서버 설계

정은경,변영철,이상준 제주대학교 공과대학 첨단기술연구소 2003 尖端技術硏究所論文集 Vol.14 No.1

In this paper, we propose the design of the application server which provides internet services for the mobile devices such as a mobile phone and PDA, etc. The neutral form of mobile application which can be requested by various kinds of mobile devices is created and deployed to the proposed application server. The mobile application server supplies the content transformed according to the constraints and features of a mobile device. By using the server, a user can use many kinds of mobile devices at the same time, and only one session can be created and maintained at the server. The mobile application server is composed of the tree modules: Mobile Request Generator, Mobile Engine, and Environmental Adoptation module. The Mobile Request Generator module receives the mobile request from a mobile device and creates the mobile request information supplied to the Mobile Engine module. The Mobile Engine module processes the mobile application requested and creates a content which will be sent to a mobile device. The Environmental Adaptation module transforms the output of Mobile Engine into the contents that a mobile device can display. In this way, the proposed mobile application server can support various kinds of mobile devices using a neutral form of internet service.

항암제 AG60이 흰생쥐 위점막 상피세포의 DNA합성에 미치는 영향 : 자기방사법적연구

박경호,안의태,고정식,하상선,한영복,정영신,홍은경,유보림,김상건,이경영,강종구 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

Acriflavine-Guanosine 복합제 (AG60)의 조직내 분포에 대한 형광현미경적 연구

고정식,임수재,안의태,김진국,김상건,이경영,강종구,홍은경,정영신,유보림,한영복 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

후두백반증의 임상-병리학적 검색 -추적 생검 및 p53과 PCNA의 발현 양상

박양순,옥순애,공경엽,허주령,유은실,이인철,김상윤,최기영 대한병리학회 1996 Journal of Pathology and Translational Medicine Vol.30 No.4

Preoperative total cholesterol is predictive of prognosis in epithelial ovarian cancer

( Yung-taek Ouh ),( Na Young Bae ),( Yoo Jin Lee ),( Sung Eun Kim ),( Hyun Woong Cho ),( Jin Hwa Hong ),( Jae-kwan Lee ) 대한산부인과학회 2018 대한산부인과학회 학술대회 Vol.104 No.-

Objective: To investigate the prognostic implication of preoperative total cholesterol (TC) level in patients with epithelial ovarian carcinoma (EOC). Methods: Medical records of patients who underwent primary debulking surgery and adjuvant platinum-based chemotherapy from January 2002 and December 2015 were reviewed. The association among preoperative TC level, clinical prognostic factors, and outcome as progression free survival (PFS) and overall survival (OS) was analyzed by univariate analysis. To explore independent prognostic factors for PFS and OS, multivariate Cox proportional hazard regression was used. Results: Of total 121 patients, 99 (81.8%) had lower TC (<200 mg/dL) and 22 (18.2%) had higher TC (200 mg/dL). Higher preoperative TC was significantly associated with lower histologic grade (grade 1 or 2) and histology of mucinous and endometrioid. The patients with lower TC showed higher mortality rate (P=0.018). Patients with higher preoperative TC had a longer PFS (P=0.012) and OS (P=0.021). In multivariate analysis, preoperative TC showed a significant association with OS (HR, 0.111; 95% confidence interval [CI], 0.015-0.827, P = 0.032). Conclusion: Higher TC most likely leads to better overall survival in patients with EOC. These results suggest that the level of preoperative cholesterol could assist the identification of patients with poor prognosis in patients with EOC.

The Effect of Work Life Balance on Organizational Commitment and Turnover Intention

Eun Yung Kim,Hyun Sung Oh,Miaomiao Huo 대한경영학회 2017 대한경영학회 학술발표대회 발표논문집 Vol.2017 No.1

Design and Synthesis of Nano Electrode Materials for Fuel Cells

( Yung-eun Sung ) 한국공업화학회 2004 한국공업화학회 연구논문 초록집 Vol.2004 No.-