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이원철,유경혜,장성실,이세훈,구정완,김현욱,노영만,이경재,김형아 가톨릭 대학 산업의학 쎈타 산업의학연구소 1996 韓國의 産業醫學 Vol.35 No.1
Occupational hearing loss became the leading occupational disease by constioution 56% of all work-related diseases in Korea. However, the prevalance rates showed wide variations among the specific medical examination providers and were very low(0.8-1.4%) compared with those 8.4% in Japan. The sources of these variations was regarded in the preview study as 1) Employee audometric estings were primarily conducted by nurses and nurse-aids who had no formal training for audiometry; 2) althought audiometric testing equipment used by the spedific medical examination providers, it should be periodically calibrated, a significant number of them were not properly calibrated : 3) Initial audiometric testings were conducted at any available spaces in workplace or at the testing room without considering bachground noise level. One of solutions that can be done for sloving surrent noise related problems is to provide a noise related manual for the occupational health managers including doctors, nurses and hyginests. This study was done to provide such a manual. The main core of the manual was hearing conservation program. And the contents of the manual was the same as the main frame of hearing conservation program such as noise survey, provided of the diagram showing the core contents of each factor of the hearing conservation program. Hopefully, this manual will be the references of the standardized performances of the specific medical examination providers.
SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle
Koo, Young Do,Lee, Ji Seon,Lee, Seung-Ah,Quaresma, Paula G.F.,Bhat, Ratan,Haynes, William G.,Park, Young Joo,Kim, Young-Bum,Chung, Sung Soo,Park, Kyong Soo Elsevier 2019 clinical and experimental Vol.95 No.-
<P><B>Abstract</B></P> <P><B>Background and purpose</B></P> <P>In addition to the central nervous system-mediated action, leptin also directly induces fatty acid oxidation in skeletal muscle. Rapid induction of FAO by leptin is mediated by the AMP-activated protein kinase (AMPK) pathway, but the mechanism of prolonged FAO by leptin was previously unknown. In an earlier study, we showed that free fatty acids increase transcription of small ubiquitin-like modifier (SUMO) specific protease 2 (SENP2) in skeletal muscle, and that SENP2 stimulates expression of FAO-associated enzymes by deSUMOylating peroxisome proliferator-activated receptors, PPARδ and PPARγ. In this study, we examine whether SENP2 is involved in prolonged stimulation of FAO by leptin.</P> <P><B>Methods</B></P> <P>The Effect of leptin on expression of SENP2 and on SENP2-mediated FAO was investigated by using western blotting and real time qPCR of C2C12 myotubes, and of C2C12 myotubes in which expression of specific genes was knocked down using siRNAs. Additionally, muscle-specific SENP2 knockout mice were generated to test the involvement of SENP2 in leptin-induced FAO in vivo.</P> <P><B>Results</B></P> <P>We show that leptin treatment of C2C12 myotubes causes signal transducer and activator of transcription 3 (STAT3) to bind to the <I>Senp2</I> promoter, inducing SENP2 expression. We also show that leptin increases the binding of PPARδ and PPARγ to PPRE sites in the promoters of two FAO-associated genes: long-chain acyl-CoA synthetase 1 (<I>Acsl1</I>) or carnitine palmitoyl transferase 1b (<I>Cpt1b</I>). When SENP2 is knocked down in myotubes, leptin-induced expression of FAO-associated enzymes and prolonged increase of FAO are suppressed, but rapid increase of FAO is unaffected. In addition, leptin-induced expression of FAO-associated enzymes was not observed in muscle tissue of SENP2 knockout mice.</P> <P><B>Conclusions</B></P> <P>We demonstrate that the peripheral actions of leptin on FAO are mediated by two different pathways: AMPK causes a rapid increase in FAO, and SENP2 of the STAT3 pathway causes a slow, prolonged increase in FAO.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Leptin directly activates AMPK and STAT3 through leptin receptor in skeletal muscle. </LI> <LI> Leptin increases transcription of <I>Senp2</I> through STAT3 activation. </LI> <LI> Leptin increases expression of FAO-related genes through PPAR desumoylation by SENP2. </LI> <LI> Leptin increases FAO acutely by AMPK and later by the STAT3/SENP2 pathway. </LI> </UL> </P>
Young-Ah Koo,Kyung-A Son,Suk-Joo Choi,Byung-Koo Yoon 대한폐경학회 2019 대한폐경학회지 Vol.25 No.3
Objectives: We evaluated the effects of adding intravenous pamidronate to ongoing menopausal hormone therapy (MHT) on bone mineral density (BMD) in postmenopausal Korean women with low BMD. Methods: This retrospective cohort study included 74 postmenopausal women who received MHT for at least 1 year and had a BMD T-score of less than −2.0. Maintaining the same MHT regimen, these women were divided into two groups: oral placebo group (n = 44) and a pamidronate group of patients with gastrointestinal discomfort (n = 30) who received 15–30 mg pamidronate intravenously every 3–12 months. BMD was reviewed at 12-month follow-up. Bone resorption markers in both groups, urinary deoxypyridinoline levels in the placebo group, and serum N-telopeptide of type I collagen in the pamidronate group were assessed at 6 and 12 months. Results: At baseline, the body mass index (BMI), duration of previous MHT, and femur neck (FN) BMD differed between the groups. Within-group analysis revealed that BMD of the lumbar spine (LS) and total hip (TH) significantly increased in the placebo group, whereas those of the LS, FN, and TH increased in the pamidronate group. The increase in BMD of LS was significantly greater in the pamidronate group, after adjusting for BMI and duration of previous MHT (mean change: 3.7% vs. 6.2%; P < 0.001). There were no changes in bone resorption markers in either group. Conclusions: Adding intravenous pamidronate to ongoing MHT for 12 months might increase LS BMD in postmenopausal Korean women with low BMD.
디지털 변혁(DT) 시대 서울 소재 중소기업 최고경영진의 산업별 ICT 기술 교육 요구도 분석
노아영 ( Ah Young Noh ),김구종 ( Koo Jong Kim ),송영수 ( Young Soo Song ) 한국인적자원관리학회 2022 인적자원관리연구 Vol.29 No.3
Due to the Fourth Industrial Revolution, companies are facing numerous internal and external changes. Respond to these changes, company should adopt digital transformation by applying ICT technologies for continuous growth and development. However, SMEs that have limitations in purchasing and procuring physical and human resources experience difficulties in responding to these changes. As one of the alternatives to this, the need to strengthen the ICT technology capabilities of SME’s members is proposed. To improve the effectiveness of education to strengthen ICT technology capabilities of SME, the purpose of this study were to do the training need assessment of ICT technology by industry in the Digital Transformation era. For conducting the study, First, collect data from people who have completed ‘Digital Leadership courses for Seoul SME’ by Seoul Business Agency. Second, Based on collected data, conduct t-test, Borich’s educational need equation and the Locus for Focus model. The result of this study founds that ICT technologies belonging to the top priority group were different for each industry. In addition, Artificial Intelligence and Virtual reinforcement Reality was found to be factors that should be considered first in most industries. Also, Big data was found to be a factor that should be considered first in a specific industry. Based on the findings, theoretical and practical implication were discussed to improve the effectiveness for SME’s ICT technology capabilities.
내화성 경량 무기 발포보드를 이용한 커튼월 시스템의 열성능에 관한 연구
구영아(Koo, Young-Ah),오창원(Oh, Chang-Won) 한국건축친환경설비학회 2011 한국건축친환경설비학회 논문집 Vol.5 No.4
The purpose of this study is to suggest curtain wall systems using Light-weight Inorganic Composite Foam Board(LI-CFB) to further improve the fire resistance than the existing systems. LI-CFBs, new materials with excellent fire resistance are currently under development. Curtain wall systems using those meet or exceed the existing system’s thermal performance. So, for the comparing both systems, computer simulation was conducted with THERM 6.3/ WINDOW 6.3 Program. U-value is calculated and the results of simulation showed that there is the equivalent performance between the new and existing system. Furthermore, it is shown that new system(LI-CFB) which is coverd back-panel and mullion bar is improved 14% of U-value more than U-vaule of existing system by this study.
조산 또는 만삭 분만 후 진단된 뇌성마비의 임상적 양상
구영아 ( Young Ah Koo ),최동석 ( Dong Seok Choi ),최석주 ( Suk Joo Choi ),오수영 ( Soo Young Oh ),장윤실 ( Yun Sil Chang ),박원순 ( Won Soon Park ),김현숙 ( Hyeon Sook Kim ),노정래 ( Cheong Rae Roh ),김종화 ( Jong Hwa Kim ) 대한산부인과학회 2006 Obstetrics & Gynecology Science Vol.49 No.12
Objective: To investigate the perinatal and clinical characteristics of cerebral palsy (CP) following preterm or term birth. Methods: A total of 75 infants born and diagnosed as CP in our hospital from October 1994 to December 2004 were recruited retrospectively. Their maternal and perinatal outcomes and the type, involved lesion and severity of CP were analyzed. Results: The incidence of CP was 0.23%, which showed decreasing pattern according to advancing gestational age at birth. CP was more frequent (6.7-times) in multifetal pregnancy. Male to female ratio was 1.5: 1. After excluding five infants with major congenital anomalies, 55 (79%) infants were born before 37 weeks` gestation (preterm CP) and 15 (21%) infants were born beyond 37 weeks` gestation (term CP). Eighty-six percent of preterm CP had significant neonatal morbidities, but only 6 out of 15 infants in term CP had significant perinatal events including hypoxic ischemic encephalopathy, meconium aspiration syndrome, and seizure of unknown origin. The most common type of preterm CP was spastic (95%), whereas the types of term CP were more diverse; spastic in 67%, athetoid in 20%, dystonic in 7%, and hypotonic in 7%. Regarding the involved lesions, the most common type was diplegic in preterm CP and quadriplegic in term CP. Conclusion: In contrast to preterm CP, term CP had significantly less perinatal risk factors, and their type and involved lesion showed more diverse patterns. These findings may implicate that more heterogenous etiologies are involved in pathogenesis of term CP.