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톨루엔을 포함한 유기용제의 직업적 폭로로 인한 신경내분비계 영향
이채언,이종태,정의화,손혜숙,문덕환,전진호,강정학,이창희,김휘동,김종한,정귀옥 大韓産業醫學會 1995 대한직업환경의학회지 Vol.7 No.2
Long term occupational exposure to solvent mixtures may cause adverse effects to the central nervous system with neurobehavioral symptoms. And some organic slovents have been suggested to cause impairment of tuberoinfundibular dopaminergic activity and neurochemical mechanisms controlling pituitary secretion. For the purpose of assessing neuroendocrine effects in occupational solvents exposure, hormonal study settings (shoes-manufacturing industry & fishing products industry) and compared with nonexposed controls(33 men, 85 women). Male workers exposed to solvent mixtures had significantly lower plasma level of follicle-stimulating hormone(FSH) than nonexposed male controls. While female workers exposed to solvent mixtures had significantly lower plasma levels of growth hormone(GH), and thyroid-stimulating hormone(TSH) than nonexposed female controls. The results of significant decrease in plasma concentrations of pituitary hormones(FSH, GH, and TSH) in workers exposed solvent mixtures indicate that occupational exposure to solvent mixtures may induce neuroendocrine effects through an effect on hypothalamic pituitary axis.
담관 결찰 시 혈장 빌리루빈 농도와 GPT 활성도의 ICG 농도에 대한 상관관계
배진우,이태의 건국대학교 의과학연구소 1998 건국의과학학술지 Vol.8 No.-
Plasma clearance rate of indocyanine green (ICG) is the most important parameter to evaluate the hepatic reserve function for liver resection. To study the relationship between ICG concentration and bilirubin concentration or GPT activity in plasma, we determined these parameters before and after the ligation of bile duct. we ligated the bile duct of rats to induce hyperbilirubinemia and high GPT activity. Before and after the ligation (one day. three days. or fourteen days). we sampled 0.5 ml blood from portal vein to determine the concentration of bilirubin and GPT activity. After removing the ligation. we injected indocyanine green (0.5 mg/kg, 0.5 mg/ml) for 30 seconds through portal vein and sampled 0.5 ml of blood from the abdominal vein to determine ICG concentration after 15 minutes. From these data, we calculated the correlation coefficient. We calculated statistical significance of these parameters of different days after the ligation and the significance between two correlation coefficients. We confirmed the linearity too. All of these parameters were significantly higher than those before ligation(p<0.05). However GPT activity showed peaks after one day, while the concentration of bilirubin and ICG showed peaks after 3 days. The correlation coefficient was 0.884 between the concentration of ICG and bilirubin, but 0.721 between the concentration of ICG and GPT activity. These correlation showed significant linearity with p<0.001 and significant difference with p<0.05. These results suggest that ICG clearance can be negatively influenced by bilirubin concentration more than by GPT activity in the plasma. Therefore, care should be taken in determining the hepatic reserve function by ICG clearance rate for patients with hyperbilirubinemia.
간외담관 폐쇄에서의 초음파소견 : 담관벽 경계소실의 중요성 Significance of Decreased Echotexture of Bile Duct Wall-Interface
신현준,손은주,이창희,최영칠,전혜정,박정희,이태의 건국대학교 의과학연구소 2002 건국의과학학술지 Vol.12 No.-
Ultrasound is very useful in evaluation of obstructive jaundice. We retrospectively evaluated the useful findings of ultrasonography in differentiating benign extrahepatic duct obstruction from malignant diseases. Among the 36 patients, 25 patients were benign extrahepatic obstruction and 11 patients were malignant obstruction. The shapes of extrahepatic dilatation were classified into fustiform, meniscus, and abrupt cut off by bowel gas. The diameter, length, and bile duct wall-interface were compared between benign and malignant groups and serum bilirubin and alkaline phosphatase were also compared between two groups retrospectively. The results were as follows. The most common form of extrahepatic dilatation was meniscus(10 of 26 patients, 38%) in benign obstruction, and fusiform(8 of 11 patients, 73%) in malignant obstruction. No significant difference was noted in diameter, length, serum bilirubin, and alkaline phosphatase between benign and malignant groups. Only one case showed decreased bile duct wall-interface in benign obstruction, but loss or decrease of bile duct wall-interface were 8 patients in malignant obstruction. The combined findings of fusiform dilatation and loss of bile duct wall-interface in ultrasonography will be helpful in differential diagnosis of malignant extrahepatic bile obstruction from benign conditions.
Lee, Beom Seok,Lee, Yang Ui,Kim, Han-Sang,Kim, Tae-Hyeong,Park, Jiwoon,Lee, Jeong-Gun,Kim, Jintae,Kim, Hanshin,Lee, Wee Gyo,Cho, Yoon-Kyoung Royal Society of Chemistry 2011 Lab on a chip Vol.11 No.1
<P>We report a fully integrated device that can perform both multiple biochemical analysis and sandwich type immunoassay simultaneously on a disc. The whole blood is applied directly to the disposable “lab-on-a-disc” containing different kinds of freeze-dried reagents for the blood chemistry analysis as well as reagents required for the immunoassay. The concentrations of different kinds of analytes are reported within 22 min by simply inserting a disc to a portable device. Using the innovative laser irradiated ferrowax microvalves together with the centrifugal microfluidics, the total process of plasma separation, metering, mixing, incubation, washing, and detection is fully automated. The analyzer is equipped with an optical detection module to measure absorbances at 10 different wavelengths to accommodate the various kinds of reaction protocols. Compared to the conventional blood analysis done in clinical laboratories, it is advantageous for point-of-care applications because it requires a smaller amount of blood (350 μL <I>vs.</I> 3 mL), takes less time (22 min <I>vs.</I> several days), does not require specially trained operators or expensive instruments to run biochemical analysis and immunoassay separately.</P> <P>Graphic Abstract</P><P>We report a fully integrated lab-on-a-disc system for simultaneous analysis of clinical chemistry and enzyme-linked immuno-sorbent assay (ELISA) from whole blood. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c0lc00205d'> </P>
Lee Seung Jae,Lee Ji-Eun,Lee Chang-Jin,Jeong Ui-Hyun,이우국,Kwon Hyo-Jun,Kim Min-Won,Shim Tae-Hun,Park Jea-Gun 한국물리학회 2022 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.81 No.10
I–III–VI-based quantum dots (QDs) are promising eco-friendly light-emitting materials for next-generation displays. Thus far, I–III–VI-based QDs (i.e., AgIn1-xGaxS2) are still insufcient as light-emitting materials for display felds because of their deteriorated optical properties caused by lattice mismatch between the core/shell materials. We designed a novel passivation process using a shell material (i.e., ZnGa2S4) with crystalline structure identical to that of AgGaS2-xSex core QDs (tetragonal). Green and red light-emitting AgGaS2/ZnGa2S4 core/shell QDs demonstrated superior optical properties owing to the minimum lattice mismatch between the AgGaS2-xSe2 core and ZnGa2S4 shell materials. In particular, a higher quantum yield (QY) and narrow full-width at half-maximum (FWHM) for the green and red light-emitting QDs were achieved, i.e., QYs of 69% and 64% and FWHMs of 26 and 28 nm, respectively. In addition, this remarkable enhancement of optical properties resulted in an increase of~94.4% in the color-space agreement with ITU-R recommendation BT.2020. This means that AgGaS2-xSex-based core/shell QDs have the potential to be used as eco-friendly QDs for light-emitting materials in next-generation displays.
Lee, Seoghyun,Ro, Hyunju,In, Hyun Ju,Choi, Ji-Hee,Kim, Mun-Ock,Lee, Jinhyuk,Hong, Sung-Tae,Lee, Su Ui Elsevier 2018 Cytokine Vol.108 No.-
<P><B>Abstract</B></P> <P>Fisetin (3,7,3′,4′-tetrahydroxyflavone), a natural flavonoid, is a therapeutic agent for respiratory inflammatory diseases such as chronic obstructive pulmonary disease (COPD). However, detailed molecular mechanisms regarding the target protein of fisetin remain unknown.</P> <P>Fisetin significantly reduces tumour necrosis factor alpha (TNF-α)-induced interleukin (IL)-8 levels by inhibiting both nuclear factor kappa B (NF-κB) transcriptional activity and the phosphorylation of its upstream effectors. We show that fisetin prevents interactions between protein kinase C (PKC)δ and TNF receptor-associated factor 2 (TRAF2), thereby inhibiting the inhibitor of kappa B kinase (IKK)/NF-κB downstream signalling cascade. Furthermore, we found that fisetin directly binds to PKCδ <I>in vitro</I>. Our findings provide evidence that fisetin inhibits the TNF-α-activated IKK/NF-κB cascade by targeting PKCδ, thereby mediating inflammatory diseases such as COPD.</P> <P>These data suggest that fisetin is a good therapeutic drug for the treatment of inflammatory lung diseases, such as COPD, by inhibiting the TNF-α/NF-κB signalling pathway.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Fisetin inhibits TNF-α-increased <I>IL-8</I> gene expression by blocking NF-κB activity. </LI> <LI> Fisetin inhibits TNF-α-mediated interactions between PKCδ and TRAF2. </LI> <LI> Fisetin inhibits PKCδ activity. </LI> </UL> </P>