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Cisplatin과 Tobramycin이 白鼠 Corti器에 미치는 영향에 關한 電子 顯微鏡的 硏究 : Ultrastructural Study
김동환,신태균,김무강,김홍선,김원식 충남대학교 의과대학 지역사회의학연구소 1989 충남의대잡지 Vol.16 No.1
In order to study the morphological changes of Corti’s organ in the rat treated with cisplatin and tobramycin, thirty-three rats, weighing between 200∼250g, were used, and divided into 4 groups, i.e., 3 rats were used for control, and 30 rats were used for 3 experimental groups. Each experimental group was divided into cisplatin-treated, tobramycin-treated, and both cisplatin and tobramycin treated group with 10 rats. Rats were injected with a single dose of 7.7㎎/㎏ of cisplatin intraperitoneally and 50㎎/㎏/day of tobramycin for 2 days intramuscularly, respectively or both. Treated rats were sacrificed on the 3rd and 5th day after the first injection. Results were as follows; 1. Cisplatin-treated group: Outer hair cells of Corti’s organ were degenerated with the formation of vacuoles and appearance of lysosomes, however, inner hair cells showed mild vacuolization. 2. Tobramycin-treated group: NO pathological changes were found in Corti’s organ. 3. Combined cisplatin and tobramycin treated group: Outer and inner hair cells showed vacuolization, appearance of lysosomes, myelin figures and multivesicular body. There were also multivesicular body in the inner phalangeal cell and myelin figure in the Reissner’s membrance. 4. Degeneration of Corti’s organ in the combined treated group was more sever than those of the single cisplatin-treated or tobramycin-treated group. 5. NO pathological differences of Corti’s organ in duration of postinjection were manifested in any groups. It can be concluded that cisplatin induces toxicity to inner ear and cisplatin enhance toxicity more in continued treated with tobramycin.
換氣窓이 설치된 中庭形 아트리움의 여름철 熱環境에 관한 測定硏究
김영철,신기식,박상동,최무혁 대한건축학회 2004 대한건축학회논문집 Vol.20 No.6
The atrium in a building is a popular design skill due to its aesthetic, open appearance. It is relatively inexpensive to build and maintain atrium, and also we can expect energy saving effect. But its indoor space is thermally different from typical space because of its tall and large shape with top light. The upper part of atrium has the thermal problem of overheating during summer season. As one of the measures to solve this problem, the ventilation windows near the top light can be used. In this study, the vertical temperatures in the atrium were measured and analysed to understand the thermal environment in the atrium and the effect of ventilation window to reduce the overheating at the upper part of atrium. The ventilation windows were proved to have the effect to lower the temperature of the upper part of atrium as 3.8℃ at the condition of outdoor air temperature of 28℃.
김태윤,백무준,김성용,신응진,박내경,이문수,김창호,송옥평 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1
Locally recurrent rectal cancer is a difficult clinical problem. Local recurrence following treatment for rectal cancer is a major cause of morbidity and mortality. The reported range of local recurrence rates following surgical treatment for rectal cancer has varied from 4% to 50%. We retrospectively reviewed the charts of 142 rectal cancer patients from January 1991 to December 1999. Analysis of patients factors included age, gender, type of surgery, and adjuvant therapy. Tumors were assessed for level, stage, and grade. Local recurrence and distant metastases were also documented. Variables influencing local recurrence in this group were identified and disease-free survival is determined. Of the 142 patients(74 males, 68 females; mean age 62.6 years), 137 consecutive patients operated on for rectal cancer and followed up to December 2000 (range 23-118months) were analyzed. Local recurrence rate was 18.3%. Age and sex of patients, type of surgery, location of tumor in the rectum, size, morphology and grading of the tumor were all unrelated to the event under investigation. At Cox regression, the Dukes stage and the postoperative radiotherapy were the only independent prognostic factors for local recurrence, and Dukes stage (Hazard ratio=2.89, p<0.001) and local recurrence (Hazard ratio=3.31, p<0.01) were the only independent factors associated with improved survival.
金武剛,趙聲煥,申台均 충남대학교 의과대학 지역사회의학연구소 1984 충남의대잡지 Vol.11 No.2
The number and distribution of retinal ganglion cells in the Korean native goats was studied with whole mount preparations stained with methylene blue and thionin. The mean area of 5 retinae is 918 mm² and the mean number of total ganglion cells was 1, 602, 000. So the mean number of ganglion cells per mm² was 1,745. The density distribution of the retinal ganglion cells showed that visual streak was located about 2mm dorsal to the optic disc, and area centralis (7,700 cells/mm') was located about 10mm temporally and 2mm dorsal to the optic disc. There was drop in density of retinal ganglion cells about the circumference of the visual streak in dorsal and ventral direction. The functional significance of the findings was also discussed.