果采類 殘留性 農藥의 突然變異 誘發性

오명철,오창경,김성홍,고용구,김수현 濟州大學校工科大學産業技術硏究所 1995 尖端技術硏究所論文集 Vol.6 No.-

Salmonella typhimurium TA 균주를 이용하여 과채류 재배에 많이 사용되는 12종의 잔류성 농약에 대한 돌연변이 유발성을 검정하였다. 본 연구에 사용된 12종의 농약 중 Tedion, Monopho, Danoton, Ometon 및 Captan에 대한 돌연변이 유발성은 강하였고, Thalonil, Prosing, EPN, Phentoate, Dicopol 및 Captan에 대한 돌연변이 유발성은 중간 정도였으나, Dicopol은 돌연변이 유발성이 없었다. TA98에서, Monopho와 Danoton은 강한 돌연변이 유발성을 나타내었고, Thalonil, Prosing, EPN, Phentoate, Parathion 및 Sappiran은 중간정도의 돌연변이 유발성, Danoton은 약한 돌연변이 유발성을 나타낸 반면, Dicopol과 Sappiran은 돌연변이 유발성을 나타내지 않았다. 한편, TA100에서는 Tedion, Danoton, Ometon 및 Captan이 강한 돌연변이 유발성을, Thalonil과 Monopho는 중간 정도의 돌연변이 유발성, Prosing, Phentoate, Parathion 및 Sappiran은 약한 돌연변이 유발성을 보인 반면, EPN과 Dicopol은 돌연변이 유발성이 없었다. 따라서, EPN은 구조이동성 돌연변이를, Sappiran은 염기치환성 돌연변이를, 그리고 이들과 Dicopol을 제외한 나머지 9종의 농약은 구조이동성 및 염기치환성 돌연변이를 일으키는 돌연변이원임을 확인하였다. Twelve residual pesticides which applied on the fruits and vegetables cultivation were tested for mutagenic activity using Salmonella typhimurium TA strain. Mutagenic activities against Tedion, Monopho, Danoton, Ometon and Captan of twelve pesticides tested were strong, Thalonil, Prosing, EPN, Phentoate, Dicopol and Captan were medium, and Dicopol were no. Tedion, Monopho and Danoton showed strong mutagenic activities on TA98, Thalonil, Prosing, EPN, Phentoate, Parathion and Sappiran showed medium, and Danoton showed weak, while Dicopol and Sappiran showed no. At the other hand, Tedion, Danoton, Ometon and Captan showed strong mutagenic activities on TA100, Thalonil and Monopho showed medium and Prosing, Phentoate, Parathion and Sappiran showed weak, while EPN and Dicopol showed no. Therefore, EPN identified mutagen which induced only frameshift mutation, Sappiran was only base-substitution, and nine except these and Dicopol of twelve pesticides tested were mutagens which induced both frameshift and base-substitution mutation.

이산대수문제에 기반한 그룹 비밀키 분배 및 갱신프로토콜

오명옥,김성열,정일용 조선대학교 전자정보통신연구소 2001 電子情報通信硏究所論文誌 Vol.4 No.2

본 논문에서는 ID 보안 기술에 기반을 둔 디지털서명, 키분배 기법을 이용하여 그룹 비밀키의 분배와 갱신을 위한 효율적인 프로토콜을 제안한다. 제안된 프로토콜의 안전성은 이산대수 어려움에 근거하고 있으며 단말기의 저장능력과 처리의 능력이 적을 경우도 적절하게 운영될 수 있고, 그룹 내에서 제외하고자하는 통화자가 동시에 여러 명일 경우에도 적용할 수 있다. 또한 통화자의 변동 없이 그룹 비밀키를 변경하고자 하는 경우에도 용이하게 키를 갱신할 수 있도록 설계되었다

성장호르몬과 프로락틴을 분비하는 뇌하수체 선종이 동반된 Albright증후군 1예

오효정,김용성,신진호,김하영,박병현,조정구 圓光大學校 醫科學硏究所 2005 圓光醫科學 Vol.20 No.1

교육대학원에 있어서 초등 과학교육 영역의 중요성과 그 운영방안

오진태,옥치율,한영욱,이형철,김용권,임채성 釜山敎育大學校 1994 부산교육대학 논문집 Vol.30 No.1

The future society is expected to be rapidly change in all areas, that is, the length of change time is becoming much smaller than that of generation time. It is very important to prepare the citizens who possess scientific literacy which actively cope with the rapid changes and specialization of society. The sources of rapid changes may be due to the developments in science and technology. Therefore, the importance of science education will be increasingly high. Scientific literacy should be improved basically and systematically from the early stages of formal education. Teachers who are responsible to educate children should be able to research in the areas of science education as well as science itself, and to have capacity to transmit them to the classroom. To do this, the graduate course and the science education within the system beyond the level of college education are essential parts of teacher education. In the graduate course, it is important that science itself and pedagogy of science should be balanced.

모 제약회사 근로자들의 직업성 천식 유병률과 약제 분말 노출수준

오성수,최용휴,김은아,이영목,장재길,유장진,박승현,김태균,정수영,김규상,강성규 大韓産業醫學會 2006 대한직업환경의학회지 Vol.18 No.2

목적: 제약회사에서 직업상 천식의 유병 규모를 파악하고 작업공정에 대한 작업환경 측정을 통해 제약회사의 약제 분말에 대한 노출수준을 평가하고자 하였다. 방법: 제약회사에서 약제 분말에 노출되는 근로자를 대상으로 천식을 선별하기 위하여 설문조사 및 진찰, 혈액검사, 폐기능 검사 그리고 피부단자시험을 실시하였고, 각 부서별 공정에 따라서 총분진과 항생제 또는 효소제 분말에 대한 작업환경 측정을 실시하였다. 직업상 천식이 의심되는 근로자에 대하여 기관지과민성에 대한 검사(메타콜린을 이용한 비특이 기관지유발시험)와 약제 분말 기관지유발시험을 실시하여 확진하였다. 결과: 설문조사 및 진찰에서 작업 관련 천식 증상이 있는 근로자는 11명(34.4%)이었고, 약제 분말을 이용한 피부단자시험에서 1+ 이상 반응을 보인 근로자 10명(31.2%)이었다. 비특이 기관지유발시험 결과 8명(25.0%)이 양성(PC20 ≤16 mg/ml)이었다. 약제 분말 기관지유발시험을 통해 직업상 천식으로 확진된 근로자는 5명(15.6%)이었다. 작업환경 측정에서 원료를 충진하거나 투입하는 작업 그리고 정립작업에서 약제 분말에 대한 노출이 많았다. 결론: 제약회사에서 직업상 천식은 주로 제조공정 중 약제 분말에 노출된 근로자에서 발생하여, 증상 및 직업성 천식의 유병률이 높았다. 따라서 원료를 충진 또는 투입하는 작업과 정립작업 등 제조과적에서 약제 분말 노출을 줄이기 위한 세심한 주의가 필요하여, 약제 분말을 취급하는 근로자에 대해서는 천식 증상 조사뿐 아니라 정기적으로 피부단자시험, 비특이 기관지유발시험 등을 실시하여야 할 것이다. Objectives: After the investigation of one worker with occupational asthma, we surveyed the preva- lence of occupational asthma and the exposure level of pharmaceutical dust of 32 workers in a pharmaceutical company. Methods: Thirty-two of the 90 employees participated in the survey which consisted of questionnaire, blood sampling, spirometry and skin prick tests with 8 common allergens as well as 9 antibiotics and 2 enzymes. Various indices of the working environment were also measured. Subjects who had a symptom suggestive of work-related asthma or positive skin prick test were further investigated by PC20 methacholine. Nine subjects who had a PC20 result of 16 mg/ml or less (n=7) or had work-related symptoms and positive skin prick test (n=2) were referred to undergo a specific bronchial provocation test to phar- maceutical dust in an academic allergic disease center. Results: Eleven of 32 workers (34.4%) had a work-related symptom suggestive of occupational asthma. Ten (31.2%) showed positive skin prick test. 8 (25.0%) had a PC20 result of 16 mg/ml or less (indicative of significant bronchial hyperresponsiveness), and 5 (15.6%) had a positive result on the specific bronchial provocation test. Exposure levels of stuffing, input of raw materials and screening process were relatively high. Conclusions: This survey showed that pharmaceutical workers have an increased risk of occupational asthma. Although pharmaceutical factories maintain a relatively good working environment, careful control of respiratory tract exposures, especially during stuffing, input or raw materials and screening process, is important to prevent occupational asthma. Pharmaceutical workers need to undergo regular skin prick and methacholine bronchial provocation tests, as well as asthmatic symptom survey, to ensure the early detection and prevention of occupational asthma.

하악골 골절에 대한 임상통계학적 연구

이성훈,김기영,조규승,소광섭,박홍주,조요기,오희균,유선열 大韓顎顔面成形再建外科學會 1998 Maxillofacial Plastic Reconstructive Surgery Vol.20 No.1

치아미백제의 미백효과에 관한 연구

이용근,이흥수,이성재,방기숙,오상엽 원광대학교 생체재료·매식연구소 1996 원광생체재료·매식 Vol.5 No.2

Human teeth vary widely in color. Practitioner and patients are concerned with preventing and correcting discolored or dark teeth to achieve and maintain stain-free, white teeth. Tooth brushing cannot after tooth color but it can remove adherent films and stains. Esthetics of natural dentition can be improved by bleaching and this process can be applied to intrinsically and extrinsically stained teeth. The need for a brighter, more attractive smile has made rapid growth in the marker for tooth whiteners. There is no doubt these products work as whiteners, at least on mild to moderate stains, but the safety of these products are unclear. In this experiment, the effect of tooth whitener application on the color of extracted human enamel was measured. RMS, RMT and NWT were used as tooth whiteners, and tooth paste(ETQ) and hydrogen peroxide solution(HPO) were used as controls. 35 caries-free extracted human molars were embedded and polished with the exposed enamel diameter of 4 mm. The tooth whiteners and control agents were according applied to the manufacturers' instructions of clinically simulated procedures for eight weeks, and measurements were repeated every two weeks. CLELAB color difference(ΔE^*) was measured using Differential Colorimeter(Model TC-6FX, Denshoku Co., Japan). The results were are follows ; 1. After application of tooth whiteners and controls for eight weeks, the color change of all groups were not significantly different from each other (p>0.01). But after application of agents for 2 weeks and four weeks, the color difference of NWT applied group and HPO applied group were significantly higher than those of others(p<0.01). 2. The application of tooth paste and paste type tooth whitener made gradual color change, but hydrogen peroxide gel type whitener and hydrogen peroxide solution made rapid color change during initial application period.

알쯔하이머병의 단일 광전자 방출 뇌전산화 촬영에서 전형적인 유형과 관계를 보이는 요인

곽용태,한일우,방오영,박찬희,구민성 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.3

연구목적 : 최근 기능적 영상진단의 발전은 치매 환자의 진단에 많은 도움을 주고 있으며 이중 단일광자방출전산화단층촬영(SPECT ; single photon emission computed tomography)은 알쯔하이머 병의 특징적인 양측 두정측두엽의 혈류 감소를 보이므로 알쯔하이머 병의 진단에 많이 사용되어지고 있다. 본 연구는 알쯔하이머병의 SPECT 소견을 분석함으로써 알쯔하이머병의 진단에 있어서 SPECT 검사의 유용성 및 알쯔하이머병에서 전형적인 유형에 영향을 미치는 요인이 무엇인지를 규명한다. 방 법 : NINCDS-ADRDA진단 기준에 의거한 probable AD환자 26명을 대상으로 SPECT 검사를 시행하였으며 이중 14명은 전형적인 SPECT 소견을 보였으며 나머지 12명은 비전형적인 SPECT소견을 보였다. 치매의 정도는 Mini-Mental State Examination(MMSE)에 의하여 결정하였고 SPECT소견은 2명의 핵의학과 전문의의 합의에 의하여 정성적으로 판독하여 분석하였다. SPECT의 전형적인 소견과 연관이 있는 요소들을 확인하기 위하여 판별함수분석을 시행하였다. 결 과 : 알쯔하이머 환자에서 SPECT의 민감도는 53.8%이며, 조기 발병군의 경우에는 민감도가 76.9%이었다. 알쯔하이머의 전형적인 형태인 양측성 두정측두엽에 혈류량이 감소한 경우는 조기 발병군에서 유의하게 관찰되었으며, 이외에 이환기간, 교육정도, 성,병의 진행정도, 아포지단백E등은 유의한 연관성이 없었다. 결 론 : SPECT검사의 민감도는 높지 않으나 이를 조기 발병군에서만 적용하였을 경우 그 임상적 유용성이 높을 것으로 생각되며 조기 발병군에서 SPECT검사의 민감도가 만기 발병군에 비하여 유의하게 높은 것으로 보아 알쯔하이머병이 단일하지 않고 이질적인 집단의 증후군일 가능성이 높을 것으로 생각된다. 즉 SPECT검사가 알쯔하이머병의 진단뿐 아니라 병태생리적 기전의 이해에 도움이 될 것으로 생각되며 앞으로 정량화와 많은 중례를 확보하여 이에 대하여 좀더 규명할 필요가 있을 것으로 생각된다. Objectives : During the past few years, the development of functional brain imaging techniques has allowed to describe brain impairment in cognitive disorders. Among them, based on the observation of bilateral parietotemporal hypoperfusion in Alzheimer's disease(AD), single photon emission computed tomography(SPECT) is advocated by some as powerful diagnostic tool in the evaluation of demented patients. The aim of this study is to investigate the usefulness of SPECT in the diagnosis of AD and to clarify the associated factors of parietotemporal hypoperfusion, the typical SPECT pattern of Alzheimer's disease(AD). Methods : We reviewed the SPECT scans of 26 patients fulfilling NINCDS-ADRDA criteria for probable AD, 14 with typical pattern of SPECT and 12 with atypical pattern of SPECT. Dementia severity was assessed by the Mini-Mental State Examination. Inage interpretation was done visually by the consensus opinion of 2 experienced nuclear medicine physicians who were blind to clinical information. To estimate the association of typical pattern of SPECT with other variables of interest, discriminant function analysis was done. Results : Though the overall diagnostic sensitivity of SPECT in AD was 53.8%, it was 76.9%, in early-onset AD patients. Typical pattern of SPECT was more frequent in the patients with early onset on the symptoms. Duration of symptoms, duration of education, se, severity of disease was not associated with this SPECT pattern. Conclusion : These findings may be useful in the clinical setting and point to heterogeneity of AD according to age at onset.

운동수행능력에 따른 경기 분석

김승일,송진석,강유원,오유성,김용무 경희대학교 사회체육연구소 1996 體育科學論叢 Vol.- No.9

The purpose of this study was to examine the nature and characteristics of competitive aspect in sporting experience through phenomenological approach. The conclusion was followings: 1. The classified characteristics and result of tough and individual game are appeared in double with classification of meaning category in the physical contacting games. Physical contacting games were mostly appreared toke tough games. Thus, human relationship would be meaning ful in the physical contacting games. The meaning ful category (which is experienced in the competitive aspect of physical contacting game) reflects the characteristics of meaning category experienced in group game. 2. The results of the study indicated that to be time and body affect in women sport such as basketball, bowling, and taekwondo while, body and space influence men sport such as football, golf, boxing, judo and taekwondo and so on.. 3. I could find that the elements of meaning category of participants in this study through experience of competition of non-physical contacting games such as golf, shooting, bowling, skiing etc reflect the elements of meaning category in individual games. This would be caused by that probably the sporting events that doesn't need physical contact are mostly individual games. The common meaning category of participants of non-physical contacting games in this study show time and body. It provides and opposite view about common opinion that non-physical contacting games are static and not active by its attribute of the games. The vivid time and body that are meaning categoty experienced with non-contacting games show that they are the field of vivid meaning experience on the assumption of live movement which th competitive aspect is alive.

과채류 잔류성 농약의 돌연변이 유발성

고용구,김성홍,오창경,오명철,김수현 濟州大學校 産業技術硏究所 1995 산업기술연구소논문집 Vol.6 No.-

Twelve residual pesticides which applied on the fruits and vegetables cultivation were tested for mutagenic activity using Salmonella typhimurium TA strain. Mutagenic activities against Tedion, Monopho, Danoton, Ometon and Captan of twelve pesticides tested were strong, Thalonil, Prosing, EPN, Phentoate, Dicopol and Captan were medium, and Dicopol were no. Tedion, hlonopho and Danoton showed strong mutagenic activities on TA98, Thalonil, Prosing, EPN, Phentoate, Parathion and Sappiran showed medium, and Danoton showed weak, while Dicopol and Sappiran showed no. At the other hand, Tedion, Danoton, Ometon and Captan showed storng mutagenic acitivities on TA100, Thalonil and Monopho showed medium and Prosing, Phentoate, Parathion and Sappiran showed weak, while EPN and Dicopol showed no. Therefore, EPN identified mutagen which induced only frameshift mutation, Sappiran was only base-substitution, and nine except these and Dicopol of twelve pesticides tested were mutagens which induced both frameshift and base-substitution mutation.