사례보고 : 하수오 복용 후 발생한 재발성 독성 간염 1예

배상훈 ( Sang Hoon Bae ),김동현 ( Dong Hyun Kim ),배영석 ( Young Seok Bae ),이광재 ( Kwang Jae Lee ),김동완 ( Dong Wan Kim ),윤정빈 ( Jeoung Bin Yoon ),홍준호 ( Joon Ho Hong ),김상현 ( Sang Hyun Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.2

Toxic hepatitis has been reported as a major cause of acute hepatitis, but its potential induction by herbal remedies and/or health foods is usually neglected. We experienced a case of toxic hepatitis associated with Polygoni multiflori, a Chinese herb commonly known as Ho-Shou-Wu. A 54-year-old woman consumed Ho-Shou-Wu for 1 month, after which she experienced fatigue and overall weakness. A diagnosis of toxic hepatitis was made based on her clinical history, the findings for viral markers and other laboratory data, and ultrasonography. Her condition improved considerably after she stopped taking Ho-Shou-Wu. However, she resumed taking Ho-Shou-Wu immediately after discharge from hospital, which aggravated her symptoms and liver function. She was immediately readmitted and stopped taking Ho-Shou-Wu. Her relapse into hepatitis immediate after resuming consumption of the herb is strongly indicative of the validity of Koch`s postulate in this case.

요통 환자의 기립위 및 좌,우 외측굴곡시 방사선 사진을 통한 요추 회전변위 분석

허동석 ( Dong Seok Heo ),박석우 ( Seok Woo-park ),박영회 ( Young Hoi Park ),금동호 ( Dong Ho Keum ) 한방재활의학과학회 2003 한방재활의학과학회지 Vol.13 No.2

Objectives : Rotation on vertebra body is common reason causing low back pain and leg radiating pain patients. The present study investigated analysis of the radiological findings on lumbar vertebra rotation between erect position and erect both lateral bending position lumbar AP views in low back pain patients. Method : The study population consisted of 70 patients(outpatients and inpatients clinic of the Dept. of Oriental Rehabilitation Medicine, Dong-Guk Oriental Medical Hospital in Bundang) who were evaluated with X-ray findings of erect position and erect both lateral bending position lumbar AP views. First, patients were measured erect position lumbar AP views by Nash-Moe`s degree. Second, patients were measured erect both lateral bending position lumbar AP views by intervertebral disc space at convexity region and rotation on lumbar vertebral body. They divided into four groups by type of Grice and Cassidy`s classification. Results : 1. The distribution of sex in the low back pain with leg radiating pain was male 30(42.86%) cases, female 40(57.14%) cases. According to age, 30-40s 23(32.9%) cases, 40-50s 15(21.4%) cases, 20-30s 13(18.6%) cases, 50-60s 9(12.9%) cases, 60-70s 5(7.1%) cases, 70-80s 3(4.3%) cases, each 10-20s and 80-90s one case (1.4%). 2. According to Nash-Moe`s degree by erect position lumbar AP view, the grade 0 was male 8(11.4%) cases, female 10(14.3%) cases, the grade Ⅰ was male 17(24.3%) cases, female 22(31.4%) cases, the grade Ⅱ was male 5(7.1%) cases, female 8(11.4%) cases. 3. According to symptoms, first, patients with low back pain were male 22(31.4%) cases, female 20(28.6%) cases. second, patients with leg radiating pain were male 8(11.4%) cases, female 20(28.6%) cases. 4. According to type of Grice and Cassidy`s classification by erect both lateral bending position lumbar AP views, the type Ⅰ was normal group 7(10.0%) cases, the type Ⅲ and Ⅳ were abnormal group each 15(21.4%) cases, 48(68.6%) cases. 5. According to abnormal group in Nash-Moe`s degree by erect position lumbar AP view, the grade Ⅰ was 39(55.7%) cases and then abnormal type Ⅲ, Ⅳ of Grice and Cassidy`s classification were 5(7.1%) cases, 33(47.1%) cases, the grade Ⅱ was 13(18.6%) cases and then abnormal type Ⅲ, Ⅳ of Grice and Cassidy`s classification were 1(1.4%) case, 12(7.1%) cases. So the relationship between rotation of vertebra by erect position lumbar AP view and type of Grice and Cassidy`s classification by erect both lateral bending position lumbar AP views had significant correction(p<0.05). 3 6. According to analysis of symptoms and X-ray findings by erect both lateral bending position at convexity region, patients with leg radiating pain were 28 cases. In the total of 28 cases, 25 cases had shown rotation of vertebra and intervertebra disc space narrowed at convexity region, while 3 cases didn`t have shown. 7. According to abnormal rotation of vertebral body on erect position, the number of group L4 was 48(32.7%) cases the most, group L3 was 43(29.3%) cases, the next group L2 was 30(20.4%) cases. Group L4, L3, L2 had significantly connection with fixation group on erect both lateral bending position(p<0.05). Conclusions : We concluded that the abnormal rotation of lumbar vertebral body had connection with the low back pain and leg radiating pain patients. So we must regard functional X-ray such as erect both lateral bending position lumbar AP views to early find cause.

자기 공명 영상을 이용한 뇌척수액 순환의 역학 분석

김동석,치중언,윤펑호,김동익,박승우 대한신경외과학회 1998 Journal of Korean neurosurgical society Vol.27 No.5

정상인 및 신기능장애환자에서 Carumonam(AMA-1080)의 약동학

임동석,이경훈,엄재호,한진석,김성권,장인진,신상구 大韓臨床藥理學會 1994 臨床藥理學會誌 Vol.2 No.1

제지폐수처리용 생물고분자응집제를 생산하는 Bacillus sp. K-111의 배양특성조사

권기석,손용호,최선택,정석관,송숙희,김동걸 7개 국립대학교 환경연구 논문집 공동발행 위원회 2002 환경연구논문집 Vol.2 No.1

Flocculant-producing microorganisms were screened from obtained strains in the laboratory using a pulp-wastewater treatment as the flocculating agent. K-111 strain that had high flocculating activity among them was selected and identified as Bacillus sp. K-111 16s rDNA sequencing. The favorable medium for the production of flocculant was glucose 1.5%, NH_4NO_3 0.2%, tryptone 0.01%, K_2HPO_4 0.08%, KH_2PO_4 0.06%, CaCO_3 0.03%, MgSO_4·7H_2O 0.005%, MnSO_4 0.005% in 1 liter of D.W. at initial pH 7.0. The optimum culture temperature and pH were 30℃ and pH 7.0, respectively. the flocculating activity was observed most highly after 36 to 48 hr of cultivation at the optimum conditions. the flocculating activity of produced biopolymer on optimum conditions was about 2.5-fold higher than that of screening medium.

농가용 저온저장고의 제어변수에 따른 성능평가

김석우,김성만,현명택,최동호,고정삼,박영하 제주대학교 공과대학 첨단기술연구소 2001 尖端技術硏究所論文集 Vol.12 No.2

The low temperature storage method has been used to increase the value of agricultural products by reducing quality deterioration and controlling respiration rate. The respiration rate of agricultural products depends on several factors such as temperature, moisture, gas composition and microbe inside the storage room. Among that temperature is the most important factor, which affects respiration rate and causes severe damage. The results obtained from these experiments are that electric consumption is decreased as setting temperature is decreasing and temperature deviation is increasing. In the ventilation experiment, the case ventilated four times a day(every six hours a day) with ten minutes operation each time, was inspected require as much electric consumption as non-ventilation case.

Correction: Direct characterization of graphene doping state by <i>in situ</i> photoemission spectroscopy with Ar gas cluster ion beam sputtering

Yun, Dong-Jin,Kim, Seyun,Jung, Changhoon,Lee, Chang-Seok,Sohn, Hiesang,Won, Jung Yeon,Kim, Yong Su,Chung, JaeGwan,Heo, Sung,Kim, Seong Heon,Seol, Minsu,Shin, Weon Ho The Royal Society of Chemistry 2018 Physical chemistry chemical physics Vol.20 No.4

<P>Correction for ‘Direct characterization of graphene doping state by <I>in situ</I> photoemission spectroscopy with Ar gas cluster ion beam sputtering’ by Dong-Jin Yun <I>et al.</I>, <I>Phys. Chem. Chem. Phys.</I>, 2018, 20, 615-622.</P>

3차원 전산화단층촬영 영상을 이용한 얼굴 연조직 두께 계측

정호걸,김기덕,한승호,신동원,허경석,이제범,박혁,박창서 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To evaluate accuracy and reliability of program to measure facial soft tissue thickness using 3D computed tomographic images by comparing with direct measurement. Materials and Methods : One cadaver was scanned with a Helical CT with 3 mm slice thickness and 3 mm/sec table speed. The acquired data was reconstructed with 1.5 mm reconstruction interval and the images were transferred to a personal computer. The facial soft tissue thickness were measured using a program developed newly in 3D image. For direct measurement, the cadaver was cut with a bone cutter and then a ruler was placed above the cut side, The procedure was followed by taking pictures of the facial soft tissues with a high-resolution digital camera. Then the measurements were done in the photographic images and repeated for ten times. A repeated measure analysis of variance was adopted to compare and analyze the measurements resulting from the two different methods. Comparison according to the areas was analyzed by Mann-Whitney test. Results : There were no statistically significant differences between the direct measurements and those using the 3D images (p>0.05). There were statistical differences in the measurements on 17 points but all the points except 2 points showed a mean difference of 0.5 mm or less. Conclusion : The developed software program to measure the facial soft tissue thickness using 3D images was so accurate that it allows to measure facial soft tissues thickness more easily in forensic science and anthropology. (Korean J Oral Maxillofac Radiol 2006; 36 : 49-54)

제 3형 급성 견봉-쇄골 관절 분리 환자의 수술적 치료 결과

한성호,양보규,이승림,정선욱,이동호,김민석 대한골절학회 2003 대한골절학회지 Vol.16 No.2

목적 : 본 연구를 통하여 Rockwood 제 3형 급성 견봉-쇄골 관절 분리 환자에서 Phemister 술식과 modified Phemister 술식의 치료 결과를 비교하고자 한다. 대상 및 방법 : 1992년 2월부터 2001년 8월까지 제 3형 급성 견봉-쇄골 관절 분리로 수술적 치료를 받고 1년 이상 추시 가능하였던 45명, 45예의 환자를 대상으로 하였다. 평균 연령은 28.1세였으며, 남자가 42명, 여자가 3명이었다. 진단은 이학적 검사와 단순 방사선 부하 촬영법을 이용하였으며, 수상일로부터 수술적 치료까지의 평균 기간은 7.8일이었다. 술장 소견상 오구-쇄골인대 봉합술이 어려운 15예에서는 Phemister 술식을 시행하였고 (Ⅰ군), 인대 봉합이 가능한 30예에서는 modified Phemister 술식을 시행하였다(Ⅱ군). 수술 후 추시 기간은 평균 16.2개월이었고, 결과 판정은 최종 추시 때의 임상 소견과 이학적 검사 및 방사선 촬영을 통해 UCLA shoulder scoring system과 acromio-clavicular separation scoring system을 이용하였다. 결과 : 술후 합병증은 Ⅱ군에만 표재성 감염이 2예, K-강선 이주가 1예에서 발생하였다. 최종 추시상 전예에서 동통, 관절 운동 범위의 제한은 없었고 , Ⅱ군에서만 방사선 촬영상 2예에서 아탈구가 관찰되었다. UCLA shoulder scoring system은 Ⅱ군에서 우수 93.3%, 양호 6.7%였고, acromio-clavicular shoulder scoring system은 Ⅱ군에서 우수 90%, 양호 10%였다. 결론 : 활동적인 연령에서 발생한 제 3형 급성 견봉-쇄골 관절 손상의 환자에서 Phemister 술식만으로도 좋은 결과를 보일 수 있을 것으로 사료된다. Purpose : The purpose of this study is to compare the Phemister technique with the modified Phemister technique for the patients with Rockwood type 3, acromio-clavicular separation. Materials and Methods : The 45 cases of 45 patients received surgical treatment for Rockwood type 3, acute acromio-clavicular separation in our hospital from Feb. 1992 to Aug. 2001 later with the follow-up study were selected as subjects. The average ages were 28.1 years old, male and female were 42, 3 persons, respectively. Physical examination and plain radiography were used for their diagnosis and the intervals between injury and surgical treatment were 7.8 days. In intraoperative finding, we performed Phemister technique in 15 cases according not to be able to repair coraco-clavicular ligament (groupⅠ), modified Phemister technique in 30 cases according to be able to repair that (groupⅡ). The average follow up period was 16.2 months, and the UCLA shoulder scoring system and the acromio-clavicular separation scoring system were used to obtain clinical results. Results : Only in Group Ⅱ, the complication after surgery were associated with superficial infection in two cases and K-wire migration in one case. At last follow up, there were no pain and limitation of range of motion in all cases, and two cases in Group Ⅱ were found to be subluxation in radiography. Clinical results revealed excellent was 93.3%, good was 6.7% in UCLA shoulder scoring system in both groups, and excellent was 90%, good was 10% for group Ⅱ in acromio-clavicular separation scoring system. Conclusion : The results are considered to be food with only Phemister technique in type 3, acute injury occurred in working ages.

이온교환된 ZSM-23 제올라이트 내에서 톨루엔 메탈화반응의 형상선택성

박동호,김태석 인제대학교 1992 仁濟論叢 Vol.8 No.2

이온 교환된 ZSM-23 제올라이트를 이용하여 톨루엔의 메틸화 반응에서의 반응 활성과 파라-선택성(p-선택성)을 실험했다. ZSM-5 제을라이트를 ZSM-23 제올라이트와 비교 실험하였다. 먼저 실험에 사용된 제을라이트 촉배로써 ZSM-23은 1.6Na2O-A1203-59. OSi02-17.9pyrrolidine-584H20, ZSM-5는 2.9Na20-A1203-1. 1H2S04-49.9Si02-4.6TPABr-1790H2O의 초기 조성비로 합성하였다. XRD와 SEM을 이용하여 합성된 ZSM-23과 ZSM-5 제올라이트의 결정 성 과 골격 구조 및 입 자 모양을 확인할 수 있었다. 합성 된 ZSM-23, ZSM-5 제올라이트에 알칼리금속을 수용액상에서 이온 교환시켜 교환된 이온종과 교환된 양에 따른 반응 활성과 선택성의 변화를 조사하였다. 즉, 1M의 NH4NO3, NaCl, CsCI의 부피를 달리하여 이온 교환량을 조절하면서 H-, Na- , Cs-제올라이트를 얻었다. 톨루엔 메틸화 반응이 일어날때 ZSM-23의 경우 HZSH-23이 반응 활성은 가장 높았고, 교환된 Na+량이 증가할수록 반응활성은 낮아지고 p-선택성은 증가되었다. 2SM-23의 경우 아주 적은 양의 Na+이온이 교환되었을 때에도 큰 Na+이온 반경에 의한 m-크실렌과 o-크실렌의 확산 지연 효과 때문에p-선택성을 나타내었다. ZSM-5의 경우 HZSM-5일 때 반응 활성은 HZSM-23 제올라이트보다 높았다. 그러나 NaZSM-23과는 달리 NaZSM-5에서 p-선택성의 증가는 나타나지 않았다. 이러한 결과는 ZSM-5의 세공 크기가 ZSM-23보다 약간 크기 때문이다. ZSH-23에 이온 교환된 경우 세공 구조의 특성에 의해 같은 조건으로 이온 교환시킨 ZSM-5보다 p-선택성이 높음을 확인할 수 있었다.