기관지천식 환자에서 Furosemide, Disodium cromoglycate 및 Heparin 흡입이 고장액 식염수 기관지유발검사에 미치는 영향

강천일,현상훈,남언정,김건우,윤종수,서영익,이종명,김능수 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : 기관지천식 환자에서 고장액 식염수의 흡입은 기도수축을 유발할 수 있으며 이는 운동유발성 천식반응과 밀접한 관계가 있는 것으로 알려져 있다. 저자들은 알레르겐 흡입이나 운동에 의해 유발되는 천식에 예방효과가 있는 것으로 알려진 disodium cromoglycate(DSCG), furosemide 및 heparin 흡입이 4.5% NaCl 기관지유발검사(BPT)에 미치는 영향을 조사하였다. 대상 및 방법 : 4.5% NaCl BPT에서 양성반응을 보이는 기관지천식 환자 13명을 대상으로 하였으며 사용된 약물은 furosemide 40㎎, DSCG 40㎎ 및 heparin 1,000μ/㎏이었다. 먼저baseline 4.5% NaCl BPT를 시행한 다음 이들 약물로 전처치후 다시 4.5% NaCl BPT를 시행하여 약물의 효과를 관찰하였다. 결과 : Furosemide 40㎎, DSCG 40㎎및 heparin 1,000μ/㎏의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였다. Furosemide와 DSCG로 전처치한 군(n=6)에서 이들의 기도수축 방어율은 각각 100.6±6.6%, 91.1±17.2%였으며 furosemide와 heparin으로 전처치한 군(n=7)에서는 각각 58.7±29.2%, 59.0±51.1%로서 각 군에서 이들 약제간의 방어율에는 유의한 차이가 없었다. 결론 : Furosemide(40㎎), DSCG(40㎎) 및 heparin(1000μ/㎏)의 흡입 전처치는 고장액 식염수에 의한 기도수축 반응에 뚜렷한 예방효과를 보였으며, 적어도 이 용량에서 기도수축 예방 정도에는 유의한 차이가 없음을 알 수 있었다. Background: Hypertonic saline (4.5% NaCl) inhalation is known to induce broncho-constriction by affecting mast cell, epithelial cell and vagal afferent pathway in some asthmatics. Disodium cromoglycate (DSCG) is known to have a preventive effect on allergic asthma and exercise induced asthma, and recently it was reported that furosemide and heparin had similar effect. The purpose of this study was to evaluate the effects of furosemide, DSCG and heparin on hypertonic saline provocation test in asthmatics. Methods: Thirteen asthmatics with a positive response to hypertonic saline challenge were enrolled. Hypertonic saline and test drugs were generated by ultrasonic nebulizer. After taking baseline 4.5% NaCl challenge, subjects were rechallenged with 4.5% NaCl after inhalation of furosemide 40㎎, DSCG 40㎎ or heparin 1,000μ/㎏. Results: 1. There was a significant positive relationship between PC_20-methacholine and PTM-4.5% NaCl(r=0.5575, p = 0.024). 2. Furosemide, DSCG and heparin had no direct bronchodilating effects. 3. Premedication of furosemide and DSCG(n=6) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 100.6±6.6% and 91.1±17.2%, respectively. 4. Premedication of furosemide and heparin(n=7) showed significant protective effects on 4.5% NaCl induced broncho-constriction. The average protection rate were 58.7±29.2% and 59.0±51.1%. respectively. Conclusions: Furosemide(40㎎), DSCG(40㎎) and heparin(1.000μ/㎏) had significant protective effects on hypertonic saline induced broncho-constriction in asthmatics, and there were no significant differences in their potency of protection rate.

補陽還五湯과 加味補陽還五湯이 Endotoxin으로 誘發된 白鼠의 血栓症에 미치는 影響

金性勳,全英秀 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 혈전증이란 생체의 혈관 또는 심장내에서 응고된 혈액의 덩어리, 즉 혈전을 만드는 현상을 말하는 것으로, 뇌경색·심장기능장애 및 패혈증 등을 야기할 수도 있으며 관상혈관폐색 또는 복부대동맥혈전에 의하여 갑자기 사망에 이르게 할 수도 있다. 이에 백서에 혈전증 모델을 유발하고 기허혈어증에 응용하는 보양환오탕 및 그 가미방을 투여하여 그 치료효과를 입증하고자 한다. 방법 : Rat에 endotoxin을 주사하여 혈전증을 유발시키면서, 보양환오탕과 가미보양환오탕을 투여하여 혈소판수, FDP 농도, fibrinogen, prothrombin time, fibrinolytic activity, platelet aggregation 등을 측정한다. 결과 : 혈소판수 및 FDP 농도는 치료군에서 유의성있게 증가하였으며, proth-rombin time은 단축되었고 fibrinolytic activity, platelet aggregation에서도 유의성이 인정되었다. 결론 : 보양환오탕 및 가미보양환오탕은 혈전증의 한방치료 및 예방에 응용할 수 있을 것으로 생각된다. This study was performed to prove the clinical effects of Boyangwhanohtang(BYT) and Kami-Boyangwhanohtang(KBT) by way of experimental methods. The fibrolytic activity was studied in vitro several concentrations of BYT & KBT extracts. The intravascular coagulation was induced by injection of endotoxin into the caudal vein of rats. And liquid extracts of Boyangwhanohtang and Kami-Boyangwhanohtang were administered orally to the rats. Then the number of platelets, concentration of fibrinogen, FDP(fibrin-fibrinogen degradation products) and prothrombin time was measured. The results were obtained as follows ; 1. Prothrombin time was significantly shortened in BYT- and KBT-treated groups as compared with the control group. 2. The number of platelets was significantly increased in BYT- and KBT-treated groups in comparison with the control group. 3. Fibrinogen was significantly increased in BYT- and KBT-treated groups as compared with the control group. 4. FDP was significantly decreased in BYT- and KBT-treated groups in compared with the control group. 5. Fibrinolytic activity was significantly recognized in BYT- and KBT-treated groups as compared with the control group. 6. Aggregation was significantly increased in BYT- and KBT-treated groups as compared with the control group. From the above results, it was thought that Boyangwhanotang and Kami-Boyangwhanotang could be applied effectively in the thrombosis.

질의 공간 탐사를 위한 유전자 알고리즘 모델

이재훈,김영천,이성주 조선대학교 전자정보통신연구소 2003 電子情報通信硏究所論文誌 Vol.6 No.1

정보검색은 사용자가 필요로 하는 문서를 문서집합으로부터 가장 적합한 문서를 검색할 수 있어야 한다. 질의어가 문서에 대하여 어느 정도의 유사성을 가지고 존재하느냐를 기준으로 문서가 적합한 문서인지를 순서화 하다 보면 질의어와 비적합한 문서들이 순서화 된 경우가 있다. 본 논문에서는 유전자 알고리즘을 이용하여 전역적인 문서 공간은 탐색하여 사용자의 요구에 가장 적합한 문서를 검색하고, 다양한 모델의 문제를 해결하기 위해서 지식 베이스 연산자를 사용하였다.

두가지 혈류 유발방법에 의한 새로운 심폐소생술(이중 혈류 유발 심폐소생술)장치의 개발

황성오,김현,조준휘,오범진,임종천,최경훈,윤정한,이승환,김영식,이강현,이윤선 大韓應急醫學會 1999 대한응급의학회지 Vol.10 No.2

Background: There have been many efforts to augment blood flow during cardiopulmonary resuscitation. These efforts have focused on maximizing the effect of cardiac pump or thoracic pump alone. However, considering that the heart is the biggest blood reservoir and increase of intrathoracic pressure can generate blood flow, simultaneous exploitation of both mechanisms may have synergistic effect. We hypothesized that simultaneous chest constriction in addition to sternal compression by standard CPR may have additive hemodynamic effects by preventing deformation of the chest and increase of intrathoracic pressure. Methods and results: we built a new mechanical device to perform compression and thoracic constriction simultaneously. The device consists of two main elements. Piston in the center is to depress the sternum. Strap is to constrict the thorax circumferentially. Strap is attached to both sides of the piston. When the piston is pushed down, it depresses the sternum and pulls on the thoracic strap. To determine strap width to produce optimal hemodynamic effect, we measured hemodynamic parameters with variable widths of strap in two dogs after induction of ventricular fibrillation. Result of the experiment showed that 10cm wide strap was determined to be most effective. We also determined optimal depth of compression to produce maximal hemodynamic effect with animal experiments using two dogs. Animal experiments showed that the highest aortic pressure could be generated when the stemum was depressed to 5 cm. Cardiopulmonary resusciation using a new device could generate higher systolic aortic pressure, coronary perfusion pressure and end-tidal carbon dioxide tension in comparison with standard cardiopulmonary resuscitation in a pilot animal study using two dogs. Conclusion: New cardiopulmonary resuscitation method using a mechanical device designed by us could perform sternal compression and simultaneous thoracic constriction, and generate better hemodynamic effects than standard cardiopulmonary resuscitation in pilot animal experiments.

부산 경남지방에 발생한 쭈쭈가무시병 64예의 임상적 고찰

이상훈,전명호,신병철,박기찬,김영효,배성,전광수,김종성 동아대학교의과대학 1992 동아의대학술지 Vol.4 No.1

Transarticualr portal를 이용한 주관절의 관절경술

김성재,박인섭,김주영,정재훈,류상욱,천용민 대한견.주관절학회 2003 大韓肩.주關節學會誌 Vol.6 No.2

AI/CFRP 혼성튜브의 적층각과 단면형상에 따른 축방향 압궤 특성

김선규,이길성,김성훈,차천석,김정호,양인영 朝鮮大學校 機械技術硏究所 2004 機械技術硏究 Vol.7 No.1

알루미늄은 수송기계용 구조부재로 널리 쓰이고 있으며 복합재료가 이러한 수송기계용 구조부재로 쓰일 때 경량화와 많은 에너지 흡수 측면이 기대된다. 알루미늄 튜브는 CFRP(탄소 섬유 강화 복합재료)튜브에 비해 압궤하중은 낮지만 안정적인 소성변형에 의해 압궤되는 반면 CFRP 튜브는 알루미늄 튜브에 비해 압궤하중은 높지만 불안정한 취성파괴에 의해 압궤된다. 따라서 알루미늄과 CFRP의 조합은 안정적이며 뛰어난 에너지흡수를 기대할 수 있다. 본 연구에서는 알루미늄 원형과 사각튜브의 외측을 CFRP로 감싸 Al/CFRP 혼성튜브를 제작하여 축방향 압궤특성에 관하여 연구하였다. 알루미늄 튜브와 CFRP 튜브의 압궤특성을 기초로 하여, Al/CFRP 흔성튜브의 이방성 재료인 CFRP의 적층각과 단면형상의 변화를 주었다. 실험결과, Al/CFRP 흔성튜브는 알루미늄 튜브의 좌굴을 계기로 하여 CFRP 튜브의 불안정한 취성파괴의 단점을 보완하였다. 경량화 측면에서 단위 질량당 흡수에너지는 원형튜브가 사각튜브에 비해 약 45~70% 이상 높았으며 CFRP 적충각이 90˚일 때 가장높았다. Aluminum materials have been widely used in various vehicle structures. If composite materials are applied to vehicle structures, it is expected that not only the weight of the vehicle is decreased but also it absorb large amounts of energy. Aluminum tubes are lower than CFRP (Carbon Fiber Reinforced Plastics) tubes in the collapse load but absorb energy by stable plastic deformation. On the other hand, CFRP tubes are higher than aluminum tubes in the collapse load but absorb energy by unstable brittle failure. The combination of aluminum and composite may result in stable deformation and excellent energy absorption efficiency. The compressive axial collapse tests were performed to investigate collapse characteristics of Al/CFRP compound tubes which are aluminum tubes wrapped with CFRP outside the aluminum circular and square tubes. Based on collapse characteristics of aluminum tubes and CFRP tubes respectively, the axial collapse tests were performed for Al/CFRP compound tubes which have different CFRP orientation angles and cross-sections. Test results showed that Al/CFRP compound tubes supplemented the unstable brittle failure of CFRP tubes due to ductile nature of inner aluminum tubes. In the light-weight aspect, Absorbed energy per unit mass of circular tubes was higher than square tubes'. Absorbed energy per unit mass showed highest when CFRP orientation angle was 90 degrees.

경부도상 피판을 이용한 구강내 결손부의 재건

양동규,신상훈,서종천,이성근,김종렬 大韓顎顔面成形再建外科學會 1995 Maxillofacial Plastic Reconstructive Surgery Vol.17 No.3

Various cutaneous as well as myocutaneous flaps have been designed for the reconstruction of tissue defects caused by the excision of oral cancer. Among these flaps, cervical island skin flap have been introduced by Farr et al and more have developed by Tashiro et al. This flap has many advantages. The flap minimizes donor size by use of cervical operation wound, flap size available is adequate for most oral defects and the procedure is relatively simple and time saving. However, this flap is not applicable in patients where there are large tissue defects and metastasis is suspected. We used this flap for it's rapid simple, and effective, primary closure of oral defects after cancer ablation and we have found this flap very useful for the reconstruction of relatively small oral defects.

부비동 악성 종양의 임상적 분석

백병준,유명상,신재민,김효진,박훈,김장묵,오천환 순천향의학연구소 2003 Journal of Soonchunhyang Medical Science Vol.9 No.2

Background and Objectives : Paranasal sinus cancer is rare when compared with cancers of other sites. Because paranasal sinus is anatomically located adjacent to the orbit and skull base, it is difficult to remove the tumor completely with tumor free margin in advanced paranasal sinus cancer. This report was conducted to investigate clinical characteristics, histologic type and treatment outcome of paranasal sinus cancer. Material and Methods : Twenty-six cases with paranasal sinus cancer diagnosed at the Department of otolaryngology-Head and Neck Surgery, Soonchunhyang Cheonan Hospital from January 1991 to September 2000 were studied by chart review, telephone interview and letters retrospectively. Results : The male to female ratio was 4.2 : 1. Most patients were 6th and 7th decade. The maxillary sinus was the most commonly affected site(61.5%), followed by the ethmoid sinus(34.6%). The most common histologic type of malignancy was squamous cell carcinoma(57.6%), followed by adenocarcinoma(19.2%). Most patients presented with T_(3)/T_(4) or locally advanced disease, N_(0)(91.3%), and M_(0)(100%) Sixtynine pertcent of this study group underwent sugery as part of a mutimodality curative treatment plan or alone as curative treatment. Eighteen patients(69.2%) developed recurrent disease at a median time of 278 days after initial treatment. Kaplan-Meier analysis revealed the 5-year disease specific survival was 34.6%. Conclusion : Most patients with paranasal sinus cancer presented with locally advanced disease. Adanced T stage was highly predictive of poor prognosis. Recurrence rate was high and mostly occured within the second year after treatment.

全蝎 抽出物이 血栓症, 全腦虛血 및 腦細胞毒性에 미치는 影響

백명현,황영근,정지천,강정준,김성훈 동국대학교 한의학연구소 1999 東國韓醫學硏究所論文集 Vol.8 No.1

본 실험은 전갈 추출물이 어혈병태 모델과 KCN으로 유발된 전뇌허혈, 뇌세포독성 등에 미치는 영향을 관찰하였다. 전갈은 Dextran에 의해 유도된 혈전으로 감소된 혈소판수, fibrinogen량, hemocrit치를 유의성 있게 증가시키고. 증가된 prothrombin time을 유의성 있게 단축시켰다. 전갈은 thrombin과 ADP에 의해 유도된 혈소판 응집을 억제하였으나 collagen에 의해 유도된 혈소판 응집에는 저해효과를 나타내지 않았다. 또한 collagen과 epinephrine에 의해 유도된 pulmonary embolism에 대하여 보호 효과를 나타내었다. 전갈은 KCN에 의한 전뇌허혈 유발 실험에서 혼수시간을 유의성 있게 단축시켰고, Amyloid β protein(25-35)에 의해 유도된 PC12 세포의 독성에 대하여 보호효과를 나타내었다. This following is effect of Buthus martensi Karsch (BMK) extract on dextran-thrombus model, KCN-induced coma, cytotoxicity of brain etc. BMK extract significantly increased number of platelet and fibrogen and significantly shortened the prothrombin time as compared with control group treated with dextran. BMK extract didn't affect the changes of hematocrit as compared with control group treated with dextran. BMK extract induced a significant inhibition of human platelet aggregation induced by thrombin and ADP but did not affect human platelet aggregation induced by collagen. BMK extract showed a protective effect on pulmonary thrombosis induced by collagen and epinephrine. BMK extract prolonged the duration of KCN-induced coma and showed a protective effect on cytotoxicity of PC12 cells induced by amyloid β protein(25-35) in a dose dependent manner. These results suggested that BMK extract might be usefully applied for prevention and treatement of thrombosis and brain damage.