Baseline High Blood Pressure is Associated with Clinico-Pathologic Findings and Later Renal Progression in Chronic Glomerulonephritis

Ji Yung Lee,Hyung-Seok Ihm,Jin Sug Kim,Hyeon Seok Hwang,Kyung-Hwan Jeong,Chun-Gyoo Ihm 전해질고혈압연구회 2019 Electrolytes & Blood Pressure Vol.17 No.2

Background: Several factors had been suggested to contribute to the development of hypertension in chronic glomerulonephritis (GN). This study was conducted to find the association of baseline blood pressure (BP) with pathophysiologic findings and later renal progression in chronic GN. Methods: Clinico-pathological findings including serum creatinine (Cr), proteinuria, pathological findings, and urinary Na excretion were analyzed in a total of 233 patients with IgA nephropathy from The Kyung-Hee Cohort of GN. Glomerular surface area (GSA) was measured by imaging analysis and urine angiotensinogen (AGT) concentrations by human ELISA kits. Results: Systolic BP was ≥130mmHg in 124 patients (53%). Systolic BP was negatively correlated with follow-up eGFR (r=-0.32, p<0.0001) and positively serum uric acid concentrations, while it had no significant relationships with initial serum Cr and eGFR. As compared with patients with systolic BP <130 mmHg, those with ≥130 mmHg were older and showed higher serum Cr, proteinuria, 24 hr urinary Na excretion, mean GSA, and T-I fibrosis, lower follow-up eGFR, and steeper decline in slope of eGFR. The results in patients with normal serum Cr concentrations were comparable to those in whole group. Systolic BP was positively correlated with age, baseline and follow-up proteinuria, serum uric acid concentrations and IgM deposit and negatively with follow-up eGFR. In subgroup analysis, systolic BP was also positively correlated with mean GSA and urinary AGT concentrations. Conclusion: This study showed that baseline systolic BP is related to urinary Na excretion, glomerulomegaly, T-I fibrosis and later renal progression in patients with IgA nephropathy.

종격동 종양 47 치험례 : Report of 47 cases

이영,김종인,양기민,노준량,손광현,김종환,서경필,이영균 최신의학사 1971 最新醫學 Vol.14 No.10

Fourty-seven cases of mediastinal tumors originating in the mediastinum or metastasized from other organs were reviewed and classified on the basis of histopathological types and specific anatomical location in this department, during 13 years and six months period from Jan. 1959 to Jun. 1971. In thirty-seven cases, diagnosis was confirmed by histological findings. Range of age was 3 to 63 years and sex ratio was 1.4:1 male to female. In this series, metastatic mediastinal carcinomas of unknown pimary site were most frequent and thymoma ranked second in frequency, comprising 24.3% and 16. 2% of the total cases. The operative mortality was 3.1 There were histologically 11 different kinds of mediastinal tumors in this series.

정신분열증과 우울증의 지각결핍의 비교

이수형,송경의,이형영,하형욱 大韓神經精神醫學會 1984 신경정신의학 Vol.23 No.4

정신분열증 환자의 지각결핍을 타 질환군과 비교해 보기 위하여 1983.6.1부터 동년 8월 31일 까지 전남의 대병원 정신과 외래에 다니는 우울증 환자 20명 국립나주정신병원에 입원한 정신분열증 환자 20명을 임의 선택하여 Garner의 모형을 이용 카드 분류를 시행하고 그 자료를 토대로 수정분류시간, 공제지수, 비율지수 등을 산출하여 변량분석한 결과 다음과 같은 결론을 얻었다. 1. 양 군의 수정시간을 변량 분석한 결과 유의한 차이를 발견할 수 없었다. 2. 공제지수와 비율지수를 변량분석한 결과 과다성 분류와 여과분류에서는 공제지수와 비율지수에서 아무런 유의차가 없었다. 3. 주사분류에서는 공제지수 비교에서 1% 수준에서 비율지수 비교에서 5% 수준으로 우울증의 분류시간이 긴 것으로 나타났다. 이상의 결과를 살펴볼 때 여과기능의 결함이라는 지각결핍은 정신분열증의 고유한 장애가 아닐 수도 있겠다. The perception of stimuli with two dimensions (size and figure) was investigated using Garners card sorting method into schizophrenic and depressive patients. The comparison of three performance indices (redundancy, filltering, scanning) between two study groups revealed that 1) the analysis of variance of the corrected time shows no significant difference between two groups, 2) in redundancy and filtering sorting the subtractive and ratio indices show no significant difference between two groups, 3) in scanning sorting the depressive group shows significantly longer sorting time than schizophrenic group(p<0.01 in subtractive index, p>0.05 in ratio index). The above findings suggest that the previously known perceptual deficit(mainly filtering deficit) may not be specific only to schizophrenia.

靑色症활로四徵의 手術療法 : 23例 報告 Report of 23 Cases

李寧均,閔成基,林昌濟,朴京民,金烱默,徐景弼 中央醫學社 1940 中央醫學 Vol.9 No.2

Twenty-three cases of palliative surgery were done for tetra logy of Fallot; fifteen cases of Glenn operation, three Brock, and five Blalock operation. There were four cases of operative mortality, three due to anoxia and one due to aspiration pneumonia on the opposite lung. Two cases of late death occurred, one during postoperative empyema drainage and the other due to acute superior vena cava syndrome followed by right upper lobe pneumonia, two years after Glenn operation. A twenty years old girl was complicated by left hemiplegia post-operatively probably due to hypoxia during operation. After two months physio-therapy, motility of the muscles recovered except some residual weakness of the small hand muscles. All the survivors showed beneficial effects of palliative surgery; increased exercise tolerance and pulmonary vascularity. Decrease of dyspnea and cyanosis was remarkable. Survivors were followed for one month to four years. During this period four cases expired without surgery, while waiting for admission.

복압성요실금(Stress urinary incontinence)과 절박성요실금(Urge incontinence)환자에서 TVT 수술 결과의 비교

이경구,이준호,권용욱,정태융,심희영,이상익 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1

Tension-free vaginal tape(TVT) has been widely used in the management of stress urinary incontinence(SUI), and has been applied to urge incontinence (UI). We evaluated and compared the outcomes between SUI and UI for patients who had undergone TVT. Patients were categorized into SUI(33 patients) and UI(26 patients). Before treatment, we asked about LUTSs using female bladder questionnaire. And we asked about sexual function. After treatment, the same questionnaires were repeated. During the postperative period, the objective and subjective success rate were evaluated. For operation outcome results, in SUI group there were 29 cases of cure (87.9%)and 2 of improvement(6.1%), and in UI group there were 20 cases of cure(76.9%)and 3 of improvement(11.5%) (p>0.05). The operation satisfaction rate of patients was 90.9% in SUI group and 84.6% in UI group(p>0.05). Improvement of sexual satisfaction occurred in 6(20.0%) of SUI group, and 3 (18.8%) of UI group, respectively(p>0.05). The objective success rate, satisfaction rate and sexual satisfaction of SUI patients did not significantly differ from the women with UI. Also, these results shows that TVT procedure improves some LUTSs in both groups. We consider the TVT procedure to be an effective treatment not for stress urinary incontinence but also urge incontinenece.

국내에서 유행하는 HIV의 전파 경로에 따른 Subtype 분포

이주실,남정구,김성순,강춘,최병선,김옥진,박미선,성봉모,서순덕,전수경,변승옥,신영오,조해월 대한감염학회 2001 감염 Vol.33 No.5

Background : Previous data have been reported that subtype B is prevalent in South Korea, but neither the extent nor the proportion of subtypes could be evaluated. This study was designed to analyze the distribution of HIV-1 subtypes, temporal instructions and transmission dynamics between epidemiological groups. Methods : 1,280 Koreans had been diagnosed as HIV seropositive during the period 1985 to 2000. Among them, 134 individuals were selected for this molecular epidemiological study. 134 DNAs were isolated from uncultured or cultured peripheral blood mononuclear cells. V3-V5 (0.7 kb) fragment of HIV-1 env gene was amplified by nested polymerase chain reaction and was sequenced. Results : HIV-1 isolates from thirty-seven homosexuals were all subtype B (100%). On the other hand, 66 isolates from 94 heterosexuals were subtype B (70%) and 28 were non B subtypes (30% : 13 A, 4 C, 2 D, 8 E , 1 G). Only subtype B strains were isolated from 73 males who were infected with HIV inside Korea while 16 B and 20 non B subtype strains were isolated from 36 males who were HIV infected outside of Korea. However, B and non B strains were isolated half and half from females who were infected inside Korea except one. Conclusion : The HIV-1 subtype B strains are prevalent in Korea from the early HIV infection until present in both homo and heterosexuals. Non B strains have been transmitted from men who were infected outside Korea to their spouses and casual partners. So, we need further study to monitor subtype B and non B HIV transmission in epidemiological groups of Korea, (Korean J Infect Dis 33:311∼318, 2001)

항암제 AG60이 흰생쥐 위점막 상피세포의 DNA합성에 미치는 영향 : 자기방사법적연구

박경호,안의태,고정식,하상선,한영복,정영신,홍은경,유보림,김상건,이경영,강종구 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

태아 26예에서 신장단위의 미세구조적 발달

김혜영,주의탁,김경용,이원복 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.2

위에 발생한 거대 위장관 간질종양 1예

이경영,유영범,김태원,이경룡 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

Gastrointestinal tumors(GIST) are rare group of neoplasias of the gastrointestinal track, which originate from or differentiate into interstitial cells of Cajal (ICC). GIST traditionally have been designated as smooth muscle tumor. However, with increasingly accurate analytic tools, immunohistochemistry and ultrastructure, most investigators were able to demonstrate that ICC, a complex cellular network postulated to act as pacemaker cells of the gastrointestinal track, which exhibit both myoid and neural features, could be a candidate for tumor histogenesis. Most ICC are only c-kit-positive, however a subset are positive for both c-kit and CD34. Most GISTs are asymptomatic and are thus usually discovered incidentally during routine check, at operation of other organs. When symptoms occur, GISTs usually present with gastrointestinal bleeding due to ulceration of the overlying gastric mucosa. Bleeding may be massive, leading to hematemesis and melena. Recently, we experienced a large sized(5×5×5 cm) GIST on the upper body of the stomach, which caused massive upper gastrointestinal bleeding in a 61-year-old man and was treated by local resection with adequate safety margin about 2 cm.

사람태아 간적혈구형성에 따른 간세포의 변화

박영양,김경용,이원복,김동창 중앙대학교 의과대학 의과학연구소 1992 中央醫大誌 Vol.17 No.1

The ultrastructural development of fetal liver cells according to the activity of hepatic erythropoiesis was studied with 15 human fetal livers from 7 to 34 weeks of gestation. 1) The 1st state(7-8 weeks of gestation) : The nucleus of hepatocyte was oval with granular euchromatin evenly dispersed throughout the interior and prominent nucleoli. The hepatocytes often exhibited many mitochondria and short dilated rERs but no sERs and glycogen deposit. Two types of reticulum cells with intracellular organells developed with close relation with erythropoietic cells. The nucleus of the 1st type was similar with that of hepatocyte and the cytoplasm was full of well-developed multiayered rERs and numerous mitochondria. The nucleus of the 2nd type was irregular and has high electron-dense nucleoplasm. and the cytoplasm was packed with more developed multiayered rERs and oval mitochondria. 2) The 2nd state(9-22 weeks of gestation) : Most of hepatocytes differentiated well and exhibited numerous mitochondria and free ribosome, 5 to 6 layered rER, glycogen deposit, and there were sppearance of sER and hemosiderin in the cytoplasm. With age, the 2nd type reticulum cell became the majority and had more glycogen deposit and less rER. The space of Disse was well-developed but the sinusoidal wall still immature. 3) The 3rd state(23-34 weeks of gestation) : The majority of hepatocytes were mature cells. Reticulum cells, greatly decreasing with age, exhibited increasing lipid storage and decrease of mitochondria and rER. In summary, the maturation of hepatocyte and activity of reticulum cell may influence the hepatic erythropoiesis.