Electronic PCK 쇄석기를 이용한 요석환자의 치료경험

정태융,심희영 관동대학교 의과학연구소 2000 關東醫大學術誌 Vol.4 No.1

Purpose : To review the results of primary in situ extracorporeal shock wave lithotripsy(ESWL) far the treatment of urinary tract stones using a third-generation lithotriptor, the Electronic PCK. Materials and Methods : The study comprised a retrospective review of treatment outcome in 131 stones who were treated with primary in situ ESWL, assessing the success and complication of this approach. Results: 92% of cases were stone-free : 10 cases failed ESWL and 9 cases were treated by ureteroscopic stone extraction and 1 case by open pyelolithotomy with no complication, Stone-free rates were 91% far renal stones, 94% for upper ureteral stones, 83% for lower ureteral stones. Complication rates were 30% for renal stones, 37% for upper ureteral stones, 33% for lower ureteral stones. Conclusions : Primary in situ ESWL remains an effective form of treatment for urinary tract calculi, although stone-free rates are lower for larger stones.

The Effect of Posterior Colporrhaphy Performed Concurrently with Midurethral Sling Surgery on the Sexual Function of Women with Stress Urinary Incontinence

정태융,양승애,서주태 대한배뇨장애요실금학회 2010 International Neurourology Journal Vol.14 No.3

Purpose: and hypothesis Some women choose to undergo posterior colporrhaphy (PC) concurrently with procedures for SUI to regain sexual confidence and improve sexual function. We determine the effect of PC on sexual function in women requiring a midurethral sling for SUI. Materials and Methods: A total of 119 women were retrospectively reviewed 81 women had the midurethral sling alone (Group A), and 38 women voluntarily had PC concurrently with the midurethral sling (Group B). Sexual function was evaluated using the FSFI before and after surgery. Results: The postoperative composite scores were significantly increased in both groups (Group A: p=0.02; Group B: p=0.04), and significant increases were observed in ‘desire,’ ‘arousal’ and ‘satisfaction’. However, there were no significant differences in the composite score or six domainscores between the two groups. Conclusion: PC performed concurrently with midurethral sling for treatment of SUI does not provide any additional benefits towards improving the sexual function.

Bcl-2 유전자 발현이 신세포암 전이에 미치는 영향

정태융,최한용,이상익 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.2

Purpose: To investigate whether the up-regulation of Bcl-2 gene expression may be associated with chemotherapy resistance and malignant progression in human renal cell carcinomas(HRCC). Materials and Methods: The HRCC cell line, SN12C, was cultured in MEM medium, supplemented with 10% FBS. Full length of Bcl-2 cDNA was obtained using the sense primer(5'-ATGGCGCACGCTGGGAGAACGG- 3') and the antisense primer(5'-TCACTTGTGGCTCAGATAGG-3') and inserted into SN12C cells to establish stable cells expressing the Bcl-2 gene (SN12C/smcb2). To investigate the response to doxorubicin in orthotropic organs, SN12C/smcb2 and parental cells were implanted into the subcapsular renal tissue of nude mice(n=5). The mice were treated with doxorubicin(8mg/kg) on days 8 and 15 following tumor cell implantation. Tumor tissues, obtained from the kidneys and lungs, were ex vivo cultured (SN12C/smcb2-kidney and SN12C/smcb2-lung, respectively). To compare the metastatic potential in these cell lines, the gelatinolytic activity was measured by zymogram and the expression of type IV collagenase (MMP-9) examined by western blot. Results: In the in vitro study, the SN12C/smcb2 was more resistant to doxorubicin than the parental cells, and treatment and those cells produced a higher rate of tumor formation and metastasis. The SN12C/ smcb2-kidney showed higher gelatinolytic activity than the parental cells. Higher expression levels of type IV collagenase were detected in the SN12C/smcb2-lung and SN12C/smcb2-kidney, but barely detected in SN12C. Conclusions: The up-regulation of Bcl-2 gene expression in HRCC cells induces drug resistance to doxorubicin and increases the metastatic potential. Although the drug resistance induced by Bcl-2 over-expression enhances distant metastasis(lung), the up-regulation of Bcl-2 may enhance the malignant potential of tumor cells and produce distant metastasis.

악성 종양에 의한 요관폐색에서 요관부목 설치의 성공에 영향을 미치는 요인

정태융,박해영,이춘용 大韓泌尿器科學會 1999 Korean Journal of Urology Vol.40 No.12

Grade Ⅲ 방광류 환자에서 여분의 전질벽 조직을 이용한 슬링술식의 초기 경험

정태융,이경구,이상익 대한비뇨의학회 2005 Investigative and Clinical Urology Vol.46 No.4

Purpose: In patient with grade III cystocele, to determine whether the anterior vaginal wall tissue, remnant at the anterior colporrhaphy, is an appropriate sling material, we retrospectively reviewed the outcomes of sling operations that used remnant anterior vaginal wall tissue. Materials and Methods: An anterior colporrhaphy and sling operation using remnant vaginal wall tissue was undertaken in 21 patients. The preoperative evaluation included the patients' history, a physical examination, urinalysis, an urodynamic test, a voiding cystourethrogram and incontinence staging with Stamey grade. The surgical outcomes and stress- related leakage, emptying ability, anatomy, protection, inhibition(SEAPI) were assessed. Results: The mean follow-up period, operation time and hospital stay were 18 months(12-36), 45.4 minutes and 8.6 days, respectively. 18 patients (85.7%) were cured and 3(14.3%) improved. The total subjective SEAPI score of 8.48 decreased postoperatively to 1.78. The pre- and post-operative complications were unremarkable. Conclusions: The remnant anterior vaginal wall sling was helpful in minimizing the postoperative complications and cost effectiveness. Although long-term follow-up data might be required, this technique could be a good alternative method to replace conventional fascial or synthetic pubovaginal slings with grade III cystocele

복압성요실금에서 TVT(Tension-free Vaginal Tape)수술의 결과

정태융,이경구,이준호,심희영,이상익 關東大學校 醫科大學 醫科學硏究所 2004 關東醫大學術誌 Vol.8 No.2

We evaluated the clinical outcome and complication of a TVT(tension-free vaginal tape) procedure for the surgical treatment of stress urinary incontinence in women. Between Jan. 2001 and Apr. 2004, 29 women with stress urinary incontinence underwent TVT procedure under spinal or general anesthesia. Preoperatively, patients were evaluated with history taking, urinalysis, urine culture, physical examination, full urodynamic study with VLPP(valsalva leak point pressure). voiding cystourethrogram. Cure of incontinence after the procedure was defined as the absence of subjective complaint of leakage and absence of objective leakage on stress testing. The mean follow-up period was 11.69±7.42 months. The mean operation time was 34.5±1.25 minutes and the mean age of patients was 51.17±9.64 years. Of the 29 patients follow-up, 27 patients(93.1%) were completely cured, 1 patient(3.4%) was improved incontinence, and 1 patient(3.4%) who developed postoperatively urge incontinence was failed(3.4%). There were 1 bladder perforation and I lower abdominal discomfort occurred postoperatively. We consider the TVT procedure is a safe and simple, effective surgical procedure for the surgical treatment of female urinary incontinence. However, longer follow-up is necessary to determine long term effect.

Grade Ⅲ 방광류를 동반한 복압성 요실금에서 여분의 질전벽 조직을 이용한 슬링술식의 초기경험

정태융,홍종철,이상익,심희영,류기영 關東大學校 醫科大學 醫科學硏究所 2002 關東醫大學術誌 Vol.6 No.1

To determine whether anterior vaginal wall tissue is proper sling material which is at the anterior colporrhaphy in the treatment of grade Ⅲ cystocele with stress urianry incontinence. We reviewed our experience between November 2000 and May 2002. Anterior colporraphy and sling procedure with remnant vaginal wall tissue in 7 patients. The outcome was assessed using the SEAPI scoring system. Mean age of patients was 67 years old. Perioperative and postoperative complication were unremarkable. All patients were satisfied with their results. The remnant anterior vaginal wall sling was helpful to minimized postoperative complication and cost effectiveness. Although long-term follow-up data might be required, this technique could be a good alternative method that replace conventional fascial or synthetic pubovaginal sling.

상부요관결석의 치료경험

정태융 관동대학교 의과대학 2000 명지병원학술지 Vol.2 No.-

음경음낭전위가 동반된 근위부요도하열의 치료 경험

정태융,유성하,이종진,신기용,박해영,이춘용,유영남 大韓泌尿器科學會 1999 Korean Journal of Urology Vol.40 No.6

비조영증강 전산화단층촬영 소견에 따른 요관결석의 자연배출 예측인자

송동우,정태융,이상익,김동준 대한비뇨의학회 2008 Investigative and Clinical Urology Vol.49 No.12

Purpose: We performed a prospective study to determine whether unenhanced helical computed tomography(UHCT) findings predict the spontaneous passage of ureteral calculi. Materials and Methods: Between April 2006 and June 2007, 175 patients with a single ureteral calculus <1cm in diameter were enrolled in this study, and a UHCT was performed. All of the patients were managed conservatively for 2 weeks. Patients without spontaneous passage of ureteral calculi within 2 weeks were treated by ureteroscopy or extracorporeal shock wave lithotripsy(ESWL). The secondary signs (hydronephrosis, perinephric edema, and the tissue rim sign) were graded on a scale of 0-3. We evaluated whether spontaneous passage of ureteral calculi was associated with stone diameter, location, Hounsfield units(HU), and the degree of secondary signs. Results: Ninety-two patients(52.6%) had spontaneous passage of ureteral calculi. The mean stone diameter was significantly smaller in the passage group than the non-passage group(4.28mm vs. 6.73mm, p=0.002). The rate of spontaneous passage was significantly higher involving distal ureteral calculi(66.1%) than proximal ureteral calculi(30.3%, p<0.001). The incidences of hydronephrosis and perinephric edema were significantly lower in the spontaneous passage group than the non-passage group(8.7% vs. 73.5% and 5.4% vs. 69.9%, respectively). The grades of hydronephrosis and perinephric edema were significantly lower in the spontaneous passage group than the non-passage group(p=0.001). Although there was a tendency toward increasing grades of hydronephrosis and perinephric edema with increasing stone size, the grades were more frequent and severe in the non-passage group in patients with similarly sized stones. Conclusions: The degree of hydronephrosis and perinephric edema are useful ancillary signs in predicting the likelihood of spontaneous passage of ureteral calculi. Purpose: We performed a prospective study to determine whether unenhanced helical computed tomography(UHCT) findings predict the spontaneous passage of ureteral calculi. Materials and Methods: Between April 2006 and June 2007, 175 patients with a single ureteral calculus <1cm in diameter were enrolled in this study, and a UHCT was performed. All of the patients were managed conservatively for 2 weeks. Patients without spontaneous passage of ureteral calculi within 2 weeks were treated by ureteroscopy or extracorporeal shock wave lithotripsy(ESWL). The secondary signs (hydronephrosis, perinephric edema, and the tissue rim sign) were graded on a scale of 0-3. We evaluated whether spontaneous passage of ureteral calculi was associated with stone diameter, location, Hounsfield units(HU), and the degree of secondary signs. Results: Ninety-two patients(52.6%) had spontaneous passage of ureteral calculi. The mean stone diameter was significantly smaller in the passage group than the non-passage group(4.28mm vs. 6.73mm, p=0.002). The rate of spontaneous passage was significantly higher involving distal ureteral calculi(66.1%) than proximal ureteral calculi(30.3%, p<0.001). The incidences of hydronephrosis and perinephric edema were significantly lower in the spontaneous passage group than the non-passage group(8.7% vs. 73.5% and 5.4% vs. 69.9%, respectively). The grades of hydronephrosis and perinephric edema were significantly lower in the spontaneous passage group than the non-passage group(p=0.001). Although there was a tendency toward increasing grades of hydronephrosis and perinephric edema with increasing stone size, the grades were more frequent and severe in the non-passage group in patients with similarly sized stones. Conclusions: The degree of hydronephrosis and perinephric edema are useful ancillary signs in predicting the likelihood of spontaneous passage of ureteral calculi.