유제놀에 의한 즉시형 알레르기 반응의 억제

김상현,신태용,김형룡,이영미,이은희,신보경,김윤철,안년형,김형민 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

The current study evaluates the capacity of eugenol to regulate immediate allergic reaction by control of histamine release. Administrations of eugenol (1 M/kg. i.p.) at 60 min before and 5.10 min after the compound 48/80 treatment (8 mg/kg.i.p.) were shown the mortality rates as 0.44.4. and 77.8%. respectively. A 60 min before administered group revealed a singificant inhibition of serum his-tamine release compared with those of 5 and 10 min after the compound 48/80 injection. Eugenol (6-48mM) was also showed a dose-dependent activity on the compound 48/80-induced histamine release from the highly purified population of Alcian Blue-positive peritoneal mast cells. These results indicate that in vitro treatment with exogenous eugenol inhibited the active response of mast cell populations and modulated its characteristics.

토착형 P. vivax에 의한 Malaria 4례

박형렬,이성원,이경미,김태겸,한진영,손춘희,정원태,김성은,김종성 동아대학교의과대학 1997 동아의대학술지 Vol.9 No.2

형광검출 역상 액체크로마토그래피에 의한 Histamine의 정량

유희춘,김형룡,김상현,김대기,이영미,김형민,안년형,신태용 우석대학교 의약품개발연구소 1996 藥學硏究誌 Vol.1 No.-

Histamine을 정확하고 신속하게 정량하기 위해 9.Fiuorenylmethyl chloroformate를 형광유도체화제로 하여 역상 HPLC법으로 정량하였다. 히스타민을 형광유도체화할 때 반응액의 pH, 반응시간, 형광유도체화제의 농도 등 최적 반응 조건을 검토하였다. 이 방법으로 히스타민을 분석한 결과 0.1~0.5ug/ml의 농도범위에서 상관계수가 0.922인 양호한 직선성을 나타내었으며 검출한계는 0.01??/ml였다. A rapid and simple method for the determination of histamine by reverse-phase high performance liquid chromatography with fluorescence detection was established. 9-Fluorenylmethyl chloroformate(FMOC) was used as fluorescent derivative reagent. The optimum conditions for the derivatiation such as pH, reaction time and he concentration of FMOC were investigated. Linearity of calibration curve was obtained between 0.1ug/ml/and 0.5ug/ml(r=0.922) and the limit of detection was 0.01ug/ml.

근로자 건강증진 실천에 영향을 미치는 요인

김은경,김병권,박종태,김형렬,구정완 대한산업의학회 2007 대한직업환경의학회지 Vol.19 No.1

목적: 본 연구에서는 사업장 근로자들의 건강증진 실천 현황을 알아보고, 실천에 있어서 장애요인이 되는 것이 무엇인지 파악하여 효율성과 실효성이 있는 사업장 건강 증진 사업의 발전방향을 모색하는데 그 목적을 두었다. 방법: 경기도 K대학병원, 서울시의 C대학병원에서 보건관리대행사업 또는 국고지원사업을 받고 있는 사업장 중 서울경기지역의 사업장 규모별 비율을 고려하여 사업장 규모별로 사업장 근로자수의 20%를 대상으로 사업장 건강증진사업 현황에 대한 설문조사를 시행하였다. 결과: 대상자 중 건강증진 활동을 하고 있는 비율은 51.3%로 나타났으며 건강증진을 실천하고 있는 경우, 금연을 하고 있다는 응답이 가장 많았고 실천의 계기로는 TV 또는 언론매체의 자극에 의한 경우가 33.4%, 건강진단에서 이상 소견 및 건강이상을 느껴서 시작한 경우가 22.1%였다. 근로자들이 가장 필요로 하는 사업장내 건강증진프로그램은 운동이 41.9%로 가장 높았고, 스트레스 관리가 그 뒤를 이었다. 건강증진사업에 대한 기대 정도는 상당히 효과가 있다고 응답하거나 어느 정도 효과가 있을 것이라고 응답한 경우가 84.8%로 건강증진사업에 대하여 근로자들이 긍정적으로 평가하고 있으며 기대도가 높은 것을 확인할 수 있었다. 건강증진 실천 여부에 영향을 주는 요인은 근로자의 건강상태, 직무자율성 등으로 나타났다. 결과: 개인의 의지 부족이나 시간, 비용 등이 건강증진 활동의 장애요인으로 작용하고, 근로자의 건강상태나 직무자율성 등이 건강증진 실천에 영향을 주고 있는 것으로 나타났다. 장애요인은 개인의 건강증진 실천 의지를 북돋아 주기 위한 사업장 단위의 근로자의 건강증진 활동의 유지 및 지지를 위한 프로그램 강화를 통해 극복할 수 있다. 또한 사업주의 시간적 배려, 사업주와 국가의 경제적 지원책, 지역사회 공공 체육시설 이용 개방 등을 고려할 필요가 있다. 건강증진 활동 실천집단과 비실천집단에 연령, 학력, 결혼여부, 연봉, 근무 일정 등의 차이가 있었는데 이를 통해 건강관리에 있어 시간, 경제, 개인의 생활환경이나 지식수준이 관여한다고 볼 수 있다. 결론: 이상의 결과를 통해 볼 때 건강증진 활동의 효과에 대해서 84.8%가 긍정적으로 평가하고 있다는 것을 알 수 있다. 현재 사업장 건강증진 활동은 금연이나 운동을 중심으로 이루어지고 있으나 본 연구 결과 운동이나 스트레스 관리에 대한 요구도가 높은 것을 확인할 수 있었다. 이에 따라 근로자들의 운동을 위해 사용이 용이한 운동 시설을 마련해야 하며 본 연구에서 긍정적으로 평가 되었던 바와 같이 사업장 밖에 공공 건강증진시설의 확대 방안을 강구하고, 스트레스 관리를 위한 구체적인 방안을 마련해야 할 것이다. Objective: The aim of this paper was to develop efficient and practical health promotion strategies in the workplace by investigating both the present status of health promotion and the barriers to its practice. Methods: A questionnaire was administered to 20% of industrial workers in the workplaces which receives the health care agency enterprise or are supported by a grant from the national treasury, K University Hospital in Gyeong-Gi province, and C University Hospital in Seoul. Results: According to the questionnaire survey, 51.3% workers were practicing health promotion activities and smoking cessation was the most common method among them. Regarding the factors that prompt workers to commence health promotion activities, TV or the mass media had a 33.4% effect, followed by a 22.1% effect for an abnormal finding at regular health screening. The most necessary health promotion activity in the workplace was exercise (41.9%), followed by stress management. When asked about their expectations of the health promotion program, 84.8% of the respondents answered that they expected it to be significantly or somewhat effective. Factors affecting the health promotion activities of workers were worker' s health status and job control. Conclusions: This study demonstrated that workers evaluate health promotion activities positively and that some workers are unable to participate in these activities despite their willingness to do so due to the barrier of circumstances. To encourage worker' s participation, the government and employers should remove barriers.

윈도우 기반 PLC구동 프로그램 개발

김태형,정원지,엄태진,홍대선 國立 昌原大學校 産業技術硏究所 2000 産技硏論文集 Vol.14 No.-

As personal computers are being developed, most softwares are based on window-based operating systems recently. The programmable logic controllers (PLC's) which are usually operated based on the DOS system should be adapted to the window-based environment in order to have the multi-tasking and flexibility of PLC programs. In this paper, the PLC driving programs which are based on the window-based operating systems are developed for the hardwares in which only DOS-based driving programs are being used currently.

다양한 절삭이송속도로 가공한 A1 7075-T6 소재의 쇼트피닝 전후 피로수명에 관한 연구

김형태,이재헌,신기훈,노승남,서성원 서울産業大學校 2005 논문집 Vol.54 No.1

Aluminum alloy 7075-T6 is ideally used for highly stressed parts such as aircraft components because of its excellent strength to weight ratio. This paper presents a study on the effect of feedrate changes on the fatigue life of A1 7075-T6 specimens before and after shotpeening. For this purpose, five groups of specimens, each of which consists of eight specimens, were first machined at five different feedrates (0.05, 0.10, 0.15, 0.20 0.25mm/rev). Half of eight specimens in each group were then peened and the others remained un-peened. Finally, the fatigue life of each specimen was measured by using 4-point rotatry bending machine. In this paper, comparison of fatigue life among ten sets of specimens is presented. One observation is that the fatigue life of unpeened specimens are inversely proportional to the feedrates. On the other hand, the fatigue life of peened specimens are similarly improved regardless of feedrates except 0.05. Based on the results, it is concluded that shotpeening may improve the fatigue life of Aluminium alloy regardless of feedrates. Therefore, machining productivity may also be increased by choosing higher feedrates for structural conponents that need to be strain-hardened by shotpeening after machining

일개 제빵회사 근로자의 제빵공 천식 유병률

김정민,권영준,주영수,임형준,이태경,강혜련,백도명 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.3

목적: 일개 제빵회사에서 제빵공 천식 유병률을 조사하여 제빵공 천식으로 인한 국내 질병부담을 파악하는데 기초자료를 제공하고자 하였다. 방법: 일개 제빵회사의 생산관련 근로자 596명에서 수습기간(3개월) 중이거나 참여를 거부한 216명을 제외하고,380명을 연구대상으로 하였다. 밀가루분진 노출형태에 따라 직접노출군과 간접노출군으로 직무 카테고리를 분류하고,설문조사는 ISAAC 설문항목에 직업력 등을 추가한 설문지를 사용하였다. 설문조사에서 천식이나 알레르기병과 관련된 증상이나 병력이 전혀 없는 간접노출군은 임상검사대상에서 제외하였다. 임상검사대상 233명에게 피부단자검사,혈청 특이 IgE 항체검사,산업의학 전문의와의 면담을 시행하였고,면담에서 천식이나 알레르기비염과 관련된 증상이나 병력이 확인된 31명을 연속적 PEFR 측정대상으로 하였다. PEFR 변동률로써 메타콜린 기관지유발검사대상을 선정하였고,메타콜린 기관 지유발검사에서 기관지과민성이 확인된 경우에 특이 기관지유발검사를 시행하였다. 제빵공 천식은 특이 기관지유 발검사에서 천식반응이 확인된 경우로 정의하였다. 결과: 연구대상의 밀가루 민감화율은 21.0%(직접노출군 25.9%,간접노출군 13.3%), 제빵공 천식 유병률은 3.2%(직접노출군 5.1%,간접노출군 1.8%)였다. 직접 노출군이 간접노출군에 비해 밀가루에 민감화될 위험이 높았으며(OR 2.15,95% CI=1.03∼4.51), 제빵공 천식에 이환될 위험은 통계적으로 유의하지 않았다(PR 2.52,95% CI=O.78∼8.18). 밀가루에 민감화된 군이 그렇지 않은 군에 비해 제빵공 천식에 이환될 위험이 매우 높았다(PR 38.63, 95% CI=6.14∼243.22). 결론: 이번 연구결과는 직업적으로 밀가루에 노출되는 국내 근로자에서 제빵공 천식이 적지 않을 것임을 시사하고 있다. 향후 제빵공 천식으로 인한 질병부담을 보다 정확히 파악하기 위해서는 국내에서 연구된 바 없는 밀가루 취급 사업장(제분회사 등)에 대한 연구가 필요하며,근로자의 건강과 사회경제적 위치를 보호하기 위한 체계적인 연구도 요구된다. Objectives: To determine the prevalence of baker's asthma due to flour dust in an industrial bakery in Korea. Methods: Of the 596 active workers, 380 were allocated to a category of either direct exposure (DE) or indirect exposure (IE) to flour dust and completed a modified ISAAC questionnaire. Of the 380 participants, 233 were screened by an occupational physician interview, a skin prick test, and an ELISA for serum-specific IgE antibodies to wheat flour extracts. Selected workers received serial monitoring of peak expiratory flow rate (PEFR), and positive PEFR respondents received a methacholine challenge test. The diagnosis of baker's asthma was confirmed by a specific inhalation challenge with wheat flour extracts. Results: The prevalence of sensitization to wheat flour and baker's asthma was 21.0% (25.9% DE, 13.3% IE) and 3.2% (5.1 % DE, 1.8% IE), respectively. DE had an increased risk of sensitization to wheat flour (OR 2.15, 95% CI = 1.03∼4.51). Sensitization to wheat flour and the prevalence of baker's asthma correlated significantly (PR 38.63, 95% CI = 6.14∼243.22). Conclusions: These findings indicate a considerable prevalence of baker's asthma among flour-exposed workers in Korea. Future studies will be required to survey the situation in flour mill companies and seek ways to protect the health and socioeconomic position of flour industry workers.

요통환자에 대한 임상적 고찰 : 한·양방 협진병원 내원 환자를 중심으로

김형태,류규수 慶山大學校 保健福祉硏究所 1997 保健福祉硏究 Vol.1 No.-

With 160 lumbago patients (85 inpatients and 75 outpatients) who received both Oriental and Western medical treatment from December, 1994 to April, 1995 at the acupuncture section and rehabilitation section of the H Hurb Hospital which is located in Seoul, a clinical study on the realities of lumbago was carried out. Findings from such a study are as follows: 1. It appeared that regarding the distribution of sex, 80 lumbago patients(50%) were male while the same number of lumbago patients were female, thereby presenting a distributional rate of male and female, 1:1 ; regarding the distribution of age groups, from the age group which consists a large number of lumbago patients, they were the age group of 30s 44 lumbago patients(which is 27.5% of total lumbago patients), age group of 60s or more than that, age group of 50s, and age group of 20s ; regarding the distribution of job, from the group which consists a large number of lumbago patients, they were the group of housewives, group of the unemployed(or the aged), group of clerical workers, group of professional job, etc. 2. It appeared that the causes of the attack of lumbago are unknown etiology 56 lumbago patients(35.0%), heavy lifting 39 patients(24.4%), longtime standing 24 patients(15%), sprain 20 patients(12.5%), and accidents and contusion 11 patients(6.9%) in the order from the most case. 3. Regarding the relapse rate among the subjects, it appeared that 106 lumbago patients(66.2%) had more than relapse, and 54 patients(33.8%) were newpatients; and among the patients having more than relapse, the case of 3rd recurrence outnumbered the case of 2nd recurrence. Regarding the distribution other relapse rate according to age groups, it appeared that the most case was in the group of 60s and more than that with 28 patients(26.2%), then the next case in the group of 30s, then the case in the group of 20s, and then the case in the group of 50s. Regarding the distribution of the relapse rate according to job, it appeared that from the most case, there were 28 lumbago patients of housewives(28.0%), 27 patients(24.7%) of theunemployed(an aged population), and 19 patients(17.8%) of clerical workers. 4. Regarding the distribution of the causes of relapse, it appeared that the most case was due to unknown etiology with 43 patients(40.2%), then the next case due to heavy lifting, then due to longtime standing, then due to sprain, and then due to accidents and contusion. Regarding the distribution of the causes of relapse accoriding to age groups, it appeared that the most case was due to unknown etiology which was seen in all the age groups ; in the age group of 30s, due to heavy lifting, then due to longtime standing, and then due to sprain; and in the age group of 60s and more than that, due to heavy lifting, then due to longtime standing, and then due to contusion. Regarding the causes of relapse according to job, it appeared that the most case was due to unknown etiology or no special cause of attack ; in the group of the unemployed(an aged population), due to heavy lifting, and then due to longtime standing in the order from the most case ; in the group of service workers, due to heavy lifting, and then due to contusion ; and in the group of clerical workers, due to heavy lifting, then due to sprain, and then due to longtime standing in the order from the most case. 5. Regarding the results of the combined treatment of Oriental medicine and Western medicine, it appeared that 86 patients(53.8%) were in a superior state, 45 patients(28.1%) in a good, satisfactory state, 15 patients(9.4%) in the evenly improved state, 8 patients(5.1%) in a lightly improved state, and 6 patients(3.8%) in a poorly improved or inferior state, showing a valid rate of 96.2%. 6. Regarding the required period of medical treatment according to the case history of lumbago, it appeared that the acutest patients(82 patients : 51.3%) required 17.5days, the semi-acute(29 patients ; 18.1%) 20.9 days, the acute(10 patients ; 12.5%) 28.1 days, and the chronic(29 patients; 18.1%) 30.5 days(p=0.0874). Regarding the required period medical treatment according to the degree of the pain, 40 patients(25.2%) having an pain in a degree of an even ache required 18.2 days, 87 patients(54.6%) having a severe pain 22.6 days, 26 patients(16.4%) having a very severe pain 27.9 days, and 7 patients(4.6%) having a light pain 29.4 days(p=0.5857). 7. Regarding the period of medical treatment according to the diagnosed names of lumbago, it appeared that in Western medicine, 57 patients(35.7%) of Accute back pain required 10.1 days, 20 patients(12.4%) of Chronic back pain 24.3% days, 57 patients(37.0%) of HNP 26 days, 19 patients(11.9%) of degenerative spondylosis 26.5 days, 4 patients(2.5%) of Spondyolisthesis 33.3 days, 1 patients(0.6%) of Spinal stenosis 25.5 days(p=0.0108) ; in Oriental medicine, 29 patients(18.2%) of Shensu-zwasum lumbago 31.7% days, 46 patients(28.8%) of Shensu lumbago 25.7 days, 27 patients(16.9%) of Zwasum-yihyul lumbago 20.6 days, 55 patients(34.4%) of Zwasum lumbago 15.5 days, 2 patients(1.3%) of Yihyul lumbago 21 days, and 1 patients(0.6%) of Shi lumbago 2 days(p=0.2762). 8. Regarding the period of medical treatment according to the diagnosed names of lumbago in case of new patients and old patients(or relapsed patients), it appeared that new patients required a period of medical treatment of 18.4 days in general or average for curing lumbago while old patients required a period of 24.1 days in general or average ; this indicates that new patients were cured earlier than old patients. Regarding the period of medical treatment according to the diagnosed names of lumbago, it appeared in Oriental lumbago, when the diagnosed names was Zwasum lumbago and Yihyul lumbago, the required period of medical treatment was short ; in Western medicine, when the diagnosed name was Acute back pain, the required period of medical treatment was short ; in Western medicine, when Shensu lumbago and Shensu lumbago develop into Chronic back pain and HNP, medical treatment of them required more days ; regarding the period of medical treatment in case of new patients and old patients, new patients required a shorter period than old patients ; in particular, in case of Shensu lumbago in Oriental medicine and Chronic back pain in Western medicine, it was understandable that the required period of medical treatment necessitates more days.

금속 결합제를 사용한 Nd-Fe-B 영구자석에 관한 연구

金炯太,金學信 全北大學校 1994 論文集 Vol.38 No.-

Recently there has been a great deal of interests Nd-Fe-B permanent magnet materials because of the broad availability, the low cost of constituents and impressive magnetic properties. Powder metallurgical method is mostly used for fabrication of Nd-Fe-B hard magnets. Nd-Fe-B plastic magnets are fabricated by mixing melt spun magnetic powders with resin. In this study metal powders as a binder are used. MQ powder and Nd-Fe-B alloy powder by mechanical grinding compacted, heat-treated and hot-pressed with additive Zn, Ag-Zn, Al-Cu binders and the magnetic properties on two kinds of permanent magnets were investigated with DC-fluxmeter, SEM and AES. The results obtained in this experiment are as follows; 1. Nd-Fe-B isotropic magnets with mechanical grinding and additive Zn, Ag-Zn, Al-Cu were fabricated, but obtained not above B_r 4.5kG because of no densitification. 2. Nd-Fe-B isotropic magnet which used MQ powder with additive 6wt% Zn and heat-treated at 650℃ for 1 hour is increased to _iH_c 2.7kOe, while Nd-Fe-B magnet with additive 6wt% Ag-Zn at 700℃ for 1 hour is increased _iH_c 5.5kOe. 3. Nd_16Fe_78B_6 isotropic permanent magnet which added Al-Cu 3wt% and hot-pressed at 700℃ is obtained B_r 6.7kG, _iH_c 18.4kOe.

에어로빅스 하이킥시 운동화 중저의 경도에 따른 지면반력의 변화 및 발의 안정성에 관한 연구

김태형,이기청 한국운동역학회 1996 한국운동역학회지 Vol.6 No.1

본 연구는 에어로빅스 운동 중 하이 킥 동작시 운동화 중저의 경도 변화에 따른 바른 안정성과 지면반력의 변화를 연구함으로써 적당한 운동화의 경도를 연구하는 데 있다. 피험자는 에어로빅스 운동을 하는 20대 여성 7명을 대상으로 하였으며, 운동화는 경도를 40(연질), 50(중질), 60(경질)으로 분류하였다. 지면반력과 3차원 영상분석을 통해 운동학적, 운동역학적 변인들의 측정치를 비교 분석한 결과는 다음과 같다. 첫재, 중저의 경도는 제 1 이지시 아킬레스 건각과 후족각에는 영향을 미치나 그 밖의 각도 변인에는 영향을 미치지 않았다. 그리고 경도가 작을수록 회내 운동이 크게 나타나서 후족의 안정성에는 부정적인 영향을 미쳤다. 둘재, 중저의 경도는 최대 충격력, 최대 수직 지면반력, 최대 수직 지면반력 도달 시간, 충격량, 착지 속도에는 크게 영향을 미치지 않는 것으로 나타났는데, 이러한 변인들은 단지 동작의 변화에 따라서 크게 영향을 받는 것으로 사료된다. 즉, 본 연구 결과 중저의 경도가 증가함에 따라서 발이 안정되는 경향을 나타내지만 지면반력에는 큰 영향을 미치지 않는 것으로 나타났다. This study was performed to investigate the influence of midsole hardness of aerobic shoes on motion and attenuation during high kick in order to find out the optimal midsole hardness of aerobic shoes suitable for young females. The subjects on this study were 7 young females who had experienced in aerobics. Three types of aerobic shoes with the midsole hardness of 40, 50, 60 durometers were selected. The lower leg motion during the high kick were measured using a force platform and two 16mm high speed camera. The findings of the study were as follows : 1. The midsole hardness influenced on the initial achilles tendon and rear foot pronation angles, but did not influence the the others angles. As the midsole hardness decreased, the pronation was increased. It brought the nagative effect on the rearfoot stability. 2. The midsole hardness did not influnce on maximal vertical ground reaction force and time to maximal vertical ground reaction force, impluse, take off velocity.