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Kim, S.-H.,Lee, S.-O.,Park, I.-A.,Park, S.J.,Choi, S.-H.,Kim, Y.S.,Woo, J.H.,Park, S.-K.,Park, J.S.,Kim, S.C.,Han, D.J. Blackwell Publishing Inc 2010 Transplant infectious disease Vol.12 No.2
<P>S.-H. Kim, S.-O. Lee, I.-A. Park, S.J. Park, S.-H. Choi, Y.S. Kim, J.H. Woo, S.-K. Park, J.S. Park, S.C. Kim, D.J. Han. Diagnostic usefulness of a T cell-based assay for latent tuberculosis infection in kidney transplant candidates before transplantation.Transpl Infect Dis 2010: <B>12:</B> 113–119. All rights reserved</P><P>Background</P><P>The presence of latent tuberculosis (TB) infection (LTBI) should be evaluated before kidney transplantation. Although a new T cell-based assay for diagnosing LTBI gave promising results, this assay has not yet been compared with the tuberculin skin test (TST) for diagnosing LTBI in renal transplant candidates before transplantation.</P><P>Patients and methods</P><P>All adult patients admitted to a single institute for renal transplantation over a 1-year period were prospectively enrolled. A clinically predictive risk of LTBI was defined as: (i) recent close contact with a person with pulmonary TB; (ii) abnormal chest radiography; (iii) a history of untreated or inadequately treated TB; or (iv) a new infection (i.e., a recent conversion of TST).</P><P>Results</P><P>Of 209 renal recipients, 47 (22%) had a positive TST≥5 mm, 21 (10%) had a positive TST≥10 mm, 65 (30%) had a positive T-SPOT.<I>TB</I> test, and 25 (12%) had an indeterminate T-SPOT.<I>TB</I> test. The induration size of TST was significantly associated with a high positivity rate on T-SPOT.<I>TB</I> (<I>P</I><0.001). Agreement between T-SPOT.<I>TB</I> test and TST≥10 mm was fair (<I>k</I>=0.24, 95% confidence interval 0.11–0.36). However, neither univariate nor multivariate analysis showed any association between the clinical risk for LTBI and positivity on T-SPOT.<I>TB</I> or TST.</P><P>Conclusion</P><P>T-SPOT.<I>TB</I> test was more frequently positive than TST in renal transplant candidates. However, further longitudinal studies are awaited to determine whether the ability of T-SPOT.<I>TB</I> assay to detect LTBI in renal transplant recipients can better predict the development of TB than can TST after transplantation.</P>
Shin, J.W.,Son, H.J.,Kim, S.K.,Min, K.S. Pergamon Press 2013 Polyhedron Vol.52 No.-
Chiral dinuclear nickel(II) complexes, [Ni(L<SUP>R,R</SUP>)(C<SUB>2</SUB>O<SUB>4</SUB>)Ni(L<SUP>R,R</SUP>)](ClO<SUB>4</SUB>)<SUB>2</SUB>.4CH<SUB>3</SUB>CN (3) and [Ni(L<SUP>S,S</SUP>)(C<SUB>2</SUB>O<SUB>4</SUB>)Ni(L<SUP>S,S</SUP>)](ClO<SUB>4</SUB>)<SUB>2</SUB>.4CH<SUB>3</SUB>CN (4) and chiral polymeric compounds, [Ni(L<SUP>R,R</SUP>)(CrO<SUB>4</SUB>)]<SUB>n</SUB>.2H<SUB>2</SUB>O.CH<SUB>3</SUB>CN (5) and [Ni(L<SUP>S,S</SUP>)(CrO<SUB>4</SUB>)]<SUB>n</SUB>.2H<SUB>2</SUB>O.CH<SUB>3</SUB>CN (6) have been synthesized and characterized (L<SUP>R,R/S,S</SUP>=1,8-di((R/S)-α-methylbenzyl)-1,3,6,8,10,13-hexaazacyclotetradecane). These chiral compounds were characterized by X-ray crystallography, circular dichroism, and molecular magnetism. The nickel(II) ions in 3 and 4 have a distorted octahedral geometry by coordination with four nitrogens of a macrocyclic ligand with chiral pendents in a folded conformation and two oxygens of an oxalate ion in the cis positions. The nickel(II) ions in 5 and 6 have a distorted octahedral geometry by coordination with four nitrogens of a macrocyclic ligand in a planar conformation and two oxygens of two chromate ions in the axial positions. Complexes 3 and 4 show strong antiferromagnetic interactions [3: g=2.36, J/k<SUB>B</SUB>=-29.9K (-20.8cm<SUP>-1</SUP>); 4: g=2.18, J/k<SUB>B</SUB>=-25.5K (-17.7cm<SUP>-1</SUP>)], while 5 and 6 exhibit weak antiferromagnetic couplings [5: g=2.25, J/k<SUB>B</SUB>=-1.20K (-0.83cm<SUP>-1</SUP>); 6: g=2.25, J/k<SUB>B</SUB>=-0.68K (-0.47cm<SUP>-1</SUP>)]. The former complexes occur strong antiferromagnetic interactions via the oxalato bridges within the nickel(II) dimers, the latter compounds are weak antiferromagnetic interactions through the chromate ions within the 1D polymers. The circular dichroism (CD) spectrum of 3 has exhibited two negative peaks at 336 and 533nm, and that of 4 has displayed an enantiomeric pattern. The CD spectrum of 5 has appeared a negative absorption above ca. 550nm, while that of 6 has shown an enantiomeric pattern in the same wavelength region.
Runx3 is required for the differentiation of lung epithelial cells and suppression of lung cancer
Lee, K-S,Lee, Y-S,Lee, J-M,Ito, K,Cinghu, S,Kim, J-H,Jang, J-W,Li, Y-H,Goh, Y-M,Chi, X-Z,Wee, H,Lee, H-W,Hosoya, A,Chung, J-H,Jang, J-J,Kundu, J K,Surh, Y-J,Kim, W-J,Ito, Y,Jung, H-S,Bae, S-C Macmillan Publishers Limited 2010 Oncogene Vol.29 No.23
Human lung adenocarcinoma, the most prevalent form of lung cancer, is characterized by many molecular abnormalities. K-ras mutations are associated with the initiation of lung adenocarcinomas, but K-ras-independent mechanisms may also initiate lung tumors. Here, we find that the runt-related transcription factor Runx3 is essential for normal murine lung development and is a tumor suppressor that prevents lung adenocarcinoma. Runx3−/− mice, which die soon after birth, exhibit alveolar hyperplasia. Importantly, Runx3−/− bronchioli exhibit impaired differentiation, as evidenced by the accumulation of epithelial cells containing specific markers for both alveolar (that is SP-B) and bronchiolar (that is CC10) lineages. Runx3−/− epithelial cells also express Bmi1, which supports self-renewal of stem cells. Lung adenomas spontaneously develop in aging Runx3+/− mice (∼18 months after birth) and invariably exhibit reduced levels of Runx3. As K-ras mutations are very rare in these adenomas, Runx3+/− mice provide an animal model for lung tumorigenesis that recapitulates the preneoplastic stage of human lung adenocarcinoma development, which is independent of K-Ras mutation. We conclude that Runx3 is essential for lung epithelial cell differentiation, and that downregulation of Runx3 is causally linked to the preneoplastic stage of lung adenocarcinoma.