폐암과 동반되어 나타난 기관기관지병증 골연골형성증 1예

이영진,전현수,박시형,김모세,김현주,이승헌,이영민,이현욱,이현경 仁濟大學校 白病院 2010 仁濟醫學 Vol.31 No.-

Tracheobronchopathia osteochondroplastica (TPO) is a rare benign disease of unknown etiology characterized by multiple cartilaginous or bony submucosal nodules, which project into the tracheobronchial lumen. Although some disorders were reported combined with TPO, these seemed to be considered casual. We report a case of TPO that combined with adenocarcinoma of lung. She was 50-year-old non smoking woman presented with chronic cough with right chest pain. Lung mass on right lower lobe was found on chest x-ray, so lung cancer was suspected. Multiple scattered whitish small elevations from trachea to bronchial trees were found on bronchoscopic exam. We mistook these lesions for metastases from lung cancer and biopsies of these lesions were done. Transbronchial biopsy for right lower lobe mass lesion was also done. But biopsies from trachea and bronchus revealed TPO rather than lung cancer. Transbronchial lung biopsy of right lower lobe mass was diagnosed adenocarcinoma of lung. So TPO combined with adenocarcinoma of lung was diagnosed.

프롤린 함량 증가 및 내건성 강화 관련 새로운 RING-Type E3 유비퀴틴 리가아제 애기장대 atrzf1 돌연변이체의 생리적 기능 연구

주현우,민지희,정문수,김철수 전남대학교 농업과학기술연구소 2021 농업생명과학연구동향 Vol.59 No.-

The covalent attachment of ubiquitin to proteins plays a fundamental role in the regulation of cellular function through biological events involving abiotic of biotic stress responses, immune responses, and apoptosis, Here, we characterize the biological function of the Arabidopsis thaliana RING Zinc Finger 1 (AtRZF1) in dehydration response. AtRZF1 was significantly reduced by drought stress. The atrzf1 mutant was less sensitive to osmotic stress than the wild-type during early seedling development, wheareas transgenic pants overexpressing AtRZF1 were hypersensitive, indicating that AtRZF1 megatively regulates drought-mediated control of early seedling developmeng. Moreover, the ectopic expression of the AtRZF1 gene was very significantly influential in drought sensitiv parameters including proline content, water loss, membrance ion leakage and the expression of dehy-dration stress-relat genes. ARZF1 is a functional E3 ubiquitin ligase, and its conserved C3H2C3-type RING domain is likely important for the biological function of AtRZF1 in drought response. Together, these results suggest that the E3 ligase AtRZF1 is an important regulator of water deficit stress during early seedling development.

Cyclodextrin Glucanotransferase와 Cyclodextrinase를 생산하는 Bacillus 속 세균의 분리와 그 효소들의 특성

권현주,남수완,김광현,곽영규,김병우 한국미생물생명공학회 ( 구 한국산업미생물학회 ) 1996 한국미생물·생명공학회지 Vol.24 No.3

토양으로부터 CGTase와 CDase를 함께 분비·생산하는 내열성 세균을 분리하였으며, 동정결과 Bacillus stearothermophilus로 판명되어 KJ16으로 명명하였다. Bacillus stearothermophilus KJ16 균주는 회분배양할 경우 2단계 성장을 하며 일차증식기에 CGTase를 생산하고 이차증식기에 CDase를 생산하는 양상을 보였다. 배치 pH를 7.0으로 조절하면서 배양할 경우, CGTase는 균의 증식에 따라 증가하고 CDase는 CGTase보다 뒤에 생산되었다. 그 생산양은 pH 비조절 배양에 비해 CGTase는 최대 12배(1300 mU/ml)까지, CDase는 2배(225 mU/ml)정도 증가되었다. 분리균주가 생산하는 CGTase는 분자량이 65,000 dalton으로 pH 6.0, 60℃에서 최적활성을 보이며 HPLC 분석을 통해 α-, β-, γ-CD를 42: 46: 12의 비율로 생산하는 α/β 혼합형 CGTase였다. 또한 CDase는 분자량이 68,000 dalton으로 pH 6.0, 55℃에서 최적활성을 보이며 최적기질은 γ-CD였다. A bacterium named as Bacillus stearothermophilus KJ16. The growth of the isolated strain occurred in two steps, and syntheses of CGTase and CDase were dependent on the growth cycle of the cell. CGTase was constitutively synthesized during the 1st growing phase, while CDase was synthesized inducibly during the 2nd growing phase. When the medium pH was controlled at 7.0, the maximun enzyme activities of CGTase and CDase were increased by 12-fold(1300 mU/ml) and 2-fold (225 mU/ml), respectively, compared with the pH-uncontrolled batch culture. The CGTase of the isolate converted soluble starch to CDs with the ratio of α-CD: β-CD: γ-CD=42:46:12 at 55℃. The optimal pH and temperature of CGTase were 6.0 and 60℃, respectively and the optimal pH and temperature of CDase were 6.0 and 55℃. The molecular weights of the purified CGTase and CDase were estimated to be 65,000 and 68,000 dalton, respectively. Among serveral substrates, γ-CD was most rapidly hydrolyzed by the purified CDase.

Propylthiouracil 투여에 의한 갑상선 기능저하 흰쥐 조직에서 알코올 탈수소효소 활성의 변화

백상현,김동선,이창범,박용수,안유헌,김태화,기춘석,강주섭 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2

Background: Thyroid hormone has been known to affect hepatic alcohol dehydrogenase (ADH) activity. Although the liver is the principal site of ethanol metabolism, stomach is also responsible in part for ethanol oxidation. The effects of thyroid hormone on ADH activity in gastric mucosa and other tissues of rats had not been previously examined. Method: The effects of thyroid hormone on liver, stomach, lung, and kidney ADH activities (nM of NADH/min/mg of cytosolic protein) have been investigated in male Sprague Dawley rats treated with propylthiouracil (50 mg/kg) for 14 days. Results: Whereas hepatic ADH activities were not changed by treatment with PTU(42.9(8.6 vs 45.2 (10.1), gastric ADH activities in PTU-treated rats increased by 258.8% of control rat (6.3 ( 0.6 vs 2.2 ( 1.2, p〈0.001). In the activities of other tissues, PTU treatment decreased lung ADH activity by 59.7% of control, and increased kidney ADH activities by 247.1% of control rats. Conclusion: These data suggest that hypothyroidism causes an increase of gastric alcohol metabolism, and that the increase of gastric ADH activity can partly restore the first pass metabolism of ethanol in hypothyroid rats.

Cyclodextrin Glucanotransferase와 Cyclodextrinase를 생산하는 Bacillus 속 세균의 분리와 그 효소들의 특성

권현주,남수완,김광현,곽영규,김병우 동의대학교 기초과학연구소 1997 基礎科學硏究論文集 Vol.7 No.1

A bacterium producing Cyclodextrin Glucanotransferase (CGTase) and Cyclodextrinase (CDase) was isolated from soil, and named as Bacillus stearothermophilus KJ16 . The growth of the isolated strain occurred in two steps, and syntheses of CGTase and CDase were dependent on the growth cycle of the cell. CGTase was constitutively synthesized during the 1st growing phase. while CDase was synthesized inducibly during the 2nd growing phase. When the medium pH was controlled at 7.0, the maximun enzyme activities of CGTase and CDase were increased by 12-fold (1300 mU/ml) and 2-fold (225 mU/ml), respectively, compared with the pH-uncontrolled batch culture. The CGTase of the isolate converted soluble starch to CDs with the ratio of α-CD:β-CD:γ-CD=42:46:12 at 55℃. The optimal pH and temperature of CGTase were 6.0 and 60℃,respectively and the optimal pH and temperature of CDase were 6.0 and 55℃. The molecular weights of the purified CGTase and CDase were estimated to be 65,000 and 68,000 dalton, respectively, Among serveral substrates, γ-CD was most rapidly hydrolyzed by the purified CDase.

천연자원을 이용한 간기능 증진제 개발 연구 : Benzo(a) pyrene에 의해 유도된 간기능 장해에 미치는 세신 추출액의 영향 The Effect of Asiasari Radix on Benzo(a)pyrene Induced Hepatotoxicity

윤수홍,박은주,오관현 효성여자대학교 부설 한국환경위생연구소 1994 환경위생연구 Vol.4 No.1

Effect of Asiasari Radix, which is a herbal drug used frequently in the oriental prescriptions, water extract on the liver-protective activities were investigated in the rats. Asiasari Radix extract, when administered into the gast-ric intubation, produced liver-protective effect against benzo(a)pyrene induced liver damage. The results obtainedfrom liver microsomal enzyme assay, measurement of serm and liver alanine·aspartate aminotransferase and lipid accumulation, indicated that alismatis extract showed significant liver-protective activities agai-nst benzo(a) pyrene poisoning.

HGCMP기반 서버 시스템상의 전달지연 연구

조현주,김한수,이광휘 昌原大學校 基礎科學硏究所 1995 基礎科學硏究所論文集 Vol.7 No.-

In this thesis, the message transmission delay on a server system using HGCMP for group communication protocol was analyzed. The queue model of a server system was modeled by queueing theoretic approach. As the feedback structure was imbedded in the queue model, it is difficult to analyze the delay. To solve this problem, the simplification of the queue model was performed. After the simplification process, the queue model was modeled M/M/1. The transmission delay of a server system is calculated using average waiting time and service time in a server system.

TDMA 셀룰라 시스템에서 개별-탭 계수를 이용한 적응 등화기에 관한 연구

홍성수,박래수,한현택,김학춘,정찬주,나상동 조선대학교 동력자원연구소 1995 動力資源硏究所誌 Vol.17 No.1

Demodulation wants to adaptive equalizer to minimize interference of intersymbol which generate in multipath fading channel results from signal time and variety multi propagation through channel in digital radio network systems. Therefore using transition ratio of transfer and receiver system and the number of forward and backward using existing individual taps, we study improvement algorithms which generated bit error ratio by signal in frequence select fading. We analysis and compare linear equalizer and decision feedback nonlinear equalizer. Proposed algorithm is more efficent in fading environment when compared of step size by channel character which estimated existing least square and ITLMS algorithm. In this paper, using ITLMS algorithm by decision feedback BER is reduced for intersymbol interference by narrowband TDMA multipath fading in invironment without individual tap weight overlay.

Benzo(a) pyrene에 의해 유도된 간기능 장해에 미치는 시호와 황금의 병용 효과

尹水弘,吳官絃,朴銀珠 대구효성가톨릭대학교 1992 연구논문집 Vol.45 No.1

This study was attempt to evaluated the effect of Bupleuri Radix extract and Scutellariae Radix extract as the hepatotropic agents. In addition, we measured the relative effectiveness of drug combined treatment in comparison to that of alone treatment. The results are as follows ; 1. Serum and liver AST, ALT activities and liver bilirubin content of B(a)P treated group were significantly increased in comparison to normal group. After administration of Bupleuri Radix extract these enzyme activity and bilirubin content were decreased. 2. Scutellariae Radix extract decreased the increase of serum and liver AST, ALT, liver LDH activities and bilirubin content in B(a)) treated group. 3. After combined treatment of Bupleuri Radix and Scutellariae Radix extract, the serum and liver AST, ALT activities and liver bilirubin content were significantly decreased in comparison to that of drug alone treatment. 4. Buplerui Radix extract prevented the leakage of serum and liver total cholesterol, serum phospholipid and triglyceride levels caused by B(a)P treatment. 5. Scutellariae Radix extract prevented the leakage of serum and liver triglyceride and liver total cholesterol levels caused by B(a)P treatment. 6. After combined treatment of Bupleuri Radix and Scutellariae Radix extract, the lipid accumulation of serum and liver was significantly decreased in comparison to that of drug alone treatment. 7. The hepatotropic effect of drug extracts against B(a)P induced hepatotoxicity was superior to combined treatment of Bupleuri and Scutellariae Radix extract and after-treatment in comparison to that of alone treatment and pretreatment.

쌍태아에서 제 1태아의 분만 후 제 2태아의 지연분만 : 중례보고

김주환,서민정,유희정,노권일,조대현,박정규,이정헌,조성남,손영수 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.3

With the widespread use of fertility medications and techniques of in vitro fertilization, multiple gestation has become epidemic in modern obstetric practice. Delivery of the initial fetus in a multiple gestation usually is followed by delivery of the subsequent fetus or fetuses shortly thereafter. However in rare circumstances, the delivery is delayed for days due to disappearance of uterine contraction after delivery of the first fetus. When uterine activity ceases after the delivery of the first neonate, a policy of nonintervention may be considered in case of an immature or very premature delivery, in order to achieve a gestational age for the remaining fetus(es) more compatible with neonatal survival. We report a case of twin gestation with prolongation of the delivery interval between the twins for 46 days.