봉독약침이 류마티스 관절염 환자의 관절 통증, 종창 및 급성 염증 반응에 미치는 영향

이상훈,이현종,백용현,김수영,박재경,홍승재,양형인,김건식,이재동,최도영,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective In order to study the effects of bee venom(BV) on the pain, edema, and acute inflammatory reactant of rheumatoid arthritis(RA) patients. Methods Patients with RA who met the ACR(American College of Rheumatology) 1987 revised criteria for the diagnosis of RA were treated with the BV therapy twice a week for 3 months. Tender Joint counts, swollen joint counts, Visual analog scale(VAS), morning stiffness, ESR. C-reactive protein(CRP) were analyzed before and after BV therapy. Results The results as follows. 1. Tender joint counts in patients after BV therapy were significantly lower than those before BV therapy(9.0±7.9 vs 15± 11.4, p=0.002). 2. Swollen joint counts of the patients after BV therapy were significantly lower than those before BV therapy(50±61 vs 15±23, p=0.001). 3. VAS in patients after BV therapy was significantly lower than those before BV therapy(608± 17.6 vs 380± 159, p=0.000). 4. Duration of morning stiffness in patients after BV therapy was significantly reduced compared with that before BV therapy(119.1± 112.6 min vs 59.0±89.7 min, p=0.009). 5. ESR and CRP were not significantly changed before and after BV therapy, suggesting BV itself could make inflammatory reaction as well as therapeutic effect. Conclusions BV therapy improved tender joint counts, swollen joint counts and duration of morning stiffness in this study, and further study is needed on long-term effect of BV therapy.

體育.스포오츠事故에 관한 法的問題의 考察

鄭琮潤,鄭琮勳,鄭永銖,朴相甲 東亞大學校 附設 스포오츠科學硏究所 1985 스포츠科學硏究論文集 Vol.3 No.-

In Modern Society, physical education and sports are getting popularization and leisureliness. From this tendency point of view, accidents of physical education and sports are getting on the increase. Nevertheless, out country is not discussed from important social problems by surrounding about accidents of physical education and sports. In connection with the importance about physical education-sports accidents, this study should also be important our civil law §750,§751,§752,§756 and national reparation law §2,§5,§6. Therefore, I would like to suggest that this study is considered a counterplan on accidents-responsibility and accidents-reparation about physical education-sports accidents.

뇌졸중 후 중추성 통증 환자에 대한 동서협진이 진통과 재활에 미치는 영향

이현종,김수영,이상훈,서동민,이두익,김건식,이재동,이윤호,양형인,박재경,최도영 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Purpose : In order to study the effectiveness of East-West pain treatment on central poststroke pain(CPSP), we evaluated its effect on alleviation of pain and rehabilitation of CPSP Patients who were treated with electroacupuncture and west pain treatment for four weeks. Methods : Twenty four patients diagnosed by their pain characteristics of central pain from stroke were treated with sympathetic nerve block, gabapentin, amitriptyline, and electroacupuncture for four weeks. Pain intensity through the visual analogue scale(VAS), and improvements of mobility and rehabilitation through the modified Barthel index(MBI) and Rankin scale(RS), respectively, before and after pain treatment were also assessed. Results : VAS pain scores were significantly improved from 7.7±1.7 to 4.4±2.0 with pain treatment(p<0.05). In accordance with improvement of pain scores, RS and MBI scores were also improved from 2.88±0.95 to 2.13± 1.01 and from 83.0± 16.9 to 94.7±9.5(p<0.05), respectively, with pain treatment(p<0.05). Conclusions : It was suggested that the active pain treatment was contributed to the rehabilitation of CPSP patients, resulting in improvement of quality of life of CPSP patients. Futhermore, East pain treatment in combination with West pain treatment may be useful modality to alleviate CPSP.

하드웨어, 소프트웨어 및 서비스산업 간의 연결에 관한 연구 : 창원공단을 중심으로 Based on Chang-Won Industrial Complex

김경훈,정종윤 昌原大學校 産業經濟硏究所 1994 産經硏究 Vol.11 No.-

RAW264.7 세포에서 interferon-r 및 LPS에 의해 유도되는 NO생성에 미치는 TALT-35의 영향

박종일,박경석,김종석,박지훈,윤은진,송경섭,서강식,김훈,윤완희,박승길,임규,황병두 충남대학교 생물공학연구소 2006 생물공학연구지 Vol.12 No.-

TALP-35 purified from human term placenta is known to increase microtubule polymerization and stabilize the polymerized microtubule. To examine the effect of TALP-35 on immune system this study was performed. MTT assay was performed to investigate the effect of TALP-35 on the proliferation of RAW264.7 cells. TALP-35 dose dependently suppress the proliferation of RAW264.7 cells at high concentration (above 1 μM) in unstimulated cells, in case of 10 μM TALP-35 treated cells the suppression was 25% but in stimulated cells it was only 15%. Cosedimentation assay was carried out to investigate whether TALP-35 can bind to tubulin of RAW264.7, monocyte/macrophage lineage of mouse, and polymerize it. TALP-35 polymerize the tubulin of RAW264.7 cells and sedimented in dose-dependent manner. To investigate the effect of TALP-35 on the expression of iNOS protein western blotting was performed. The expression level of iNOS was decreased dose dependently in high concentration of TALP-35 treatment. To examine the activity of iNOS, secreted NO was determined by method based on Griess reaction. Interferon-γ and LPS-stimulated production of NO from RAW264.7 cells was decreased dose dependently above 0.1 μM concentration of TALP-35 and 50% is decreased at 10μM of it. This study shows TALP-35 can control cytokine induced-iNOS expression therefore it might control inflammatory diseases.

관상동맥 조영술상 정상인 고혈압환자에서 관상동맥 혈류 예비력의 결정인자

고종훈,윤명호,최소연,탁승제 관동대학교 의과대학 의과학연구소 2005 關東醫大學術誌 Vol.9 No.1

Background ; Several studies were reported that reduction of coronary flow reserve(CFR) might lead to myocardial ischemia in the absence of epicardial coronary stenosis. In addition left ventricular hypertrophy might be associated with impairment of coronary flow reserve. The aim of the this study was to assess whether relation exists between CFR and left ventricular mass index(LVMI) and to evaluate the major determinant factors of CFR. Method ; We studied 32 inpatients with hypertension and normal coronary angiogram. Control group consised of 19 subjects(M:F=10:9, mean age 52.6±9.7), group Ⅰ included 14 subjects (LVMI is below 125mg/m2,M:F=6.8 mean age 55.3±14.6) and group Ⅱ consist of 18 subject (LVMI is exceeded 125mg/m2,M:F=5:13 mean age 55.8±9.4). We measured the left ventricular mass(LVM) by M-mode echocardiogram using Devereus and Reichek's method. Left ventricular mass index was calculated as LVM / BSA. We measured average peak velocity at baseline(B) and at adenosine induced hyperemie(H) at the proximal segment of left anteriror descending artery(LAD) using a 0.014 inch 15MHZ doppler wire, CFR was calculated as the hyperemic/baseline(H/B) average peak velocity ratio. Result : 1) There was no significant difference In heart rate, systolic blood pressure or diastolic blood pressure between the two hypertensive groups. 2) The B-APV was significantly increased in hypertensive group compared to the control group(14.4±4.7./21.7.±7.5/23.1±8.1cm/sec p<0.05). 3) CFR was significant reduced in groupⅠand groupⅡ than in the control group (3.2±0.4/2.53±0.6/2.38±0.7 p<0.05). Conclusion ; In hypertensive patients with angiographicaly normal coronary arteries, coronary flow reserve was significantly reduced than normal control group. and CFR was mainly determinant by baseline average peak velocity and not by left ventricular mass index.

초격자 고경도 나노 다층막 소재의 복합경도 해석을 통한 계면 강화 효과 분석

김성훈,이윤희,박종극,백영준,권동일 대한금속재료학회 2003 대한금속·재료학회지 Vol.41 No.12

Multilayer coatings consisting of very thin layers of nitride materials deposited by magnetron sputtering (sometimes called superlattices) exhibit hardnesses over 50 GPa, much higher than that of single layers. Several explanations for this hardness increase have been proposed, including dislocation blocking by layer interfaces, Hall- Petch strengthening, strain effects at layer interfaces, and the supermodulus effect. Among these, dislocation blocking has been generally accepted as a dominant factor in large hardness enhancement. However, the interface between two materials consisting of multilayers is broadened due to interdiffusion. The magnitude of hardness enhancement by the interface has not yet been quantified for real systems. In this study, the concept of composite hardness is introduced to quantify the interface-related hardness enhancement. We suggest a composite hardness equation and quantifythe magnitude of hardness increase by using an equation based on the interface hardness and the interface thickness derived by comparing results derived from this equation and those determined in nanoindentation tests. Three multilayer systems, such as TiN/VN, TiN/NbN and CrN/NbN were used in the equation.

봉독약침이 류마티스 관절염 환자의 기능회복 및 삶의 질에 미치는 영향

이상훈,이현종,박상민,김수영,박재경,홍승재,양형인,이재동,최도영,김건식,이두익,이윤호 WHO COLLABORATING CENTRE FOR TRADITIONAL MEDICINE 2003 東西醫學硏究所 論文集 Vol.2003 No.-

Objective: To evaluate the effects of bee venom acupuncture(BVA) on the rehabilitation and quality of life in rheumatoid arthritis(RA) patients Methods: Patients with RA were treated with the BVA therapy twice a week for 3 months. Tender joint counts, swollen joint counts, morning stiffness, Erythrocyte Sedimentation Rate(ESR), C-reactive protein(CRP), patient global assessment, physician global assessment, Korean health assessment questionnaire(KHAQ) were estimated and analyzed before and after BVA therapy. Results: Tender joint counts, swollen joint counts, morning stiffness showed significant decrease after BVA therapy. But, as acute inflammatory reactants, ESR showed no significant difference and CRP showed significant increase after BVA therapy. Patient global assessment physician global assessment, and KHAQ index showed significant improvement after BVA therapy. Conclusions: BVA therapy can improve rehabilitation and health-related quality of life RA patients as well as clinical symptom and signs. Further study is required in more population with large scale including acute inflammatory reaction of BVA therapy.

액체크로마토그래피/질량분석법을 이용한 랫트 혈장내의 Surfactin C의 정량법에 관한 연구

임종환,김명석,이동연,이상훈,백경진,김태원,정두순,박병권,윤효인 충남대학교 수의과대학 동물의과학연구소 2004 動物醫科學硏究誌 Vol.12 No.-

Surfactin isolated from Bacillus subtilis has a strong surface tension-lowering activity, together with antiviral, antitumor, fibrinolytic and hypocholesterolemic activities. LC/MS is a simple, rapid and effective technique for the determination of surfactin C in rat serum. The separation of surfactin was achieved on reverse phase column. The mobile phase consisted of 0.1% trifluoracetic acid in water (A) and acetonitrile (B). As a result of analysis of blank rat serum samples, matrix interference was not shown. The values of precision and accuracy were satisfied w the guideline. A newly developed LC/MS method for the determination of surfactin C was successfully applied in its pharmacokinetic analysis.

四肢의 Scar Revision에 있어 Modified Millard's Trick의 利用

金勳男,崔性玔,李斗炯,李圭源,皇甫宗演 大韓成形外科學會 1976 Archives of Plastic Surgery Vol.3 No.1

No matter how various methods may be tried, for scar repair of extremities, the results were not so acceptable unfortunately. Of these procedures, Millard's trick (The Double-Breasted Vest Principle) is the one of most popular methods and which has been loved by many surgeons, esp, plastic surgeons, up to date. However, even this method couldn't satisfied us, because of undesirable disadvantages, and our new repair method, entitle "Modified Millard's Trick Method" was designed with supplement of disadvantages of Millard's Tric in mind and has been used in attempt to prevent recurrence of the usual spread. This approach is advocated for scars in area where stretch-ing is usual or where a careful regular repair has failed to prevent it. If there is any depression associated with the scar, this is corrected simultaneously by advancing both skin flaps in opposite direction. We have tired this new method for 1- cases of patients, esp. for relatively wide linear scar (over 5cm) on extremities.