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      • 日本腦炎바이러스의 弱毒化에 關한 硏究

        皇甫宗演 고려대학교 의과대학 1981 고려대 의대 잡지 Vol.18 No.3

        Japanese encephalitis (JE) is an arbor viral disease and it has been prevalent for last 50 years in the Far East. Very recently, there were several large epidemic of the encephalitis with 30% mortality both in the countries of South East and Mid-West Asia. The formalin inactivated vaccine derived form mouse brain inoculated with JE virus has been used in human for prevention of the disease in Asia since 1940. However, the vaccinee under age of 12 in the endemic areas of the disease has to receive the booster dose of the vaccine every year for maintaining high level of neutralizing antibody against the virus. It is hoped to develope an attenuated strain of JE virus in tissue culture cells for preparation of live vaccine which could be used to produce a long lasting immunity against JE. The author inoculated two different strains of JE virus into normal and malignant cell cultures to propagate serially. The cytopathic effect in cell cultures and the pathogenicity of the virus in albino mice were observed and the results were as follow. 1. The cytopathic effect of the virus to the Maben, clonal liver and conjunctiva cells were not observed. 2. The pathogenicity of the virus which were passaged serially in clonal liver and conjunctiva cell cultures against albino mice was decreased significantly. 3. However, the virus propagated serially in Maben cell culture did not loose the pathogenicity against albino mice. The above results indicate that attenuation of JE virus could be developed in tissue culture cells.

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        내안각인대에 발생한 "Fibroma Durum"의 치험례

        황보종연,이두형,이용호 大韓成形外科學會 1979 Archives of Plastic Surgery Vol.6 No.2

        Fibroma may occur at any age and in any site in the body, although they show a definite predilection for the connective tissue sheaths of nerves, the sheaths and fascia of muscules, the periosteum of bones and the dermal connective tissue. But, fibroma which develops on the medial canthal ligament has not been reported up to date. We experenced such a case recently and report the case with the review of literature.

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        이차성구순열에서 골이식술을 동반한 비부변형의 수정술

        김홍래,이두형,황보종연,최성천 大韓成形外科學會 1980 Archives of Plastic Surgery Vol.7 No.1

        In the cleft lip patients, several anatomical, functional and embryological deformities in mid-face are usually present. Among them, deformities of ala, septal cartilage and maxillary hypoplasia are more prominant according to its degree of deformity. Up to date, there are many operative variations in successful correction of nasal deformity and hypoplastic maxillary pyriform in cleft patients. During the past 4 years, form Jan., 1975, to Dec., 1978, we have observed 19 patients of secondary nasal deformity of cleft lip who had been treated with corrective rhinplasty and iliac free bone graft on depressed and hypoplastic pyriform area. This paper reviews our experience of secondary nasal deformity in cleft patient and results are summarized as follows; 1) There were much more satisfactory appearance in patients who had been operated at adult age. 2) There was about 20% absorption in grafted bone within 1 year. 3) There was none of alteration of position in all grafted bone that were fixed with pyriform by making hook-like groove in bone fragment.

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        유리식피술을 이용한 수지부 화상반흔연축 수정에 대한 임상적 고찰

        장세명,이두형,황보종연 大韓成形外科學會 1980 Archives of Plastic Surgery Vol.7 No.2

        As the hand is an exposed area,the frequency of burn on the hand is higher than the other site of the body.The hand,although representing small body surface area of less than 2 percent represents an extremely important functional aspect of human. For this reason,the ultimate purpose of correcting the contracted hand due to burn is to recover maximal function. The author studied 83 cases of burn scar contracture of the hand which recieved free skin graft with aggressive physiotherapy in Department of Plastic Surgery,Kyung Hee Medical Center during the period from March,1974 to April,1979. The results were as follows. 1)Among 83 cases of burn contracted hands,the results of 68 were satisfactory. 2)Age and sex showed no relation with the recovery of function. 3)The duration from burn to skin graft had an important effect on the result:the longer,the worse. 4)In the volar side of the hand,the result of full thickness skin graft was superior to that of split skin graft. 5)In the dorsal side of the hand,the result of split skin graft was superior to that of full thickness skin graft. 6)The postoperative result of the circumferential burn was worse than that of the one side burn. 7)The results from glove design and zigzag design cross the medlateral line to normal tissue were satisfactory.

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        中間層遊離植皮術이 瘢痕戀縮된 關節에 미치는 影響

        李斗炯,崔性玔,皇甫宗演 大韓成形外科學會 1977 Archives of Plastic Surgery Vol.4 No.2

        Secondary scar contracture on soft tissue, especially, joint region, due to burn or trauma bring out many problems. For solution of these problems, surgeons have used full thickness skin graft up to date. But, in department of plastic surgery in Kyung Hee university hospital, seventy five cases of restricted joint motion from Dec. 1975 to Jun. 1976, have been carried out split thickness skin graft instead of full thickness skin graft. The results was summarised as follows: 1) By using the thickness skin graft on restricted area of joint motion, we obtained satisfactory result similar to the full thickness skin graft. 2) In postoperative care, the split was applied for a month during the day and night, and sponge compression began about 8th to 10th day after graft and continued for 3 or 6 months. On neck region, Thomas collar and sponge compression began about 8th to 10th day after graft and continued up to 6 months. 3) Split and sponge compression is a principal means of preventing contracture and early maturation of scar. 4) In baby and child, prolonged restriction of joint motion arise serious problem of soft tissue growth on involved joint region. Early skin is the best choice of treatment in these cases.

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        四肢의 Scar Revision에 있어 Modified Millard's Trick의 利用

        金勳男,崔性玔,李斗炯,李圭源,皇甫宗演 大韓成形外科學會 1976 Archives of Plastic Surgery Vol.3 No.1

        No matter how various methods may be tried, for scar repair of extremities, the results were not so acceptable unfortunately. Of these procedures, Millard's trick (The Double-Breasted Vest Principle) is the one of most popular methods and which has been loved by many surgeons, esp, plastic surgeons, up to date. However, even this method couldn't satisfied us, because of undesirable disadvantages, and our new repair method, entitle "Modified Millard's Trick Method" was designed with supplement of disadvantages of Millard's Tric in mind and has been used in attempt to prevent recurrence of the usual spread. This approach is advocated for scars in area where stretch-ing is usual or where a careful regular repair has failed to prevent it. If there is any depression associated with the scar, this is corrected simultaneously by advancing both skin flaps in opposite direction. We have tired this new method for 1- cases of patients, esp. for relatively wide linear scar (over 5cm) on extremities.

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        埋沒耳의 修正術

        이혜영,장세명,이두형,황보종연 대한성형외과학회 1991 Archives of Plastic Surgery Vol.8 No.1

        Cryptotia is a rare congenital anomaly of the auricle characterized by failure of extrusion of cartilage framework from the side of the head and byrying under the temporal skin. Several kinds of surgical reconstructions have been suggested to effect esthetic improvement and to permit the wearing of spectacles since Kubo's V-Y plasty. The aims of and repair are threefold-to release the upper ear from the side of the head, to correct malposition, and to restore the retroauricular groove. The main emphasis of the operation are to cover the skin defect on the posterior aspect of the ear after it is dessected from the head, and to repair the cartilagenous deformity. authors have experienced 9 patients of the cryptotia during 5 years from Jan. 1975 to dec. 1980. and got satisfactory results using Ohmori method and Onizuka method.

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        Tongue Flap을 利用한 廣範圍한 赤唇部 缺損의 修復

        金勳男,林慶全,李圭源,皇甫宗演,李斗炯 大韓成形外科學會 1975 Archives of Plastic Surgery Vol.2 No.1

        Many different techniques of cheiloplasty have been proposed and developed to reconstruct a vermilion defect for many years. The purpose of this paper is to propose another donor site, tongue, which is available for lining a new lip. A 37 year-old male patient was admitted to our department by the extensive defect of the lower lip vermilion due to human bite. We have used musculo-mucosal flap from the tip of the tongue in the reconstruction of the lower lip vermilion. Here, the result was satisfactory, and patient was discharged with nearly normal state to aesthetic and functional fidelity.

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