허혈성 심질환에서 나타나는 황상화지수, 사이토카인 및 염증지표의 변화

전상훈,안지훈,방덕원,온영근,현민수,김성구,권영주 순천향대학교 의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

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CAT용 스펙트럼 분석기 모듈에 적용한 인터페이스 설계및 구현에 관한 연구

전동근,강지훈,김재형 國立 昌原大學校 産業技術硏究所 1992 産技硏論文集 Vol.6 No.-

As factory automation is rapidly propelled, automatic manufacturing facility is developing widely. But the development of ATE(Automatic Test Equipment) is not reached than that of it. In this paper, we designed intermodule interface for measurment device for computer and CAT(Computer Aided Test) for automatic testing device of spectrum analyzer and implemented real time processing program for control of measurement device. OOP(Object Oriented programming) technique was used in control program to be interfaced with other measurement equipment easily. And we constructed of GUI(Graphical User Interface) method that can be used softwere for user.

허혈성 심질환에서 나타나는 항산화지수, 사이토카인 및 염증지표의 변화

전상훔,안지훈,방덕원,온영근,현민수,김성구,권영주 순천향대학교 교수학습개발센터 2004 Journal of Soonchunhyang Medical Science Vol.10 No.3

Purpose : As diet habits change and the elderly popuation increases conronary artery disease(CAD) has also increased. Recent ongoing studies on varous inflammatory indexes in acute coronary syndrome(ACS) are underway. Several study results have shown that total antioxidant status(TAS) was remarkably lower in unstable angina than in chronic stable angina and levels of interleukin-(IL-6), C-reactive protein(CRP), monocyte chemoattractant protein-1(MCP-1), P-selectin were reported to be elevated in unstable angina and acute myocardial infarction(AMI). In our study, we studied and compared the level changes of cytokines and inflammatory indexes that play important roles inside the blood vessel. Methods : Study subjects were patients who were admitted and underwent coronary angiography at the cardiology department in Soonchunhyang university hospital. Subjects were divided into 4 groups, a control group, a stable angina and unstable angina group and an acute myocardial infarction group. The clinical findings, TAS, inflammatory cytokines(P-selectin, MCP-1, IL-6), anti-inflammatory cytokines(IL-10), Homocysteine and CRP levels in each group were measured and compared. Results : The total number of study participants was 86 patients, with 26 patients in the control group, 21 patients with stable angina, 15 patients with unstable angina, and 24 patients with AMI. There were significant differences in the TAS among the 4 grouops. 1.7±0.51 mmol/L, 1.6±0.60 mmol/L, 1.4±0.20 mmol/L, 1.4±0.29 mmol/L respectively. IL-6 levels also showed a significant difference between groups, averaging 0.8±2.47 pg/ml, 2.7±3.77 pg/ml, 6.8±10.63 pg/ml, 10.9±17.43 pg/ml respectively. Homocysteine levels averaged 8.0±2.47 pg/ml, 6.8±10.63 pg/ml, 10.9±17.43 pg/ml restectively. Homocysteine levels averaged 8.0±1.0 μmol/L in the control group, 14.3±5.14 μmol/L in patients with stable angina, 16.0±4.66 μmol/L in patients with unstable angina, and 17.3±10.08 μmol/L in AMI patients. Conclusion : Compared to the control group, the TAS levels were significantly lower in patients with unstable angina and AMI. there was no difference between the control group and those with stable angina. IL-6 and homocysteine levels were also higher in patients with unstable angina and AMI. Therefore we concluded that measurements of TAS, IL-6 and homocysteine are useful in measuring the inflammatory index of coronary artery diseases and may be important factors in predicting the states and prognosis of cardiovascular disorders.

DES를 기반으로 하는 암호기 구현에 대한 연구

지훈,이준용 弘益大學校 科學技術硏究所 1998 科學技術硏究論文集 Vol.9 No.1

The Data Encryption Standard (DES), which was announced by the National Bureau of Standard (NBS), is the most widely used to protect information. The DES is stronger than the other cryptosystems in the security. But, due to the rapid development of hardware techniques and decreased processing time for cryptanalysis, the DES may be attacked by other systems using parallel process. Therefore, the DES will require strengthening to ensure cryptographic security in the days to come. This paper describe the DES algorithm and the implementation by VHDL.

히스토아크릴을 이용한 십이지장 궤양 출혈의 지혈 후 발생한 급성췌장염

유재훈,문원,노지훈,구동영,조영화,김기수,윤준모 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.1

Upper gastrointestinal bleeding is common and potentially life threatening medical emergency. Emergency endoscopy is the first choice of diagnostic and treatment measure for patients with active upper gastrointestinal bleeding. Histoacryl should be considered a second-line treatment modality when conventional treatments were failed. However, it might cause several complications. Herein, we report a case of acute pancreatitis developed after histoacryl injection therapy for active duodenal ulcer bleeding. A 71-year-old man was admitted with melena and hematemesis. On emergency endoscopy, a 2 cm sized active ulcer with bleeding from an exposedvessel was seen at the duodenal bulb. Attempts to arrest the bleeding with hemoclipping and submucosal epinephrine injection were tried, but failed. We changed the method to endoscopic histoacryl injection, and obtained hemostasis immediately. A few hourslater, after successful hemostasis, patient complained diffuse abdominal pain. Ultrasonography revealed hyperechoic heterogenous diffuse pancreatic enlargement and right pararenal space fluid collection, this ultrasonographic findings and elevated serum pancreatic enzymes are compatible with acute pancreatitis.

소아 난치성 무긴장성발작에서의 Deflazacort의 병용투여 효과

강훈철(Hoon Chul Kang),변지윤(Ji Yoon Byun),고창준(Chang Jun Coe) 대한소아신경학회 2002 대한소아신경학회지 Vol.10 No.1

목적:난치성 무긴장성 발작을 보이는 소아 환자에서 corticosteroid 성분의 deflazacort 병용 투영의 발작 조절 효과와 부작용을 알아보고자 본 연구를 시행하였다. 방법:2000년 6월부터 2000년 12월까지 연세의대 세브란스 병원 소아신경과에 6개월 이상의 무긴장성발작 또는 무긴장성발작을 동반한 Lennox-Gastaut 증후군으로 내원한 환아 중, 항간질제를 두가지 이상 최대 용량으로 투여하였음에도 난치성을 보이는 48명의 환아를 대상으로 전향적 개방형 연구를 시행하였다. 약물 투여 전 4주간의 관찰기 이후 최초 4주간은 deflazacort 2 mg/kg/d를 3회 분복하여 투여하였으며 이후 발작 조절을 관찰하면서 20주간은 deflazacort 2 mg/kg/q.o.d로 총 24주간 투여하였다. 4주 간격으로 간질 발작 빈도와 함께 부작용 여부를 측정하였고 deflazacort의 유효성을 평가하기 위한 주결과 변수로 관찰기 동안과 약물 투여 6개월간의 발작회수감소율의 중앙값을 통계적으로 검정하였으며 보조 결과 변수로 간질 발작 빈도가 50% 이상 감소한 환아들과 발작이 완전히 소실된 환아들의 비율을 조사하였다. 더불어 Lennox- Gastaut 증후군에 동반된 무긴장성발작과 무긴장성발작만을 발현하는 예 간에 발작회수감소율의 차이를 분석하였으며 50% 이상 발작 감소를 보인 반응군과 비반응군 간의 임상 양상의 차이를 비교 관찰하였다. 결과:48명의 환아를 대상으로, 관찰기와 약물투여 6개월 기간 중 발작회수감소율의 중앙값은 42.7%로 통계적으로 유의하게 감소됨을 확인할 수 있었다. Lennox- Gastaut 증후군의 발작회수감소율의 중앙값은 48.9%였으며 무긴장성발작 형태로만 발현하는 경우는 39.3%로 Lennox- Gastaut 증후군에서 다소 효과가 높은 경향이 있었으나 통계적으로 의미는 없었다. 간질 발작 빈도가 50% 이상 감소한 예는 22명(45.8%)이였으며, 간질 발작이 완전히 소실된 경우는 4명(8.3%)이였다. 발작 빈도가 50% 이상 감소한 반응군과 비반응군 간의 임상 양상에 있어 통계적으로 의미 있는 차이는 없었다. 부작용은 20명(41.6%)에서 나타났으며 행동장애가 4명(8.3%),체중 증가와 쿠싱 형상이 16명(33.3%)에서 보였다. 하지만 약물을 중단하지는 않았으며 추적 관찰중이다. 결론:항간질제에 난치성을 보이는 소아 무긴장성발작에서 deflazacort의 병용 투여는 간질 발작 조절에 효과가 있었으며, 부작용으로 경한 행동장애와 쿠싱 형상이 있었으나 약물 투여 중단을 요하지는 않았다. PURPOSE: This is a clinical study to evaluate the efficacy and adverse reactions of deflazacort as adjunctive therapy in childhood intractable atonic seizure including Lennox- Gastaut syndrome. METHODS: This is a clinical prospective, add-on, and open-label study performed for 6 months from Jun. 2000 to Dec. 2000 at the pediatric neurology clinic of Severance Hospital. Subjects were selected according to the following criteria, 1) Patients were diagosed as refractory atonic seizure disorder including Lennox-Gastaut syndrome during more than 6 months, 2) Patients had been on maximal doses of at least 2 anticonvulants including sodium valproate and clonazepam or clobazam. We observed seizure frequency of 4 weeks and 24 week medication period as well as adverse reactions every 4 weeks. Those data were analysed primarily for median seizure frequency reduction rate and other efficacy variables such as responder rate with frequency reduction more than 50% and seizure free rate. We also compared the clinical aspects between responder and non responder group. RESULTS: 48 patients were evaluated for efficacy and adverse reactions. Median seizure frequency reduction rate was 42.7%, responders were 22 patients(45.8%) and seizure free patients were 4(8.3%). In Lennox-Gastaut syndrome, median seizure frequency reduction rate was 48.9% and in atonic seizure only 39.3%. However, there were no statistically significant differences in efficacy. We compared clinical aspects between responder and non responder groups, but couldn't find any difference. The number of patients manifesting adverse reactions was 20(41.6%) in an descending order of frequency, weight gain in 16 patients(33.3%), and irritability in 4 patients(8.3%). CONCLUSION: Deflazacort is believed to be an effective and safe anticonvulsant when used as adjunctive therapy for atonic seizure including Lennox-Gastaut syndrome. However, long term follow up is required to evaluate relapse rate and its adverse reactions.

신경섬유종증 환자에게서 발생한 특발성 혈소판 감소증 1예

권세훈,김형호,강지인,장재혁,원경준,장재현,김상용,배학연 朝鮮大學校 附設 醫學硏究所 2006 The Medical Journal of Chosun University Vol.31 No.3

Idiopathic thrombocytopenic purpura is a disease characterized by thrombocytopenia in peripheral blood with positive anti-platelet antibody titer, no splenomegaly, the presence of megakarocyte. The causes of idiopathic thrombocytopenic purpura were usually related to autoimmune disease, infection and drugs. A 46-years-old man was admitted for evaluation of abdominal mass. He has many cafe-au-lait spots and nodules in almost skin for 30 years. Several years ago, he palpated mass in Lt. inguinal area. hIe has known the abdominal mass after checking abdomen CT in local clinic and visited our hospital for evaluation of abdominal mass. At admission, laboratory tests showed hemoglobin 12.5 g/dL, hematocrit 38.4 %, WBC 5,460 /㎣ (neutrophil 64.5%, lymphocyte 21.7%, monocyte 4.1%, eosinophil 5.4%), reticulocyte 0.7%, Platelet 52,000 /㎣, total protein 6.51 g/dL, albumin 3.80 g/dL, alkaline pohsphatase 161 IU/L, AST 110.7 IU/L, ALT 64.9 IU/L, total bilirubin 0.44 ㎎/dL, BUN 18.4 ㎎/dL, creatinine 0.79 ㎎/dL. Peripheral blood smear showed normocytic normochromic anemia, thrombocytopenia. Bone marrow aspiration smear showed normoplastic myeloid and erythroid precursor. The bone marrow biopsy section shows normocellular marrow (35%) for his age and mildly increasing myeloid cell lineage. We have experienced a case of idiopathic thrombocytopenic purpura in a patient being in neurofibromatosis and therefore reporting it with documentary records. 저자들은 신경섬유종증 환자에서 특별한 원인을 발견할 수 없었음에도 특발성 혈소판 감소증이 발생한 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다.

항 혈소판 요법을 이용한 관동맥내 Stent 삽입술의 조기 결과

손지원,김영준,손민수,오세진,안태훈,최인석,신익균 대한순환기학회 1998 Korean Circulation Journal Vol.28 No.6

골수염으로 발현된 재발성 콕시디오이데스 진균증 1예

백지현,박은영,정윤숙,홍재원,채윤태,진성준,최희경,신소연,한상훈,진범식,김창오,최준용,송영구,조남훈,김준명 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Coccidioidomycosis is a fungal infection that results from inhaling the airborne arthroconidia of the Coccidioides species. It is an endemic disease in the southwest part of North America and rarely diagnosed in Korea. As tourism to endemic areas and the number of immunocompromised patients have been increasing, the incidence of this infection has increased in non-endemic areas. Treatment is usually successful with antifungal agents; however, recurrence is common. It is difficult to decide when to discontinue the antifungal treatment especially in non-endemic areas where doctors are not familiar with the disease. We report a case of recurrent coccidioidomycosis manifesting as osteomyelitis after the treatment of the patient for disseminated coccidioidal infection. The complement fixation test was a useful tool for the assessment of patient response and to evaluate suspected recurrence.

멕시코와 네팔도입 고추 유전자원의 두 가지 점무늬병에 대한 저항성

조은형,김정훈,전수경,이지선,김병수 慶北大學校 農業科學技術硏究所 2005 慶北大農學誌 Vol.23 No.-

Pepper genetic resources consisting of introductions from Mexico and Nepal and susceptible and resistant controls were tested for resistance to gray leaf spot and to bacterial spot by serially inoculating the two disease pathogens, Stemphylium spp. first and Xanthomonas campestris pv. vesicatoria next, with application of fungicide after evaluation of resistance to gray leaf spot first. KC866, KC872, KC902, KC905 were resistant to gray leaf spot in addition to known resistance sources, KC43, KC47, KC220, KC319, KC320, KC380. KC897 was on the top of the resistance sources list, even better than KC177(163192), and was followed by KC889, KC896, KC898, all of which were introductions from Nepal.