치은연하 파절로 치조골 소실을 동반한 상악측절치에서 orthodontic extrusive remodeling후 임플란트 식립을 통한 심미수복 : 증례보고

황수연,손원준,한영철,배광식,백승호,이우철,금기연 大韓齒科保存學會 2008 Restorative Dentistry & Endodontics Vol.33 No.1

심미적으로 중요한 전치부에서 단일 치아 임플란트를 이용한 보철수복은 임상의에게 새로운 도전과제 중의 하나가 되었다. 그러나 전치부에서 single-unit implant는 식립할 부위의 치조골 상태가 양호해야 하는데 치은연하 파절로 인해 치아 주위에 골 손실이 있는 경우 immediate implant는 심미적으로 문제를 야기할 수 있다. 따라서 본 증례는 "orthodontic extrusive remodeling"을 통해 파절치와 주위 조직을 교정적으로 정출시켜 임플란트 식립을 위한 연조직과 경조직을 증대시킨 후 임플란트 식립을 통해 상악측절치에서 성공적인 심미수복을 이룬 증례에 관한 것이다. The treatment of esthetic areas with single-tooth implants represents a new challenge for the clinician. In 1993, a modification of the forced eruption technique, called "orthodontic extrusive remodelling" was proposed as a way to augment both soft- and hard-tissue profiles at potential implant sites. This case report describes augmentation of the coronal soft and hard tissues around a fractured maxillary lateral incisor associated with alveolar bone loss, which was achieved by forced orthodontic extrusion before implant placement. Through these procedures we could reconstruct esthetics and function in a hopeless tooth diagnosed with subgingival root fracture by trauma.

천마의 항 불안 효과

김여환,최형철,손의동,이광윤,김원준,박형배,하정희 대한생물치료정신의학회 1996 생물치료정신의학 Vol.2 No.2

천마(Gastrodia elata Blume)의 근경을 말린 것은 한방에서 오래전부터 여러 형태의 간질발작 치료 목적으로 이용되어지고 있었으나 어떤 활성물질에 의해 또 어떤 작용 기전을 통해 약리작용을 나타내는지를 충분하게 설명하지 못하고 있다. 최근 항경련 작용기전 연구 결과 천마추출물의 GABA성 신경전달계에 대한 조절작용과 관련이 있을 것이라는 연구 결과가 보고되었으며, 소량으로도 뇌억제 및 진정작용이 있다는 문헌을 참고하여 볼 때 천마의 항불안 작용 가능성이 시사되었다. 이에 본 연구를 통하여 천마를 사용하여 실험동물에서 항불안 작용을 검색하고 그 작용기전의 일부를 밝히고자 항불안작용 기전에 중요한 benzodiazepine 수용체와의 상호작용을 관찰하였다. 실험 결과, 천마 추출물의 경구 장기투여는 생쥐의 elevated plus maze 검사에서 개방 통로에로의 진입 및 개방통로에서의 체류시간을 증가시킴으로써 항불안 효과를 나타내었다. 천마의 에탄올 추출물은 benzodiazepine수용체 길항제인 [³H] Ro15-1788결합을 억제하였으며, 천마 추출물은 [³H] Ro15-1788의 수용체 결합에 대한 최대 결합력(Bmax)은 변화시키지 않고, 친화력(affinity)을 감소시킴으로써 상경적인 결합 양상을 나타내었다. 또 천마의 에탄올 추출물은 benzodiazepine 수용체의 효현제인 flunitrazepam의 수용체 결합반응을 억제시켰는데, 이러한 억제는 GABA 존재하에서 항진되는 것을 관찰하였다. 이상의 결과로 미루어보아 천마의 에탄올추출물 내에는 항불안작용을 나타내는 성분이 함유되어 있을 가능성을 예상케한다. Gastrodia elata Blume is a medicinal plant which has been used as anticonvulsant in oriental medicine, and has been used as sedatives. A survey of the relevant literature has indicated that the putative anxiolytic activity of G.elata Bl. has not been scientifically investigated. Therefore, the present study was designed to assess anxiolytic property and interaction with benzodiazepine receptor of G. elata BI. The putative anxiolytic activity of ethanol extract of G. elata BI. was performed in mice using an elevated plus maze paradigm. Chronic oral administration of G. elata BI. showed anxiolytic action in mice. It was suggested that regulation of GABAergic neurotarnsmission may be important in the action of G. elata BI. The interaction of G. elata BI. with benzodiazepine receptor was investigated using rat cortices. Ethanol extract of G. elata inhibited the binding of [³H] Ro15-1788, a selective benzodiazepine receptor antagonist to benzodiazepine receptor. The inhibition of [³H] Ro15-1788 binding by G. elata BI. appeared to be competitive. Further, GABA significantly enhanced the potency of this extract in inhibiting [³H] flunitrazepam, a selective benzodiazepine receptor agonist, binding to benzodiazepine receptor. From these findings, it can be concluded that substance or substances with neurochemical properties characteristic of a benzodiazepine receptor agonist may contribute to the anxiolytic property of G. elata BI.

갈륨액체금속 이온원과 인듐액체금속 이온원의 빔 특성에 대한 연구

현정우,임연찬,정강원,정원희,박철우,이종향,강승언 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

본 연구에서는 인듐 액체금속이온원을 제작하여 빔 특성에 대해 연구를 하였으며, 기존에 연구를 하였던 갈륨 액체금속이온원의 빔특성과 비교 분석 하였다. 빔특성 분석을 위해 빔 안정도, 전류-전압특성곡선, 에너지 퍼짐을 측정하였다. 액체금속이온원에 사용되는 액체금속 저장소 및 바늘전극(tip)은 500μm의 직경을 갖는 텅스텐을 사용하였으며, 국내에서 제작된 제품을 사용하였다. 액체금속 저장소의 구조는 이전에 구상하여 연구가 이루어진 6개의 pre-etching된 텅스텐와이어(wire)가 묶여진 형태를 사용하였다.

부산·울산·경남지역 직업병 감시체계

김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1

Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.

FLUID FLOW ANALYSIS OF AN EJECT CIRCULATOR

Youn Cheol Park,Gang-Soo Ko,Ildong Kim,Won Bin Ko,Taek-Kyu Lim,Jong-Phil Won 한국신재생에너지학회 2018 AFORE Vol.2018 No.8

우주 발사체 구조 요소의 비파괴검사

공철원(Cheol-Won Kong),윤종훈(Jong-Hoon Youn),박재성(Jae-Sung Park),은세원(Se-Won Eun),장영순(Young-Soon Jang),이영무(Yeong-Moo Yi) 한국비파괴검사학회 2009 한국비파괴검사학회지 Vol.29 No.4

우주 발사체는 매우 높은 신뢰도의 경량구조가 필요하다. 비파괴검사 방법 등을 이용한 구조 건전성 관리가 중요하다. 본 논문에서는 우주발사체의 제작 및 검사에 실제 사용되었던 비파괴검사 사례 중 일부를 정리하였다. 겸사 방법으로는 초음파, X-ray, tapping, 음향방출 등이 사용되었고, 하드웨어로는 페이로드 페어링, 고압탱크, 체결부 및 접합부 등을 대상으로 하였다. 페이로드 페어링에서는 샌드위치 미접착 검사의 정량적 기준을 제시하였고, 고압탱크는 내압 인증시험시 내압증가에 따른 음향방출 데이터를 정리하였다. 샌드위치 체결부에서는 음향방출 신호의 주파수 변화에 따른 파손모드를 분석하였고, 이종재료 접합 구조에서는 미접착부 초음파검사를 위한 표준시편을 제시하였다. 이러한 분석 및 기록은 발사체 시스템을 구성하여 어떠한 상황이 발생하여도 신속하게 판단할 수 있는 근거가 될 수 있으며 발사체 시스템의 신뢰도를 높여주는 역할을 한다. Space launch vehicles require highly reliable, lightweight structures. It is thus important to monitor the structural health of these components with nondestructive inspections. In this paper, we studied an example of a nondestructive inspection that was partially applied to the manufacture and inspection of a launch vehicle. Ultrasonic tests, X-rays, tapping, and acoustic emissions comprised the inspection method. A payload fairing, high pressure tank, fastener part, and bonding part were used as hardware to be inspected. We proposed a quantitative standard for debonding inspection of the payload fairing and acoustic emission data for the proof test of the high pressure tank. We analyzed the fracture mode of the sandwich fastener part according to frequency changes. We also proposed a standard specimen for ultrasonic inspection of bonds of different materials. The present analyses and results provide data for evaluation of the launch operation sequence to ensure launch vehicles afford high reliability.

Temporal Trends of De Novo Malignancy Development After Heart Transplantation

Youn, Jong-Chan,Stehlik, Josef,Wilk, Amber R.,Cherikh, Wida,Kim, In-Cheol,Park, Gyeong-Hun,Lund, Lars H.,Eisen, Howard J.,Kim, Do Young,Lee, Sun Ki,Choi, Suk-Won,Han, Seongwoo,Ryu, Kyu-Hyung,Kang, Seo American College of Cardiology 2018 Journal of the American College of Cardiology Vol.71 No.1

<P><B>Central Illustration</B></P><P>[Figure]</P><P><B>Abstract</B></P><P><B>Background</B></P><P>Malignancy is a concern in cardiac transplant recipients, but the temporal trends of de novo malignancy development are unknown.</P><P><B>Objectives</B></P><P>The goal of this study was to describe the temporal trends of the incidence, types, and predictors of de novo malignancy in cardiac transplant recipients.</P><P><B>Methods</B></P><P>The authors analyzed the temporal trends of post-transplant incidence, types, and predictors of malignancy using 17,587 primary adult heart-only transplant recipients from the International Society for Heart and Lung Transplantation registry. The main study outcomes included the incidence of, types of, and time to de novo malignancy.</P><P><B>Results</B></P><P>The risk of any de novo solid malignancy between years 1 and 5 after transplantation was 10.7%. The cumulative incidence by malignancy type was: skin cancer (7.0%), non-skin solid cancer (4.0%), and lymphoproliferative disorders (0.9%). There was no temporal difference in the time to development according to malignancy type. However, the cumulative incidence of de novo solid malignancy increased from 2000 to 2005 vs. 2006 to 2011 (10.0% vs. 12.4%; p < 0.0001). Survival in patients after de novo malignancy was markedly lower than in patients without malignancy (p < 0.0001). Older recipients and patients who underwent transplantation in the recent era had a higher risk of de novo malignancy.</P><P><B>Conclusions</B></P><P>More than 10% of adult heart transplant recipients developed de novo malignancy between years 1 and 5 after transplantation, and this outcome was associated with increased mortality. The incidence of post-transplant de novo solid malignancy increased temporally, with the largest increase in skin cancer. Individualized immunosuppression strategies and enhanced cancer screening should be studied to determine whether they can reduce the adverse outcomes of post-transplantation malignancy.</P>

Acute Intramuscular Toxicity Study of Typhoid Vaccine in Rats and Beagle Dogs

Won Woo Lee,Jeong Hwan Che,Guang Xun Li,Byeong Cheol Kang,Jong Hee Ihm,Ji Youn Jung,Yong Soon Lee 한국독성학회 1999 Toxicological Research Vol.15 No.1

Effect of HBV Reactivation on the Recurrence of Hepatitis B-related Hepatocellular Carcinoma after Curative Resection in Patients with Low Viral Load

Won Sohn,Jong Man Kim,Choon Hyuk Kwon,Jae Won Joh,Jemma Ahn,Ju Yeon Cho,Dong Hyun Sinn,Geum-Youn Gwak,Moon Seok Choi,Joon Hyeok Lee,Kwang Cheol Koh,Seung Woon Paik,Byung Chul Yoo 한국간담췌외과학회 2014 한국간담췌외과학회 학술대회지 Vol.2014 No.4

Severe Hypothyroidism Induced by Thyroid Metastasis of Colon Adenocarcinoma: A Case Report and Review of the Literature

YOUN, Jong Chan,RHEE, Yumie,PARK, Soo Young,KIM, Won Ho,KIM, Soo Jung,CHUNG, Hyun Cheol,HONG, Soon Won,LIM, Sung-Kil The Japan Endocrine Society 2006 Endocrine journal Vol.53 No.3

<P>An 85-year-old man who had undergone a right hemicolectomy for colon cancer presented with severe hypothyroidism and hoarseness 21 months after the operation. The serum thyrotropin (TSH) was markedly elevated to 118.14 μIU/mL and serum free thyroxine (fT4) level was markedly suppressed to 0.34 ng/dL. Symptoms of hoarseness and neck swelling were already evident 4 months prior at which time tests for normal thyroid function were performed. The patient was referred due to aggravated pain on his diffusely enlarged hard goiter. An enlarged thyroid with some calcification was noticed in the neck ultrasonography with multiple cervical lymphadenopathies. Core biopsy of the thyroid gland showed invasion of poorly differentiated adenocarcinoma cells. Immunohistochemical studies showed positive staining only for carcinoembryonic antigen (CEA). There were multiple lung parenchymal nodules and adrenal masses at the time of evaluation. The patient was started on palliative chemotherapy with thyroid hormone replacement and gradually became euthyroid. From these findings and the clinical observations, thyroid metastasis with hypothyroidism developing acutely from metastatic colon adenocarcinoma was diagnosed.</P>