東醫壽世保元의 醫源論中 四象醫學의 醫源 및 特徵에 關한 硏究

崔賢,文錫哉,嚴泰植 圓光大學校 漢醫科大學 1984 圓光漢醫大論文集 Vol.- No.2

This thesis is an attempt to study in regard to a distinguishing mark and an origin of Sa-Sang (Four aspects) Medicine in Eui weun Noun (醫源論) : medical History) of the Domg-Eui-Su-Sae-Bo-Weun (東醫壽世保元) which was written by Lee Je Ma who was the one of the excellent oriental medical scholar in Korea, and futhermore to deep comprehension in Sa-Sang Constitutional medicine (四象體質醫學) which is Unique and sciantific. In this study, we has come to the conclusion ad follows ; 1. S.S.C.M. which was created by Dong-Moo (東武公) is the unique and excellent medicine. 2. In S.S.C.M. it is emphasized that an unballanced emotion is the one of the most important etiological factor. 3. S.S.C.M. come within the category of the traditional theory of the oriental medicine.

뇌졸중후 우울증

문석우,서정석,남범우,최진영 건국대학교 의과학연구소 2004 건국의과학학술지 Vol.14 No.-

In recent years, depression is most commonly reported psychiatric condition after stroke, poststroke depression(PSD) has attracted world-wide interest. This review focuses on the major research themes that have emerged. Pooled data from studies, have wide variation in results is due to different criteria for patient selection, different evaluation methods, diagnostic criteria and poststroke intervals, conducted throughout the world have found prevalence rates for from 18% to 65%. The diagnosis of PSD is most appropriately based on a structured mental state exam and DSM-N criteria for depression due to stroke with major depressive-like episode or depressive features. Rarely, poststroke patients may also develop bipolar mood disorder. The treatment of PSD, single antidepressant showing efficacy and electroconvulsive theraphy(ECT) and behavioral therapies have also effective. The progression of recovery following stroke can be altered by treating depression, which has been shown to improve recovery in activities of daily living(ADL) and cognitive impairment and to decreased mortality. The mechanisms underlying the association of stroke and mood disorder are important areas for future investigation.

手拈散煎湯液이 Streptozotocin으로 誘發된 實驗動物의 膵臟損傷에 미치는 影響

崔極來,文九,文錫哉 圓光大學校 韓醫學硏究所 1994 원광한의학 Vol.4 No.1

Sujoˇmsan(수점산) is used in treatmint of Bi-Sim-Tong(脾心痛) and pancreatitis. This study has been carried out to investigate effect of Sujoˇmsan extract on analgesia, antiinflammation, complete blood cell count, glucose level, lactate dehydrogenase (LDH) level, amylase level in the pancreatic damage of experimental animal induced by stretozotocin. The result were obtained as follows. 1. On the experiment of analgesic effect of Sujoˇmsan extract, the writhing syndrome induced by acetic acid was reduced by administration of Sujoˇmsan extract. In the pancreatic damage of mice induced by streptozotocin, the writhing symdrome induced by acetic acid was reduced, too. 2. Anti-inflammatory effects were increased by administration of Sujoˇmsan extract on the edema of the hind paw in rats induced by acetic acid. In the pancreatic damage of rats induced by streptozotocin, anti-inflammatory effects were increased, too. 3. In the pancreatic damage of rats induced by streptozotocin, the WBC count, glucose level, LDH level and the amylase level were decreased. but hemoglobin and hicatocrit were increased comparing with control group by administration of Sujoˇmsan extract. According to these results, Sujoˇmsan extract may be used for curing in the pancreatic damage.

전경대원에서 발생한 결핵의 임상 양상

문창기,박상준,조민구,김영중,김소연,김윤권,정준오,안석진,김은실,서승오,김지훈,최원제,이윤영,박형기,최규영,김현근 대한감염학회 2006 감염과 화학요법 Vol.38 No.6

Background: The purpose of this study was to document the incidence and clinical characteristics of patients with tuberculosis (TB) in combat and auxiliary police, living in a group, in Korea where the incidence rate of active TB in a general population is higher than in Western countries. Materials and Methods:We retrospectively reviewed the medical records of all tuberculosis patients diagnosed at National Police Hospital from January 2002 through December 2004. Results:In 2002-2004, a total of 156 cases of tuberculosis were identified with the mean (Standard deviation) age of 20.6 (±1.0) years. Of these, 134 (85.9%) patients were registered as new cases, 11 (7.1%) as relapse, 2 (1.3%) as failure, 5 (3.1%) as treatment-after-default cases whereas 4 (2.6 %) patients were not included in any categories. Average annual new TB rate and smear-positive TB rate were 86.5/10^(5) and 17.4/10^(5) person-years, respectively. In 12 of 31 smear-positive cases, time from onset of symptoms to diagnosis was more than 30 days. Two multidrug-resistance TB cases were identified and two suspected outbreak episodes of TB had occurred during 3 years. Conclusion:There was no statistically significant difference in the incidence rate of new cases of TB between the general population aged 20 to 29 years and combat and auxiliary police in Korea. 배경 : 국내 결핵의 발생은 감소 추세에 있으나 여전히 후진국형 발생양상을 보이고 있다. 특히 집단생활을 하는 젊은이들에서 발생하는 결핵의 유행이 간헐적으로 알려지고 있어 우려를 낳고 있다. 이에 저자들은 최근 전경대원의 결핵 발병 양상에 대해 알아보고자 본 연구를 시행하였다. 재료 및 방법 : 2002년 1월부터 2004년 12월까지 3년간 경찰병원에서 결핵 진료를 받은 전경대원의 의무기록을 후향적으로 분석하여 연도별 결핵 신환발생률, 도말양성결핵 신환율, 진단 지연, 집단발병, 다제내성결핵을 조사하였다. 결과 : 연도별 결핵 신환자 수(10만명당 발생추정치)는 2002년 50명(83.6명), 2003년 42명(83.7명), 2004년 42명(93.5명)이었고 도말양성 폐결핵 신환자 수는 2002년 10명(16.7명), 2003년 11명(21.9명), 2004년 6명(13.4명)이었다. 3년간 도말양성 폐결핵 환자는 31명이 있었고 그 중 12명은 호흡기 증상 발생 30일이 지나서 진단을 받았다. 다제내성 결핵은 2명이 있었으며 결핵의 집단발병이 의심되는 사례는 2차례 있었다. 결론 : 전경대원과 20-29세 연령군 일반인의 결핵 신환발생률, 도말양성 폐결핵 발생률의 통계적으로 유의한 차이는 없었다.

左金丸이 腸運動 및 胃液分泌에 미치는 影響

崔斗鎬,文九,文錫哉 圓光大學校 韓醫學硏究所 1993 원광한의학 Vol.3 No.1

Effects of Joakeumwhan(左金丸) extract on the gastrointestinal tract were investigated in rabbits and rats. Treatment of Joakeumwhan extract caused an increase of contractile response of the isolated rabbit ileum. Generally the magnitude of increase was related to the dose of Joakeumwhan extract. The contracting effect of Joakeumwhan extract was not changed by pretreatment of Atropine. The contracting effect of Joakeumwhan extract was inhibited by pretreatment of Pheniramin maleate. The contracting effect of Joakeumwhan extract was inhibited by pretreatment of Cyproheptadine. The contractile response of the isolated lieum was reduced by retreatment of Joakeumwhan extract. The gastric secretion of rat was increased by treatment of Joakeumwhan extract. The gastric acidity of rat was not changed by treatment of Joakeumwhan extract.

Corynebacterium hofmannii에 依한 전신감염 1예

문대혁,최강원,박석건,이광호 대한감염학회 1984 감염 Vol.16 No.1

Corynebacterium of hoffmannii is a part of normal pharyngeal flora. Human infection caused by C. hofmannii is very rare. All reported cases involve prosthetic or native cardiac valve. This patient sufered from chronic alcohlism, diabetes mellitus, and acute suppurative inflammation of brain, meninges and soft tissue. And he failed to show any clinical response to various antimicrobial therapy and died after discharge.

유산소성 운동이 여성 노인들의 체력과 반응시간에 미치는 영향

이규문,최종환,류석윤 忠北大學校 平生體育硏究所 1998 平生體育硏究所 論文集 Vol.10 No.-

This study was performed to investigate the effect of aerobic exercise program on physical fitness and whole body reaction time, and to see the relationship between the level of physical fitness and level of whole body reaction time in the elderly women. The study subjects were consisted of 44 old women with mean age of 67.3 years. They were tested on their physical fitness and whole body reaction time level at the begin and end of the 12-week program(pre-post tests). Assessment included measures of strength, power, balance, agility, flexibility, %body fat, endurance, and body simple and choice reaction times in the elerly women. For data analysis, mean and standard deviation scores were calculated, and paired t-test and person's correlation coefficient were used. The results were follow: 1. After the aerobic exercise program, power, balance, agility, flexibility, %body fat, and endurance were significantly imroved in the elerly women. 2. After the aerobic exercise program, body simpel and choice reaction times were also significantly improved in the elderly women. 3. After the aerobic exercie program, old womens' simple and choice reaction time of whole body were significantly related to strength, power, balance, agility, and flexibility. In conclusion, even though the elderly women had participated in the aerobic exercise program for the short period time(3 months), they showed the improved physical fitness and whole body reactin time, which are related to physical health.

국제 인터넷상호접속협정 이슈 분석 : 아시아·태평양지역을 중심으로

김문수,최기석 한국정보사회진흥원 2007 정보화정책 Vol.14 No.2

인터넷은 지식정보사회의 가장 핵심적인 인프라로 자리매김하고 있으며 특히, 일상생활에서 필수재로 인식되고 있는 상황이다. 그러나 이러한 인터넷 서비스의 보편적 이용은 국가별로 매우 큰 차이를 보이고 있으며, 이러한 차이는 국가 간 정보격차의 가장 큰 요인으로 작용하고 있다. 특히, 아시아∙태평양 지역의 경우 일부 국가를 제외하고는 대부분의 국가에서 인터넷 이용률 측면 뿐 아니라 하부네트워크의 구축은 매우 열악한 상황이다. 또한, 전 세계 인터넷과의 연결을 위해서는 북미 혹은 유럽계 인터넷 백본 사업자와의 상호접속이 필수적인데 이러한 상호접속은 중계접속협정의 방식으로 발생되는 모든 비용을 전액 지불하는 형태로서 아∙태 지역 최종 이용자의 부담을 가중시키고 있다. 이러한 배경에서 본 논문은 국제인터넷상호접속서비스(IIS)와 관련한 지역 간 이슈를 불공평성(inequity), 반경쟁성(anticompetitive) 그리고 인터넷 분열(balkanization) 등 세 가지 측면에서 검토, 분석하고 이를 해결할 수 있는 대안을 지역적 및 국제적 측면에서 아∙태 지역 입장을 반영하여 논의, 제시한다. The Internet is a worldwide network connecting to others and connected to by others in order to exchange information and data. The initial zero settlement peering arrangement, however, has now been replaced by commercial transit arrangement, as backbone providers have begun to seek to recoup their network infrastructure investments and generate commercial profits. This is a key reason emerged issues and debates on international internet interconnection service (IIS) between developed and developing countries. This study is generally concerned with the current interconnection settlement arrangement which disfavors ISPs and end-users in the Asia-Pacific region. The main issues raised in recent years in relation to IIS between Asia-Pacific and Western region are summarized into 3 categories; inequity, anti-competitive concerns and a prognosis of balkanization of the Internet. And then in order to resolve those issues and improve the IIS market in Asia-Pacific region, we discuss practical recommendations at two points, i.e., regional and international perspective.

PHI기술을 이용한 신축공동주택 베이크아웃 실험 및 적용성 검토

이정재,문성민,최석용 東亞大學校 建設技術硏究所 2007 硏究論文集 Vol.31 No.1

Building materials which are not properly verified their harmful chemical emission have been widely used in architecture. The fact has caused air pollution and become a big issue in Korea. As living environment for human body became a concern, many studies about reducing air pollution in living areas are going on nowadays. This study analyzed the resisting effect of HCHO and VOCs based on data obtained from experimentation on newly built apartments by PHI cell, which has been used in developed countries(like the usa), and by bake-out, also analyzed about energy expenditure of bake-out and PHI operation. The result of this experiment shows that PHI is more efficient than bake-out as considering the contaminate density reduction rate and energy expenditure. However, it doesn’t exactly coincide with the standard indoor air quality of Korea. For practical use of PHI system, we need to continue studying how to multiply the size of PHI cell and the fan adhered to unit.

법랑모세포 분화와 법랑질 형성과정에서 OD314, Apin protein의 발현 및 기능

박종태,최용석,김흥중,정문진,오현주,신인철,박주철,손호현 대한치과보존학회 2006 Restorative Dentistry & Endodontics Vol.31 No.6

본 연구에서는 법랑모세포 분화와 법랑질 형성에 연관이 있는 OD314 일명 Apin protein의 기능을 밝힐 목적으로, in-situ hybridization에 의한 OD314 mRNA 발현과 법랑모세포 세포주에서 OD314 enamel matrix protein의 발현, 그리고 OD314 유전자를 과발현/억제시킬 수 있는 construct를 제작한 후 법랑질 형성 중에 OD314의 기능을 알아보고자 RT-PCR를 시행하여 다음과 같은 결과를 얻었다. 1. OD314 mRNA는 발생중인 상아모세포보다 법랑모세포에서 강하게 발현되었다. 2. Tuftelin은 석회화 결정이 형성되는 14일까지 발현이 지속되고, 그 이후부터 점차 감소하였다. Amelogenin과enamelin은 7일부터 그 발현이 점점 감소하였다. 3. U6-OD314 siRNA construct를 이용하여 transfection한 법랑모세포 세포주는 OD314와 tuftelin,MMP2 mRNA 발현이 감소하였으며, CM-OD314를 transfection하여 OD314의 과발현을 유도한 경우에는 OD314와 MMP20 mRNA의 발현이 뚜렷이 증대되었다. 이 결과는 OD314가 법랑모세포의 분화와 법랑질의 형성 그리고 석회화 과정에 중요한 역할을 하는 새로운 인자임을 시사한다. This study was aimed to elucidate the biological function of OD314 (Apin protein), which is related to ameloblast differentiation and amelogenesis. Apin protein, calcifying epithelial odontogenic (pindborg) tumors (CEOTs)-associated amyloid, were isolated from CEOTs, and has similar nucleotide sequences to OD314. We examined expression of the OD314 mRNA using in-situ hybridization during tooth development in mice. Expression of OD314 and several enamel matrix proteins were examined in the cultured ameloblast cell line up to 28 days by reverse transcription-polymerase chain reaction (RT-PCR) amplification. After inactivation and over-expression of the OD314 gene in ameloblast cell lines using U6 vector-driven RNA interference and CMV-OD314 construct, RT-PCR were performed to evaluate the effect of the OD314 during amelogenesis. The results were as follows: 1. In in-situ hybridization, OD314 mRNAs were more strongly expressed in ameloblast than odontoblast. 2. When ameloblast cells were cultured in the differentiation and mineralization medium for 28 days, the tuftelin mRNA expression was maintained from the beginning to day 14, and then gradually decreased to day 28. The expressions of amelogenin and enamelin were gradually decreased according to the ameloblast differentiation. 3. Inactivation of OD314 by U6-OD314 siRNA construct down-regulated the expression of OD314, MMP-20, and tuftelin, whereas over-expression of OD314 by CMV-OD314 construct up-regulated the expression of OD314 and MMP-20 without change in tuftelin. These results suggest that OD314 is considered as an ameloblast-enriched gene and may play the important roles in ameloblast differentiation and mineralization.