알코올에 의한 α-Tocopherol이 혈액성분에 미치는 영향

김영순,이상한,김창세,조만희 순천향의학연구소 1995 Journal of Soonchunhyang Medical Science Vol.1 No.2

This study was done in order to observe the effects of ethanol and a-tocopherol on the serum ALP, BUN and uric acid concentrations. The white Sprague-Dawley rats were classified with 4-grops : 0.9% NaCl administration was group A control, 25% ethanol administration for the each 5, 10 and 15 days was group B(Bl, B2 and B3), 25% ethanol administration for the each 5, 10 and 15 days and 50% a-tocopherol for the 2 and 7 days administration was group C (Cl and C2) and 50% a-tocopherol pretreated for the each 5, 10 and 16 days and 25% ethanol for the 2, 7 and the 10 days administration was group D(Dl, D2 and D3) The following results were obtained. 1. The changes of serum ALP activity was significantly increased in ethanol treated group. The group C and D was decreased. 2. The changes of serum BUN concentration between each group were not significant and however B2, B3, C2 and Dl was significantly increased. 3. The changes of serum uric acid concentration between each group were not significant. However group Cl and Dl was slightly decreased patterns.

악성종양에서 골수면역신티그라피를 이용한 골수전이의 평가 : 99mTc-MDP 뼈스캔과의 비교

고창순(Chang Soon Koh),김노경(Noe Kyeong Kim),김병국(Byoung Kook Kim),최창운(Chang Woon Choi),정준기(Jun Key Chung),방영주(Yung Jue Bang),이경한(Kyung Han Lee),정홍근(Hong Keun Chung),이명철(Myoung Chul Lee) 대한핵의학회 1994 핵의학 분자영상 Vol.28 No.1

N/A Although bone scan is a highly sensitive test for detecting bone metastasis, its findings are often limited in specificity and cannot be used for assessing the bone marrow. Bone marrow scintigraphy may provide useful information but previous experience with radiolabelled colloid has been disappointing. Recently, 99mTc labeled anti-granulocyte rnonoclonal antibody (anti-NCA-95 MAb) has been introdueed as a new bone marrow imaging agent. To evaluate the usefulness of 99mTc anti-NCA MAb bone marrow scans for detecting skeietal metastasis, bone marrow scans of 44 malignant tumor patients were evaluated and compared with bone scan fmdings. Bone scan showed abnormal lesions in 26(59%) cases, and 18 of these patients also had an abnormal bone marrow scan. Seven of the 8 patients who had normal bone marrow scan despite bone scan lesions were confirmed to be free from metastasis. There was one case with a marrow defect despite normal bone scan but the presence of metastasis was not determined due to loss of follow up. Bone scan demonstrated a total of 64 lesions while bone marrow scan showed 38 lesions. Fifty percent (32/64) of the bone scan lesions had matching marrow defects while the rernaining 50% did not. Most of these non matched lesions were suggested to be nonspecific 1esions such as rib fractures or degenerative change. Meanwhile bone marrow scan was able to detect 6 new lesions not detected by bone scan, but metastasis in each lesion was not confirmed. Bone marrow scan was also helpful in assessing equivocal bone scan lesions to be of metastatic nature in 10 patients by demonstrating a matched marrow defect. Thus 99mTc anti-NCA MAb bone marrow scan can help exclude metastasis in patients with nonspecific bone scan lesions and may be able to detect metastatic lesions not seen with bone scan. It appears useful as a complementary study to bone scan in evaluating malignant tumor patients.

약물 중독 시 위 세척에 의한 산 - 염기 평형 및 전해질의 변화

윤형란(Hyung Ran Yun),손동현(Dong Hyun Sohn),이창범(Chang Bum Lee),이재웅(Jae Woong Lee),양석철(Suck Chul Yang),한동수(Dong Soo Han),손주현(Ju Hyun Sohn),김순길(Soon Kil Kim),김호중(Ho Jung Kim) 대한내과학회 1998 대한내과학회지 Vol.54 No.4

N/A Objectives: There is little information on the imbalance of electrolyte and acid-base metabolism associated with gastric lavage in acute drug intoxication patients. This study was aimed to analyze the acid-base and electrolyte abnormalities associated with gastric lavage in acute drug intoxication patients. Methods: We studied 24 acute drug intoxication patients who had performed gastric lavage with 10 liters of 0.9% NaC1. Electrolyte parameters and arterial blood gas analysis were carried out before and after gastric lavage. Results: After gastric lavage, acidosis was reduced in general. But there was no significant change in pH (7.34±0.02 vs. 7.38±0.15, p=NS). In acid-base balance, the mixed form of metabolic acidosis and respiratory acidosis was reduced from 7 to 2 cases, and the simple form of respiratory acidosis was reduced from 3 to 1 case. In contrast, normal form was increased from 5 to 7 cases and the simple form of metabolic acidosis was increased from 2 to 6 cases. In electrolyte parameters, serum sodium was reduced significantly (145±1.0 mEq/L vs. 141±0.8 mEq/L, p<0.01), but there was no case of significant hyponatremia (<135mEq/L). Bicarbonate level (20±1.1 mEq/L vs. 22±0.9 mEq/L, p< 0.05) and anion gap (19±1.6 mB vs. 13±1.3 mEq/L, p< 0.01) showed significant change. But, blood levels of potassium (3.6±0.1 mEq/L vs. 3.8±0.1 mEq/L, p=NS), chloride (106±0.6 mEq/L vs. 106±0.6 mEq/L, p=NS) and F'aCO2 (36±1.mmHg vs. 37±1.5 mmHg, p=NS) were no significant change before and after gastric lavage. Conclusions: Gastric lavage with 10 liters of 0.9% NaC1 in acute drug intoxication patients did not show clinically significant changes in electrolytes and acid-base balance.

대량의 각혈로 사망한 장티푸스 1예

한상우,유진홍,권순석,김성훈,박지찬,홍은정,최경성,박용완,장준희,안지원,박유경,강지영,박상미,신완식 대한감염학회 2004 감염과 화학요법 Vol.36 No.5

We experienced a 25 year-old male patient with typhoid fever complicated with massive hemoptysis. Pulmonary complication in typhoid fever is very rare and to our knowledge, there has been no report of hemoptysis as a main cause of death with this disease. We herein report a rare case of typhoid fever.

平面式 太陽熱集熱機를 利用한 紅蔘乾燥

張奎燮,金相達,洪淳根,尹漢敎 한국응용생명화학회 1982 Applied Biological Chemistry (Appl Biol Chem) Vol.25 No.3

密閉式물 交換太陽 熱集熱乾燥製置를 利用하여 紅蔘을 乾燥할때의 集熱效率, 乾燥效率. 乾燥特性 및 製品의 品質을 各各 調査하였다. 乾燥其間은 太陽熱集熱製置를 利用한 것이 慣行法보다 3分의 1程度를 더 短 할 수 있었다. 乾燥其間中集熱機의 最大效率은 14.42% 最低效率은 4.73%였고 乾燥效率은 集熱製置를 利用한 것이 28.34%, 對照區가 13.45%로서 純粹乾燥效率은 14.89%이었다. 紅蔘의 乾燥率曲線은 減率乾燥期만을 나타내었으며, 이 때의 式은 Y=50.7023t.-014138 이었다. 乾燥紅蔘의 色度는 慣行法과 比較하여 더 높았으며, diphenylpicryl hydrazyl 遇元能도 같은 傾向을 보였다. A closed solar collector drying system by water exchange was evaluated for the drying of ginseng. The thermal efficiency of solar collector, drying efficiency, drying characteristics and product quality were investigated. The drying period was reduced by one-thirds in comparison with typical method. The maximum and minimum thermal efficiency of the solar collector during drying period were 14.42%, and 4.73%, respectively. The drying efficiency of solar collector and control system showed 28.34%, and 13.45%, respectively: net drying efficiency being 14.8%. The drying rate curve of red ginseng showed only falling rate period, and its equation was Y=50.7023t.^(-0.4138) The brown color intensity of red ginseng was higher in solar collector drying system than in typical method, and reductivity by diphenyl picryl hydrazil solution in red ginseng extract showed similar result to brown color intensity.

하시모토 병과 동반된 악성 빈혈 1 예

한 호,안명주,최정혜,이창범,이영열,최일영,김인순,이웅수 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.2

Pernicious anemia is the most common cause of vitamin B12 deficiency and is caused by autoimmune destruction of parietal cell containing gastric mucosa region. This disease is significantly associated with autoimmune endocrinopathies and anti-receptor autoimmune disease. We report here a case of 26-year old man who was diagnosed pernicious anemia with high level of autoantibody titer (antithyroglobulin antibody 1:25,600 and antimicromosomal antibody 1:6,400) indicating subclinical Hashimoto's thyroiditis. Since other autoimmune diseases are frequently associated with pernicious anemia even without evidence of clinical symptoms, screening test for the presence of autoimmune disease should be evaluated in these patients.

요추간판탈출증에서 현미경 수술과 경피적 자동수핵제거술에 대한 비교연구

신원한,장재칠,주교성,김범태,최순관,변박장 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.1

A retrospective study of operative results were carried out in a series of 164 patients who were performed microdiscectomy and 57 patients performed automated percutaneous lumbar discectomy (APLD) for herniated lumbar discs between January 1, 1990 and June 30, 1996 at the Department of Neurosurgery, Soonchunhyang University Hospital. The operative results were analysed, and the correlation between preoperative clinicoradiological factors and postoperative clinical results were statistically assessed. The major results were as follows : 1. Of 164 microdiscectomy cases, 102 were males and 62 were females, mean age was 42.4 years and incidence was the highest in the 5th decade, and of 57 APLD cases, 43 were male and 14 female, mean age was 32.2 years and incidence was the highest in the 3rd decade. 2. The preoperative symptoms and signs were lumbago(98.2%), radiating pain(96.3%), positive straight leg raising test(77.4%), motor weakness(27.4%), claudication(13.4%) & voiding difficulty(2.4%) in microdiscectomy cases, and lumbago(98.2%), radiating pain(98.2%), positive straight leg raising test(70.2%) & motor weakness(17.5%) in APLD cases. 3. Number of operated levels were performed 226 in microdiscectomy and 74 in APLD. The most commonly operated levels of two groups were L4-5 level. 4. Operative results 1) The overall success rates by Prolo's scale were 87.1% in microdiscectomy and 80.7% in APLD, respectively. 2) In younger age group (below 30 years) and in non-compensatory group, success rates were significantly higher in microdiscectomy. 3) As to protrusion and degeneration on MRI, clinical results of moderate protrusion and degeneration of discs in microdiscectomy were statistically significant, and those of mild protrusion and degeneration of discs in APLD were also statistically significant. 4) The most common cause of failure was inappropriate removal of disc material in microdiscectomy and sequestered discs in APLD. According to the above results, there were no differance in overall success rates between microdiscectomy and APLD. But clinical results seem to be influenced by the age, existence of compensation, and by the degree of protrusion and degeneration of discs as prognostic factors. If the selection of operative procedure between microdiscectomy and APLD for herniated lumbar disc is carefully done with clinical and radiologic findings of patients, good outcome might be achieved.

적응 퍼지 제어기를 이용한 유연성 빔의 위치제어

탁한호,이병로,김병철,전중창,황석순,정민우 진주산업대학교 산업과학기술연구소 2003 산업과학기술연구소보 Vol.- No.10

In this paper, applications of adaptive fuzzy controller to position control of flexible beam are considered. When a flexible beam is rotated by a motor through the fixed end, transverse vibration may occur. The architecture and learning underlying adaptive networks based fuzzy inference system (ANFIS) is presented, which is a fuzzy inference system implemented in the framework of adaptive networks. By using a hybrid learning procedure, the proposed ANFIS can construct an input-output mapping based on both human knowledge and stipulated input-output data pairs. Therefor, a dynamic model for a flexible beam is derived, and then a comparative analysis was made with before learning and after learning adaptive fuzzy controller through an simulation. The results are presented to illustrate the advantages and improved performance of the proposed position control cver the after learning adaptive fuzzy controller.

에스트라다이올(17β-estradiol)과 에스트로겐 질항제 타목시펜에 의한 세포주기 조절 단백질 발션 조절

김창근,신순영,김정희,이영한 한양대학교 이학기술연구소 2005 이학기술연구지 Vol.8 No.-

타목시펨(tamoxifen)은 비스테로이성 triphenylethylene 유도체로서 항에스트로젠 기능과 유방암 성장을 억제시킨다. 그러나 함암효과에 대한 메카니즘은 완전히 밝혀지지 않았다. 본 연구에서 E2와 항에스트론제 타목시펜에 의한 세포주기 조절 단백질 변화능을 조사하였다. Tamoxigen(TAM)is a triphenylene antiestrogens which is known to inhibit the growth of some human breast cancer cells However the mechanism for the anti-tumor effect of TAM is not fully understood In the present study we investigated the effect of estradiol and TAM on the regulation of cell cycle progression.

아세클로페낙 연질캡슬(클란자 에스 연질캡슬)의 개발

용철순,이경희,최진석,박병주,정세현,김용일,박상만,배명수,김귀자,김영식,유창훈,강성룡,유봉규,이종달,최한곤 한국약제학회 2004 Journal of Pharmaceutical Investigation Vol.34 No.1

To develop and aceclofenac soft capsule, four preparations with various solubilizers were prepared and their dissolution test was carried out. Among four preparations tested, a preparation with ethanolamine was selected a formula of aceclofenac soft capsule (Clanza S^(™), since it showed the fastest dissolution rate. Bioequivalence of aceclofenac tablet, Airtal^(™)(Dae-Woong Pharmaceutical Co., Ltd.) and aceclofenac soft capsule, Clanza S^(™)(Korea United Pharmaceutical Co., Ltd.) was evaluated according to the guideline of KFDA. Fourteen normal male volunteers (age 20-25 years old) were divided into two groups and a randomized 2×2 cross-over study was employed. After oral administration of one tablet or capsule containing 100 ㎎ of aceclofenac, blood ws taken at predetermined time intervals and the concentration of aceclofenac in plasma wa determined with an HPLC method under UV detector. The pharmacokinetic parameters (C_(max), T_(max) and AUC_(t)) were calculated and ANOVA was utilized for the statistical analysis of parameters using logarithmically transformed AUC_(t), C_(max) and T_(max) between Airtal tablet and Clanza soft capsule were 2.89%, 0.18% and 43.0%, respectively. There were no sequence effects between two formulations in these parameters. The 90% confidence intervals using logarithmically transformed data were within the acceptance range of log(0.8) to log(1.250(e.g.log(0.81) - log(1.23) and log(0.89) - log(1.14)) for AUC_(t) and C_(max), respectively. Thus, the criteria of the KDFA guidelines for the equivalence was satisfied, indicating that Clanza S^(™) soft capsule is bioequivalent to Airtal^(™) tablet.