골수 유래 기질 줄기세포의 탐식작용 매개성 케모카인 수용체 발현 연구

정영신,변향민,신지영,김정목,정형민,오유경 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.4

To design gene delivery systems which can deliver higher amounts of genes into stem cells, we studied the expression of receptors involved in the receptor-mediated endocytosis of bone marrow stromal stem cells. Bone marrow was isolated from ICR mice, and bone marrow stromal stem cells were isolated based on their plastic adherence property. Several cultrure conditions were screened for effective and continuous culture of marrow stromal stem cells. MesenCult medium was finally used to cultivate marrow stromal stem cells in vitro. As candidate receptors, various chemokine receptors were studied. Both bone marrow cells and marrow-derived stromal stem cells showed expression of CC chemokine receptors (CCR) and CXC chemokine receptors (CXCR). Marrow stromal stem cells showed higher expression of CCR5 and CXCR4 chemokine receptors as compared to other types of chemokine receptors. Moreover, though the expression chemokine receptors generally decreased in most chemokine receptors with the cultivation of marrow stromal stem cells, CCR5 and CXCR4 chemokine receptors retained the higher lever of receptor expressions over prolonged periods. These results suggest that the ligands exhibiting specific binding to CCR5 or CXCR4 might be used to modify gene delivery systems for increased level of receptor-mediated gene delivery into stromal stem cells.

실비우스 수도를 경유한 뇌낭미충 낭종의 이주 -증례 보고-

김정훈,송준혁,김명현,박향권,김성학,신규만,박동빈 대한신경외과학회 1999 Journal of Korean neurosurgical society Vol.28 No.4

형질전환 제초제저항성 벼 밀양 204호의 농업적 특성

정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.

This study was conducted to investigated the major characteristics of genetically modified rice of "Milyang 204" originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Junambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of "Milyang 204" showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic "Milyang 204" showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the nontransgenic varieties rice.

고령인구에서 신기능 부전의 유병률과 위험인자

서정열,정수석,김향,이규백 대한신장학회 2004 대한신장학회잡지 Vol.23 No.1

이태리 문화유산의 생물손상

서정호,이향범 공주대학교 문화재보존과학연구소 2004 문화재과학기술 Vol.3 No.1

예술작품의 손상은 특히 많은 문화재를 보유한 이태리 같은 나라에서 커다란 문제가 되고 있다. 사실, UNESCO 보고에 따르면, 국제적으로 알려진 문화재의 2/3가 이태리에 있다고 한다. 고고학적 가치를 지닌 지역, 조각상, 건축물, 박물관, 교회와 유물, 지하 환경물 (동물 등)은 지정학적 위치, 오염수준, 인쇄물의 종류, 보존상태 등에 따라 다르지만 다양한 스트레스를 받기 쉽다. 이러한 모든 요인들이 다양한 양상의 생물적 공격에 영향을 끼친다. 석조물이 생물손상은 이태리 연구자들의 주요 관심분야 중의 하나이나 이외에도 서적, 유리, 목조 및 직물 등에서의 생물손상에 대해서도 관심을 보여 왔다. 이 연구의 재조사는 (i) 예술품의 생물손상에 영향을 주는 요소, (ii) 생물손상의 반응조직의 주요 범위, (iii) 연구자들이 진행하는 주요주제, 그리고 (iv) 이태리의 문화재 보존 생물손상 연구 분야 협회의 주요 업무를 파악하는 4가지 목적을 갖고 있다. The problem of deterioration of works of art is particularly relevant in countries like Italy that are rich in cultural heritage. In fact, following UNESCO data, in Italy are located 2/3 of the cultural heritage known in the world. Archeological areas, statues, buildings, museums, churches and items there located, hypogean environments, are subjected to different stresses due the geographical position, different degree of pollution, great variety of typology of materials and consequent status of conservation. All together these factors contribute to the different modality of biological attack. Biodeterioration can be defined as the irreversible loss of value and/or information of an object of art following the attack by living organisms. Biodeterioration of stone monuments is one of the principal field of interest of Italian researchers. However, other groups are also concerned with the biodeterioration of other materials as books, glass, wood textile and other materials. This review describes four main contents such as (i) factors affecting the biological deterioration of works of art, (ii) main groups of organisms responsible of biodeterioration, (iii) ongoing researches and main thematics, and (iv) main institutions and groups operating in the field of biodeterioration of cultural heritage in Italy.

식도를 포함한 전위장관을 침범한 전이성 악성 흑색종 1예

최정영,김준기,신성하,고영춘,조상욱,서강석,강명원,임연근,여향순,김경수 全南大醫大 2001 전남의대학술지 Vol.37 No.1

대학수학능력시험 수리영역의 특징과 97학년도 문항분석

신향근,양기열,정권수,송영무 順天大學校 師範大學 附屬 科學敎育硏究所 1996 科學과 敎育 Vol.4 No.-

Since the academic year of 1994, the Scholatic Ability Test(abbr. S.A.T) was given for students who wanted to get adimssions from universities and colleges in Korea. This test has revolutionized the pattern of teaching and learning mathematics in most highschool classrooms. In this paper, we will show a feature of S.A.T. and analyze mathematics problems of 1997's S.A.T.

위 전절제술을 받았던 환자에서 아급성 연합성 변성 1예

한정호,하현욱,이정석,송은향,김우정,김두응,최진영 건국대학교 의과학연구소 2000 건국의과학학술지 Vol.10 No.-

Subacute combined degeneration is a metabolic disorder of the spinal cord caused by vitamin B12 deficiency. A 72-year old man was admitted with weakness and tingling sensation of the bosh upper extremities. 9 years ago, he was diagnosed as having stomach cancer. So total gastrectomy with splenectomy was done at that time. The complete blood cell counts and morphology revealed megaloblastic anemia. Nerve conduction velocity study(NCV), electoromyography(EMG) and somatosensory evoked potentials(SEP) showed diffuse sensorimotor peripheral neuropathy. Magnetic resonance imaging(MRI) showed an increased T2-weighted signal, mild decreased T1-weighted signal, and slight contrast enhancement of the posterior columns of the cord in the cervical and upper thoracic spinal region. He was treated with vitamin B12 supplements and improved gradually. If abnormal sensation and muscle weakness was developed after gastrointestinal surgery, subacute combined degeneration should be considered in the differential diagnosis. We describe MRI findings of a typical case of subacute combined degeneration, which was induced by total gastrectomy.

최근 10년간 원광의대병원에서 시행한 소아 심장혈관 수술의 임상적 고찰

윤향석,정수미,최두영,오광수,오연균,김종덕,양현웅,이삼윤,김형곤,최종범,최순호,노병석 圓光大學校 醫科學硏究所 1995 圓光醫科學 Vol.11 No.2

We reviewed 10 years experiences of the clinical aspects and early postoperative results in 544 pediatric patients(age less than 16 years old). Among them. 529 cases had the congenital heart diseases, and 15 had the acquired diseases. Open heart surgery was performed in 413 patients. 115 cases were treated with non-open heart surgery. 16 with interventional catheterization. Annual increase of the cardiac patients was not significant in recent 10 years, except slight increase in 1994. The mean age of the study patients had been evidently changed to younger year by year. Total mortality rate of the open heart surgery was 6.4%. The cyanotic congenital heart diseases were high in early postoperative mortality by 25.7%, whereas 4% in acyanotic group. The age group less than one month was most highest in surgical mortality(66.7%). There were no deaths in patients with patent ductus arteriosus(103 cases), atrial septal defect(83 cases) or pulmonary stenosis(17 cases). Among 220 patients with ventricular septal defects(VSD). 10(4.5%) were died early postoperatively. In cyanotic group, the patients with pulmonary atresia with ventricular septal defects(PAVSD), transposition of the great arteries(TGA), interrupted aortic arch(IAA), complex cardiac anomalies with isomerism seemed to be most susceptible to an early death.

난소의 성숙 낭성 기형종에서 발생한 원발성 유암종 : 1예 보고 A case Report

조향정,민부기,문형배 圓光大學校 醫科學硏究所 2002 圓光醫科學 Vol.17 No.1

저자들은 우측 난소의 성숙 낭성 기형종에서 발생한 원발성 유암종 1예를 경험하였기에 문헌고찰과 함께 보고하는 바이다. 본 예는 수술 후 상부 소화기 내시경검사, 대장 내시경 검사 및 복부와 골반에 대한 전산단층촬영을 시행하였으나 특이 소견은 없었고 현재 6개월정도 추적 관찰중이다. The most common malignant change in cystic teratoma is squamous cell carcinoma, followed by carcinoid tumor and adenocarcinoma. Ovarian carcinoid tumor can be seen in the ovary as a metastasis of a tumor located in the gastrointestinal tract or elsewhere, as a component of adult cystic teratoma, or as a primary pure neoplasm of the ovary. The prognosis in primary carcinoid tumors (whether pure or as a component of cystic teratoma) is very good, whereas metastatic carcinoids have a poor outcome. We report a case of a primary carcinoid tumor arising in a mature cystic teratoma of the ovary that developed in a 38-year-old woman with a brief review of literature.