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역상 크로마토그래피에서 peptides의 용출 곡선에 따른 충진물 구조의 영향
최두영,이승기,노경호 한국화학공학회 2007 화학공학의이론과응용 Vol.10 No.1
크로마토그래피에서 용출되는 피크의 평형 또는 속도론적 특성을 파악하기 위해 모멘트가 사용된다. 1차 절대 모멘트 (μ₁)는 곡선 분포와 관련하여, 라플라스변환에 의해 계산된 체류시간의 분포를 나타낸다. 선형 등온 시스템의 경우, 1차 절대 모멘트 데이터는 흡착상수의 결정에 영향을 미친다. Intraparticle의 각 물질전달 단계에서 분리가 일어나고, 이것은 2차 중심모멘트(μ₂′)에 연관된다. 모멘트 방법을 적용하기 위한 수학적 모델식에서 충진물 입자 외부의 이동상에서의 축 방향 확산과 이동상과 입자간의 물질전달, 입자 내부에서의 확산, 그리고 입자 외부에서의 1차 가역흡착을 가정한다. 입자와 공극 크기가 다른 충진물에 의해서 intraparticle에서의 확산 영향을 모멘트 계산을 하여 예측 할 수 있다. μ₁은 컬럼 출구에서 시간에 따른 용질의 농도의 함수와 피크 면적의 관계로 계산된다. μ₂′는 총단의 면적과 체류시간과 1차 모멘트의 차의 제곱의 관계로 계산된다. 1, 2차 모멘트의 분포에서 컬럼 입구에서의 펄스는 무시된다고 가정한다. 모든 계산은 Microsoft(R) Excel 2000를 이용하였다. 컬럼 충전물질의 입자 크기(5, 15 ㎛), 세공 크기(100, 300 Å), 유속(0.5, 0.75, 1.0, 1.25, 1.5 ㎖/min)의 차이에 따른 3종류의 peptide (Angiotensin II, Bradykinin, Leucine)의 곡선으로부터 1, 2차 모멘트를 계산한 실험 결과 유속이 증가함에 따라 μ₁은 감소하였다. 동일한 입자 크기에서는 입자의 크기가 증가함에 따라 μ₂′는 감소하였고, 세공 크기가 증가함에 따라 μ₂′는 감소하였다.
최두영,박진영 한국고분자학회 2021 한국고분자학회 학술대회 연구논문 초록집 Vol.46 No.2
In this study, electrochemical impedimetric biosensors were fabricated by electropolymerization of molecular imprinted materials on the patterned gold electrode for detecting trypsin (Trp). The gold patterns were grown among the hexagonal close-packed polystyrene colloid particles through chronoamperometry to fabricate hemispherical pore-patterned gold surface. Trypsin imprinted poly(o-phenylenediamine) films (Trp-MIP) were synthesized through CV under the optimized conditions. Adsorption properties such as limit of detection and selectivity of the Trp-MIP on the gold pore-patterned electrodes were investigated using electrochemical impedance spectroscopy and CV. In addition, the quantity of adsorption was evaluated by quartz crystal microbalance (QCM). The thin patterned Trp-MIP films confirmed a higher imprinting factor (IF = 3.51) in 48 μg/mL of Trp concentration than non-imprinted polymer (NIP) films and showed excellent selectivity.
최두영,최선명,임길채,남순열 대한이비인후과학회 2002 대한이비인후과학회지 두경부외과학 Vol.45 No.7
Background and Objectives:The Voice Handicap Index (VHI) was developed to asses patients' perception on the severity of their voice disorders. The purpose of this study was to determine the severity of handicap expresed by patients with various voice disorders, and to help clinicians in making future treatment plan. VHI may also be used as a guideline in making diag-nosis according to diferent factors of voice quality. :The people who had visited the Asan Medical Center with hoarsenes from August 2000 to August 201 were studied. They filled out the questionnaire composed of 30 questions about their voice disorders. The subjects were consisted of 6 groups;50 patients with vocal cord nodule, 43 pati-ents with laryngitis, 42 patients with vocal cord polyp, 25 patients with glottic cancer and 14 patients with unilateral vocal cord paralysis. Descriptive statistics were used to analyze the data and mean value of VHI scores. Results:The mean score of VHI was found to be statistically higher in the subjects with the history of voice abuse (p<0.002). Overall, the group with unilateral vocal cord paralysis showed the highest VHI score that was statisticaly significant (p<0.001). When the functional factor is considered, groups with unilateral vocal cord paralysis and glottic cancer had shown higher scores compared to the other groups. When the physical factor is considered, groups with unilateral vocal cord paralysis and vocal cord polyp had shown higher scores. When the emotional factor is considered, groups with unilateral vocal cord paralysis had shown higher scores. Conclusion:verity of the problems that cannot be asesed through visual perception or objective acoustic and aerodynamic measures. In addition, the measurement of VHI score was easy to perform, non-invasive, and inexpensive. In using this method, we expect to reveal the efficacy of the treatment for voice disorders. (Korean J Otolaryngol 2002;45:706-10)
영화기획적 측면에서 본 각색영화 연구 -소설 『살인자의 기억법』을 각색한 영화 <살인자의 기억법>을 중심으로-
최두영 한국영상제작기술학회 2018 영상기술연구 Vol.- No.29
The purpose of this study is to examine the method of delivery of a novel and a film and the issues to be considered in adaptation for film planning development through comparison between the novel <Ma Memoire Assassine = Memoir of a Murderer> and the film <Memoir of a Murderer>. There are three different types of the relationship between a ‘novel’ and a ‘film’ in the manner of developing a ‘story.’ The first type is when a film faithfully represents a novel. The second type is when a film and a novel are harmoniously advocating each other. The third type is when a novel is only a starting point for a film. This research considers the interrelationship between the novel <Memoir of a Murderer> and the film <Memoir of a Murderer> as the second type, and demonstrates its thematic consciousness and aesthetic value. While the novel <Memoir of a Murderer> explores ‘the existential fears facing in two-fold nightmare which consists of the world around the protagonist and the world that he believes he has destroyed,’ the film <Memoir of a Murderer> simplifies it to ‘paternal love to save his daughter from the murderer.’ The novel <Memoir of a Murderer> abstracts protagonist narrator ‘s inner fear based on his memory and description, whereas the film <Memoir of a Murderer> spreads fear through the conflict behaviors between the hero and the serial killer. The reason why memory is adapted as a delusional behavior and the monologue as conflict is because novel has the power of narrative while film has the power of scenic composition. In this thesis the plot composition of the film <Memoir of a Murderer> is analyzed to present the practical considerations when adapting a novel to a film at the early stages of film planning.