A case report of chronic granulomatous disease presenting with aspergillus pneumonia in a 2-month old girl

이은,오석희,권지원,김병주,유진호,박찬정,홍수종 대한소아청소년과학회 2010 Clinical and Experimental Pediatrics (CEP) Vol.53 No.6

Chronic granulomatous disease (CGD) is an uncommon inherited disorder caused by mutations in any of the genes encoding subunits of the superoxide-generating phagocyte NADPH oxidase system, which is essential for killing catalase producing bacteria and fungi, such as Aspergillus species, Staphylococcus aureus,Serratia marcescens, Nocardia species and Burkholderia cepacia . In case of a history of recurrent or persistent infections, immune deficiency should be investigated. Particularly, in the case of uncommon infections such as aspergillosis in early life, CGD should be considered. We describe here a case of CGD that presented with invasive pulmonary aspergillosis in a 2-month-old girl. We confirmed pulmonary aspergillosis noninvasively through a positive result from the culture of bronchial alveolar lavage fluid, positive serological test for Aspergillus antigen and radiology results. She was successfully treated with Amphotericin B and recombinant IFN-γ initially. Six weeks later after discharge, she was readmitted for pneumonia. Since there were infiltrates on the right lower lung,which were considered as residual lesions, voriconazole therapy was initiated. She showed a favorable response to the treatment and follow-up CT showed regression of the pulmonary infiltrates.

Dynamics of Gut Microbiota According to the Delivery Mode in Healthy Korean Infants

이은,김병주,강미진,최길용,조현주,김영호,양송이,정영호,김현영,서주희,권지원,김효빈,이소연,홍수종 대한천식알레르기학회 2016 Allergy, Asthma & Immunology Research Vol.8 No.5

Microbial colonization of the infant gut is unstable and shows a wide range of diversity between individuals. Gut microbiota play an important role in the development of the immune system, and an imbalance in these organisms can affect health, including an increased risk of allergic diseases. Microbial colonization of young infants is affected by the delivery mode at birth and the consequent alterations of gut microbiota in early life affect the development of allergic diseases. We investigated the effects of the delivery mode on the temporal dynamics of gut microbiota in healthy Korean infants. Fecal samples were collected at 1-3 days, 1 month, and 6 months after birth in six healthy infants. Microbiota were characterized by 16S rRNA shotgun sequencing. At the first and third days of life, infants born by vaginal delivery showed a higher richness and diversity of gut microbiota compared with those born by cesarean section. However, these differences disappeared with age. The Bacteroides genus and Bacteroidetes phylum were abundant in infants born by vaginal delivery, whereas Bacilli and Clostridium g4 were increased in infants born by cesarean section. The Firmicutes phylum and Bacteroides genus showed convergent dynamics with age. This study demonstrated the effect of delivery mode on the dynamics of gut microbiota profiles in healthy Korean infants.

[Life] Health-``스트레스 공화국``…불면증 국민 54만 명

이은 연합뉴스 동북아센터 2017 마이더스 Vol.2017 No.8

[동화 부문] 그냥시계방

이은 아동문학평론사 2015 兒童文學評論 Vol.40 No.4

남해안지역 신석기시대 생업활동 연구 - 패총 출토 유물을 중심으로 -

이은 한국신석기학회 2016 한국신석기연구 Vol.- No.31

This paper was to find out the aspects of livelihood activities in the Southern coastal area during Neolithic Era through animal remains excavated from shell mound relics. First, we reviewed the Neolithic Era environment and distribution of the ruins and analyzed relics by dividing artifacts associated with livelihood activities excavated from ruins and animal remains into stone tools, bone tools and shellfish, fish, mammals, birds, respectively. As a result, various univalve shells, mussel and pacific oyster account for the majority in shellfish. Fishing activities were carried out by combined fishing and harpoons and fish excavated from Southern coastal area are mainly red sea-breams and various breams. Mammals are mainly sea lions of marine mammals and deer and wild pigs which are land mammals and can be seen to have been used as the main food resource and this is the same as the mammal aspect in the Korean peninsula during the Neolithic Era. It can be also seen that fishing activities were actively carried out in the southern coast where Yeoseodo Shell Mound, Ando Shell Mound and Dongsam-dong Shell Mound are located and there were exchanges with Jeju Island and European Region through the sea.

한 광역시공무원의 건강증진행위 실천도와 관련요인

이은,김기순,류소연 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Objective: This study was performed to investigate the relationship between practice of health promoting lifestyle and its related factors among civil servants in Gwang-Ju Metropolitan city. Methods: We enrolled 500 civil servants who worked in Gwang-Ju Metropolitan city hall by random sampling and 419 cases were analyzed. The collection of data was done by self-administered questionnaire which composed of the general characteristics, the occupational characteristics, health related activity, stress, self-efficacy and the Health Promoting Lifestyle Profiles (HPLP). We analysed the data by t-test, analysis of variance, Pearson's correlation analysis, and multiple regression analysis. Results: The mean score of HPLP was 113.6±19.8. In univariate analysis, HPLP was related to marital status, education level, business career, perceived health status, age, body mass index, stress and self-efficacy. As a result of multiple regression analysis, the statistically significant related factors with HPLP were business carrier, perceived health status, and self-efficacy. However, marital status, body mass index and stress were not statistically significant. Conclusions: We concluded that the health promoting activities were related with good subjective perception about their health status, high degree of self-efficacy and longer duration of business carrier.

양심과 자존심 가진 과학자들이 필요하다

이은,Lee, Eun 한국과학기술단체총연합회 2006 과학과 기술 Vol.39 No.6

외음부통증 환자 3례의 임상증례 보고

이은 대한한방부인과학회 2019 大韓韓方婦人科學會誌 Vol.32 No.4

Objectives: The purpose of this study is to report the effect of Korean medicine treatments on a vulvodynia. Methods: The patients appealed for chronic vulvar pain with no clear identifiable cause. Two patients suffered from generalized vulvodynia, one suffered from provoked vestibulodynia. They were treated by Korean medical treatments, such as herbal medicine, acupuncture and moxibustion. Results: After the treatment, the vulvar pain decreased. One suffered from provoked vestibulodynia succeeded in having non-painful penetrative sexual intercourse. Conclusions: This study shows that Korean medicine treatments were effective in reducing symptoms of vulvodynia.

Effect of Cinnamon Extract on the Inflammatory Response in the LPS-shock Rat

이은 한국자원식물학회 2015 한국자원식물학회지 Vol.28 No.3

This study measured the plasma and liver concentrations of cytokines, the distribution of blood lymphocyte subpopulations (CD4 and CD8), plasma levels of nitrite (NO3 –) and nitrate (NO2 –), intercellular adhesion molecule 1 (ICAM-1), cytokine-induced neutrophil chemoattractant 1 (CINC-1), prostaglandin E2 (PGE2), and peritoneal lavage fluid (PLF) levels of monocyte chemotactic protein 1 (MCP-1) and CINC-1 in order to examine the anti-inflammatory activity of the cinnamon extract in lipopolysaccharide (LPS)-exposed rats. The plasma concentrations of interleukin (IL)-1β, IL-6, and tumor necrosis factor α (TNF-α) were lower in the cinnamon extract groups than in the control group at both 2 and 5 h after LPS injection. Furthermore, the liver concentrations of IL-1β, IL-6, and TNF-α were lower in the cinnamon extract groups than in the control group at 5 h after LPS injection. Plasma IL-10 concentrations were higher in the cinnamon extract groups than in the control group at both 2 and 5 h after LPS injection, and liver concentrations of IL-10 did not differ significantly among all treatment groups at 5 h after LPS injection. The distribution of CD4 tended to increase, and that of CD8 tended to decrease in the cinnamon extract groups. The CD4/CD8 ratio was increased in the cinnamon extract groups. The plasma concentrations of NO3 –/NO2 –, ICAM-1, CINC-1, and PGE2 and the PLF concentrations of MCP-1 and CINC-1 exhibited a tendency to decrease in the cinnamon extract groups. These results indicate that cinnamon extract can exert functional anti-inflammatory effects.

Two Cases of Chloromethylisothiazolinone and Methylisothiazolinone-associated Toxic Lung Injury

이은,손승국,윤지선,조현주,양송이,정성수,도경현,조영아,이소연,박동욱,홍수종 대한의학회 2018 Journal of Korean medical science Vol.33 No.16

Previous animal studies have not conclusively determined the association between exposure to humidifier disinfectants (HDs) containing 5-chloro-2-methyl-4-isothiazolin-3-one (CMIT) and/or 2-methyl-4-isothiazolin-3-one (MIT) and development of HD-associated lung injuries. Nonetheless, patients exposed to HDs containing only CMIT and/or MIT showed clinically similar lung injuries to those exposed to HDs containing polyhexamethylene guanidine (PHMG) or oligo (2-[2-ethoxy]ethoxyethyl) guanidinium chloride (PGH). Here, we report twin sisters with lung injuries associated with exposure to CMIT/MIT-containing HDs. At 6 months of age, a younger twin sister presented with the 3-day history of cough, sputum, and respiratory difficulty. Chest radiography revealed multiple patchy consolidation and ground-glass opacities with pneumothorax and pneumomediastinum. Thoracostomy was performed due to pneumothorax at admission and she was discharged at 11 days of hospitalization. At 5 years of age, multiple tiny nodules and faint centrilobular ground-glass opacities were observed with the small pneumatocele. The elder sister visited a tertiary hospital due to dyspnea at 12 months of age. Chest radiography showed consolidation, pneumomediastinum, and pulmonary interstitial emphysema. There was no response to the administration of immunosuppressant drugs and antifibrotic agents. At 5 years of age, chest CT revealed ground-glass opacity and multiple tiny centrilobular ground-glass opacities nodules in both lungs with exercise intolerance.