Generalized Joint Hypermobility in Healthy Female Koreans: Prevalence and Age-Related Differences

권지원,이원재,박시복,김미정,장성호,최창권 대한재활의학회 2013 Annals of Rehabilitation Medicine Vol.37 No.6

Objective Objective To evaluate the prevalence of generalized joint hypermobility (GJH) in healthy female Koreans and to determine whether the degree of GJH differs between children and adults.Methods Two groups of females were enrolled, a group of girls from an elementary school (n=404) and women from a call center (n=266). GJH was diagnosed using the Beighton score, which is composed of an evaluation of bilateral knees, elbows, thumbs, and fifth fingers as well as thoracolumbar joint. The GJH and localized hypermobility of each joint was compared between the two groups, and the pattern of hypermobility according to age and dominant hand was investigated.Results Total prevalence of GJH was 50.0% (335/750), and it was more frequently observed in the group of girls (58.9%, 238/404) than women (36.5%, 97/266). The degree of GJH expressed in terms of Beighton score was inversely correlated with age (p<0.05). Significant differences in localized hypermobility of the thumb and fifth finger were found between the two groups and were postulated as the cause for the decline in GJH with age. The pattern of decreased mobility proportional to aging differed between the two joints. Decreased mobility occurred equally on both sides of the thumb but was biased toward the fifth finger of the dominant side (mostly the right).Conclusion The female Koreans appeared to have a high prevalence of GJH. The incidence of GJH decreased as age increased as a result of decreased mobility of the fifth finger on the dominant side.

서울교통공사의 Digital Transformation

권지원 한국IT서비스학회 2018 한국IT서비스학회 학술대회 논문집 Vol.2018 No.-

Changes in the Prevalence of Childhood Asthma in Seoul from 1995 to 2008 and Its Risk Factors

권지원,김병주,송영화,서주희,김태희,유진호,김효빈,이소연,김우경,김경원,지혜미,김규언,김호,홍수종 대한천식알레르기학회 2011 Allergy, Asthma & Immunology Research Vol.3 No.1

Purpose: To investigate the prevalence of asthma and determine its risk factors in elementary school students in Seoul. Methods: A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire was used to survey 4,731 elementary school students from five areas in Seoul between April and October, 2008. Results: In elementary school children, the lifetime and recent 12-month prevalence of wheezing were 11.7% and 5.6%, respectively. The lifetime prevalence of asthma diagnosis was 7.9%, and the recent 12-month prevalence of asthma treatment was 2.7%. Male sex (adjusted odds ratio [aOR], 1.90; 95% confidence interval [CI], 1.36–2.66), history of atopic dermatitis (AD) (aOR, 2.76; 95% CI, 1.98–3.84), history of allergic rhinitis (AR) (aOR, 3.71; 95% CI, 2.61–5.26), history of bronchiolitis before 2 years of age (aOR, 2.06; 95% CI, 1.39–3.07), use of antibiotics during infancy for >3 days (aOR, 1.88; 95% CI, 1.35–2.62), parental history of asthma (aOR, 2.83; 95% CI, 1.52–5.27), exposure to household molds during infancy (aOR, 1.84; 95% CI, 1.18–2.89), and the development or aggravation of asthma symptoms within 6 months after moving to a new house (aOR, 11.76; 95% CI, 5.35–25.86) were the independent risk factors for wheezing within 12 months. Conclusions:The prevalence of wheezing and asthma in elementary school students in 2008 was similar to that in the past decade. Male sex, history of AD, history of AR, history of bronchiolitis before 2 years of age, parental asthma, use of antibiotics during infancy, exposure to molds in the house during infancy, and development or aggravation of asthma symptoms within 6 months after moving to a new house, could be risk factors for wheezing within 12 months.

새로운 천식 표현형의 등장

권지원,홍수종 대한 소아알레르기 호흡기학회 2012 Allergy Asthma & Respiratory Disease Vol.22 No.2

Asthma is a complex and heterogeneous disease, which is comprised of seperate phenotypes sharing common characteristics, such as airway inflammation, bronchial hyperresponsiveness and variable airflow limitation. Traditionally, asthma phenotypes have been described by combinations of clinical characteristics, according to the expert’s recommendation, but they are now focusing on the pathobiologic mechanisms often using exploratory statistical methods. Several phenotypes and endotypes have been suggested by biased or unbiased phenotyping approaches. However, more detailed studies are still needed. In the future, more integrated large-scaled consortium of cohorts,including clinical information, genetics, molecular biology, and experiments will promote to understand the pathobiologic mechanisms of asthma phenotypes for the personalized therapy.

노안이란 무엇인가?

권지원 대한의사협회 2019 대한의사협회지 Vol.62 No.12

Presbyopia is an aging eye. All parts of our body may lose their function with aging. The representative aging diseases in the field of ophthalmology is cataract, and macular degeneration. Presbyopia is also a natural aging phenomenon that people has difficulty in focusing on near subject. There is a structure called lens in our eye and the function of lens is a refraction of lignt. Lens helps us focusing an object that we want to see with changing its thickness. When we try to focus on near subjects, ciliary muscle contracts to release the lens zonule and the lens becomes thicker. When we try to see far subjects, ciliary muscle relaxes and lens becomes thinner. These changes of lens thickness occurs very fast in young people, but with aging, the speed of changing the thickness of lens becomes slow. Finally, aged people can’t change the lens thickness and can’t focus on near subject without the help of near glasses and so on. In this case, we call it presbyopia.

Arthrodesis Using Bilateral Dual Iliac Screws with Autologous Iliac Bone Transfer for the Treatment of Pyogenic Sacroiliitis

권지원,신종관,문성환,이환모,이병호 연세대학교의과대학 2020 Yonsei medical journal Vol.61 No.2

Pyogenic sacroiliitis is a relatively rare condition that often leads to surgical treatment, including debridement and arthrodesis. Here we introduce a new surgical technique using bilateral dual iliac screws to secure early ambulation and maximal fusion successrate for the treatment of pyogenic sacroiliitis. We retrospectively reported a case and technical reports of pyogenic sacroiliitistreated by a new bilateral dual iliac screw fixation arthrodesis technique using radiologic outcomes, including plain X-rays and MRIscans, as well as outcomes based on the visual analogue scale for pain measurement. This technique improved uncontrolled pyogenicsacroiliitis with immediate stability that enabled ambulation and secured firm fixation for extensive evacuation of infecteddebris and subsequent autograft bone arthrodesis. In conclusion, we recommend bilateral dual iliac screw fixation for the treatmentof pyogenic sacroiliitis, as this technique can improve uncontrolled pyogenic sacroiliitis with immediate stability.

서울 송파지역 초등학생에서 알레르기비염 유병률과 항원 감작과의 관련성

권지원,홍수종,서주희,유진호,김병주,김효빈,이소연,김우경,김경원,지혜미,김규언,신의진,김명희,김호 대한 소아알레르기 호흡기학회 2011 Allergy Asthma & Respiratory Disease Vol.21 No.1

Purpose:We investigated the relationship between allergic rhinitis (AR) and allergen sensitization in students at an elementary school in Seoul. Methods:A modified International Study of Asthma and Allergies in Childhood (ISAAC) questionnaire survey was administered to 1,376 elementary school children in the Songpa area of Seoul. Serum total IgE, blood eosinophils, and skin prick tests for 18 common allergens were performed. Results:The prevalence of AR symptoms during the last 12 months and the current AR, defined as having AR symptoms during last 12 months with a history of AR diagnosis from the doctor, were 39.0% and 24.2%, respectively. Males were more likely to have current AR than females (26.6% vs. 21.5%, P=0.04). Independent risk factors for current AR were parental allergic disease (adjusted odds ratio [aOR], 3.78, 95% CI, 2.76-5.18), history of atopic dermatitis (AD; aOR, 1.47; 95% CI, 1.05-2.04), history of asthma (aOR, 3.48; 95% CI, 2.15-5.61), and higher maternal education (aOR, 1.42; 95% CI, 1.02-1.99). The subjects with higher quartiles of serum total IgE (P value for trend <0.001), more than 4% of eosinophil fraction (aOR 1.76; 95% CI, 1.24-2.48), and allergen sensitization house dust mites [aOR, 1.54; 95% CI, 1.10-2.15], dog [aOR, 2.95; 95% CI, 1.38-6.28], cat [1.85; 95% CI, 1.02-3.34], Alternaria [aOR, 2.37; 95% CI, 1.06-5.32] and late- blooming tree pollen mixture [aOR 2.26; 95% CI, 1.12-4.57] were more likely to have current AR. Conclusion:The prevalence of AR in children has increased during the last decade. The sensitization to common allergens and increased sensitization were associated with the development of current AR. House dust mites, dog, cat, alder, and Alternaria were the important allergens for current AR. 목적:본 연구는 서울지역 초등학생 알레르기비염 유병률 및 위험인자를 확인하기 위해 시행되었다. 방법:연구대상은 서울 송파지역 1개 초등학교 학생 1,376명(남아 740명, 여아 636명)이었고, 개량된 ISAAC 설문지를 통해 알레르기비염의 유병률 분석을 시행하였고, 알레르기 피부반응검사 및 혈액 내 총 IgE, 호산구 분율 검사를 시행하여 생체지표에 따른 현증 알레르기비염의 위험도를 분석하였다. 결과:설문지의 회수율은 98.3%였고, 대상군의 연령은 9.43±1.76세였고 남아가 746명, 여아가 636명으로 남녀의 비율은 53.8%, 46.2%였다. 최근 12개월 내 알레르기비염 증상 유병률은 39.0%, 알레르기비결막염 증상 유병률은 13.1%였으며, 평생 동안 의사에게 진단받은 알레르기비염의 유병률은 38.5%, 최근 12개월 내에 알레르기비염 치료 유병률은 29.5% 였다. 현증 알레르기비염의 유병률은 24.2 %였다. 현증 알레르기비염의 위험인자로는 아토피피부염 진단 병력(aOR=1.47, 95% CI 1.05-2.04), 천식 진단 병력(aOR=3.48, 95% CI 2.15-5.61), 부모의 알레르기질환(aOR=3.78, 2.76-5.18), 어머니의 대졸이상 학력 (aOR=1.42, 95% CI 1.02-1.99) 등이 있었다. 또한 호산구 분율이 높을수록(P value for trend =0.001), 혈청 IgE가 높을수록(P value for trend <0.001), 알레르겐 감작수가 많을수록(P value for trend <0.001) 위험도가 증가하였다. 집먼지진드기(1.54, 1.10-2.15), 개 항원(2.95, 1.38-6.28), 고양이 항원(1.85, 1.02-3.34), 오리나무 (2.71, 1.09-6.71), Alternaria 감작(2.37, 1.06-5.32)은 현증 알레르기비염의 독립적인 위험인자였다. 결론:서울 초등학교 알레르기비염 유병률은 과거 자료와 비교하여 증가하고 있으며, 아토피피부염과 천식의 병력, 부모의 알레르기질환력, 모의 높은 교육수준 등의 경우에 그 위험도가 높았다. 혈액 내 호산구 분율, 혈청 IgE, 알레르겐 감작수는 현증알레르기비염과 용량반응관계의 위험도를 보였으며, 집먼지진드기, 개, 고양이 항원, 오리나무, Alternaria는 서울 송파지역 초등학생 알레르기비염의 주요 원인 항원이었다.

서울 북부지역에 거주하는 정상 아동의 모발 미네랄 함량

권지원,김병의,박미정,김상우 대한소아청소년과학회 2006 Clinical and Experimental Pediatrics (CEP) Vol.49 No.1

Purpose : The reliability of hair mineral analyses regarding nutritional status, environmental exposure or diseases is controversial. The aim of this study was to determine the normal reference range of hair mineral concentration of Korean children. Methods : We examined hair mineral concentrations of 223 children(3-12 yrs old, 110 boys, 113 girls, mean age 8.8±2.2 yrs old) living in the northern area of Seoul. The trace elements including six toxic elements(Al, As, Cd, Ba, Hg, Pb) and 11 nutritional elements(Na, Mg, P, K, Ca, Cr, Mn, Fe, Cu, Zn, Se) were analyzed by inductive coupled plasma mass spectrometry(ICP-MS). Results : The mean concentrations of Ca and Mg were higher in girls than in boys. The mean concentrations of Cd, Pb and Cr were higher in boys than girls. The Zn, Ca, Mg, Cu and Hg levels in hair samples were positively correlated with increasing age. The Zn levels of the Korean children's hair samples appear to be lower than that of other countries' reference values. Conclusion : There are considerable differences in hair mineral concentrations by age, sex and race. Additional research is needed to establish Korean reference values, and to evaluate the usefulness of hair mineral analyses as a screening tool for nutrition- and environment-related childhood diseases. 목 적 : 영양상태, 환경 오염원에 노출, 질병상태의 한 검진 방법으로서 모발 미네랄검사의 타당성에 대해 아직 많은 이견이 있으며 아직 국내 정상 소아의 참고치는 연구된 바 없다. 이에 저자들은 건강한 아동들의 모발 미네랄 함량의 정상 참고치를 산출하고 그 특성을 알아보고자 하였다.방 법 : 서울시의 북부지역에 거주하는 3-12세 사이의 질병이 없는 건강한 정상 아동 223명(남아 110명, 여아 113명, 평균 연령 8.8±2.2세)을 대상으로 모발을 채취하여 유도결합플라즈마질량분석기(ICP-MS)를 통해 영양 미네랄 11가지(나트륨, 마그네슘, 인, 칼륨, 칼슘, 크롬, 망간, 철, 구리, 아연, 셀레늄)와 독성 미네랄 6가지(알루미늄, 비소, 카드뮴, 바륨, 수은, 납)의 함량을 측정하고 이를 분석하였다.결 과 : 칼슘 및 마그네슘의 농도는 여아에서 남아보다 높았고 카드뮴, 납 및 크롬의 농도는 남아에서 여아보다 높았다. 아연, 칼슘, 마그네슘, 구리 및 수은은 연령이 증가할수록 모발 중 함량이 증가하는 상관관계를 보였다. 한국 아동의 모발 미네랄 함량의 참고치를 외국과 비교하였을 때 우리나라 아동은 아연치가 외국에 비해 낮은 경향을 보였다.

컴퓨터 마우스를 이용한 저시력보조기구의 개발

권지원,김헌규,김성준,위원량,이진학,Ji Won Kwon,Hun Gyoo Kim,Sung Jun Kim,Won Ryang Wee,Jin Hak Lee 대한안과학회 2006 대한안과학회지 Vol.47 No.3

Comparison of the Prevalence of Low Back Pain and Related Spinal Diseases among Smokers and Nonsmokers: Using Korean National Health Insurance Database

권지원,하중원,이태성,문성환,이환모,박융 대한정형외과학회 2020 Clinics in Orthopedic Surgery Vol.12 No.2

Background: To compare the risk of low back pain (LBP) and related spinal diseases between smokers (exposure group) and nonsmokers (non-exposure group). No large registry study has so far investigated the association between smoking and LBP-related spinal diseases such as intervertebral disc disease, spinal stenosis, spinal instability, and spondylolisthesis. Methods: A random sample was taken from the Korean National Health Insurance Research Database. In total, 204,066 men (160,105 smokers, 43,961 nonsmokers) who were followed up between 2002 and 2013 were included in the analysis. Patients with previous back pain or spinal disease in 2003 and 2004, patients with inappropriate data, and women (due to the lower percentage of smokers) were excluded. The Cox proportional hazard model was used to investigate the risk of LBP and related spinal diseases associated with smoking, while adjusting for demographic, clinical, and socioeconomic factors. Results: The overall median follow-up period was 5.6 years (interquartile range, 3.48–8.43 years). Compared to the nonsmoker group, the smoker group had a higher incidence of LBP (p = 0.01), intervertebral disc disease (p < 0.001), spinal stenosis (p = 0.004), spinal instability (p < 0.001), and spondylolisthesis (p = 0.023). Compared to the nonsmoker group, the smoker group had a higher adjusted hazard ratio (HR) per year of LBP (HR, 1.18; 95% confidence interval [CI], 1.15 to 1.21), intervertebral disc disease (HR, 1.25; 95% CI, 1.21 to 1.30), spinal stenosis (HR, 1.52; 95% CI, 1.41 to 1.64), spinal instability (HR, 1.33; 95% CI, 1.24 to 1.44), and spondylolisthesis (HR, 1.49; 95% CI, 1.23 to 1.80). Conclusions: Smokers in male samples were at higher risk for LBP and related spinal diseases than nonsmokers.