대한천식알레르기학회 알레르기 면역요법 진료지침

이화영,강성윤,김경훈,김주희,류광희,민진영,박경희,박소영,성명순,이영수,양은애,지혜미,하은교,신유섭,이상민,정은희,최선희,고영일,김선태,남동호,박중원,심정연,안영민,한두희,한만용,이용원,최정희,대한천식알레르기학회 면역요법/알레르겐연구팀,Hwa Young Lee,Sung-Yoon Kang,Kyunghoon Kim,Ju Hee Kim,Gwanghui Ryu,J 대한천식알레르기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.3

Allergen immunotherapy (AIT) is a causative treatment of allergic diseases in which allergen extracts are regularly administered in a gradually escalated doses, leading to immune tolerance and consequent alleviation of allergic diseases. The need for uniform practice guidelines in AIT is continuously growing as the number of potential candidates for AIT increases and new therapeutic approaches are tried. This updated version of the Korean Academy of Asthma Allergy and Clinical Immunology recommendations for AIT, published in 2010, proposes an expert opinion by specialists in allergy, pediatrics, and otorhinolaryngology. This guideline deals with the basic knowledge of AIT, including mechanisms, clinical efficacy, allergen standardization, important allergens in Korea, and special consideration in pediatrics. The article also covers the methodological aspects of AIT, including patient selection, allergen selection, schedule and doses, follow-up care, efficacy measurements, and management of adverse reactions. Although this guideline suggests the optimal dosing schedule, an individualized approach and modifications are recommended considering the situation for each patient and clinic.

Characteristics of the Elderly Asthma

( Deok In Kim ),( Hyouk Soo Kwon ),( Woo Jung Song ),( Sang Min Lee ),( Sae Hoon Kim ),( Seong Wook Sohn ),( Chang Han Park ),( Heung Woo Park ),( Sun Sin Kim ),( Sang Heon Cho ),( Kyung Up Min ),( Yo 대한천식알레르기학회 2008 천식 및 알레르기 Vol.28 No.2

배경: 노인 천식은 한 보고에서 우리나라 유병률이 12.7%에 달하며 전세계에서 가장 빠르게 고령화 사회로 진입하고 있는 우리나라에서 점차 더 임상적으로 중요한 위치를 차지할 것이다. 노인 천식에 대한 다각적인 연구가 필요한 시점이다. 목적: 노인 천식에서 성별, 발병 연령 등에 따른 임상적 차이를 알아보고자 하였다. 방법: 분당서울대학교병원 천식 및 알레르기 클리닉을 방문한 65세 이상의 환자들을 대상으로 성별, 발병 연령에 따른 임상 양상에 대해 연구하였다. 65세 이전 발병의 경우를 조기 발병 천식, 65세 이후 발병의 경우를 후기 발병 천식으로 분류하였다. 결과: 총 180명 중, 81명이 조기 발병 천식, 99명이 후기 발병 천식이었다. 조기 발병 천식의 유병 기간은 18.8±17.1년, 후기 발병 천식은 3.4±3.5년이었다. 조기 발병 천식에서 천명음, 피부단자검사 양성, 기관지확장 소견이 더 높게 나타났으며, 기도 폐쇄 정도가 더 심하였으나, 천명 외의 다른 호흡기계 증상, 약물 요구 정도, 혈청 총 IgE에는 차이가 없었다. 일부 환자에서 유도객담을 분석하였고 후기 발병 천식에서 호중구 분율이 높았다. 결론: 65세 이상의 천식 환자를 일반적으로 노인 천식 환자라 부르고 있으나, 발병 연령에 따라 임상적인 차이가 있으며 후기 발병 천식에서는 호중구의 역할을 시사하는 연구결과를 보였다. 따라서 관련 연구 진행이나 진료에 있어 발병 연령에 따른 고려가 필요할 것으로 사료된다. (Korean J Asthma Allergy Clin Immunol 2008;28:98-104)

대한천식알레르기학회 설하면역요법 진료지침

류광희,지혜미,이화영,강성윤,김경훈,김주희,박경희,박소영,성명순,이영수,양은애,민진영,하은교,이상민,이용원,정은희,최선희,고영일,김선태,남동호,박중원,심정연,안영민,한만용,최정희,신유섭,한두희,대한천식알레르기학회 면역요법/알레르겐연구팀,Gwanghui Ryu,Hye Mi Jee,Hwa Young Lee,Sung-Yoon Kang,Kyunghoon Kim,J 대한천식알레르기학회 2024 Allergy Asthma & Respiratory Disease Vol.12 No.3

Allergen immunotherapy (AIT) has been used for over a century and has been demonstrated to be effective in treating patients with various allergic diseases. AIT allergens can be administered through various routes, including subcutaneous, sublingual, intra-lymphatic, oral, or epicutaneous routes. Sublingual immunotherapy (SLIT) has recently gained clinical interest, and it is considered an alternative treatment for allergic rhinitis (AR) and asthma. This review provides an overview of the current evidence-based studies that address the use of SLIT for treating AR, including (1) mechanisms of action, (2) appropriate patient selection for SLIT, (3) the current available SLIT products in Korea, and (4) updated information on its efficacy and safety. Finally, this guideline aims to provide the clinician with practical considerations for SLIT.

제 26 회 대한 천식 및 알레르기학회 추계학술대회 : 소아 천식 환자의 삶의 질에 대한 다기관 공동 연구

이하백(Ha Baik Lee) 대한천식알레르기학회 1999 대한천식알레르기학회 추계학술대회 초록집 Vol.1999 No.-

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제 26 회 대한 천식 및 알레르기학회 추계학술대회 : 한국의 성인 기관지천식환자의 삶의 질 평가를 위한 설문 - KAQLQ 의 개발 및 유용성 평가를 위한 다기관 연구

박중원(Jung Won Park),조유숙(You Sook Cho),이순영,남동호(Dong Ho Nahm),김윤근(Yoon Keun Kim),문희범(Hee Bom Moon) 대한천식알레르기학회 1999 대한천식알레르기학회 추계학술대회 초록집 Vol.1999 No.-

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제 26 회 대한 천식 및 알레르기학회 추계학술대회 : 직업과 기관지천식

박해심(Hae Sim Park) 대한천식알레르기학회 1999 대한천식알레르기학회 추계학술대회 초록집 Vol.1999 No.-

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소아천식환자에 대한 RAST 및 알레르기 피부검사의 진단적 가치 평가

이기영 대한천식알레르기학회 1987 천식 및 알레르기 Vol.7 No.2

RAST has been used frequently as a test to detect specific IgE for the diagnosis of atopic allergic diseases. But many reports have shown that RAST is correlated well with allergy skin test and not better than the latter in its significance for confirming causative allergens. The purpose of this study is to know whether RAST can detect the patients who could not be detected by allergy skin test. 108 cases who had asthma like symptoms and shown negative or equivocal reactions to D. farinae or D. pteronyssinus by allergy skin test as a screc.,'ng test were performed RAST with about 10 allergens which are frequently positive in Korean children including house dust mite allergen. In cases who were positive by RAST, allergy skin test with same allergens were performed and the results were analyzed. The results obtained from this study were as fol- lows: 1. Ninty-nine cases(91.6%) were negative to house dust mite allergen and only 9 cases(8.4%) showed equivocal or positive reactions to same allergen by RAST. 2. Seven out of 9 cases who had equivocal or positive reactions to house dust mite by RAST were per- formed allergy skin test with same allergen as a follow-up study. The result of allergy skin test on house dust mite was correlated very well with RAST. The possibility of correlation with RAST on the other 2 cases who had not performed allergy skin test were also discussed. 3. Twenty-one allergens other than house dust mite were equivocal or positive reactions by RAST. Allergy skin tests were performed with same allergens on these cases. Seven allergens (cat hair in 5 cases, house dust and ragweed in each case) were negative by allergy skin test. Therefore, it can be concluded that detection of house dust mite allergen by allergy skin test in the diagnosis of atopic respiratory diseases is reliable method because skin test is correlated very well with RAST. But it is recommendable to perform allergy skin test more than once in suspicious cases in diagnosis.

학생들의 식품알레르기 유병률 및 학교급식 식품알레르기 표시제에 대한 인식

이아현 ( Ah Hyun Lee ),김규언 ( Kyu Earn Kim ),이경은 ( Kyung Eun Lee ),김성희 ( Seong Hui Kim ),왕태환 ( Tae Whan Wang ),김경원 ( Kyung Won Kim ),곽동경 ( Tong Kyung Kwak ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3

Purpose: Prevalence of food allergy and perceptions on food allergen labeling in school foodservice among elementary, middle, and high school students were investigated in Korea. Methods: A total of 1,000 elementary, middle, and high schools were selected in 16 cities and provinces of Korea and students attending the schools were surveyed using a questionnaire modified from the Korean International Study of Asthma and Allergies in Childhood questionnaire in July 2012. Responses from 27,679 students were used for data analysis. Results: The ratio of the students who had experienced food allergy was 12.6%; 7.6% of the responding students had food allergy reactions last 12 months and 6.8% of the students had been diagnosed for food allergy by doctors. Eggs, milk, peach, and crabs were the most frequent allergenic foods for the elementary school 1st graders, 5th graders, middle, and high school students, respectively, who had experienced food allergy last 12 months. The students with food allergy read menus more frequently and were more interest in food allergen labeling in school foodservice than their counterparts. Both of the student groups with and without food allergy perceived food allergen labeling important for the students with food allergy and their parents. Conclusion: The prevalence of food allergy and major allergenic foods varied by school years. The Korean students had positive perception on allergic food labeling in school foodservice. An effective food allergen labeling system for school foodservice should be developed and implemented that reflects prevalence, symptoms, and food allergens among Korean students. (Allergy Asthma Respir Dis 2013;1:227-234)

소아 천식 환자에서 비염과 천식과의 관계: 알레르기비염과 비알레르기비염 비교

권은별 ( Eun Byul Kwon ),백지현 ( Ji Hyeon Baek ),김형윤 ( Hyeong Yun Kim ),윤정원 ( Jung Won Yoon ),신윤호 ( Youn Ho Shin ),지혜미 ( Hye Mi Jee ),최선희 ( Sun Hee Choi ),한만용 ( Man Yong Han ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3

Purpose: We aimed to determine the prevalence of allergic rhinitis and nonallergic rhinitis, difference in symptoms between allergic rhinitis and nonallergic rhinitis, and the association between lung function and the degree of asthma control in children with asthma. Methods: One hundred seventy patients who were followed-up for asthma treatment at the department of pediatrics of CHA Bundang Medical Center were enrolled in this study. We conducted the questionnaire regarding coexistence of rhinitis, childhood asthma control test (C-ACT), and the basic lung function test. The patients were classified as allergic rhinitis group and nonallergic rhinitis group according to the response to 11 common inhalation and food allergens, and assessed the degree of asthma control and the severity of rhinitis. Results: One hundred thirty patients (73%) were found to have rhinitis. Of these, 79 patients (53%) had allergic rhinitis and 34 patients (20%) had nonallergic rhinitis. The allergic rhinitis group was older than the nonallergic rhinitis group or the nonrhinitis group (7.73±2.85 vs. 5.97±2.48 vs. 6.12±2.70, P<0.001). Nasal itching sense was more prevalent in the allergic-rhinitis group than in the nonallergic rhinitis group (3.23±1.90 vs. 2.44±1.56, P=0.036). There was an inverse correlation between the rhinitis and C-ACT (r= -0.329, P<0.05). Of note, nasal obstruction symptom was highly correlated with C-ACT (r=-0.334, P<0.001). Conclusion: Allergic rhinitis and nonallergic rhinitis were highly prevalent in the pediatric patients with asthma and both of them had a significantly adverse impact on asthma control by rhinitis-itself. Therefore, regardless of atopic status, clinicians should focus on relieving rhinitis symptoms. (Allergy Asthma Respir Dis 2013;1:241-247)

부천지역 초등학생의 식품알레르기 발생 실태 및 다른 알레르기질환과의 연관성

박재영 ( Jae Young Park ),박가영 ( Ga Young Park ),한영신 ( Young Shin Han ),신미용 ( Mee Yong Shin ) 대한천식알레르기학회 2013 Allergy Asthma & Respiratory Disease Vol.1 No.3

Purpose: This study was performed to evaluate the current status of food allergy (FA) and to analyze the relationship between allergy to individual foods and other allergic diseases in elementary school children. Methods: We performed a questionnaire survey for FA, asthma, allergic rhinitis, and atopic dermatitis using International Study of Asthma and Allergies in Childhood questionnaires. A total of 1,929 students in 3 elementary schools were enrolled. Results: A total of 324 students (16.8%) had ever suffered from FA symptoms more than once. Only 64 out of 324 students (19.8%) were diagnosed with FA by doctors. The presence of soy allergy was associated with the increased risk of bronchial asthma (adjusted odds ratio [aOR], 5.90; 95% confidence interval [CI], 1.87 to 18.59). The presence of egg (aOR, 1.91; 95% CI, 1.04 to 3.52) and wheat allergy (aOR, 5.45; 95% CI, 1.94 to 15.36) were associated with the increased prevalence of allergic rhinitis. The allergic symptoms to fruits/tomato was associated with the increased risk of allergic rhinoconjunctivitis symptoms (aOR, 2.98; 95% CI, 1.18 to 7.47). The allergic symptoms to egg (aOR, 2.29; 95% CI, 1.22 to 4.29), wheat (aOR, 4.91; 95% CI, 1.86 to 12.95), and shrimp/crab (aOR, 2.48; 95% CI, 1.37 to 4.49) were associated with the presence of atopic dermatitis. Conclusion: The prevalence of FA of elementary school students in Bucheon-city was 16.8%. A significant positive association between the suspected foods and the other allergic diseases was found. Soy allergy was significantly correlated to having bronchial asthma and fruits/tomato allergy correlated with allergic rhinoconjunctivitis. (Allergy Asthma Respir Dis 2013;1:266-273)