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We had one female ALS patient. The patient was diagnosed with ALS by EMG and Symptoms. We diagnosed the patient as Jinshang(筋傷) and Pishenyangxu(脾腎陽虛). We gave Shaoyaogancao-tang jiami(芍藥甘草湯加味) and Sijunzi-tang he Lizhong-tang jiami(四君子合理中湯加味) based on the differentiation of symtoms. We report the changes of the ALS patient's disphagia, lalopathy, and hypotonia after two months treatment with Riluzole and oriental medical treatment.
Several children presenting with mild symptoms of respiratory tract infection were diagnosed with unclassified interstitial pneumonia with fibrosis. Their clinical and radiological findings were similar to those of acute interstitial pneumonia, but there were some differences in the pathological findings. Unclassified interstitial pneumonia with fibrosis is characterized by histological findings of centrilobular distribution of alveolar damage and bronchiolar destruction with bronchiolar obliteration. This report describes two different series of familial cases of unclassified interstitial pneumonia with fibrosis, which developed almost simultaneously in the spring. Some of the individual cases showed rapidly progressive respiratory failure of unknown cause, with comparable clinical courses and similar radiological and pathological features, including lung fibrosis. Each family member was affected almost simultaneously in the spring, different kinds of viruses were detected in two patients, and all members were negative for bacterial infection, environmental and occupational agents, drugs, and radiation. These findings implicate a viral infection and/or processes related to a viral infection, such as an exaggerated or altered immune response, or an unknown inhaled environmental agent in the pathogenesis of unclassified interstitial pneumonia with fibrosis.
We diagnosis two patients who have severe vertigo and gait inbalance as ‘dizziness due to retention of phlegm’ (痰暈) and gave Zexie-tang(澤瀉湯). They improved enable to walk balance and no more vetigo. Therefore we could assume that Ku-ren-xuan-mao(苦人眩冒) which is the main symptom of Zexie-tang means the vertigo and gait imbalance due to vestibular disorder.
- Effects of Galgeun (Pueraria radix) extracts on plasma and liver lipid composition, liver function andantioxidative capacity were investigated in rat fed high oxidized fat. Plasma total cholesterol and triglycerideconcentration increased in the high oxidized fat groups, however these values showed a tendency to decrease in theGalgeun extracts groups. Plasma HDL-cholesterol concentration revealed a tendency to increase in Galgeun extractsgroups. The concentration of liver total cholesterol showed no significantly different in all treatment groups, howeverliver triglyceride concentration showed a tendency to decrease in galgeun extracts groups. Thiobarbituric acid (TBARS)concentration in plasma and liver showed a tendency to decrease in galgeun extracts groups. The galgeun extractssamples have also decreased the plasma GOT and GPT activities, whereas they have increased the liver glutathioneperoxidase, superoxide dismutase and catalase activity.Key words - Galgeun (Pueraria radix) Extracts, Cholesterol, Triglyceride, Thiobarbituric acid, Glutathione peroxidase,Superoxide dismutase, Catalase
Interstitial lung disease in children (chILD) is a group of disorders characterized by lung inflammation and interstitial fibrosis. In the past recent years, we noted an outbreak of child in Korea, which is possibly associated with inhalation toxicity. Here, we report a series of cases involving toxic inhalational injury-associated chILD with bronchiolitis obliterans pattern in Korean children. This study included 16 pediatric patients confirmed by lung biopsy and chest computed tomography, between February 2006 and May 2011 at Asan Medical Center Children’s Hospital. The most common presenting symptoms were cough and dyspnea. The median age at presentation was 26 months (range: 12-47 months), with high mortality (44%). Histopathological analysis showed bronchiolar destruction and centrilobular distribution of alveolar destruction by inflammatory and fibroproliferative process with subpleural sparing. Chest computed tomography showed ground-glass opacities and consolidation in the early phase and diffuse centrilobular nodular opacity in the late phase. Air leak with severe respiratory difficulty was associated with poor prognosis. Although respiratory chemicals such as humidifier disinfectants were strongly considered as a cause of this disease, further studies are needed to understand the etiology and pathophysiology of the disease to improve the prognosis and allow early diagnosis and treatment.
Objectives : Bipolar disorder is an illness with significant morbidity and mortality that contributes to disturb social function. Our objective for this study is to revise Korean Medication Algorithm Project for Bipolar Disorder 2006 for rapid cycling. Methods : The questionnaires to survey the expert opinion of medication for rapid cycling were completed by the review committee consisting of 70 Korean expert psychiatrists. We classified the experts’ opinion to 3 categories based on the lowest category in which the confidence interval fall (6.5≤ for first-line and 3.5≤ for second-line treatment). Results : The first-line treatment is the combination of a mood stabilizer and an atypical antipsychotic. Combination of two mood stabilizers was preferred as next strategy. The first-line medications in all cases are valproic acid, lithium, quetiapine, and olanzapine. For the treatment of depressive phase, lamotrigine is the first-line medication. Conclusion : Compared to the surveys in 2006, the preference for lamotrigine and atypical antipsychotics has increased while that of carbamazepine and antidepressant has decreased. (J of Kor Soc for Dep and Bip Disorders 2011;9:103-108)
This study was carried out to effects of Allium victorials extract on lowering lipid, anti-oxidation andconcentration of inflammatory mediators in rats fed high oxidized fat. Concentration of free fatty acid(FFA),triglyceride(TG), total cholesterol and LDL-cholesterol in plasma decreased in the Allium victorials extract groups andplasma HDL-cholesterol concentration revealed a tendency to increase in Allium victorials extract groups. Concentration oftotal cholesterol and TG in liver showed a tendency to decrease in Allium victorials extract groups. Concentration ofthiobarbituric acid(TBARS) in plasma and liver showed a lower values in Allium victorials extract groups than that ofcontrol group. Activities of glutathione peroxidase(GSH-Px), superoxide dismutase(SOD) and catalase(CAT) in livershowed a tendency to increase in Allium victorials extract groups. Concentration of nitrogen oxide(NO), ceruloplasmin and α1-acid glycoprotein in plasma showed a lower values in Allium victorials extract groups than that of control group. Theseresults indicate that the Allium victorials extract have an functional material for lowering lipid, anti-oxidation andanti-inflammatory effect. 본 연구는 산마늘추출물이 과산화지질을 급여한 비만쥐의 지질강하, 항산화효과 및 염증매개물질의 생산에 미치는 영향을 검토했다. 그 결과 혈장 FFA, TG, totalcholesterol 및 LDL-cholesterol 농도는 산마늘추출물 처리군 들에서 감소했으며, 혈장HDL-cholesterol 농도는산마늘추출물 처리군 들에서 증가했다. 간장 내 totalcholesterol 농도 및 TG 농도는 산마늘추출물 처리군 들에서 감소하는 경향을 나타내었다. 혈장 및 간장의 TBARS농도는 산마늘추출물 처리군 모두가 대조군보다 낮은 경향을 보였다. 간장 GSH-Px, SOD 및 CAT활성치모두가 산마늘추출물 처리군 들에서 증가하는 경향을 보였다. 혈장NO, Ceruloplasmin 및 α1-acid glycoprotein 농도는 산마늘추출물 투여군 들이 대조군보다 낮은 경향을 나타내었다. 이와 같은 결과는 산마늘추출물에 지질강하, 항산화 및항염증작용에 효과를 나타내는 기능성물질이 내재하고 있음을 시사한다.