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간경변증 환자에서 식도정맥류 출혈의 계절적 변화의 관련 요인 분석
이선해 ( Sun Hae Lee ),김선주 ( Sun Joo Kim ),정승원 ( Seung Won Jung ),김지욱 ( Ji Wook Kim ),김환열 ( Hwan Yeol Kim ),김영훈 ( Young Hoon Kim ),이보영 ( Bo Young Lee ),함정호 ( Jeung Ho Ham ),김인호 ( In Ho Kim ),정일권 ( Il ksu 대한소화기학회 2002 대한소화기학회지 Vol.40 No.6
Background/Aims: The circadian variation of portal blood pressure and diurnal incidence of esophageal variceal bleeding (EVB) is well known, but the seasonal variation of EVB is still controversal. This study was performed retrospectively to evaluate the seasonal variation of EVB in patients with liver cirrhosis. Methods: Three hundred and seventy-five liver cirrhotic patients with EVB were enrolled. We evaluated the seasonal variation of EVB and correlations between bleeding and other clinical factors including recent alcohol intake. Results: The incidence of EVB was highest in April (50% higher than the monthly average), followed by March and lowest in July and August (45.8% lower than the monthly average), which did not reach statistical significance. The pattern of seasonal variation in patients with a history of recent alcohol intake was similar to that in the overall patient population, whereas the incidence of EVB was highest in December and lowest in August in patients without a history of recent alcohol intake. This may indicate that a history of recent alcohol intake is an important factor for EVB. Other factors such as age and Child-Pugh classification did not correlate with the seasonal variation of EVB. Conclusions: There seems to be a seasonal variation of EVB in patients with liver cirrhosis and alcohol intake may affect this seasonal variation. This result could be explained by the fact that the spring is a busy farming season and suitable for drinking in a rural district. (Korean J Gastroenterol 2002;40:386-393)
젊은 성인에서 흡연에 의한 상완동맥 내피기능의 부전에 관한 연구
이상철,권영주,방덕원,이선해,이보영,김지욱,김영훈,온영근,현민수,김성구 순천향의학연구소 2002 Journal of Soonchunhyang Medical Science Vol.8 No.1
Background and Objectives : Cigarette smoking is a major factor and the most modifiable risk factor for atherosclerosis. Endothelial dysfunction is an early event in atherosclerosis, before the structural change of the systemic arteries. We hypothesized that endothelial dysfunction might be present in the systemic arteries of young adult smokers and that this might be dose-dependent phenomenon. Therefore, we try to certify that smoking is associated with endothelial dysfunction in healthy young adults without other risk factor of atherosclerosis. Subjects and Methods : we studied noninvasively 29 subjects aged 3 to 4 decades without other risk factor of atherosclerosis, they were composed of the two groups, current smokers(n=15) and nonsmokers(n=14). Smoking history varied from 3 to 20 pack years. Using high-resolution ultrasound, vessel diameter and mean flow rate were measured at rest, during reactive hyperemia(with flow-mediated endothelium-dependent dilation), and after sublingual nitroglycerin(NG-induced endothelium-independent vasodilation). Result : Flow mediated endothelium dependent dilation was observed in the control subjects (9.4±3.44%) but was impaired in the smokers(5.8±2.51%)(p=0.004). NG-induced endothelium independent dilation is no difference in all subjects. Conclusion : Cigarette smoking is associated with endothelial dysfunction in healthy young adults.
최수정,김영석,김나리,정승원,이선해,정준성,류권호,차상우,홍수진,유창범,문종호,김연수,이문성,심찬섭,김부성,권계원,김병용 대한간학회 2002 Clinical and Molecular Hepatology(대한간학회지) Vol.8 No.4
Hepatocellular carcinoma is one of the most common causes of death in Koreans. Most cases of hepatocellular carcinoma are beyond the stage of curative resection at the time of diagnosis due to extrahepatic metastasis as well as wide distribution of tumor in the liver. The lung is the most common site of extrahepatic metastasis but metastasis to gingiva is very rare in hepatocellular carcinoma. We report a case hepatecellular carcinoma with gingival methststasis in a 59 year old male patient.(Korean J Hepatol 2002;8:495-499)