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재생불량성 빈혈의 병태생리에서 Fas 항원과 Apoptosis의 역할
원종호,이남수,김숙자,정희정,이규택,박성규,백승호,김성일,홍대식,박희숙,Won, Jong-Ho,Lee, Nam-Su,Kim, Sook-Ja,Cheong, Hee-Jeong,Lee, Kyu-Taeg,Park, Seung-Kyu,Baick, Seung-Ho,Kim, Sung-Il,Hong, Dae-Sik,Park, Hee-Sook 대한면역학회 2002 Immune Network Vol.2 No.1
Background: Clinical observations and laboratory studies have supported an immune basis for most acquired aplastic anemias, with the majority of patients responding to immunosuppressive therapy. Fas, a member of the tumor necrosis factor (TNF) receptor superfamily is a critical downregulator of cellular immune responses. Proinflammatory cytokines like interferon gamma (IFN-${\gamma}$) and TNF-${\alpha}$ can induce Fas expression and render hematopoietic progenitor cells susceptible to Fas-induced growth suppression and apoptosis. Methods: In order to investigate the involvement of apoptosis in the pathogenesis of aplastic anemia (AA), we measured the expression of Fas antigen and caspase-3 on bone marrow (BM) mononuclear cells (MNCs) of AA in the presence or absence of IFN-${\gamma}$, TNF-${\alpha}$, or macrophage inflammatory protein 1-${\alpha}$ (MIP-$1{\alpha}$). Results: We confirmed that AA BM MNCs were more apoptotic and highly expressed Fas antigen than normal donors. Stimulation by IFN-${\gamma}$, TNF-${\alpha}$, or MIP-$1{\alpha}$ increased Fas antigen and caspase-3 expression in AA BM MNCs than BM MNCs of normal donors. Anti-Fas monoclonal antibody enhanced IFN-${\gamma}$, TNF-${\alpha}$, or MIP$1{\alpha}$ mediated caspase-3 expression in BM MNCs of normal donors. Among these three cytokines, IFN-${\gamma}$ enhanced apoptosis most strongly via Fas-caspase-3 pathway. Conclusion: These results suggest that Fas signal pathway may play a role in the pathophysiology of aplastic anemia and negative hematopoietic regulators like IFN-${\gamma}$ can induce apoptosis of bone marrow progenitors in part by Fas induction.
원종호,박원규,김주환,김건희,Won, Jong-Ho,Park, Won-Kyoo,Kim, Ju-Hwan,Kim, Geon-Hee 한국기계가공학회 2003 한국기계가공학회지 Vol.2 No.1
Machining technique for optical crystals with single point diamond turning tool is reported in tills paper. The main factors influencing the machined surface quality are discovered and regularities of machining process are drawn. Optical crystals have found more and more important applications in the field of modern optics. Optical crystals are mostly brittle materials of poor machinability The traditional machining method is polishing which has many shortcomings such as low production efficiency, poor ability to be automatically controlled and edge effect of the workpiece. SPDT has been widely used in manufacturing optical reflectors of non-ferrous metals such as aluminum and copper which are easy to be machined for their proper ductility. But optical crystals being discussed here are characterized by their high brittleness which makes it difficult to obtain high quality optical surfaces on them. The purpose of our research is to find the optimum machining conditions for ductile cutting of optical crystals and apply the SPDT technique to the manufacturing of ultra precision optical components of brittle materials. As a result, the cutting force is steady, the cutting force range is 0.05-0.08N. The surface roughness is good when spindle is above 1400rpm, and feed rate is small. The influence of depth of cut is very small.
원종호,이용우,Won, Jong-Ho,Lee, Young-Woo 한국해양학회 2015 바다 Vol.20 No.1
동해남부연안에서 해수 중 해양환경특성의 시공간적 분포양상을 살펴보기 위해서 2012년 5월부터 2013년 2월까지 계절별로 현장조사를 실시하였다. 표층수 중 영양염류(용존무기질소, 용존무기인, 용존무기규소)의 농도는 봄과 여름에 비해 수직혼합이 활발하게 일어나는 가을과 겨울에 높게 나타났다. 여름에 chlorophyll a 농도가 높게 나타나 이 시기에 낮은 영양염 농도는 밀도약층의 강화로 인한 아표층으로부터 영양염류의 공급 감소와 식물플랑크톤의 광합성에 의한 소비로 판단된다. 반면 봄에는 chlorophyll a 농도가 낮게 나타나 봄에 표층수 중 낮은 영양염 농도는 육상 및 아표층으로부터 영양염류의 공급 감소에 의한 것으로 판단된다. 조사기간 동안 표층수와 저층수 중 용존무기질소와 용존무기인의 비는 각각 연평균 15.6, 14.8로 유사하였으나, 표준편차는 각각 13.6, 4.2로 표층수가 저층수에 비해 상대적으로 크게 나타났다. 특히, 봄에 용존무기질소에 대한 용존무기인의 비가 상대적으로 낮게 나타나(평균 $8.35{\pm}4.67$) 이 시기에 용존무기질소가 식물플랑크톤의 성장에 제한인자로써 작용했을 것으로 판단된다. In order to elucidate the spatiotemporal variations of marine environmental parameters, we collected seawater samples in the south-western region of the East Sea in May, August, and November 2012 and February 2013. The concentrations of dissolved inorganic nutrients (dissolved inorganic nitrogen, phosphorus, and silicate) in surface seawater during the summer season were lower than those during autumn and winter seasons, which the mixed layer is deeper. The low nutrient concentration in spring and summer seasons seems by consumption of dissolved inorganic nutrients by phytoplankon photosynthesis (high chlorophyll a concentration) and the limited supply of dissolved inorganic nutrients from subsurface layer having high nutrients. The low nutrient concentration during spring season seems to be related to the limited supply of dissolved inorganic nutrients from land and subsurface layer because the concentration of chlorophyll a was low. The DIN:DIP ratio was a wide range of average $15.6{\pm}13.6$ in the surface seawater compared to that of average $14.8{\pm}4.2$ in the bottom seawater during sampling periods. The dissolved inorganic nitrogen might act as a limiting factor of the growth of phytoplankton because the DIN:DIP ratio (on average $8.35{\pm}4.67$) was low during the spring season.
원종호,박원규,김주환,김건희,Won, Jong-Ho,Park, Won-Kyoo,Kim, Ju-Hwan,Kim, Geon-Hee 한국기계가공학회 2003 한국기계가공학회지 Vol.2 No.1
The aspherical lenses are used as objective lens of optical pickup. To examine the design factor the sample product is made before manufacturing of injection mould of lens. The optimum cutting condition of PMMA lens sample with ultra precision SPDT, the roam spindle speed, the depth of cut, the feedrate are found. The demanded surface roughness 100m Ra, aspherical form error $0.5{\mu}m$ P-V for aspherical lens of optical data storage device are satisfied.
경화처리된 (硬化處理) 탄소강의 (炭素鋼) 마찰가공에 의한 표면 거칠기의 비교에 관한 연구
원종호(Jong Ho Won) 대한공업교육학회 1980 대한공업교육학회지 Vol.5 No.2
Friction-working which is one of the precision finishing methods makes the surface smooth effectively by sliding motion under the pressure of the hard material to the soft material. The minimum surface roughness and the optimum working conditions when the medium carbon steels of the various surface structure were friction-worked with the tungsten carbide were compared in this paper. Lublication oil for machine tool were used in friction-working and the surface roughness of specimen was kept to be constant at 0.3μ Ra with the grinding process in this study. main results were obtained as follow; 1) If the structure and hardness of midium carbon steel varied with heat-treatment, though their chemical compositions are same, the inflection points apear at different position as the method or the degree of heat-treatment. 2) The magnitude of contact load does not depend upon hardness only. 3) The minimum surface roughness of hardened carbon steel is worse than that of carbon steel which is not hardened. 4) Even if the hardness of medium carbon steel become higher with heat treatment, the optimum values of contact load to be minimum surface roughness are almost between 30-40㎏, and the optimum sliding speed is 150~250m/min. at material 1 and 150m/min., 100m/min. at each material 2, material 3.
EAI기반의 장애인정보 레파지터리 구성을 위한 정보연계 모델
원종호 ( Jong-ho Won ),황종선 ( Chong-sun Hwang ) 한국정보처리학회 2004 한국정보처리학회 학술대회논문집 Vol.11 No.2
지식정보화 사회에서는 정부기관 간 정보연계가 정보의 원활한 운영을 위해서는 필수적인 요소가 되었다. 하지만, 효율적이고 체계적인 정보연계를 위해서는 서비스 제공 측면뿐만이 아니라 DB관리, 연계대상, 확장성 등을 종합적으로 고려한 정보 레파지터리가 필요하고, 이를 위해서는 보다 효과적인 정보연계 모델이 필요하다. 특히 산재되어 있는 장애인 정보는 기관간의 독립적인 정보시스템에 의해 정보연계가 물리적인 기법과 서비스적 측면에 한정되어 있다. 이에 따라 본 논문에서는 연계의 용이성 및 효율성을 고려한 EAI 기반의 장애인정보 레파지터리 정보연계 모델을 제시한다. EAI 구조는 데이터 라우팅 등으로 이기종간의 정보연계를 용이하게 해주며, 장애인정보 레파지터리는 기존 서비스측면의 정보연계의 한계점을 극복할 수 있는 형태이다. 이로써 본 논문에서 제시한 연계모델을 이용하여 저비용고효율의 정보연계가 가능하게 되어 정부/공공기관 간 정보교류가 활발히 이루어질 수 있을 것이다.
철근이 부식된 철근콘크리트 벽체의 구조성능 평가에 대한 실험적 연구
원종호 ( Won¸ Jong-ho ),한남희 ( Han¸ Nam-hee ),정란 ( Chung¸ Lan ) 한국구조물진단유지관리공학회 2000 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.4 No.2
This paper presents an experimental study on evaluation of structural performance on corroded reinforced concrete walls under only axial load. This test was carried on the thirty-nine reinforced concrete walls with 120×300×500mm size subjected to combined axial load. Effects of key variables such as the corrosion level, the number of horizontal bar, the corrosion rate are studied in this program. The results of this study show that the capacity of wall axial force was decreased as corrosion level was increased, especially, rapid development was shown after 9% corrosion level. Also it was found that influence of corrosion was decreased to number of horizontal bar was increased.