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박광식,손기영,황유식,김정아,정일천,신재일,박지민,안선영,유철주,이재승,Park, Kwang-Sik,Son, Ki-Young,Hwang, You-Sik,Kim, Joung-A,Cheung, Il-Chun,Shin, Jae-Il,Park, Ji-Min,Ahn, Sun-Young,Lyu, Chuhl-Joo,Lee, Jae-Seung 대한소아신장학회 2007 Childhood kidney diseases Vol.11 No.2
목 적 : 세계적으로 급성 신부전을 가진 소아중환자의 경우 신대체요법으로서 CRRT가 우선적으로 적용되고 있는데 국내에서 CRRT에 대한 치료 결과나 이에 미치는 예후인자에 대한 연구가 드문 설정이다. 이에 저자들은 CRRT를 시행 받은 소아 환자군을 대상으로 치료결과와 예후인자를 알아보기 위해 본 연구를 시행하였다. 방 법 : 2003년 1월부터 2006년 12월까지 세브란스 어린이병원 소아과에서 CRRT를 시행 받은 소아 중환자 32명을 대상으로 하여 환자들이 입상적 특징과 생존율, 그리고 이에 미치는 예후인자를 생존군과 사망군으로 나누어 비교하였다. 결 과 : 총 32명의 평균 나이는 7.5세로 범위는 생후 4일에서 16살까지였고 평균 몸무게는 25.8kg로 최소 3.2kg 최고 63kg였다. 기저 질환 중 조혈모세포이식과 악성종양 환자군이 가장 많았고, 이 군에서 생존율이 가장 낮았다. 전체 생존자는 11명으로 생존율은 34.4%였고 예후인자에 대한 연구에서 CRRT 시작시 PRISM III 점수($9.8{\pm}5.3$ vs. $26.7{\pm}7.6$, P<0.0001), 승압제 사용 수 ($2.1{\pm}1.2$ vs. $3.0{\pm}1.0$, P=0.038)와 수분 저류 정도 (%FO, $5.2{\pm}6.0$ vs. $15.0{\pm}8.9$, P=0.002)가 사망군보다 생존군에서 의미 있게 낮았다. 또 다중 회귀분석을 통해 높은 수분 저류만이 독립적 위험인자임을 확인하였다. 결 론 : 저자는 이 연구를 통해 소아 급성 신부전 환자에서 생존율이 환자의 중증도와 체내 수분 저류와 연관성이 높다는 것을 확인하였고, 환자의 전신상태가 보다 좋을 때 특히 수분 저류가 시작되기 전에 CRRT를 빨리 시작하는 것이 생존율을 높일 수 있다는 결론을 얻을 수 있었다. Purpose : Continuous renal replacement therapy(CRRT) has been the first choice for the treatment of acute renal failure in critically ill children not only in western countries but also in Korea. However, there are very few studies that have analyzed the outcome and prognosis of this modality in Korean children. We performed this study to evaluate the factors associated with the outcome and prognosis of patients treated with CRRT. Methods : We retrospectively reviewed the medical records of 32 children who had received CRRT at Severance hospital from 2003 to 2006. The mean age was 7.5 years(range 4 days-16 years) and the mean body weight was 25.8 kg (range 3.2-63 kg). Results : Eleven(34.4%) of the 32 patients survived. Bone marrow transplantation and malignancy were the most common causes of death and underlying disease leading to the need for CRRT Mean patient weight, age, duration of CRRT, number of organ failures, urine output, estimated glomerular filtration rate(eGFR), C-reactive protein, and blood urea level did not differ significantly between survivors and nonsurvivors. (1) Pediatric risk of mortality(PRISM) III score at CRRT initiation($9.8{\pm}5.3$ vs. $26.7{\pm}7.6$, P<0.0001), (2) maximum pressor number ($2.1{\pm}1.2$ vs. $3.0{\pm}1.0$, P=0.038), and (3) the degree of fluid overload($5.2{\pm}6.0$ vs. $15.0{\pm}8.9$, P=0.002) were significantly lower in survivers than in nonsurvivors. Multivariate analysis revealed that fluid overload was the only independent factor reducing survival rate. Conclusion : CRRT was successfully applied to the treatment of acute renal failure in a wide range of critically ill children. To improve survival, we suggest the early initiation of CRRT to prevent the systemic worsening and progression of fluid overload in critically ill children with acute renal failure. (J Korean Soc Pediatr Nephrol 2007;11:247-254)
박광식,최필선,이상협,이철우,류지성,최성수,류홍일,최덕일,Park, Kwang-Sik,Choi, Pil-Son,Lee, Sang-Hyeop,Lee, Chul-Woo,Rhu, Ji-Sung,Choi, Sung-Su,Rhu, Hong-Il,Choi, Doug-Il 한국독성학회 1998 Toxicological Research Vol.14 No.3
Endocrine disruptor is an exogenous substance that changes endocrine function and causes adverse effects at the level of the organism, its progeny, and/or (sub)populations of the organisms. Purported adverse effects are cancers, declines in reproductive health, developmental learning disabilities in humans, and declining populations, altered morphology, physiology or behavior in wildlife. In these days, expert groups on chemicals in IPCS, IFCS and OECD are intensively discussing the identification of endocrine disruptors and the proper management of those chemicals. In this study, we screened the endocrine disrupting effects of lead using fertilized eggs of Oryzias latipes. In brief, the eggs were exposed to lead with different concentrations at Ringer's solution, and the mortality, the incidence of deformation, the body movement and the hatching success were determined after incubation. The histological analysis of normal and deformed larvae was also carried out. Compared to control, the mortality and the heart rate of eggs and/or larvae increased, but the hatching success and the tail movement decreased. The morphological observation showed the asymmetrical deformation of larvae and the distortion of spinal cord. The absorption of the liquid in yolk sac was hindered. The adverse effects of lead in the ontogeny of fertilized eggs of Oryzias latipes seemed to be stronger in pH5.6 than in pH7.5 solution. In summary, lead showed adverse effects on the ontogeny of fish fertilized eggs plays critical role in regulating biological systems and controlling developmental processes as an endocrine disruptor.
고장력 압력용 기강 용접부의 고온균열 발생률과 선형 중회귀 분석과의 관계
박광식(Kwang-Sik Park) 산업기술교육훈련학회 2012 산업기술연구논문지 (JITR) Vol.17 No.4
This paper was to study the solidification crack generation of a root pass in one side FCAW process on the SPPV490 is a high strength pressure vessel steel on the 590MPa class and SWS400 is a welding structure steel. A main parameters of it were welding materials and welding conditions. For the purpose of it, a shape coefficiency and linear regression analysis were used. And then the crack generation rate was discussed to the SPPV490 and SWS400.
항공사 마일리지 적립의도에 따른 FFPs 보상서비스 선호가치 분석
박광식(Kwang Sik Park),윤문길(Moon Gil Yoon) 한국경영과학회 2010 經營 科學 Vol.27 No.3
This paper focuses on frequent flyer programs (FFPs), which have long been used by most airlines as a powerful marketing tool. Since the preference for FFPs reward services and the customer perceived values of mileage points differ among FFPs members, airlines should design a customer-oriented reward service based on customer preference to motivate the use of mileage points. The intention for using mileage points is affected by various kinds of attributes such as reword items, consuming mileage points for rewards and time of usage. In this paper, we focus on evaluating customer perceived values of attributes of FFPs reward services. A conjoint analysis model is applied to get the preference value of each attribute. Some empirical experiments are conducted in relation to Korean customers. From the empirical survey, the preference values of attributes are evaluated for different scenarios with respect to the number of mileage points. With the preference values of attributes, we can find several implications for airlines regarding the development of various FFPs strategies.