조혈모세포이식 환자에서 발생한 Cytomegalovirus 질환의 특징 : 일개 대학변원에서 최근 10년간의 경험

최수미,이동건,박선희,김시현,김유진,민창기,김희제,이석,최정현,유진홍,김동욱,이종욱,민우성,신완식,김춘추 대한감염학회 2009 감염과 화학요법 Vol.41 No.1

Background : Studies on cytomegalovirus (CMV) diseases in Korean hematopoietic stem cell transplant (HSCT) recipients are lacking and do not reflect the recent trends of advances and changes. Therefore, we tried to analyze the clinical features of CMV diseases in HSCT recipients over the past 10 years at a tertiary university hospital in Korea. Methods : Retrospective review of medical records was done for all adult HSCT patients who received transplant at the Catholic HSCT Center from January 1998 to January 2008. Results : Forty-four cases (2.2%) of CMV diseases were identified. CMV pneumonia was diagnosed in 17 patients, retinitis in 16 patients, enterocolitis in 7 patients, esophagitis 1 patient, gastritis in 1 patient, duodenitis in 1 patient, and hepatitis in 1 patient. The median onset of symptom was 90 days after transplantation. Late CMV diseases accounted for 47.7%. CMV related death varied from 0 to 58.8% according to the involved organ. CMV retinitis was diagnosed relatively later in the course of transplantation mostly in patients who had chronic graft versus host disease (GVHD). On the contrary, CMV enterocolitis mainly occurred in patients who suffered from acute GVHD. The overall concurrent CMV reactivation was documented to be 63.6%: the concurrent CMV reactivation was observed only in 37.5% of patients with retinitis. Conclusions : We observed some differences in the pattern of CMV disease manifestation according to the involved organ and reconfirmed the fact that CMV pneumonia is the most common and fatal disease in HSCT recipients. Additionally, CMV retinitis was not uncommon in HSCT recipients. Since specific marker does not exist in predicting retinitis, regular ocular examination should be done thoroughly, especially in patients with chronic GVHD.

성인 지역사회 폐렴의 원인 미생물에 대한 전향적 다기관 연구 : Legionella, Leptospira, Hantaan virus and Orientia tsutsugamushi

김민자,정희진,손장욱,심희선,박대원,박승철,우준희,강재명,김유겸,신완식,김양리,이환종,김지희 대한감염학회 2001 감염 Vol.33 No.1

Background : Despite rigorous investigations, the etiology of community-acquired pneumonia remains unknown in about 50% of hospitalized patients. The diagnosis of the etiological agent is becoming more challenging and more critical as number of newer pathogens have been recognized in recent years. In the 3-year period prospective study we investigated adult patients with community-acquired pneumonia for Legionella, Leptospira, Hantaan virus and Orientia tsutsugamushi as potential etiologic agents. Methods : A prospective multicenter study was performed from May 1997 to April 2000. A total of 431 patients with community-acquired pneumonia under the inclusion criteria were examined for specific microbial diagnosis; sputum culture and PCR, and serologic teats including indirect immunofluorescence antibody (IFA) test for Legionella, and hemagglutination tests for Leptosoira, Hantaan virus and O. tsutsugamushi. Etiologic diagnosis was determined on the basis of the review of case record forms and specific laboratory diagnostic criteria. Results : During the study period a total of 385 sputum and 283 serum samples were examined. Legionella pneumonia was diagnosed in 2.3% (10/431) of the cases examined : 1.4% cases with PCR-positive (5/367) and 2.1% with positive IFA test (6/283). Leptospirosis and scrub typhus were diagnosed in 0.4% (1/252) and 2.0% (5/252), respectively. All 5 cases with scrub typhus occurred in late fall, and rash or eschar was not found. None of cases was Hantaan virus infection. Conclusion : The results suggest that Legionella, Leptospira, and O. tsutsugamushi should be considered in the etiologic diagnosis and empirical antibiotic therapy of community-acquired pneumonia. (Korean J Infect Dis 32:24∼31, 2001)

골밀도 검사에서 골다공증의 관련인자 분석

김혜완,김희상,안경회,김덕윤,이규훈,황치문 大韓再活醫學會 1999 Annals of Rehabilitation Medicine Vol.23 No.1

高校生의 100m 疾走能力 分析 硏究

李完熙 春川敎育大學 1985 論文集 Vol.25 No.-

I studies for the 100r3 running ability of the students in the High School. This study is purposed on the Surveying of the factors to be needed for the inprovement on the running record and on the materials which can be used in the fields of education, Two hundred and forty three students(boys and girls in the all grades of C. boys highschool and C. girls high school in chun cheon.) served as assubjects. They were tested and analyged during septemter, 17-22, 1984. The results are as follows ; As shown in the above 1. The boy-students were faster than the girls in average running records in each section without relating to their ages. 2. The boy-students speed average also faster than the girls in each section. 3. The total numbers of the step3 for the boys were less frequency than for girls in each section without relating to their ages. 4. The average distance per step of the boys lager than of the girls in each section without relating to their ages. 5. The speed maintenance rate of the girls, except the case of 18 years, was higher than of the boys. 6. The speed deceleration rate of the girls, except the case of 18 year3, was lower than of the boys. 7. The speed acceleration rate of the boys higher than of the girls without relating to their ages.

大學生의 100m 疾走能力 分析硏究

李完熙 春川敎育大學 1986 論文集 Vol.26 No.-

팔공산 화강암지역 지하수에 대한 지구환경화학적 연구

李基完,朴喜烈 東新大學校 1997 論文集 Vol.9 No.-

Recently, the importance of groundwater is higher as the use of groundwater for drinking, agriculture and industry sisnificantly increases. However, groundwater has been contaminated by industrial waste, domestic sewage, landfill leachate and seawater intrusion. Therefore, it is necessary to understand the chemical characteristics and water-rock interaction of groundwater for the preservation of groundwater resources. The purpose of this study is to find out the magnitude of groundwater contamination, and its water-rock interaction characteristics in granitic regions. The Cretaceous Palgongsan granitic regions are selected as the study area. The results are as follows : Groundwater is contamimated by NO_3^- in a Part (CP-3, CP-4, CP-5) of study region. K^+/Na^+ in groundwater of study legion is equivalent to 1/10 for K_2O/Na_2O of rock. Groundwater's evolution is being progressed to noncarbonate hardness tupe of Ca^2+ -HCO_3^-, continuously noncabonate alkali type of Ca^2+, Cl^-, SO_4^2-. Saturation index of aluminosilicate minerals for groundwater is dominated kaolinite. This indicates the initial evolution process of groundwater.

이온화에너지 처리 아이스크림 및 우유의 단회투여 독성시험

이희준,최현종,한선경,구본철,신명수,함준상,조철훈,이완규 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.1

본문참조

중국에서 이식한 종어 (Leiocassis longirostris Gunther)의 외부 형태 및 초기생활사

이완옥,김경환,김대희,조용철,김응오 한국어류학회 2004 韓國魚類學會誌 Vol.16 No.1

한국에서 절멸된 것으로 알려진 종어 (Leiocassis longifostris)를 국내에 복원하고, 양식대상종으로 개발하기 위하여 중국에서 도입하여 외부형태를 비교하고, 난발생 과정 및 부화자어의 형태를 연구하였다. 도입된 표본의 계수·계측형질을 국내와 중국에 알려진 문헌과 비교한 결과 큰 차이를 보이지 않았다. 중국에서 도입한 암수 한쌍의 성어에서 채란하였고, 습식법으로 수정하였다. 수정란의 크기는 2.01∼2.10 mm(n=10)이었으며, 알의 형태는 원반형이고, 난막은 무색투명하였으며, 강한 접착력이 있었다. 난황은 담황색이고 유구는 없었다. 수정 1시간 후에 배반이 완성되었고, 1시간 30분 후에 난할이 시작되었다. 수정란의 수온을 21.5∼23.0℃로 유지할 때 30∼50분 간격으로 이후 난할이 계속되었다. 수정 후 상실기는 6시간에 도달하였고, 낭배기는 20시간 20분 후에 완성되었다. 난황 표면에서 관찰되는 특이한 연동운동은 상실기에 시작되어 포배기 말기인 30% epiboly기까지 계속되었다. 수정 75시간 후에 부화에 이르렀고, 부화 직후 자어의 크기는 전장 5.91∼6.10 mm 이었다. 부화 3일 후에 입이 열리고, 수염과 부레가 완성되었으며, 전장 9.07 ∼9.37 mm까지 자랐다. 부화 15일후에는 모든 지느러미가 완성되어 후기자어기 상태이었고, 전장 14.80∼16.50 mm로 자랐으며, 부화 25일 후에는 체형, 체색 그리고 생활습성 등이 성체와 유사하고, 전장은 18.59∼22.35 mm까지 성장하였다. The Long-snout bullhead, Leiocassis longirostris, is an introduced fish from China which had become extinct in Korea. Its morphological characteristics and early life history was studied to obtain useful information required for restoration of the species and also for its utilization as an aquaculture fish. Measurements and counts of specimens introduced into Korea were included in the range of those taken from the known literature of Korea and China. Eggs were obtained by fertilization by wet method in the laboratory using one mature male and female adults of introduced L. longirostris. The fertilized eggs measured 2.01-2.10 ㎜ (n = 10) in diameter. The eggs were diskshaped and strongly adhesive, with colorless transparent membrane. The yolk was pale yellow in color with no oil globule. The blastodisc was formed in about 1 hour and cleavage started around 1 hour 30 minutes after fertilization. The cleavage intervals were about 30-50 minutes at 21.5-23℃. The morula stage was reached at 6 hours, and gastrulation was completed at 20 hours 20 min. after fertilization. Peristalsic movements of the yolk surface started at the morula stage and continued to the blastula stage (30% epiboly). Hatching occurred 75 hours after fertilization, and newly hatched larvae were 5.91-6.10 ㎜ (n = 10) in total length (TL). The mouth was open, and barbels and the air-bladder were completely formed 3 days after hatching, at 9.07-9.37 ㎜ TL. All the fin rays were completely formed and the larvae became a postlarva 15 days after hatching at 14.80-16.50 ㎜ in TL. Body shape, color pattern, and habitat behavior were similar to those in the adult at 25 days after hatching and a size of 18.59-22.35 ㎜ TL.

호중구 감소성 발열환자에게 경험적으로 투여한 Teicoplanin의 효과

이동건,임동석,최수미,박선희,유진홍,최정현,민우성,신완식,김춘추 대한감염학회 2004 감염과 화학요법 Vol.36 No.2

목적 : 호중구감소성 발열 환자에게 경험적으로 teicoplanin을 투여할 때의 효과를 알아보고자 전향적 연구를 시행하였다. 방법 : 2003년 7월부터 12월까지 가톨릭조혈모세포이식센터에 입원하여 항암치료 혹은 조혈모세포이식을 시행하고 호중구감소성 발열이 있는 환자 중 초기 항균요법에 반응이 없어 경험적 teicoplanin 투여가 필요한 49명을 대상으로 A, B 제조회사에서 제공한 teicoplanin을 무작위로 어느 한 쪽 치료군에 배정하여 투여하였다. 용량은 첫날 400㎎ 부하용량을 정맥내 bolus로 투여하고 매 24시간마다 200㎎ 유지용량을 투여하였다. 결과 : A군 27명, B군 22명이 연구에 참여하였고 대부분의 환자가 신독성이 있는 약제를 병용하고 있었다. A군 8명, B군 7명에서 그람양성균이 동정되었고, teicoplanin에 대한 내성률은 A군 22.2%, B군 28.6%로 유의한 차이는 없었다(P=1.00; 0.61<95%CI<1.95). 미생물학적 확인 감염이 있었던 환자 중 평균 53.3%에서 완치 혹은 개선의 반응이 있었고 양 군간 유의한 차이는 없었다(A군 4명 [50.0%], B군 4명 [57.1%], P=1.00; 0.29<95%CI<2.60). 미생물학적 제거율은 평균 62.5% (A군 55.6%, B군 71.4%)이었고 그 외 미생물학적 효과는 A군에서 제거 후 재발 2명(22.2%), 내성 2명(22.2%)이었고 B군에서 각각 0명(0.0%), 2명(28.6%)이었으며 양 군간 유의한 차이는 없었다(P=0.28). 발열기간(P=0.89), teicoplanin 사용기간(P=0.47) 및 전체적인 사망률(P=1.00; 0.78<95%CI<1.24)도 양 군간 유의한 차이는 없었다. 이상반응 중 신독성은 16.3% (A군 18.5%, B군 13.6%)에서 나타났고 양 군에 차이는 없었으며(P=0.72; 0.39<95%CI<3.51), 신기능 이상과 관련있는 약제를 적어도 2개 이상 병용하고 있었다. 피부발진은 A군에서 1명, B군에서 3명 발생하였다(P=0.31; 0.93<95%CI<1.34). 결론 : 호중구감소성 발열환자에게 teicoplanin을 투여하였을 때 임상적 반응률은 평균 53.3%(A군 50.5%, B군 57.1%), 미생물학적 제거율은 평균 62.5%(A군 55.6%, B군 71.4%)이었고 두 제조회사간 차이가 없었고 이상반응도 양 군간 차이가 없었다. 앞으로 국내 호중구감소증 환자에서의 teicoplanin의 적정 용량, 용법 등을 알기 위한 집단 약동학 등의 연구를 시행할 예정이다. Background : This study was done to elucidate the efficacy of teicoplanin as the empirical treatment for febrile neutropenia. Methods : Patients were randomized to two groups according to pharmaceutical company (company A or B). Total of 49 patients (A, 27; B, 22) with neutropenic fever were studied prospectively for 6 months (Jul. 2003-Dec. 2003). Patients received 400 mg i.v. once, then 200 mg i.v. once daily. Results : Groups were matched for all demographic variables. Most of the patients were concurrently receiving nephrotoxic drugs. Gram positive microorganisms were isolated in 8 patients for A and 7 patients for B. Resistance rate against teicoplanin was 22.2% in A and 28.6% in B (P=1.0; 0.61 < 95% confidence interval [Cl] < 1.95). Among the patients with microbiologically documented infection, clinical cure or improvement was seen in 4 (50%) of 8 patients for A and 4 (57.1%) of 7 patients for B (P=1.00; 0.29 <95%CI <2.60). Bacteriologic efficacy was assessed as follows; elimination in 5 (55.6%), elimination with relapse in 2 (22.2%), resistance in 2 (22.2%) out of 9 gram-positive bacteria for A and 5 (51.4%), 0 (0.0%), 2 (28.6%) out of 7 bacteria for B, respectively (P=Q.28). There were no significant differences in duration of fever, duration of use of teicoplanin, and overall mortality. The incidence of nephrotoxicity and ototoxicity was not significant. Conclusion : For using teicoplanin as the empirical therapy for febrile neutropenia, the rate of clinical, microbiological response, and nephrotoxicity was 53.3%, 62.5%, and 16.3% respectively with no significant differences between the 2 preparations of teicoplanin. Supplementary evaluation on the adequate dose and duration of teicoplanin may be required.

韓國 씨름의 育的 考察

李完熙 淸州敎育大學校 1970 論文集 Vol.6 No.-