정신분열병에 대한 Risperidone의 효과 및 안전성에 관하여

신석철,왕성근,지익성,이선우,이규광,이봉희,이진영,황선희,신용재,배경도,김정란 충남대학교 의과대학 지역사회의학연구소 1997 충남의대잡지 Vol.24 No.1

In order to evaluate the efficacy and safety of risperidone, 10 patients with chronic schizophrenia were examined for 8 weeks in a silgle-open study. After the wash-out period of 1 week, risperidone was administered. Efficacy was evaluated by means of Positive and Negative syndrome Scale for Schizophernia(PANSS) and Clinical Global Impression(CGI). Safety assessment included the Extrapyramidal Symptom Rating Scale(ESRS), vital signs, body weight, ECG, and laboratory tests. The results were as follows 1) On the PANSS total score, there was significant improvement of total score after 1 week (P<.05) of administratiom. 2) On the PANSS positive and negative subscal, there were significant improvement of posotive and negative scores after 2 weeks (P<.05) of administration. 3) On the PANSS general psychopatholgy subscals, there were significant improvement of general psychopathologyscores after 1 week (P<.05) of administratiom. 4) On the CGI, there was significant decreasement of clinical impression of severity of schizophrenia score after 2 week (P<.05) of administration. 5) A statistically significant increase in body weight (P<.05) was observed after 8 weeks of administration. 6) EPS reached the peak at the end of the 1st week of administration of risperidone (11.8± 24.25) but they were easily relieved by addition of benztropine and clonazepam. There was not significant change in laboratory tests, vital sign, ECG after 8 weeks of administration. These results suggest that Risperidone is an effective antipsychotics and clinically safe except for increased body weight in chronic schizophrenia.

HPLC/FLD를 이용한 성별·연령별 혈장 homocysteine 정상치 조사

이경옥,류광석,이규범,이경옥,류광석,이규범 대한임상검사정도관리학회 1999 臨床檢査와 精度管理 Vol.21 No.1

화학적 요부 교감신경절 차단에서 한 분절 차단과 두 분절 차단의 비교

김종일,이규종,이상곤,민병우,반종석,문철준 대한마취과학회 2001 Korean Journal of Anesthesiology Vol.41 No.4

Chemical Lumbar Sympathetic Block: Comparison of One- Versus Two-needle Techniques Chul-Jun Mun, M.D., Kyu-Jong Lee, M.D., Sang-Gon Lee, M.D., Jong-Il Kim, M.D.^* Jong-Suk Ban, M.D., and Byung-Woo Min, M.D. Department of Anesthesiology, Fatima Hospital, Daegu, Korea ^*Kim Jong Il Pain Clinic, Daegu, Korea Background: It was frequently noticed in the course of performing a two-needle sympathectomy, that satisfactory spread of contrast solution could be produced by injection through only one of the needles. This led to a closer examination of the merits of single-needle technique. Methods: Forty patients were randomized into two groups. Patients in the single-needle group (n = 20) were injected at the second or third lumbar sympathetic ganglia, while patients in the two-needle group (n = 20) were injected at the second and thired lumbar sympathetic ganglia. Lumbar sympathetic blocks were performed using 3 ml of alcohol and the spread of injectate was verified with C-arm fluoroscopy. The indicators of a successful sympathetic block are increasing skin temperature, decreasing pain, and anhidrosis in the distal extremity. Results: The duration of anhidrosis was 12.2 ?? 2.6 months (mean ?? SD) in the single-needle group versus 13.6 ?? 3.6 months (mean << SD) in the two-needle group. Conclusions: As these results were not significantly different from those obtained in patients having considered to be effective for a neurolytic ;i,bar sympathectomy. (korean J Anesthesiol 2001; 41: 439~443)

엔지오텐신이 Norepinephrine의 신혈관 반응에 미치는 영향

이석호,김종규,양훈모,민영기,임한혁 순천향의학연구소 1999 Journal of Soonchunhyang Medical Science Vol.5 No.2

To determine the effect of angiotensin Ⅱ(ANG Ⅱ)-induced hypertension on the renal hemodynamic response of norepinephrine(NE), mongrel dog instrumented for checking of renal blood flow(RBF) was followed as the step increases every 2 minutes in the rate of norepinephrine infusion into the renal artery during 5 conditions (C : control, C+PD : control+pressure decompression of aorta, ACEI : angiotensin converting enzyme inhibitor, ACEI+ANG Ⅱ : angiotensin converting enzyme inhibitor+ANG Ⅱ, ACEI+ANG Ⅱ+PD : angiotensin converting enzyme inhibitor+ANG Ⅱ+pressure decompression of aorta) Without relation of increase (C, C+PD) or decrease (ACEI+ANG Ⅱ, ACEI+ANG Ⅱ+PD) of the plasma ANG Ⅱ level when NE is infused into vessel, there were no differences in RBF response to NE infusion between C and C+PD and between ACEI+ANG Ⅱ and ACEI+ANG Ⅱ+PD, which implies that renal arterial pressure(RAP) does not play an important role in controling the renal hemodynamic response to NE. When renin angiotensin system was blocked by captopril without adding to ANG Ⅱ supply (ACEI), RBF can be severe decreased to approximately 90% at much lower rates of NE infusion than occurred when the sufficient concentration of ANG Ⅱ were present in the plasma. As the increased sensitivity of NE did not occur at lower renal arterial pressure, when ANGⅡ was present in the plasma in sufficient concentrations, it seems that protective effect on renal function is possible by ANGⅡ during renal sympathetic stimulation.

양극성 정동장애 및 정신분열증 환자군에서 성별에 따른 TRH 자극검사

이규환,신석호,백인호 大韓神經精神醫學會 1991 신경정신의학 Vol.30 No.1

This study was designed to evaluate the hypothalamic-pituitary-thyroid axis abnormalities and the possible influence of gender on the TSH response to TRH in bipolar patients and schizophrenics by using TRH stimulation test. The subjects were consisted of 34 bipolar patients(male : 14, female : 20) and 24 schizophrenics(male : 11, female : 13). The results were as follows ; 1) There was a significant difference in the baseline TSH level of female subjects before TRH administration between bipolar patients and schizophrenics. 2) The TSH levels at 60 and 90 minutes after TRH administration in female bipolar patients were significantly higher from those of female schizophrenics(P〈0.05). 3) In female subjects, the response of TSH level after TRH administration was significantly different between the two groups(P〈0.005).

유리섬유강화 복합절연재료의 열화특성에 관한 연구

이규철,유근민,김경석,박홍태 울산대학교 1996 공학연구논문집 Vol.27 No.2

본 연구에서는 주위 환경 열화에 따른 복합절연재료의 절연특성과 수명을 향상시키기 위해 고온에서 흡습량을 변화시켰을 때와 탈습량을 변화시켰을 때 흡십시료와 탈습시료의 전기적 특성 및 기계적 특성을 조사하였다. 유리섬유 각층의 흡습상수는 각각 1층에서 0.0117, 2층에서 0.0123, 3층에서 0.0152를 나타냈다. 전기적 특성 및 기계적 특성은 복합재료의 흡습에 따라 크게 떨어졌다. 70℃에서 습기가 완전히 건조되어도 흡습전의 전기적 및 기계적 특성을 얻기가 어려운 것으로 나타났다. 수분에 의해 발생한 복합절연재료내에 존재하는 많은 결함들은 에폭시 메트릭스와 필라사이에 존재하였다. The electrical and mechanical properties of moisture absorbed and moisture desorbed specimens were investigated to improve the insulating characteristics and the reliability of composite materials against environment aging. Moisture absorption constants with the layers of glass fiber showed 0.0117 in 1 layer, 0,0123 in 2 layer and 0.0152 in 3 layer, respectively. Although moisture was removed at 70℃, it was impossible to obtain the initial electrical and mechanical properties. Many defects induced by moisture were observed at the interface between epoxy matrix and filler in composite materials.

유사학과 조정 및 교양교과과정개편에 관한 연구

이종범,김규연,전지용,이춘의,홍석주 朝鮮大學校 1995 교과교육연구 Vol.17 No.-

지역전통문화의 디지털 콘텐츠와에 관한 연구

이규식,박정민,김태곤,홍석구 慶北專門大學 2003 慶北專門大學 論文集 Vol.22 No.-

It investigates the website and a technique in order to make the culture property of the area with digital contents, it presented a method to make digital contents through investigation of Young-Ju area culture property. The results of this study ① It minimizes the loss of information ② Must come to be processed with the form which corresponds in objective of information delivery ③ for the result, It is necessary to grafting on new digitizing techniques.

청소년의 스포츠활동 참가유무와 학교생활 적응에 관한 연구

이학래,김석규 漢陽大學校 體育科學硏究所 2003 體育科學 Vol.23 No.23

This study in order to make sure the relationship between adolescents sports activity and the fitness of school life, at first I examine the difference of school life's fitness according to the sport activities experience. Second, this study was to examine the effect of sport activities on the fitness of school life. To make use of Stratified Cluster Random Sampling Method, all 320students(160 participants, 160 non-participants) being in middle & high school sin Seoul presently were selected as a sampling group, the only half of whom have the experience of sports activity participation. Questions are made up of such variables as a characteristic of a home back ground, sports activity participation and the fitness of school life. Dependability and appropriateness of questions were verified through improvement of question quality, preliminary inspection, investigation of literature studies and experts' conference. Especially as a result of questions about the fitness of school life by preliminary inspection those questions showed comparatively high dependability that the price of alpha comes to be 0.637. And statistics method used for data analysis in this study are Frequencies, ANOVA. By verifying experimentally an hypothesis about the relationship between sports activity participation of adolescents and the fitness of school life, acquired results are as follows. Participation in sports activity has an effect on adolescents the fitness of school life. In general the rate of the fitness by participants group in sports activity is higher than the rate of non-participants group.

움직임 보상을 통한 움직임 기반의 디인테레이싱 기법

이성규,강석규,이동호 漢陽大學校 工學技術硏究所 2001 工學技術論文集 Vol.10 No.-

본 논문에서는 움직임 보상을 이용한 움직임 기반의 디인터레이싱 알고리즘을 제안한다. 정확한 움직임 추정을 위해 전처 리로서 EBMF(Edge Based Median Filter)를 사용하며 2 개의 같은 위상을 갖는 필드와 1개의 다른 위상을 갖는 필드를 이용한 새로운 BMA(Block Matching Algorithm) 움직임 보상 방법을 제안한다. 시간축 필터로서 모션 미싱 에러를 제거하기 위해 입력 영상의 움직임 영역에 따라 각각 다른 임계값을 적용하는 AMPDF(Adaptive Minimum Pixel Difference filter)를 적용하였으며 MMD(Maximum Motion Detection)와 SAD(Sum of Difference)를 이용하여 빠른 움직임 영역에서 화질을 향상시켰다. 최종적으로 잘못된 움직임 보상에 기인하는 화질의 열화를 방지하기 위한 후처리로서 움직임 보정 필터를 제안한다. 모의 실험을 통해 제안하는 방법이 기존의 방법에 비해 우수한 성능을 갖는 것을 확인하였다. In this paper, we propose a motion-adaptive de-interlacing method using motion compensated interpolation. In a conventional motion compensated method, a simple pre-filter such as line averaging is applied to interpolate missing lines before the motion estimation. However, this method causes interpolation error because of inaccurate motion estimation and compensation. In the proposed method, EBMF(Edge Based Median Filter) as a pre-filter is applied, and new matching method, which uses two same-parity fields and opposite-parity field as a reference, is proposed. For further improvement, motion correction filter is proposed to reduce the interpolation error caused by incorrect motion. Simulation results showed that the proposed method provides better performance than existing methods.