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손수경,한영인,김경희 고신대학교 전인간호과학연구소 2003 전인간호과학연구 학술모음집 Vol.2 No.-
Purpose. The purpose of this study was to identify the relationship between fatigue and nutritional status in patients with gastric cancer. Design. A orrelational and crossectional study design was used Method. The data was collected from July to August 2002. 59 subjects with gastric cancer were recruited K university hospital in Busan, Korea. Fatigue was measured using the Revised Piper Fatigue Scale developed by Piper et. al (1998). The parameters for nutritional status included body weight, body mass index, hemoglobin, Hct, total protein, albumin and lymphocyte count. Result. 1) The fatigue score was mean 94.31±22.08(mean average 4.48±1.00) The subdimension that showed behavior/severity score at 34.15±8.76, cognitive/mood score at 22.00±7.93, sensory score at 21.67±5.56, and affective score at 20.81±6.69. And among the parameters for nutritional starus, BMI, Hb, Hct were not included normal rage. 2) There was a significant difference in present diet(F=3.343, P= .026) according to general characteristics in the fatigue in patients with gastric cancer. 3) The disease-related characteristics such as Age, treatment type, after period diagnosis, care giver, payment were frequently related to poorer nutritional status. Subjects received chemotherapy showed lower lymphocyte level than subjects received operation, and the subjects were diagnosis less than 1 month, were showed lower Hematocrete level. 4) There was a significant negative correlation between fatigue and nutritional status(r= -.371, P=.004). Conclusion. Patients with gastric cancer experience in fatigue. Considering the relationship between fatigue and nutritional status, nurses can identify the risk group most vulnerable to fatigue and malnourishment in order to provide appropriate interventions for them
국내 다기관에서 조사한 지역사회획득 메티실린내성 황색포도알균의 빈도와 임상적 특성
송진수,최평균,송경호,조재현,김성한,방지환,이창섭,박경화,박경운,신수,최희정,김의석,김동민,이미숙,박완범,김남중,오명돈,김의종,김홍빈,최강원 대한감염학회 2006 감염과 화학요법 Vol.38 No.6
목적 : 최근 전세계적으로 지역사회획득 메티실린내성 황색포도알균(community-associated methicillin-resistant Staphylococcus aureus, CA-MRSA)의 보고가 증가하고 있다. 하지만, 우리나라에서는 CA-MRSA 감염증에 대한 증례보고만 있을 뿐 아직까지 체계적인 연구결과가 없는 실정이다. 저자들은 국내에서 CA-MRSA의 빈도, 감염증의 임상적 양상, 분리된 균주의 항균제내성 양상을 조사하였다. 재료 및 방법 : 2005년 1월부터 2005년 6월까지 7개 병원에서 MRSA가 분리된 환자의 명단을 파악한 후 의무기록지와 건강보험심사평가원의 자료를 검토하였다. 외래나 응급실에서 혹은 입원 후 72시간 이내에 균주가 분리되고 MRSA 획득과 관련된 위험인자가 없는 경우 CA-MRSA로 정의하였으며, 분리된 균주의 임상적 의미에 따라 원인병원체(pathogen), 집락화(colonizer), 미결정(undetermined)으로 분류하였다. Penicillin과 oxacillin을 제외하고 3개 이상의 다른 계열 항균제에 내성이면 다제내성으로 정의하였다. 결과 : 연구기간동안 총 3,251주의 황색포도알균이 분리되었으며, 이 중 MRSA는 1,900주(58.4%)였다. MRSA 가운데 CA-MRSA는 114주(6.0%) 였으며, 이들이 분리된 부위는 귀(62주), 비뇨기계(14주), 피부 및 연부조직(11주), 호흡기계(10주), 혈액(3주) 등이었다. CA-MRSA 균주 가운데 집락균은 22주, 원인병원체는 22주였으며, 나머지 균주에 대해서는 그 임상적 의미를 결정할 수 없었다. 항균제 감수성 검사를 시행한 73균주 중 47주(64.4%)는 다제내성이었다. CA-MRSA 감염증 22예 중 피부 및 연부조직 감염(9예)과 중이염/외이도염(9예)이 가장 흔하였다. 침습적 감염증(invasive infection)은 4명(원발성 균혈증 3예, 감염성 관절염 1예)에서 확인되었지만, CA-MRSA 감염증으로 사망한 환자는 없었다. 결론 : 병원내 감염증에서는 MRSA가 심각한 문제이지만, 아직까지 지역사회 감염증에서 CA-MRSA는 흔하지 않았다. Background : Methicillin-resistant Staphylococcus aureus (MRSA) infection has emerged in patients who do not have the established risk factors. In Korea, little is known about the epidemiology and clinical features of community-associated MRSA (CA-MRSA). Material and Methods : Clinical microbiology laboratory databases of 7 hospitals were reviewed to identify the patients from whom MRSA was isolated during the period of January to July 2005. Only one isolate per patient was enrolled. In order to identify the risk factors of MRSA acquisition, the medical records and the Health Insurance Review Agency databases were reviewed. CA-MRSA was defined as MRSA isolated from patient without established risk factors. We analyzed patient demographics, underlying medical conditions, characteristics of infection, and antimicrobial susceptibility profiles. Results : Of total 3,251 S. aureus isolates, 1900 (58.4%) were MRSAs. Of the MRSA isolates, 114 (6.0%) were CA-MRSA. Of 114 CA-MRSA isolates, 22 (19.3%) were colonizers, 22 (19.3%) were pathogens, and the clinical significance of remaining 70 (61.4%) could not be determined. Median age of the 22 patients with CA-MRSA disease was 47 years. Nine patients had skin and soft tissue infections, 9 ear infections, 3 bacteremia, 1 septic arthritis. Seven patients had underlying medical disease. None died of the CA-MRSA infections. Of the 73 isolates of CA-MRSA, 47 (64.4%) were resistant to more than 3 classes of antibiotics besides β-lactams. Conclusion : Although MRSA is highly prevalent among hospital-associated S. aureus infection, CA-MRSA infections are not common.
P202 : Role of Crif-1 in hair growth
( Sue Jeong Kim ),( Jung Min Shin ),( Dae Kyoung Choi ),( Kyung Cheol Sohn ),( Myung Im ),( Young Lee ),( Chang Deok Kim ),( Young Joon Seo ),( Jeung Hoon Lee ) 대한피부과학회 2013 대한피부과학회 학술발표대회집 Vol.65 No.2
Background: Crif-1 is a mitochondrial protein which regulates mitoribosome-mediated synthesis and insertion of mitochondrial oxidative phosphorylation (OXPHOS) polypeptides into the mitochondrial membrane in mammals. Objectives: To investigate whether Crif-1 affects hair growth. Methods: We created K15-Cre;Crif-1fl/fl conditional knockout mice. Results: Crif-1 gene was conditionally deleted out in hair follicle bulge by application of RU486. The hair growth of K15-Cre;Crif-1fl/fl conditional knockout mice was significantly inhibited compared to that of wild type littermates. Interfollicular epidermis of K15-Cre;Crif-1fl/fl conditional knockout mice was thinner and less proliferative than wild type littermates. Conclusion: These results suggest that mitochondrial dysfunction in hair bulge stem cells is important in hair growth.
Kim, Hyung-cheol,Lee, Ji-Young,Sung, Hyuna,Choi, Ji-Yeob,Park, Sue K,Lee, Kyoung-Mu,Kim, Young Jin,Go, Min Jin,Li, Lian,Cho, Yoon Shin,Park, Miey,Kim, Dong-Joon,Oh, Ji Hee,Kim, Jun-Woo,Jeon, Jae-Pil,J BioMed Central 2012 Breast cancer research Vol.14 No.2
<P><B>Introduction</B></P><P>Although approximately 25 common genetic susceptibility loci have been identified to be independently associated with breast cancer risk through genome-wide association studies (GWAS), the genetic risk variants reported to date only explain a small fraction of the heritability of breast cancer. Furthermore, GWAS-identified loci were primarily identified in women of European descent.</P><P><B>Methods</B></P><P>To evaluate previously identified loci in Korean women and to identify additional novel breast cancer susceptibility variants, we conducted a three-stage GWAS that included 6,322 cases and 5,897 controls.</P><P><B>Results</B></P><P>In the validation study using Stage I of the 2,273 cases and 2,052 controls, seven GWAS-identified loci [5q11.2/<I>MAP3K1 </I>(rs889312 and rs16886165), 5p15.2/<I>ROPN1L </I>(rs1092913), 5q12/<I>MRPS30 </I>(rs7716600), 6q25.1/<I>ESR1 </I>(rs2046210 and rs3734802), 8q24.21 (rs1562430), 10q26.13/<I>FGFR2 </I>(rs10736303), and 16q12.1/<I>TOX3 </I>(rs4784227 and rs3803662)] were significantly associated with breast cancer risk in Korean women (<I>P</I><SUB>trend </SUB>< 0.05). To identify additional genetic risk variants, we selected the most promising 17 SNPs in Stage I and replicated these SNPs in 2,052 cases and 2,169 controls (Stage II). Four SNPs were further evaluated in 1,997 cases and 1,676 controls (Stage III). SNP rs13393577 at chromosome 2q34, located in the <I>Epidermal Growth Factor Receptor 4 </I>(<I>ERBB4</I>) gene, showed a consistent association with breast cancer risk with combined odds ratios (95% CI) of 1.53 (1.37-1.70) (combined <I>P </I>for trend = 8.8 × 10<SUP>-14</SUP>).</P><P><B>Conclusions</B></P><P>This study shows that seven breast cancer susceptibility loci, which were previously identified in European and/or Chinese populations, could be directly replicated in Korean women. Furthermore, this study provides strong evidence implicating rs13393577 at 2q34 as a new risk variant for breast cancer.</P>
( Ji Sue Baik ),( Seo Won Mun ),( Kyoung Sook Kim ),( Shin Ji Park ),( Hyun Kyoung Yoon ),( Dong Hyun Kim ),( Min Kyu Park ),( Cheorl Ho Kim ),( Young Choon Lee ) 한국미생물 · 생명공학회 2016 Journal of microbiology and biotechnology Vol.26 No.2
We first demonstrated that cordycepin inhibited cell growth and triggered apoptosis in U87MG cells with wild-type p53, but not in T98G cells with mutant-type p53. Western blot data revealed that the levels of procaspase-8, -3, and Bcl-2 were downregulated in cordycepintreated U87MG cells, whereas the levels of Fas, FasL, Bak, cleaved caspase-3, -8, and cleaved PARP were upregulated, indicating that cordycepin induces apoptosis by activating the death receptor-mediated pathway in U87MG cells. Cordycepin-induced apoptosis could be suppressed by only SB203580, a p38 MAPK-specific inhibitor. These results suggest that cordycepin triggered apoptosis in U87MG cells through p38 MAPK activation and inhibition of the Akt survival pathway.
Gene Expression Profiling of Genotoxicity Induced by MNNG in TK6 Cell
Suh, Soo-Kyung,Kim, Tae-Gyun,Kim, Hyun-Ju,Koo, Ye-Mo,Lee, Woo-Sun,Jung, Ki-Kyung,Jeong, Youn-Kyoung,Kang, Jin-Seok,Kim, Joo-Hwan,Lee, Eun-Mi,Park, Sue-Nie,Kim, Seung-Hee,Jung, Hai-Kwan The Korean Society of Toxicogenomics and Toxicopro 2007 Molecular & cellular toxicology Vol.3 No.2
Genotoxic stress triggers a variety of biological responses including the transcriptional activation of genes regulating DNA repair, cell survival and cell death. In this study, we investigated to examine gene expression profiles and genotoxic response in TK6 cells treated with DNA damaging agents MNNG (N-methyl-N'-nitrosoguanidine) and hydrogen peroxide $(H_2O_2)$. We extracted total RNA in three independent experiments and hybridized cRNA probes with oligo DNA chip (Applied Biosystems Human Genome Survey Microarray). We analyzed raw signal data with R program and AVADIS software and identified a number of deregulated genes with more than 1.5 log-scale fold change and statistical significancy. We indentified 14 genes including G protein alpha 12 showing deregulation by MNNG. The deregulated genes by MNNG represent the biological pathway regarding MAP kinase signaling pathway. Hydrogen peroxide altered 188 genes including sulfiredoxins. These results show that MNNG and $H_2O_2$ have both uniquely regulated genes that provide the potential to serve as biomarkers of exposure to DNA damaging agents.
( Mi Ra Choi ),( Dae Kyoung Choi ),( Ki Duck Kim ),( Sue Jeong Kim ),( Dong Il Kim ),( Myung Im ),( Young Lee ),( Young Joon Seo ),( Chang Deok Kim ),( Jeung Hoon Lee ) 대한피부과학회 2016 Annals of Dermatology Vol.28 No.3
Background: Keratinocytes are the major cells in epidermis, providing barrier components such as cornified cells through the sophisticated differentiation process. In addition, keratinocytes exerts their role as the defense cells via activation of innate immunity. It has been known that pathogen-associated molecular patterns (PAMPs) including double-strand RNA and nucleotides can provoke inflammatory reaction in keratinocytes. Objective: The aim of this study is to evaluate the effect of Ampelopsis japonica Makino extract (AE) on PAMPs-induced inflammatory reaction of keratinocytes. Methods: The effects of AE were determined using poly (I:C)-induced inflammation and imiquimod-induced psoriasiform dermatitis models. Results: In cultured keratinocytes, AE significantly inhibited poly(I:C)-induced expression of inflammatory cytokines, such as interleukin (IL)-1β, IL-6, IL-8 and tumor necrosis factor-α. AE significantly inhibited poly(I:C)-induced release of caspase-1 active form (p20), and down-regulated nuclear factor-κB signaling pathway. In imiquimod- induced psoriasiform dermatitis model, topical application of AE resulted in significant reduction of epidermal hyperplasia. Conclusion: These results suggest that AE may be a potential candidate for the treatment of skin inflam-mation. (Ann Dermatol 28(3) 352∼359, 2016)