수술 고위험군에서 양측 내경동맥 협착증에 대한 동시 스텐트 시술

윤영섭,심원흠,편욱범,전국진,박경진,장양수,조승연 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.9

실외 환경의 렌더링을 위한 일광 표현

박영섭,윤경현 중앙대학교 정보통신연구소 1999 정보통신연구소논문집 Vol.1 No.1

일반적으로 태양광(sunlight)과 천광(skylight)은 컴퓨터 그래픽스에서 정확하게 렌더링을 하지 않는다. 그 이유는 높은 비용과 정확한 대기의 자료를 이용할 수 없기 때문이다. 컴퓨터 그래픽스에 적용할 때 간소하게 표현하기 위해서 실외환경의 하늘 색상은 파랑색으로 생각해왔었다. 그러나 실제 하늘의 색상은 파랑색이 아니다. 그 색상은 관찰자의 방향과 태양의 위치, 그리고 대기의 조건에 따라 변한다. 본 논문에서 제안되는 방법은 좀 더 정확하게 조도를 효율적으로 표현하여 내부 환경뿐만 아니라 외부 환경에서도 사실적인 이미지를 얻는데 목적이 있다. Sunlight and skylight are rarely rendered correctly in computer graphics. A major reason for this is high computational expense. Another is that precise atmospheric data is rarely available. The sky color in outdoors scenes is blue in computer graphics for the sake of simplicity. However, the color of sky is not simply blue. It changes according to viewing direction, the position of sun, and conditions of the atmosphere. This paper purposed that the method make it possible to efficiently calculate such illuminance accurately. Our goal is to get realistic image.

파킨슨씨병 환자에 있어서 자가부신수질 이식술

정상섭,박상근,오성훈,김선호,윤도흠,박정수,양우익,최인준,안영수,김경환,박창일,김진수,이현철 대한신경외과학회 1988 Journal of Korean neurosurgical society Vol.17 No.6

Recent experimental studies and clinical cases have suggested that grafting tissue from the adrenal medulla into the brain may alleviate the symptoms of Parkinson's disease. Autologous adrenal medullary grafts into the striatum was performed stereotactically in two patients with Parkinson's disease. Both patients were bedridden preoperatively, but 4 months after the surgery both became ambulatory and one was even capable of returning to his job. Even though the number of cases was small⑵ and the follow-up period was short, this study shows that adrenal medullary transplantation into the striatum may have some beneficial effects in patient with Parkinson's disease. Further experimental and clinical trials are necessary to see whether this procedure will be a recommendable surgical treatment for patients suffering from Parkinson's disease.

peat moss를 이용한 폐수중의 중금속 제거

이경화,김정섭,유현철,최성우,윤철종,우성훈,박승조 동아대학교 환경문제연구소 2001 硏究報告 Vol.24 No.1

Adsorption equilibrium of heavy metals ion on the peat moss was confirmed Frundlich isotherm Removal efficiency of heavy metals ion was increased from pH 2 to 10 and heavy metal removal efficiency was increased in the sequence of Cu(Ⅱ) > Pb(Ⅱ) > Cd(Ⅱ) > Mn(Ⅱ) on the PM(Peat Moss). The PM is likely to be more effective adsorption than the PAC to removal of metal ions in the solution, since PM's weakly acidic functional groups which is not founded on the PAC, in addition to its high surface area and porosity. But, the PM is not separated from the solution water by sedimentation process. So, a liquid and solid seperation between the PM and the solution water could be considered for the PM's field application. But peat moss was low cost adsorbent. Thus author propose to adopt PM as a adsorbent for heavy metal removal.

구속운동을 받는 외팔보의 혼돈진동

최봉문,류봉조,윤충섭,임경빈 大田産業大學校 2000 한밭대학교 논문집 Vol.17 No.1

When the motion of vibrating structure is restrained by the adjacent objects, its vibration frequencies and mode shapes are changed. In general, the vibration characteristics of the system becomes unpredictable. Although the importance of the study on this type of vibration model increases in many engineering areas, most studies conducted to date were focused to the theoretical study on dynamic responses of the structure with stops, including a few experimental works. Specially, the study on the nonlinear phenomena due to the impact between a structure and stops have been mainly performed theoretically. It is, therefore, desired to find a way to have a better understanding on the vibration characteristics caused by the impact of a structure to stops. In the paper, both numerical analyses and experiments are conducted for a fixed-free beam that is restrained by the stops at the free end. The chaotic vibration characteristics of the nonlinear motion and the dynamic response of the system are investigated and presented for various magnetic forces between stops.

동국대학경주병원에서 분리된 각종 병원성 세균 및 항생제 감수성 양상

하경임,고은하,전창호,정병욱,안우섭,김우택,배정수,어경윤 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

We investigated characteristics of bacterial infection and antimicrobial suscerptibility patterns of clinical specimens in Dong Guk University Kyong Ju Hospital from october 1991 to december 1992. The types of clinical specimens requested for culture were as follows ; pus(34.2%), urine(29.6%), sputum(25.2%), blood(9.2%), etc. The most frequently isolated organisms were E. coli(17.6%), Pseudomonas(12.7%), S. aureus(12.2%), and CNS(11.2%), orderly. Predominant organisms from pus, urine and sputum were S.aureus, E. coli and Pseudomonas. Blood culture was requested 1,244 samples from 614 patients, 91 pathogeni organisms were isolated(14.8% from patient and 7.3% from requested clinical samples). E. coli was most frequently isolated(29.7%) and Salmonella typhi was noted 8.8% from the requested samples. The patterns of isolated organisms according to departments were as follows ; E.coli and Klebsiella were frequently isolated in internal medicine and general surgery, E.coli and Pseudomas in Neurosurgery, S. aureus and Pseudomonas in orthopedic surgery. In ICU, Pseudomonas was predominatly isolated and the rate of mixed infection was also high(16.4%). Most of gram-negative bacilli revealed relatively high susceptibility to Chlorampenicol, Amikacin, Tobramycin and Carbenicillin, but Acinetobacter were only susceptible to Carbenicillin and Tetrecyclin, and Serratia were to Carbenicillin and Amikacin while Salmonella were susceptible to all tested first drugs. The proportions of multi-drug resistant bacteria were 34.9% of Acinetobacter, 21.1% of Serratia, 20.0% of Pseudomonas and 15.4% of Citrobacter but Aztreonam was highly susceptible(84∼100%) except Acinetobacter. S. aureus and CNS were susceptible to Chlorampenicol, Oxacillin, Cephalothin and Vancomycin, especially, 100% susceptible to Vancomycin. But Methicillin reistant Staphylococcus aureus were very high(49%) inspite of new constructed hospital. Pneumococcus and Streptococcus species were relatively high susceptible to all tested drugs.

Myristoleic Acid Promotes Anagen Signaling by Autophagy through Activating Wnt/β-Catenin and ERK Pathways in Dermal Papilla Cells

( Youn Kyung Choi ),( Jung-il Kang ),( Jin Won Hyun ),( Young Sang Koh ),( Ji-hoon Kang ),( Chang-gu Hyun ),( Kyung-sup Yoon ),( Kwang Sik Lee ),( Chun Mong Lee ),( Tae Yang Kim ),( Eun-sook Yoo ),( H 한국응용약물학회 2021 Biomolecules & Therapeutics(구 응용약물학회지) Vol.29 No.2

Alopecia is a distressing condition caused by the dysregulation of anagen, catagen, and telogen in the hair cycle. Dermal papilla cells (DPCs) regulate the hair cycle and play important roles in hair growth and regeneration. Myristoleic acid (MA) increases Wnt reporter activity in DPCs. However, the action mechanisms of MA on the stimulation of anagen signaling in DPCs is not known. In this study, we evaluated the effects of MA on anagen-activating signaling pathways in DPCs. MA significantly increased DPC proliferation and stimulated the G2/M phase, accompanied by increasing cyclin A, Cdc2, and cyclin B1. To elucidate the mechanism by which MA promotes DPC proliferation, we evaluated the effect of MA on autophagy and intracellular pathways. MA induced autophagosome formation by decreasing the levels of the phospho-mammalian target of rapamycin (phospho-mTOR) and increasing autophagy-related 7 (Atg7) and microtubule-associated protein 1A/1B-light chain 3II (LC3II). MA also increased the phosphorylation levels of Wnt/β-catenin proteins, such as GSK3β (Ser⁹) and β-catenin (Ser⁵⁵² and Ser⁶⁷⁵). Treatment with XAV939, an inhibitor of the Wnt/β-catenin pathway, attenuated the MA-induced increase in β-catenin nuclear translocation. Moreover, XAV939 reduced MA-induced effects on cell cycle progression, autophagy, and DPC proliferation. On the other hand, MA increased the levels of phospho (Thr²⁰²/Tyr²⁰⁴)-extracellular signal regulated kinases (ERK). MA-induced ERK phosphorylation led to changes in the expression levels of Cdc2, Atg7 and LC3II, as well as DPC proliferation. Our results suggest that MA promotes anagen signaling via autophagy and cell cycle progression by activating the Wnt/β-catenin and ERK pathways in DPCs.

갑상선 선지방종 1예

김형일,홍순원<SUP>1<.SUP>,김은경<SUP>2<.SUP>,윤종호<SUP>3<.SUP>,박정수,Hyoung-Il Kim,M.D.,Soon Won Hong,M.D.<SUP>1<.SUP>,Eun Kyung Kim,M.D.<SUP>2<.SUP>,Jong Ho Yoon,M.D.<SUP>3<.SUP> and Cheong Soo Park,M.D. 대한갑상선-내분비외과학회 2004 The Koreran journal of Endocrine Surgery Vol.4 No.1

Adenolipoma of the thyroid gland, also called thyrolipoma, is an extremely rare neoplasm characterized by encapsulated or tumorous mass of admixtures of mature adipose tissue and thyroid tissue. Only a few scattered cases have been reported in English literatures. It should be differentiated with encapsulated papillary carcinoma, follicular neoplasm and liposarcoma. We report an additional case of an adenolipoma of the thyroid gland. (Korean J Endocrine Surg 2003;4:51-54)

액와접근법을 이용한 무기하 내시경 갑상선 절제술 후 국소 부위 통증 조절 장치(On-Q^Ⓡ PainBuster^Ⓡ)와 자가 통증 조절 장치의 무작위 대조 연구에 대한 예비 자료

이경원,박찬흔,박용래,현기훈,윤지섭,Kyung-Won Lee,Chan-Heun Park,Yong-Lai Park,Ki-Hun Hyun,Ji-Sup Yoon 대한갑상선-내분비외과학회 2013 The Koreran journal of Endocrine Surgery Vol.13 No.4

Purpose: Gasless transaxillary approach to endoscopic thyroidectomy is a widely performed procedure for benign or malignant thyroid neoplasms. However, it requires wide dissection for approaching the target area. The intravenous patient-controlled analgesia (IV PCA) is an effective method for postoperative pain control and patients can use it according to their requirement. However, patients suffer from nausea, vomiting, sleep disturbance, etc. due to opioids. Pain pump ON-Q^Ⓡ PainBuster^Ⓡ (pain buster) has been used widely in various surgeries for control of postoperative localizing and wide area pain without side effects of opioid analgesia because it consists of Ropivacaine. Methods: From Aug. 2008 to Jan. 2013, Gasless transaxillary endoscopic thyroidectomy was performed in 90 patients in a single institution, who were divided into three groups, including the IV PCA, pain buster, and null groups. We compared postoperative outcomes, pain severity between groups. We recorded scores immediately, 6, 12, 24, and 48 hours after surgery following visual analog pain score (VAS), and investigated hospital stay and occurrence of events of nausea, vomiting, and complications. Results: In the IV PCA group, it was discontinued due to nausea in 36.7% of patients. No significant difference in pain severity following VAS score was observed among the three groups. However, smaller numbers of analgesia injections were required in the Pain buster group than in the other groups, and fewer patients suffered from constipation, compared with the PCA group. Conclusion: Pain buster showed even effects compared to IV PCA, with few side effects and less discomfort of patients, compared with the other groups. Therefore, pain buster was thought to be the proper method for pain control after dissection of the anterior chest wall, cervical area in order to secure an operative view for transaxillary endoscopic thyroi-dectomy.

A Theory of Interface between Polymer and Polymer Mixture

Yoon Kyung-Sup,Park Hyungsuk Korean Chemical Society 1994 Bulletin of the Korean Chemical Society Vol.15 No.1

We present a theoretical study of the non-symmetrical A/BC polymeric system. The polymer blends consist of two phases, a pure polymeric phase A on one side and a mixture of polymers B as a compatibilizer and C on the other. The adsorption of homopolymer B to the interface improves the interfacial adhesion between two phases. By employing the functional integral techniques, we derive the mean-field equations and solve them numerically to obtain the interfacial properties including the concentration profiles in the limit of infinite molecular weight for the polymers. Thecalculations of the interfacial properties are performed for typical values of the Flory X parameters and the volume fraction of polymer B in the asymptotic mixture phase. The interfacial adsorption of polymer B and the degrees of the specific interaction between the polymers play an important role in modification of the interfacial properties.