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The level of urinary aflatoxin M1 in Korean adults
Yong-Dae Kim1, Hyojin Kwon, Sun-In Moon, Sang-Yong Eom, Jung-Duk Park, Byung-Sun Choi, Seok-Joon Sohn, Young-Seoub Hong, Ho Kim, Ho-Jang Kwon, Ji-Ae Lim, Hae-Jung Yoon, Gwang-Jin Kim, Heon Kim 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.3
Competitive ELISA methods were used to measure the level of aflatoxin M1 (AFM1) from urine in 1008 Korean adults. Subjects were selected by random sampling in all areas of Korea, except Cheju-do. The recovery rate of AFM1 using this method was 105% (73-124%). The geometric mean of urinary AFM1 in all subjects was 3.43 pg/mL (3.67 ng/g creatinine). The level of AFM1 in males was statistically higher, compared with female subjects. However, the levels of AFM1 did not differ according to age. Subjects in Chungbuk-do showed the highest urinary AFM1 concentration, whereas subjects in Kyeongnam-do showed the lowest concentration. Assuming an excretion rate of 5%, this AFM1 excretion corresponds to approximately 0.1 microgram/day in Korean adults.
김정일,김병권,김정원,채창호,이철호,강동묵,김지홍,김진하,김영욱,이영하,이지호,김정호,윤형렬,유철인,정백근,장태원,김운규,윤동영,강진욱,김종은,안진홍,이동준,장준호,이광영,송혜란,최영희,이용환,조병만,최홍렬,고상백,김은아,이유진,홍영습,정갑열,김정만,김준연 大韓産業醫學會 2004 대한직업환경의학회지 Vol.16 No.1
Objective: Occupational medicine specialists in the Busan, Ulsan and Kyung-Nam areas established an area-based occupational disease surveillance system and used this system to collected case information for the purpose of preventing occupational diseases Methods: l l hospital participated in this system. The authors selected five main diseases, which were hand-arm vibration syndrome (HAVS), work-related musculoskeletal disorder (WRMSD), occupational asthma, occupational skin disease and occupational and occupational lung cancer and established their case definitions. All cases were reported on the web, and real time analysis was conducted. Results: Between April 2001 and April 2003, 192 cases of HAVS, 118 cases of WRMSD, 33 cases of occupational asthma, 17 cases of occupational skin disease and 17 cases of occupational lung cancer (for a total of 377 cases of these five main diseases) were reported. most of the HAVS cases came from shipbuilding, and 172 of them (92.7%) were associated with grinding. Of the four main types of WRMSD, carpal tunnel syndrome (CTS) was the most prevalent with 46 cases and shipbuilding was also the main industry involved (83.9%). The ergonomic risk factors involved mainly associated with the hand. In 19 (57.6%) and 4 (12.1%) cases of occupational asthma, the agents involved. The causative agents of occupational lung cancer included Cr, welding fume, PAH, Ni, etc. 10(58.8%) of the cases were diagnosed as squamous cell carcinoma and 5(29.4%) as adenoma. Conclusion: This result showed that an area-based occupational disease surveillance system might provide an effective method of evaluating the prevalence of such diseases, however the Busan, Ulsan and Kyung-Nam provinces are too large to be treated as individual areas. Therefore, the authors suggest that each province should establish its own surveillance system.
일부 지역 주민들의 모발 수은 농도와 혈중 수은 농도와의 상관성
김경연,서정욱,김병권,김유미,김록범,김대선,김정만,김춘진,홍영습,Kim, Gyeong-Yeon,Seo, Jeong-Wook,Kim, Byoung-Gwon,Kim, Yu-Mi,Kim, Rock-Bum,Kim, Dae-Seon,Kim, Jung-Man,Kim, Choon-Jin,Hong, Young-Seoub 한국환경보건학회 2013 한국환경보건학회지 Vol.39 No.2
Background: This study was carried out for the purpose of comprehensively evaluating the mercury exposure level of residents in several areas and the correlation between hair mercury concentration and blood mercury concentration. Method: One thousand one hundred ninety seven subjects were sampled from 30 sites using random assignment sampling. We performed a questionnaire survey and measured the level of total mercury in hair and blood samples from all subjects. Results: The geometric mean concentrations of hair and blood mercury in all subjects were 1.27 mg/kg [95% confidence interval (CI): 1.23-1.32 mg/kg] and 5.24 ${\mu}g/L$ [95% CI: 5.07-5.41 ${\mu}g/L$], respectively. Male (1.56 mg/kg in hair, 6.00 ${\mu}g/L$ in blood) was significantly higher than that of female (1.03 mg/kg in hair, 4.56 ${\mu}g/L$ in blood), and the concentrations were elevated as age increased up to the 50s. Education, smoking, alcohol drinking, and using of pesticides were also shown to influence mercury concentrations in hair and blood. The ratio of hair/ blood mercury concentration was 261.3. The total mercury concentration in hair was identified to be significantly related with total mercury concentration in blood (r=0.814, p<0.001). Conclusion: The geometric mean concentrations of hair and blood mercury were higher than the levels provided in international recommendations. The total mercury concentration in hair was positively correlated with the concentration in blood. The results of this study suggest that hair mercury be considered as a useful tool for the evaluation of mercury exposure.
Urinary arsenic species concentration in residents living near abandoned metal mines in South Korea
Jin-Yong Chung,Byoung-Gwon Kim,Byung-Kook Lee,Jai-Dong Moon,Joon Sakong,Man Joong Jeon,Jung-Duck Park,Byung-Sun Choi,Nam-Soo Kim,Seung-Do Yu,Jung-Wook Seo,Byeong-Jin Ye,Hyoun-Ju Lim,Young-Seoub Hong 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-
Background: Arsenic is a carcinogenic heavy metal that has a species-dependent health effects and abandoned metal mines are a source of significant arsenic exposure. Therefore, the aims of this study were to analyze urinary arsenic species and their concentration in residents living near abandoned metal mines and to monitor the environmental health effects of abandoned metal mines in Korea. Methods: This study was performed in 2014 to assess urinary arsenic excretion patterns of residents living near abandoned metal mines in South Korea. Demographic data such as gender, age, mine working history, period of residency, dietary patterns, smoking and alcohol use, and type of potable water consumed were obtaining using a questionnaire. Informed consent was also obtained from all study subjects (n = 119). Urinary arsenic species were quantified using high performance liquid chromatography (HPLC) and inductively coupled plasma mass spectrometry (ICP/MS). Results: The geometric mean of urinary arsenic (sum of dimethylarsinic acid, monomethylarsonic acid, As<SUP>3+</SUP>, and As<SUP>5+</SUP>) concentration was determined to be 131.98 μg/L (geometric mean; 95% CI, 116.72–149.23) while urinary inorganic arsenic (As<SUP>3+</SUP> and As<SUP>5+</SUP>) concentration was 0.81 μg/L (95% CI, 0.53–1.23). 66.3% (n = 79) and 21.8% (n = 26) of these samples exceeded ATSDR reference values for urinary arsenic (>100 μg/L) and inorganic arsenic (>10 μg/L), respectively. Mean urinary arsenic concentrations (geometric mean, GM) were higher in women then in men, and increased with age. Of the five regions evaluated, while four regions had inorganic arsenic concentrations less than 0. 40 μg/L, one region showed a significantly higher concentration (GM 15.48 μg/L; 95% CI, 7.51–31.91) which investigates further studies to identify etiological factors. Conclusion: We propose that the observed elevation in urinary arsenic concentration in residents living near abandoned metal mines may be due to environmental contamination from the abandoned metal mine. Trial registration: Not Applicable (We do not have health care intervention on human participants).
Jin-Yong Chung,Hyoun-Ju Lim,Young-Jin Kim,Ki-Hoon Song,Byoung-Gwon Kim,Young-Seoub Hong 환경독성보건학회 2014 환경독성보건학회지 Vol.29 No.-
Objectives : The purpose of this study was to determine a separation method for each arsenic metabolite in urine by using a high performance liquid chromatography (HPLC)- inductively coupled plasma-mass spectrometer (ICP-MS). Methods : Separation of the arsenic metabolites was conducted in urine by using a polymeric anion-exchange (Hamilton PRP X-100, 4.6 mm×150 mm, 5 μm) column on Agilent Technologies 1260 Infinity LC system coupled to Agilent Technologies 7700 series ICP/MS equipment using argon as the plasma gas. Results : All five important arsenic metabolites in urine were separated within 16 minutes in the order of arsenobetaine, arsenite, dimethylarsinate, monomethylarsonate and arsenate with detection limits ranging from 0.15 to 0.27 μg/L (40 μL injection). We used GEQUAS No. 52, the German external quality assessment scheme and standard reference material 2669, National Institute of Standard and Technology, to validate our analyses. Conclusions : The method for separation of arsenic metabolites in urine was established by using HPLC-ICP-MS. This method contributes to the evaluation of arsenic exposure, health effect assessment and other bio-monitoring studies for arsenic exposure in South Korea.
( Jin Seoub Kim ),( Hye Seon Kim ),( Hee Chul Nam ),( Pil Soo Sung ),( Si Hyun Bae ),( Jong Young Choi ),( Seung Kew Yoon ),( Jeong Won Jang ) 대한간학회 2020 춘·추계 학술대회 (KASL) Vol.2020 No.1
Aims: Telomerase reverse transcriptase (TERT) was recently identified as a gatekeeper driver gene with a fundamental role in multi-step hepatocarcinogenesis. This study aimed to investigate the tumor-promoting effects of TERT interaction gene set and genomic alterations in hepatocellular carcinoma (HCC). Methods: A total of 239 biopsy-proven HCC samples were analyzed for the study. Protein-protein interaction (PPI) networks through the STRING database were performed to establish a set of interacting genes with TERT. The expression of the selected gene set, TERT, and telomere length were examined by qRT-PCR. TERT promoter mutations were assessed using Sanger sequencing. Integration of hepatitis B virus (HBV) was examined using the NGS-based probe capture assay. The data were correlated with outcomes of HCC patients. Results: The PPI networks identified eight key TERT-interaction gene sets, such as CCT5, TUBA1B, mTOR, RPS6KB1, AKT1, WHAZ, YWHAQ, and TERT. Among these, TERT was the most significant differentially expressed gene, with its significantly higher expression in the tumor than non-tumor tissues. The high expression of TERT was correlated with tumor size and HCC stage progression. TERT expression and telomere lengths were positively correlated in patients with HBV-HCC invading portal vein. Together with telomere length, the presence of C228T, the hot spot mutation in the TERT promoter, as well as HBV integration resulted in a higher expression of TERT, with enhanced expression with the presence of both TERT promoter mutation and HBV integration. Patients with high TERT expression had significantly higher rates of recurrence and worse progression- free survival than those with low TERT expression. Conclusions: TERT gene alterations and expression are involved in hepatocarcinogenesis and the clinical outcomes of HCC, in terms of the development, recurrence, and disease progression. TERT pathway might serve as a potential therapeutic target for HCC.
Evaluation of mercury exposure level, clinical diagnosis and treatment for mercury intoxication
Byeong-Jin Ye,Byoung-Gwon Kim,Man-Joong Jeon,Se-Yeong Kim,Hawn-Cheol Kim,Tae-Won Jang,Hong-Jae Chae,Won-Jun Choi,Mi-Na Ha,Young-Seoub Hong 대한직업환경의학회 2016 대한직업환경의학회지 Vol.28 No.-
Mercury occurs in various chemical forms, and it is different to health effects according to chemical forms. In consideration of the point, the evaluation of the mercury exposure to human distinguished from occupational and environmental exposure. With strict to manage occupational exposure in factory, it is declined mercury intoxication cases by metallic and inorganic mercury inhalation to occupational exposure. It is increasing to importance in environmental exposure and public health. The focus on the health impact of exposure to mercury is more on chronic, low or moderate grade exposure—albeit a topic of great controversy—, not high concentration exposure by methylmercury, which caused Minamata disease. Recently, the issue of mercury toxicity according to the mercury exposure level, health effects as well as the determination of what mercury levels affect health are in the spotlight and under active discussion. Evaluating the health effects and Biomarker of mercury exposure and establishing diagnosis and treatment standards are very difficult. It can implement that evaluating mercury exposure level for diagnosis by a provocation test uses chelating agent and conducting to appropriate therapy according to the result. but, indications for the therapy of chelating agents with mercury exposure have not yet been fully established. The therapy to symptomatic patients with mercury poisoning is chelating agents, combination therapy with chelating agents, plasma exchange, hemodialysis, plasmapheresis. But the further evaluations are necessary for the effects and side effects with each therapy.