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      • 반복적인 급성 신부전을 유발한 호산구성 장염 1 예

        정혜진;김현태;김유선;정현걸;강윤경;문정섭 인제대학교 2011 仁濟醫學 Vol.32 No.-

        Eosinophilic gastroenteritis is a rare disorder of unknown etiology characterized by presence of gastrointestinal symptoms, eosinophilic infiltratio n of one or more parts of gastrointestinal tract without involvement of other organs and absence of parasitic infestation. The clinical presentation depends on the extents and depths of eosinophilic infiltration. Mucosal involvement may result in abdominal pain, nausea, vomiting, diarrhea and weight loss. We report a case of eosinophilic enterocolitis in a 55-year-old female presented with abdominal pain and watery diarrhea resulting in recurrent acute renal failure.

      • 운동처방 유형이 중년여성의 혈중지질 및 체지방량에 미치는 영향

        정혜윤,임달식,박후성,전용욱,김재호,노재성 朝鮮大學校 스포츠科學硏究所 2007 스포츠科學硏究 Vol.18 No.-

        This study was to examine the effects of Aerobic exercise program of body fat and mood state for women with obesity, and to apply this exercise program to the treatment and the promotion of health maintenance of obese women as a nursing intervention. Date were analysed by SPSS Win 12.0 program. Descriptive statistics used on demographic data of the participants was analysed in real number and percentage, body fat and the difference in mood state before and after the walking exercise program were analysed using the paired t-test . The results of this study were as follows: With administration of this program, so, the Aerobic exercise program showed and effect of the decrease for women with obesity and it also had an effect on the decrease of percentage of body fat for them. According to the results of this study, the walking exercise program as a nursing intervention had an effect of the body fat for women with obesity. however, the program did not prove the statistical significance for the change of mood state. Aerobic exercise program showed that effect is though fat woman's sieve local rate, Decrease that T-C keeps in mind from exercise rakeful and great kindness change to 207.8±23.2 as statistical difference that appeared, and decreased from great kindness change to shame upper HDL-C's exercise ago but keep in mind as statistical appear, Is looked that decrease that change before LDL-C's exercise keeps in mind as statistical by 138.1±20.5 appears. When see on the basis of result of something wrong continuous and regular abortion small success exercise because have middle age woman's physical strength E according to exercise form health promotion plan though to effect by Iteulgeot is considered, and decrease to note sieving amount power of a number and sieve local amount and appeared that abortion small success exercise exerts more affirmative effect.

      • 6-(3,4-디클로로페닐)아미노-7-클로로-5,8-퀴놀린디온의 항진균작용 및 안전성 평가

        윤여표,김동현,이병무,허문영,정해문,강혜영,최정아,김도희,유충규 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

        6-(3.4-Dichlorophenyl)amino-7-chloro-5.8-quinolinedione (RCK50) was tested for antifungal activities in mice systemically infected with Candida albicans. The therapeutic potential of RCK50 was also assessed in comparison with ketoconazole. RCK50 had ED_50 0.22±0.01 ㎎/㎏. Ketoconazole as a positive control had ED_50 6.00±1.70 ㎎/㎏. Intraperitoneally administered RCK50 at the ED_50 for 7 days and 14 days reduced Candida albicans colony count in the kidneys and liver. And administered RCK50 at the ED_50 for 14 days improved survival rates. The genotoxicities of RCK50 had been evaluated. RCK50 was negative in Ames test with Salmonella typhimurium and chromosomal aberration test in CHL cells. RCK50 did not show any clastogenic effect in mouse peripheral blood and was negative in mouse micronucleus assay. These results indicate that RCK50 has no genotoxic potential under these experimental conditions. Acute oral toxicity studies of RCK50 were carried out in ICR mice of both sexes. RCK50 did not show acute oral toxicities and LD_50 values were over 2.850 ㎎/㎏ in ICR mice.

      • 만성신부전 환자에서 발생한 파종결핵

        정가영,나선경,윤혜원,송하응,류정화,류동열 이화여자대학교 의과학연구소 2013 EMJ (Ewha medical journal) Vol.36 No.1

        Patients with chronic renal failure (CRF) are known to be more susceptible to tuberculosis infection due to impairment of the host defense mechanism. Although extrapulmonary tuberculosis is more prevalent in those subjects and it may induce dismal outcome, its diagnosis has been challenging since there is no specific symptoms of the disease and the clinical course is usually atypical. Herein, We report a case of disseminated tuberculosis diagnosed by ultrasound-guided liver biopsy in a 31-year-old CRF patient presenting sustained fever despite broad-spectrum antimicrobial therapy and progressive cholestatic jaundice.

      • 대학생의 생활스포츠활동 참여빈도별 대학생활적응도 연구

        정혜윤 朝鮮大學校 스포츠科學硏究所 2005 스포츠科學硏究 Vol.16 No.-

        This study examines the relationship between undergraduates' participation in life sports and their adaptation to campus life and focuses on examining the difference in their adaptation to campus life depending on sex, period and frequency of participation in life sports and their health on the assumption that their satisfaction with life by their participation in life sports have an affirmative influence on social life as well as campus life. The following conclusions were obtained through these research methods and procedures. First, adaptation of participants in life sports to campus life was higher in male undergraduates than in female undergraduates according to sex. Second, there was a significant difference in their adaptation to campus life according to frequency of participation in life sports. Third, there was a significant difference in their adaptation to campus life according to period of participation in life sports. Fourth, there was a significant difference in their adaptation to campus life according to intensity of participation in life sports. Their adaptation to campus life doesn't focus on developing their intellectual functions or acquiring techniques, but aims to make personality of assimilating and adapting themselves to society. That is, campus life must focus on achieving harmony between individual personality and environment and cultivating personality adaptable to society with socially dynamic abilities, attitudes and views ultimately for themselves and further society. Therefore, researches on the influence of undergraduates' participation in life sports on their adaptation to campus life are needed. Results of this study showed meaningful relationship between undergraduates' participation in life sports and their adaptation to campus life. However, peripheral conditions which undergraduates can take part in life or school sports activities are relatively lacking and poor. For overcoming these problems, the following policies can be suggested. First, for inducing undergraduates to participate in life sports, attempts to invite them to participate in life sports should be made through expansion and improvement of life sports facilities. And to extend their participation in life sports, components of life sports including life sports facilities, programs and coaches should be extended and improved quantitatively. Motivation of undergraduates to take part in life sports should be encouraged and its improvements are urgently required.

      • 식도암과 위암이 동시에 발생한 원발성 중복암 1예

        윤혜원,심기남,나선경,송도경,정정화,정가영 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

        Double primary cancers are two independently developed cancers in an individual. There have been some reports on double primary cancer since Billroth reported it for the first time in 1879. Double primary cancer of the stomach and esophagus has been revealed a very low incidence worldwide. The incidence of an esophageal cancer with another primary cancer is reported to be 9.5∼27%, but double primary cancers in the esophagus and stomach have been rarely reported to our knowledge. In this study, we present here a case of double primary esophageal and stomach cancer in a 66-year-old man because of progressive dysphagia.

      • 명사 분류의 개념과 원리

        윤혜정 숙명여자대학교 2003 숙명語文論集 Vol.- No.5

        This thesis is to investigate solutions of problems that existent thesaurus have. And a method of drawing up the Koean macrothesaurus is written by importing ways of a classification system from the other field. 1. A fine thesaurus can solve some problems of Natural Language Understanding with homonyms and polysemous words. Thesaurus are classified according to inclusion scope. One is macro-thesaurus and another is micro-thesaurus. On this thesis, study on a method of drawing up the macro-thesaurus. 2. This thesis suggest a method of drawing up the thesaurus that classify words by the way of Top-down at first and use the way of Bottom-up. And use facet when one classify words. 3. Kinds of hyponymy are class inclusion and whole-part inclusion, and both appear at classifying of one word because of facet. On class inclusion, hyponym would have same semantic components with hyperonym. There are hyponyrny, synonymy, and equal relation on words of the Korean macro-thesaurus. The equal relation is a relation of words that have an equal hyperonym and are classified according to equal node-label. And preferred term have to be selected on words of synonymy. An easiest word at the most situation is selected for the preferred term. 4. As classify words, multi-classification is a principle because of diverse meanings of word. The principle is a solution of problems on existent thesauruses by diverse meanings of word. But amount of multi-classification of a word is not same with amount of definitions of a word on dictionaries.

      • 足三里의 電鍼刺戟이 흰쥐의 中樞神經系에서 Interleukin-6의 活性에 미치는 影響 - 求心性 體感覺 情報傳達을 中心으로- : 求心性 體感覺 情保傳達을 중심으로

        이혜정,신형철,진수희,손양선,윤동학,임사비나 경희대학교 동서의학연구소 2001 東西醫學硏究所 論文集 Vol.2000 No.-

        Objectives : Acupuncture is expected to have somewhat like the efficacy parallel increasing activity of immune system in Western modern medicine. There, already, are many animal researches on activating effect of acupuncture for the immune system in peripheral organs. So, we carried out this experiment to see whether acupuncture has controlling effect on interleukin-6(IL-6) activity in rat's brain. Methods and Results : We had topical application of IL-6(1U-1pg, 10㎕) on brain of rat. It reduced afferent sensory transmission to the primary somatosensory(SI) cortex from periphery. Whereas, electrical stimulation(ES, 2Hz, 1.5V, 15min) of ST36(足三里) with application of IL-6 prominently activated afferent sensory transmission. ES of non-acupoint(proximal tail) with IL-6 showed suppression of afferent transmission. ES of ST36 without IL-6 application also exerted facilitation of afferent transmission to the SI cortex. Conclusions : Electoacupuncture(EA) on ST36 has noticeable influences on modulating activation of IL-6 in central nervous system, which do major role in immune system.

      • SCIESCOPUSKCI등재

        Platinum sensitive 재발성 난소암에서 Carboplatin/Paclitaxel의 효과

        장혜진,유희석,임윤경,문세희,장기홍,이정필 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

        목적 : 재발성 난소암에서 platinum 감수성을 기준으로 2차 항암요법으로 사용한 Carboplatin과 Paclitaxel의 효과를 알아보기 위하여 본 연구를 진행하였다. 연구방법 : 1998년 1월 1일부터 2003년 8월 31일까지 만 5년 8개월 간 아주대학교병원 산부인과에 재발성 난소암으로 입원한 환자 중에서 최초 수술로 난소암을 확진한 후 Cisplatin 또는 Carboplatin 등 platinum 제재가 포함된 항암치료를 받은 후 6개월 이후에 재발한 환자 29명을 대상으로 Carboplatin은 5 AUC를 그리고 Paclitaxel은 175 mg/m^(2)를 투여하였으며, 최소 3회에서 최고 16회까지 투여하였다. 치료효과의 판정은 CT, MRI, Ultrasonography등 영상진단상 암종괴의 크기가 완전히 소실되었을 경우를 완전반응(complete response)으로, 50%이상 감소되었을 경우를 부분반응(partial response)으로, 50% 미만으로 감소되었거나 20% 미만 증가하였을 경우를 불변(stable disease)으로, 그리고 20% 이상 증가되었을 경우를 진행(progressive disease)로 정의하였다. 결과 : 대상 환자에서 완전반응은 6명(21%), 부분반응은 11명(38%), 그리고 불변은 5명(17%)로 전체 반응율 (overall response rate)은 59% 그리고 임상적 유용성(clinical benefit=CR+PR+SD)은 76%이었다. 결론 : 재발성 난소암환자에서 기왕에 사용한 Platinum 제재에 민감한 환자에서는 Carboplatin과 Paclitaxel의 병행 투여가 효과적이었다. Objective : To ascertain the effect of Carboplatin and Paclitaxel combination as a second line regimen for recurrent ovarian carcinoma based on platinum sensitivity. Methods : From January 1st, 1998 through to August 31st, 2003, 29 patients were retrospectively reviewed who had previously underwent primary cytoreductive surgery and adjuvant chemotherapy with Cisplatin or Carboplatin for ovarian carcinoma, and who had later recurred during follow up. All 29 patients had recurred at least 6 months after therapy, and thereafter received second line chemotherapy consisting of Carboplatin (5 AUC) and Paclitaxel (175 mg/㎡) for a minimum of least 3 cycles and a maximum of 16 cycles. Treatment efficacy was assessed by imaging studies including Computerized tomography, Magnetic Resonance Imaging, or Ultrasonography. Complete response was determined as complete disappearance of tumor, partial response at least than 50% reduction in tumor volume, stable disease as less than 50% reduction or less than 20% increase in tumor volume, and progressive disease as more than 20% increase. Results : There was complete response in 6 (21%) patients, partial response in 11 (38%), stable disease in 5 (17%), showing an overall response rate of 59%. The clinical benefit (CR+PR+SD) was 76%. Conclusion : The combination of Carboplatin and Paclitaxel administration seems to be an effective mode of second line therapy in patients with recurrent ovarian carcinoma who had been sensitive to prior platinum based chemotherapy.

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