원위 대퇴골의 고립성 골연골종에서 발생한 속발성 연골 육종 1례 보고

정필현,황장수,강석,김용민,오형호,채동주,김종필 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

연골육종은 비교적 서서히 자라며 늦게 전이하는 악성 연골 종양으로 알려져 있다. 골 연골종에서 발생한 속발성 연골육종은 발생빈도는 드물며 타부위로의 전이가 적고 악성도가 낮은 경우가 많아 적합한 수술적 치료로서 좋은 예후를 보이는 것으로 보고되고 있다. 본 동국대학교 정형외과학 교실에서는 우측 대퇴골 원위부 골간단부에 생긴 고립성 골 연골종에서 이차적으로 발생한 연골육종을 치험한 바 문헌고찰과 함께 보고하는 바이다. A case of Secondary Chondrosarcoma Arising from Solitary Osteochondroma of the Distal Femur Department of Orthopaedic Surgery, College of Medicine, DongGuk University Phil Hyun Chung M.D., Jung Su Hwang M.D., Suk Kang M.D., Yang Mln Kim M.D., Hyung Ho Oh M.D., Dong Ju Chae M.D., Jong Pil Kim M.D. Chondrpsarcoma is a malignant cartilage-forming tumor that grows slowly and metastasis of this tumor occurs in late stage. Secondary chondrosarcomas arising from a solitary osteocartilaginous exostosis are rare and those have a better prognosis than other chondrosarcomas, and they rarely metastasize. We present our experience with a case of secondary chondrpsarcoma arising in solitary osteochondroma of distal metaphysis of right femur with clinical details.

니세틸 정(아세틸 - 엘 - 카르니틴 500mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,오인준,이용복,임동구,문재동,심영순,김은아,정현철 한국약제학회 2001 Journal of Pharmaceutical Investigation Vol.31 No.1

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetile^(TM) (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^(TM) (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07±7.98 ㎏ in body weight, were divided into two groups and a randomized 2 × 2 cross-over study was employed. After one tablet containing 500 ㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_(max) and T_(max) were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_(max) and T_(max) between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^(TM) tablet. The powers (1-β) for AUC_t and C_(max) were 94.87% and 87.17%, respectively. Minimum detectable differences (△) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_(max), respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_(max), respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^(TM) tablet is bioequivalent to Nicetile^(TM) tablet.

서울 서남부지역 노인 인구에서 비만증 유병률과 고지혈증과의 상관성

최경묵,조영직,김경오,김동림,김난희,백세현,안정천,서홍석,오동주,최동섭 대한노인병학회 2000 Annals of geriatric medicine and research Vol.4 No.3

니세틸 정(아세틸-엘-카르니틴 500 mg)에 대한 뉴로세틸 정의 생물학적 동등성

조혜영,김은아,정현철,심영순,임동구,오인준,문재동,이용복 전남대학교 약품개발연구소 2001 약품개발연구지 Vol.10 No.-

Acetyl-L-carnitine (ALC), an endogenous component of the L-carnitine family, is naturally occurring molecule synthesized from L-carnitine (LC) by carnitine acetyl transferase. ALC has been shown to improve the cognitive performance of patients suffering from dementia of the Alzheimer's type and proposed for treating Alzheimer's disease in pharmacological doses. The purpose of the present study was to evaluate the bioequivalence of two ALC tablets, Nicetiler^TM (Dong-A pharmaceutical Co., Ltd.) and Neurocetil^TM (Kyung-Dong Pharmaceutical Co., Ltd.), according to the guidelines of Korea Food and Drug Administration. Twenty six normal male volunteers, 22.80±2.76 year in age and 63.07 7.98㎏ in body weight, were divided into two groups and a randomized 2×2 cross-over study was employed. After one tablet containing 500㎎ of ALC was orally administered, blood was taken at predetermined time intervals and the concentrations of ALC in serum were determined using HPLC with fluorescence detector. Because of the presence of endogenous ALC, the calibration was performed using dialyzed serum. Pharmacokinetic parameters such as AUC_t, C_max and T_max were calculated and ANOVA was utilized for the statistical analysis of the parameters. The results showed that the differences in AUC_t, C_max and T_max between two tablets were 2.72%, -0.65% and -8.42%, respectively, when calculated against the Nicetile^TM tablet. The powers (1-β) for AUC_t and C_max were 94.87% and 87.17%, respectively. Minimum detectable differences (Δ) at α=0.05 and 1-β=0.8 were less than 20% (e.g., 15.58% and 19.16% AUC_t and C_max, respectively). The 90% confidence intervals were within ±20% (e.g., -11.84∼6.41 and -10.57∼11.88 for AUC_t and C_max, respectively). Two parameters met the criteria of KFDA for bioequivalence, indicating that Neurocetil^TM tablet is bioequivalent to Nicetile^TM tablet.

다이아몬드용 자동연마기의 성능평가

오재국,김우순,김동현 한국공작기계학회 2005 한국공작기계학회 춘계학술대회논문집 Vol.2005 No.-

The present study deals design and manufacture of automatic polishing machine that can cut diamond to have 58 facets in a brilliant cutting which has been hardly achieved by a conventional manually operating polishing machine. Upon the 3-dimensional Sarin M/C test and analysis on the diamond processed by the automatic polishing machine developed in this study its proportion and finishing turned out to be better than the diamond processed by the conventional method, by being rated as "very good".

不確實性下에서의 財務決定에 관한 硏究

吳東弦 濟州大學校 社會科學大學 社會發展硏究所 1985 社會發展硏究 Vol.1 No.-

별'에 대한 초등학교 교사와 학생들의 幼年的 槪念과 核心 信念 비교

오준형,채동현 경북대학교 사범대학 부속 중등교육연구소 2004 중등교육연구 Vol.52 No.1

This article presents the results which investigated elementary school students' and teachers' conceptions about the stars. Samples consisted of one hundred forty eight 5th-grade students, one hundred seventy four 6th-grade students, and thirty eight primary science teachers. Research method was paper-pencil test. Their responses to these questions revealed considerable apparent naive conceptions. and the study results proved that the items showing a high response rate of teachers' childhood concept also resulted in a high response rate of students' naive concept. A great of this apparent inconsistency could be explained by assuming that the students used, a naive core belief of the stars other than a target scientific concept of the stars. And, elementary school students and teachers often held a different naive core beliefs based on their other experiences rather than scientific theories. this paper was also discussed the core beliefs that elementary school students and teachers held to overcome these naive conceptions.

비장경색이 동반된 쯔쯔가무시병 1예

오종찬,이범주,장재현,원경준,박경희,김동민,박치영,정춘해 朝鮮大學校 附設 醫學硏究所 2005 The Medical Journal of Chosun University Vol.30 No.1

Tsutsugamushi disease is an acute febrile illness caused by Orientie. tsutsugsmushi. It is characterized by fever, myalgia, lymphadenopathy, and rash. And it can be easily diagnosed by characteristic eschar and serologic testing. Nearly all of the patients with tsutsugamushi disease improve with antibiotics such as doxycycline. However, the fatality rate of untreated cases is seven to ten percent. Splenic infarction is not common disease which is caused by occlusion of the main splenic artery or any of its branches. It is mainly caused by emboli that arise from cardiovascular disease, but sometimes by regional thrombosis associated with leukemia, myeloproliferative disorder, sickle cell anemia, pancreatitis, splenic torsion and septicemia. We experienced one case of tsutsugamushi disease with splenic infarction, which was improved after doxycycline treatment finished.

우리나라 製造業의 資本調達動向과 財務構造에 관한 硏究

吳東弦 제주대학 1980 논문집 Vol.12 No.2

Economic growth a nation is achieved by a continuing equipment investments in business enterprise, and then raising funds requiring in its investments can be divided into the two ways of internal financing and external finaning. Internal financing means raising funds by the self-saving of a business like retained earning reserved inside a business after the distribution of net income, such as devidends, tax payments and so on, among profits of results into business activities. External financing spells raising funds through capital markets or money markets, when a business cannot be full enough to being only the self-financing reqiring funds. This external financing can be classified into direct and inderect financing, whether intervened of financial intermediaries or not. If we look into the structure of raising funds in the department of a corporative business, we could point out that the majority depended upon external financing because the ratio of self-financing was too low. It seems that such a condition was continued since the enlargement of investments was supported by making rapid progress of external financing according to favorably proceeding the plan of economic development. Next, indrect financing holds a high ratio among external financing. Especially, long-termloans from banks in indirect financing take a much share. A supply of funds in the advanced countries has been already in charge of important roles of financial intermediators of insurance, trust, short-term financing facilities, otherwise, it makes remarkable features different from that coutry in Korea. As the stated above, Korea has achieved a high growth of economy by flourishing equipment investments of business enterprises, and gone on quantitavely increasing savings, investments and financial trade. But in regard to the contents, being relatively too large for a degree of dependance of a overseas department, investment intermediareis in a domestic department shrunk up. Finally, such a difficulty make it'strong to be possibility of being appeared on the factors of final hindrance in lasting economic growth.

우리나라 企業의 企業金融에 관한 硏究 : Laying Emphasis on the Fund Application 資本運用을 中心으로

吳東弦 제주대학교 1983 논문집 Vol.16 No.2

In general, Korean business enterprises have the poor factors that are stayed at relatively low level in efficiency of plant and equipment investment. Although it was inevitable owing to the boundary of the industrial policy of a light industry center, it was involved many problems in the process of propelling a heavy chemical industry. The typical examples bring about the unbalanced growth between the types of an industry, and also greatly decrease investment efficiency. Thus as it is lower efficiency investment of the big business centering a heavy chemical industry, it gives rise to waste of resoures and then, arises from declining investment in connection with a change for the worse of the business accounts. This investment efficiency that brings out the worse of the business accounts by unsoundness of the capital application repeats a vicious circle to the frailty of a capital structure. And also the propensity depended excessive creditor's capital is growing worse by the payability to a heavy burden of financial expenses. Besides, the loss of liguidity by a shortage of working capital appears on the primary factors obstructed the safty of business enterprises. Consequently, for solving the problems of the business fund application and achieving the long-range and continuous growth, we should make an every effort through a business by oneself as well as a government policy concern in the following. First, the drastic enlargement of the investment research development. Second, the inducement of an equivalent growth. Third, the investment for the high department of a related effect. Fourth, the central investment for a growing industry of comparative predominance.